Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM45_LEIBR

TriTrypDb:

LbrM.34.0100 , LBRM2903_340006000

Length:

674

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HM45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.456
CLV_C14_Caspase3-7	375	379	PF00656	0.339
CLV_NRD_NRD_1	18	20	PF00675	0.451
CLV_NRD_NRD_1	320	322	PF00675	0.433
CLV_NRD_NRD_1	394	396	PF00675	0.461
CLV_NRD_NRD_1	431	433	PF00675	0.356
CLV_NRD_NRD_1	504	506	PF00675	0.567
CLV_NRD_NRD_1	542	544	PF00675	0.450
CLV_NRD_NRD_1	611	613	PF00675	0.412
CLV_NRD_NRD_1	644	646	PF00675	0.519
CLV_NRD_NRD_1	657	659	PF00675	0.463
CLV_PCSK_KEX2_1	253	255	PF00082	0.615
CLV_PCSK_KEX2_1	320	322	PF00082	0.433
CLV_PCSK_KEX2_1	394	396	PF00082	0.463
CLV_PCSK_KEX2_1	431	433	PF00082	0.362
CLV_PCSK_KEX2_1	503	505	PF00082	0.574
CLV_PCSK_KEX2_1	542	544	PF00082	0.450
CLV_PCSK_KEX2_1	611	613	PF00082	0.441
CLV_PCSK_KEX2_1	646	648	PF00082	0.562
CLV_PCSK_KEX2_1	657	659	PF00082	0.444
CLV_PCSK_KEX2_1	77	79	PF00082	0.404
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.594
CLV_PCSK_PC1ET2_1	646	648	PF00082	0.639
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.483
CLV_PCSK_PC7_1	73	79	PF00082	0.426
CLV_PCSK_SKI1_1	106	110	PF00082	0.379
CLV_PCSK_SKI1_1	197	201	PF00082	0.586
CLV_PCSK_SKI1_1	303	307	PF00082	0.528
CLV_PCSK_SKI1_1	525	529	PF00082	0.481
CLV_PCSK_SKI1_1	612	616	PF00082	0.420
CLV_PCSK_SKI1_1	665	669	PF00082	0.569
CLV_Separin_Metazoa	36	40	PF03568	0.279
DEG_APCC_DBOX_1	524	532	PF00400	0.479
DEG_SCF_FBW7_2	516	523	PF00400	0.417
DOC_ANK_TNKS_1	504	511	PF00023	0.578
DOC_CDC14_PxL_1	37	45	PF14671	0.430
DOC_CKS1_1	256	261	PF01111	0.643
DOC_MAPK_DCC_7	242	252	PF00069	0.465
DOC_MAPK_gen_1	335	344	PF00069	0.644
DOC_MAPK_gen_1	627	635	PF00069	0.464
DOC_MAPK_MEF2A_6	335	344	PF00069	0.608
DOC_PP2B_LxvP_1	198	201	PF13499	0.479
DOC_PP4_FxxP_1	231	234	PF00568	0.666
DOC_USP7_MATH_1	280	284	PF00917	0.643
DOC_USP7_MATH_1	447	451	PF00917	0.468
DOC_USP7_UBL2_3	444	448	PF12436	0.482
DOC_WW_Pin1_4	205	210	PF00397	0.605
DOC_WW_Pin1_4	241	246	PF00397	0.729
DOC_WW_Pin1_4	255	260	PF00397	0.538
DOC_WW_Pin1_4	295	300	PF00397	0.606
DOC_WW_Pin1_4	516	521	PF00397	0.584
LIG_14-3-3_CanoR_1	240	245	PF00244	0.544
LIG_14-3-3_CanoR_1	303	313	PF00244	0.633
LIG_14-3-3_CanoR_1	582	589	PF00244	0.478
LIG_14-3-3_CanoR_1	60	65	PF00244	0.341
LIG_Actin_WH2_2	449	466	PF00022	0.575
LIG_CaM_NSCaTE_8	7	14	PF13499	0.455
LIG_CtBP_PxDLS_1	201	205	PF00389	0.452
LIG_eIF4E_1	87	93	PF01652	0.312
LIG_FHA_1	113	119	PF00498	0.316
LIG_FHA_1	16	22	PF00498	0.424
LIG_FHA_1	162	168	PF00498	0.473
LIG_FHA_1	193	199	PF00498	0.556
LIG_FHA_1	255	261	PF00498	0.559
LIG_FHA_2	102	108	PF00498	0.478
LIG_FHA_2	230	236	PF00498	0.533
LIG_FHA_2	25	31	PF00498	0.552
LIG_FHA_2	272	278	PF00498	0.638
LIG_FHA_2	346	352	PF00498	0.604
LIG_FHA_2	551	557	PF00498	0.344
LIG_FHA_2	61	67	PF00498	0.372
LIG_LIR_Apic_2	132	137	PF02991	0.411
LIG_LIR_Apic_2	228	234	PF02991	0.592
LIG_LIR_Gen_1	120	127	PF02991	0.447
LIG_LIR_Gen_1	144	155	PF02991	0.255
LIG_LIR_Gen_1	5	14	PF02991	0.258
LIG_LIR_Nem_3	120	124	PF02991	0.302
LIG_LIR_Nem_3	144	150	PF02991	0.404
LIG_LIR_Nem_3	5	10	PF02991	0.399
LIG_LIR_Nem_3	66	72	PF02991	0.314
LIG_LYPXL_yS_3	40	43	PF13949	0.426
LIG_Pex14_1	139	143	PF04695	0.349
LIG_PTB_Apo_2	50	57	PF02174	0.389
LIG_SH2_CRK	134	138	PF00017	0.396
LIG_SH2_CRK	97	101	PF00017	0.373
LIG_SH2_SRC	143	146	PF00017	0.408
LIG_SH2_STAP1	143	147	PF00017	0.337
LIG_SH2_STAP1	275	279	PF00017	0.479
LIG_SH2_STAT5	87	90	PF00017	0.384
LIG_SH2_STAT5	91	94	PF00017	0.333
LIG_SH3_1	172	178	PF00018	0.382
LIG_SH3_1	242	248	PF00018	0.730
LIG_SH3_1	253	259	PF00018	0.538
LIG_SH3_3	172	178	PF00018	0.548
LIG_SH3_3	230	236	PF00018	0.637
LIG_SH3_3	242	248	PF00018	0.614
LIG_SH3_3	253	259	PF00018	0.483
LIG_SUMO_SIM_par_1	151	158	PF11976	0.347
LIG_SUMO_SIM_par_1	478	484	PF11976	0.479
LIG_TRAF2_1	44	47	PF00917	0.516
LIG_TRAF2_1	536	539	PF00917	0.442
LIG_TRAF2_1	553	556	PF00917	0.348
LIG_TYR_ITIM	38	43	PF00017	0.437
LIG_TYR_ITIM	89	94	PF00017	0.313
MOD_CK1_1	112	118	PF00069	0.391
MOD_CK1_1	158	164	PF00069	0.329
MOD_CK1_1	205	211	PF00069	0.602
MOD_CK1_1	243	249	PF00069	0.711
MOD_CK1_1	311	317	PF00069	0.651
MOD_CK2_1	101	107	PF00069	0.480
MOD_CK2_1	229	235	PF00069	0.562
MOD_CK2_1	24	30	PF00069	0.552
MOD_CK2_1	271	277	PF00069	0.737
MOD_CK2_1	41	47	PF00069	0.383
MOD_CK2_1	550	556	PF00069	0.466
MOD_CK2_1	60	66	PF00069	0.481
MOD_GlcNHglycan	204	207	PF01048	0.694
MOD_GlcNHglycan	21	24	PF01048	0.585
MOD_GlcNHglycan	271	274	PF01048	0.611
MOD_GlcNHglycan	284	287	PF01048	0.654
MOD_GlcNHglycan	449	452	PF01048	0.481
MOD_GlcNHglycan	7	10	PF01048	0.320
MOD_GSK3_1	109	116	PF00069	0.362
MOD_GSK3_1	125	132	PF00069	0.508
MOD_GSK3_1	15	22	PF00069	0.337
MOD_GSK3_1	154	161	PF00069	0.428
MOD_GSK3_1	24	31	PF00069	0.446
MOD_GSK3_1	267	274	PF00069	0.683
MOD_GSK3_1	301	308	PF00069	0.572
MOD_GSK3_1	42	49	PF00069	0.455
MOD_GSK3_1	544	551	PF00069	0.367
MOD_GSK3_1	577	584	PF00069	0.358
MOD_LATS_1	265	271	PF00433	0.468
MOD_NEK2_1	109	114	PF00069	0.430
MOD_NEK2_1	127	132	PF00069	0.426
MOD_NEK2_1	155	160	PF00069	0.334
MOD_NEK2_1	193	198	PF00069	0.742
MOD_NEK2_1	229	234	PF00069	0.533
MOD_NEK2_1	305	310	PF00069	0.595
MOD_NEK2_2	101	106	PF00069	0.392
MOD_PIKK_1	173	179	PF00454	0.605
MOD_PIKK_1	388	394	PF00454	0.471
MOD_PIKK_1	550	556	PF00454	0.430
MOD_PIKK_1	577	583	PF00454	0.545
MOD_PIKK_1	634	640	PF00454	0.569
MOD_PKA_1	19	25	PF00069	0.342
MOD_PKA_1	432	438	PF00069	0.580
MOD_PKA_2	287	293	PF00069	0.668
MOD_PKA_2	388	394	PF00069	0.548
MOD_PKA_2	544	550	PF00069	0.360
MOD_PKA_2	581	587	PF00069	0.470
MOD_PKA_2	59	65	PF00069	0.328
MOD_PKA_2	82	88	PF00069	0.323
MOD_Plk_1	143	149	PF00069	0.498
MOD_Plk_1	46	52	PF00069	0.356
MOD_Plk_2-3	639	645	PF00069	0.526
MOD_Plk_4	143	149	PF00069	0.439
MOD_Plk_4	46	52	PF00069	0.469
MOD_Plk_4	511	517	PF00069	0.488
MOD_Plk_4	82	88	PF00069	0.360
MOD_ProDKin_1	205	211	PF00069	0.602
MOD_ProDKin_1	241	247	PF00069	0.728
MOD_ProDKin_1	255	261	PF00069	0.539
MOD_ProDKin_1	295	301	PF00069	0.601
MOD_ProDKin_1	516	522	PF00069	0.580
MOD_SUMO_for_1	456	459	PF00179	0.490
TRG_DiLeu_BaEn_2	119	125	PF01217	0.439
TRG_DiLeu_BaEn_2	45	51	PF01217	0.398
TRG_DiLeu_BaEn_4	458	464	PF01217	0.526
TRG_DiLeu_BaEn_4	555	561	PF01217	0.441
TRG_ENDOCYTIC_2	40	43	PF00928	0.426
TRG_ENDOCYTIC_2	91	94	PF00928	0.288
TRG_ENDOCYTIC_2	97	100	PF00928	0.344
TRG_ER_diArg_1	319	321	PF00400	0.456
TRG_ER_diArg_1	430	432	PF00400	0.362
TRG_ER_diArg_1	503	505	PF00400	0.606
TRG_ER_diArg_1	542	545	PF00400	0.515
TRG_ER_diArg_1	549	552	PF00400	0.535
TRG_ER_diArg_1	557	560	PF00400	0.449
TRG_ER_diArg_1	610	612	PF00400	0.508
TRG_ER_diArg_1	645	648	PF00400	0.558
TRG_ER_diArg_1	656	658	PF00400	0.544
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	335	339	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	572	576	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	647	652	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	665	669	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P614	Leptomonas seymouri	48%	97%
A0A0S4JK29	Bodo saltans	25%	85%
A0A1X0NJ66	Trypanosomatidae	31%	100%
A0A3R7KU75	Trypanosoma rangeli	29%	100%
A0A3S7X8L7	Leishmania donovani	74%	100%
A4IAQ7	Leishmania infantum	74%	100%
D0A2F8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AEI3	Leishmania major	74%	99%
E9B5P4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
V5BNB8	Trypanosoma cruzi	28%	100%