Putative 2-oxoisovalerate dehydrogenase beta subunit,mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative

Species:

Leishmania braziliensis

UniProt:

A4HM44_LEIBR

TriTrypDb:

LbrM.34.0090 , LBRM2903_340005800

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 8
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex	4	1
GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045239	tricarboxylic acid cycle enzyme complex	3	1
GO:0045240	dihydrolipoyl dehydrogenase complex	4	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990204	oxidoreductase complex	3	1

Expansion

Sequence features

A4HM44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM44

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007584	response to nutrient	3	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009063	amino acid catabolic process	4	1
GO:0009081	branched-chain amino acid metabolic process	4	1
GO:0009083	branched-chain amino acid catabolic process	5	1
GO:0009605	response to external stimulus	2	1
GO:0009987	cellular process	1	1
GO:0009991	response to extracellular stimulus	3	1
GO:0016054	organic acid catabolic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0031667	response to nutrient levels	4	1
GO:0042221	response to chemical	2	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046395	carboxylic acid catabolic process	5	1
GO:0050896	response to stimulus	1	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0003863	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	5	8
GO:0016491	oxidoreductase activity	2	8
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	4	8
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.527
CLV_NRD_NRD_1	267	269	PF00675	0.327
CLV_NRD_NRD_1	87	89	PF00675	0.343
CLV_PCSK_KEX2_1	2	4	PF00082	0.529
CLV_PCSK_KEX2_1	21	23	PF00082	0.390
CLV_PCSK_KEX2_1	43	45	PF00082	0.558
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.629
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.309
CLV_PCSK_SKI1_1	198	202	PF00082	0.245
CLV_PCSK_SKI1_1	2	6	PF00082	0.672
CLV_PCSK_SKI1_1	246	250	PF00082	0.222
CLV_PCSK_SKI1_1	280	284	PF00082	0.238
CLV_PCSK_SKI1_1	67	71	PF00082	0.254
DEG_Nend_UBRbox_1	1	4	PF02207	0.606
DOC_ANK_TNKS_1	239	246	PF00023	0.515
DOC_CKS1_1	158	163	PF01111	0.373
DOC_CKS1_1	338	343	PF01111	0.437
DOC_CYCLIN_yCln2_LP_2	338	344	PF00134	0.525
DOC_MAPK_gen_1	268	276	PF00069	0.530
DOC_MAPK_gen_1	295	302	PF00069	0.451
DOC_MAPK_gen_1	43	51	PF00069	0.282
DOC_MAPK_MEF2A_6	268	276	PF00069	0.495
DOC_PP2B_LxvP_1	328	331	PF13499	0.437
DOC_PP2B_LxvP_1	348	351	PF13499	0.360
DOC_PP4_FxxP_1	213	216	PF00568	0.454
DOC_PP4_FxxP_1	97	100	PF00568	0.437
DOC_USP7_MATH_1	14	18	PF00917	0.600
DOC_USP7_MATH_1	307	311	PF00917	0.451
DOC_USP7_MATH_1	359	363	PF00917	0.430
DOC_USP7_MATH_1	54	58	PF00917	0.441
DOC_USP7_UBL2_3	295	299	PF12436	0.525
DOC_WW_Pin1_4	157	162	PF00397	0.385
DOC_WW_Pin1_4	190	195	PF00397	0.440
DOC_WW_Pin1_4	337	342	PF00397	0.437
DOC_WW_Pin1_4	96	101	PF00397	0.451
LIG_14-3-3_CanoR_1	82	86	PF00244	0.437
LIG_FHA_1	231	237	PF00498	0.343
LIG_FHA_1	295	301	PF00498	0.470
LIG_FHA_1	66	72	PF00498	0.522
LIG_FHA_1	8	14	PF00498	0.567
LIG_FHA_1	82	88	PF00498	0.392
LIG_LIR_Apic_2	128	132	PF02991	0.437
LIG_LIR_Apic_2	230	235	PF02991	0.394
LIG_LIR_Gen_1	29	36	PF02991	0.602
LIG_LIR_Gen_1	322	332	PF02991	0.438
LIG_LIR_Nem_3	123	129	PF02991	0.451
LIG_LIR_Nem_3	230	234	PF02991	0.366
LIG_LIR_Nem_3	29	34	PF02991	0.574
LIG_LIR_Nem_3	322	328	PF02991	0.438
LIG_LIR_Nem_3	74	80	PF02991	0.437
LIG_PDZ_Class_2	361	366	PF00595	0.420
LIG_Pex14_2	77	81	PF04695	0.437
LIG_PTB_Apo_2	225	232	PF02174	0.465
LIG_PTB_Phospho_1	225	231	PF10480	0.469
LIG_SH2_CRK	232	236	PF00017	0.355
LIG_SH2_GRB2like	179	182	PF00017	0.385
LIG_SH2_PTP2	129	132	PF00017	0.437
LIG_SH2_STAT3	171	174	PF00017	0.437
LIG_SH2_STAT3	253	256	PF00017	0.440
LIG_SH2_STAT3	91	94	PF00017	0.447
LIG_SH2_STAT5	129	132	PF00017	0.438
LIG_SH2_STAT5	179	182	PF00017	0.469
LIG_SH2_STAT5	232	235	PF00017	0.342
LIG_SH2_STAT5	258	261	PF00017	0.525
LIG_SH2_STAT5	349	352	PF00017	0.319
LIG_SH3_3	188	194	PF00018	0.433
LIG_SUMO_SIM_anti_2	273	278	PF11976	0.437
LIG_SUMO_SIM_par_1	275	281	PF11976	0.437
LIG_SUMO_SIM_par_1	66	74	PF11976	0.525
LIG_TRAF2_1	223	226	PF00917	0.470
LIG_UBA3_1	356	361	PF00899	0.436
MOD_CK1_1	192	198	PF00069	0.444
MOD_CK1_1	99	105	PF00069	0.451
MOD_CK2_1	190	196	PF00069	0.492
MOD_CK2_1	219	225	PF00069	0.490
MOD_CK2_1	26	32	PF00069	0.511
MOD_CK2_1	316	322	PF00069	0.497
MOD_GlcNHglycan	16	19	PF01048	0.619
MOD_GlcNHglycan	162	165	PF01048	0.298
MOD_GlcNHglycan	221	224	PF01048	0.431
MOD_GlcNHglycan	309	312	PF01048	0.251
MOD_GlcNHglycan	56	59	PF01048	0.237
MOD_GlcNHglycan	7	10	PF01048	0.633
MOD_GSK3_1	22	29	PF00069	0.637
MOD_GSK3_1	290	297	PF00069	0.437
MOD_GSK3_1	61	68	PF00069	0.525
MOD_N-GLC_2	181	183	PF02516	0.173
MOD_NEK2_1	219	224	PF00069	0.492
MOD_NEK2_1	316	321	PF00069	0.469
MOD_NEK2_1	5	10	PF00069	0.593
MOD_PIKK_1	170	176	PF00454	0.437
MOD_PIKK_1	252	258	PF00454	0.469
MOD_PK_1	22	28	PF00069	0.640
MOD_PKA_2	81	87	PF00069	0.437
MOD_Plk_1	246	252	PF00069	0.437
MOD_Plk_1	65	71	PF00069	0.443
MOD_Plk_2-3	270	276	PF00069	0.437
MOD_Plk_4	246	252	PF00069	0.437
MOD_Plk_4	316	322	PF00069	0.447
MOD_Plk_4	359	365	PF00069	0.446
MOD_ProDKin_1	157	163	PF00069	0.385
MOD_ProDKin_1	190	196	PF00069	0.440
MOD_ProDKin_1	337	343	PF00069	0.437
MOD_ProDKin_1	96	102	PF00069	0.451
MOD_SUMO_rev_2	192	200	PF00179	0.437
MOD_SUMO_rev_2	209	219	PF00179	0.437
TRG_DiLeu_BaEn_1	196	201	PF01217	0.531
TRG_DiLeu_BaEn_1	66	71	PF01217	0.529
TRG_ENDOCYTIC_2	231	234	PF00928	0.373
TRG_ER_diArg_1	1	3	PF00400	0.532
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.278
TRG_Pf-PMV_PEXEL_1	287	292	PF00026	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5M5	Leptomonas seymouri	88%	100%
A0A0N0P8J5	Leptomonas seymouri	33%	100%
A0A0S4J2J6	Bodo saltans	32%	100%
A0A1X0NJN2	Trypanosomatidae	78%	99%
A0A1X0NY97	Trypanosomatidae	34%	100%
A0A3Q8IJ06	Leishmania donovani	94%	100%
A0A3S7WZ91	Leishmania donovani	32%	100%
A0A422N7P1	Trypanosoma rangeli	73%	100%
A0A422NGI4	Trypanosoma rangeli	32%	100%
A2CI50	Chlorokybus atmophyticus	36%	100%
A4HEH1	Leishmania braziliensis	33%	100%
A4I1L9	Leishmania infantum	32%	100%
A4IAQ6	Leishmania infantum	94%	100%
C9ZK62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D0A2G0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	99%
E9AEI2	Leishmania major	95%	100%
E9AXQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B5P3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
G0RYE0	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	33%	96%
O34591	Bacillus subtilis (strain 168)	38%	100%
O44451	Caenorhabditis elegans	35%	100%
O64688	Arabidopsis thaliana	31%	90%
O66113	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	33%	79%
P09061	Pseudomonas putida	47%	100%
P0A0A1	Staphylococcus aureus (strain Mu50 / ATCC 700699)	43%	100%
P0A0A2	Staphylococcus aureus (strain MW2)	43%	100%
P0A0A3	Staphylococcus aureus	43%	100%
P11177	Homo sapiens	33%	100%
P11966	Bos taurus	34%	100%
P21839	Bos taurus	54%	93%
P21874	Geobacillus stearothermophilus	43%	100%
P21882	Bacillus subtilis (strain 168)	41%	100%
P21953	Homo sapiens	55%	93%
P26269	Ascaris suum	33%	100%
P27746	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	38%	100%
P32473	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P35488	Acholeplasma laidlawii	44%	100%
P35738	Rattus norvegicus	58%	94%
P37941	Bacillus subtilis (strain 168)	42%	100%
P47515	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	39%	100%
P49432	Rattus norvegicus	33%	100%
P51266	Porphyra purpurea	38%	100%
P52904	Pisum sativum	36%	100%
P55573	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	24%	100%
P75391	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	41%	100%
P99063	Staphylococcus aureus (strain N315)	43%	100%
P9WF02	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	55%	78%
P9WIS0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	43%	100%
P9WIS1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	43%	100%
Q09171	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
Q0J0H4	Oryza sativa subsp. japonica	37%	97%
Q10G39	Oryza sativa subsp. japonica	33%	92%
Q1ACL0	Chara vulgaris	34%	100%
Q1RJX3	Rickettsia bellii (strain RML369-C)	35%	100%
Q1XDM1	Neopyropia yezoensis	38%	100%
Q2QM55	Oryza sativa subsp. japonica	33%	94%
Q32RM2	Zygnema circumcarinatum	34%	100%
Q32RS0	Staurastrum punctulatum	34%	100%
Q38799	Arabidopsis thaliana	36%	100%
Q4Q9R8	Leishmania major	32%	100%
Q4UKQ7	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	36%	100%
Q55FN7	Dictyostelium discoideum	62%	99%
Q5HGZ0	Staphylococcus aureus (strain COL)	43%	100%
Q5HQ75	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	42%	100%
Q5RE79	Pongo abelii	33%	100%
Q5SLR3	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	47%	100%
Q68XA8	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	35%	100%
Q6ABX8	Leifsonia xyli subsp. xyli (strain CTCB07)	42%	100%
Q6B8T1	Gracilaria tenuistipitata var. liui	38%	100%
Q6GAC0	Staphylococcus aureus (strain MSSA476)	43%	100%
Q6GHZ1	Staphylococcus aureus (strain MRSA252)	43%	100%
Q6P3A8	Mus musculus	58%	94%
Q6Z1G7	Oryza sativa subsp. japonica	37%	98%
Q72GU2	Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)	46%	100%
Q7K5K3	Drosophila melanogaster	34%	100%
Q85FX1	Cyanidioschyzon merolae (strain NIES-3377 / 10D)	34%	100%
Q86HX0	Dictyostelium discoideum	36%	100%
Q8CPN2	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	42%	100%
Q8MA03	Chaetosphaeridium globosum	36%	100%
Q92IS2	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	36%	100%
Q9C6Z3	Arabidopsis thaliana	32%	90%
Q9D051	Mus musculus	33%	100%
Q9I1M1	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	45%	100%
Q9LDY2	Arabidopsis thaliana	56%	100%
Q9MUR4	Mesostigma viride	34%	100%
Q9R9N4	Rhizobium meliloti (strain 1021)	36%	80%
Q9SAV3	Arabidopsis thaliana	57%	100%
Q9TLS3	Cyanidium caldarium	34%	100%
Q9ZDR3	Rickettsia prowazekii (strain Madrid E)	36%	100%
V5BIR9	Trypanosoma cruzi	75%	99%
V5DIT8	Trypanosoma cruzi	32%	100%