Phosphoinositide phospholipase C

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol-specific phospholipase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HM43_LEIBR

TriTrypDb:

LbrM.34.0080 , LBRM2903_340005700

Length:

729

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HM43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM43

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	17
GO:0007165	signal transduction	2	17
GO:0008152	metabolic process	1	17
GO:0009056	catabolic process	2	17
GO:0009987	cellular process	1	17
GO:0016042	lipid catabolic process	4	17
GO:0035556	intracellular signal transduction	3	17
GO:0044238	primary metabolic process	2	17
GO:0050789	regulation of biological process	2	17
GO:0050794	regulation of cellular process	3	17
GO:0065007	biological regulation	1	17
GO:0071704	organic substance metabolic process	2	17
GO:1901575	organic substance catabolic process	3	17
GO:0048015	phosphatidylinositol-mediated signaling	5	2
GO:0048017	inositol lipid-mediated signaling	4	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0004435	phosphatidylinositol phospholipase C activity	7	17
GO:0004620	phospholipase activity	5	17
GO:0004629	phospholipase C activity	6	17
GO:0005488	binding	1	15
GO:0005509	calcium ion binding	5	15
GO:0008081	phosphoric diester hydrolase activity	5	17
GO:0016298	lipase activity	4	17
GO:0016787	hydrolase activity	2	17
GO:0016788	hydrolase activity, acting on ester bonds	3	17
GO:0042578	phosphoric ester hydrolase activity	4	17
GO:0043167	ion binding	2	15
GO:0043169	cation binding	3	15
GO:0046872	metal ion binding	4	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.176
CLV_C14_Caspase3-7	379	383	PF00656	0.176
CLV_C14_Caspase3-7	535	539	PF00656	0.357
CLV_C14_Caspase3-7	615	619	PF00656	0.596
CLV_MEL_PAP_1	172	178	PF00089	0.306
CLV_NRD_NRD_1	129	131	PF00675	0.514
CLV_NRD_NRD_1	215	217	PF00675	0.268
CLV_NRD_NRD_1	415	417	PF00675	0.176
CLV_PCSK_KEX2_1	128	130	PF00082	0.459
CLV_PCSK_KEX2_1	215	217	PF00082	0.268
CLV_PCSK_KEX2_1	415	417	PF00082	0.176
CLV_PCSK_KEX2_1	43	45	PF00082	0.472
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.481
CLV_PCSK_SKI1_1	129	133	PF00082	0.516
CLV_PCSK_SKI1_1	328	332	PF00082	0.328
CLV_PCSK_SKI1_1	361	365	PF00082	0.425
CLV_PCSK_SKI1_1	415	419	PF00082	0.388
CLV_PCSK_SKI1_1	421	425	PF00082	0.390
CLV_PCSK_SKI1_1	43	47	PF00082	0.502
CLV_PCSK_SKI1_1	703	707	PF00082	0.442
DEG_APCC_DBOX_1	420	428	PF00400	0.364
DEG_COP1_1	634	646	PF00400	0.283
DEG_MDM2_SWIB_1	104	111	PF02201	0.472
DEG_SPOP_SBC_1	486	490	PF00917	0.391
DOC_CKS1_1	431	436	PF01111	0.287
DOC_CYCLIN_yCln2_LP_2	431	437	PF00134	0.176
DOC_MAPK_gen_1	25	33	PF00069	0.567
DOC_MAPK_gen_1	38	47	PF00069	0.457
DOC_MAPK_gen_1	415	424	PF00069	0.176
DOC_MAPK_gen_1	660	669	PF00069	0.330
DOC_MAPK_MEF2A_6	27	36	PF00069	0.426
DOC_MAPK_MEF2A_6	390	398	PF00069	0.391
DOC_MAPK_MEF2A_6	41	49	PF00069	0.467
DOC_MAPK_MEF2A_6	662	671	PF00069	0.469
DOC_PP1_RVXF_1	157	163	PF00149	0.445
DOC_PP1_RVXF_1	359	365	PF00149	0.347
DOC_SPAK_OSR1_1	236	240	PF12202	0.465
DOC_USP7_MATH_1	479	483	PF00917	0.407
DOC_USP7_MATH_1	6	10	PF00917	0.422
DOC_USP7_MATH_1	61	65	PF00917	0.392
DOC_USP7_MATH_1	673	677	PF00917	0.409
DOC_USP7_MATH_1	78	82	PF00917	0.432
DOC_USP7_MATH_2	710	716	PF00917	0.268
DOC_USP7_UBL2_3	25	29	PF12436	0.315
DOC_USP7_UBL2_3	440	444	PF12436	0.346
DOC_WW_Pin1_4	245	250	PF00397	0.462
DOC_WW_Pin1_4	295	300	PF00397	0.176
DOC_WW_Pin1_4	400	405	PF00397	0.287
DOC_WW_Pin1_4	430	435	PF00397	0.348
DOC_WW_Pin1_4	466	471	PF00397	0.489
DOC_WW_Pin1_4	47	52	PF00397	0.533
DOC_WW_Pin1_4	633	638	PF00397	0.469
LIG_14-3-3_CanoR_1	118	122	PF00244	0.455
LIG_14-3-3_CanoR_1	137	142	PF00244	0.504
LIG_14-3-3_CanoR_1	17	26	PF00244	0.602
LIG_14-3-3_CanoR_1	175	185	PF00244	0.384
LIG_14-3-3_CanoR_1	251	256	PF00244	0.554
LIG_14-3-3_CanoR_1	266	270	PF00244	0.407
LIG_14-3-3_CanoR_1	291	299	PF00244	0.362
LIG_14-3-3_CanoR_1	44	50	PF00244	0.430
LIG_Actin_WH2_2	19	37	PF00022	0.514
LIG_BIR_II_1	1	5	PF00653	0.642
LIG_BRCT_BRCA1_1	300	304	PF00533	0.331
LIG_BRCT_BRCA1_1	66	70	PF00533	0.500
LIG_deltaCOP1_diTrp_1	384	392	PF00928	0.244
LIG_DLG_GKlike_1	251	258	PF00625	0.376
LIG_FHA_1	220	226	PF00498	0.593
LIG_FHA_1	271	277	PF00498	0.446
LIG_FHA_1	357	363	PF00498	0.328
LIG_FHA_1	467	473	PF00498	0.552
LIG_FHA_1	522	528	PF00498	0.314
LIG_FHA_1	600	606	PF00498	0.402
LIG_FHA_1	638	644	PF00498	0.474
LIG_FHA_1	662	668	PF00498	0.385
LIG_FHA_1	683	689	PF00498	0.406
LIG_FHA_2	112	118	PF00498	0.415
LIG_FHA_2	177	183	PF00498	0.380
LIG_FHA_2	228	234	PF00498	0.440
LIG_FHA_2	368	374	PF00498	0.391
LIG_FHA_2	400	406	PF00498	0.385
LIG_FHA_2	471	477	PF00498	0.420
LIG_FHA_2	533	539	PF00498	0.391
LIG_FHA_2	613	619	PF00498	0.393
LIG_LIR_Apic_2	341	346	PF02991	0.371
LIG_LIR_Gen_1	107	116	PF02991	0.448
LIG_LIR_Gen_1	119	125	PF02991	0.437
LIG_LIR_Gen_1	161	169	PF02991	0.488
LIG_LIR_Gen_1	179	185	PF02991	0.366
LIG_LIR_Gen_1	200	208	PF02991	0.440
LIG_LIR_Gen_1	232	240	PF02991	0.468
LIG_LIR_Gen_1	67	78	PF02991	0.483
LIG_LIR_Gen_1	695	705	PF02991	0.355
LIG_LIR_Nem_3	107	111	PF02991	0.408
LIG_LIR_Nem_3	119	124	PF02991	0.352
LIG_LIR_Nem_3	161	165	PF02991	0.366
LIG_LIR_Nem_3	179	184	PF02991	0.373
LIG_LIR_Nem_3	200	204	PF02991	0.426
LIG_LIR_Nem_3	232	237	PF02991	0.429
LIG_LIR_Nem_3	254	259	PF02991	0.488
LIG_LIR_Nem_3	325	330	PF02991	0.331
LIG_LIR_Nem_3	391	395	PF02991	0.348
LIG_LIR_Nem_3	721	725	PF02991	0.277
LIG_MLH1_MIPbox_1	300	304	PF16413	0.331
LIG_PCNA_yPIPBox_3	137	149	PF02747	0.408
LIG_PCNA_yPIPBox_3	35	46	PF02747	0.325
LIG_Pex14_2	104	108	PF04695	0.436
LIG_Pex14_2	181	185	PF04695	0.424
LIG_Pex14_2	201	205	PF04695	0.365
LIG_Pex14_2	70	74	PF04695	0.379
LIG_Pex14_2	94	98	PF04695	0.529
LIG_RPA_C_Fungi	142	154	PF08784	0.296
LIG_SH2_GRB2like	207	210	PF00017	0.441
LIG_SH2_NCK_1	432	436	PF00017	0.178
LIG_SH2_SRC	503	506	PF00017	0.287
LIG_SH2_SRC	58	61	PF00017	0.494
LIG_SH2_STAT3	218	221	PF00017	0.383
LIG_SH2_STAT3	374	377	PF00017	0.336
LIG_SH2_STAT3	96	99	PF00017	0.441
LIG_SH2_STAT5	207	210	PF00017	0.480
LIG_SH2_STAT5	303	306	PF00017	0.320
LIG_SH2_STAT5	312	315	PF00017	0.300
LIG_SH2_STAT5	432	435	PF00017	0.382
LIG_SH2_STAT5	503	506	PF00017	0.402
LIG_SH2_STAT5	582	585	PF00017	0.345
LIG_SH2_STAT5	588	591	PF00017	0.378
LIG_SH2_STAT5	642	645	PF00017	0.287
LIG_SH2_STAT5	96	99	PF00017	0.424
LIG_SH3_3	580	586	PF00018	0.357
LIG_SUMO_SIM_par_1	391	397	PF11976	0.332
LIG_SUMO_SIM_par_1	45	50	PF11976	0.358
LIG_SUMO_SIM_par_1	473	478	PF11976	0.508
LIG_TRAF2_1	230	233	PF00917	0.463
LIG_TRFH_1	275	279	PF08558	0.500
LIG_TRFH_1	582	586	PF08558	0.347
LIG_UBA3_1	33	41	PF00899	0.364
LIG_UBA3_1	716	723	PF00899	0.225
MOD_CDK_SPxK_1	245	251	PF00069	0.449
MOD_CK1_1	11	17	PF00069	0.569
MOD_CK1_1	220	226	PF00069	0.346
MOD_CK1_1	227	233	PF00069	0.312
MOD_CK1_1	295	301	PF00069	0.347
MOD_CK1_1	308	314	PF00069	0.322
MOD_CK1_1	320	326	PF00069	0.328
MOD_CK1_1	383	389	PF00069	0.361
MOD_CK1_1	430	436	PF00069	0.391
MOD_CK1_1	482	488	PF00069	0.433
MOD_CK1_1	594	600	PF00069	0.280
MOD_CK1_1	64	70	PF00069	0.385
MOD_CK1_1	721	727	PF00069	0.338
MOD_CK2_1	111	117	PF00069	0.426
MOD_CK2_1	15	21	PF00069	0.486
MOD_CK2_1	158	164	PF00069	0.433
MOD_CK2_1	174	180	PF00069	0.475
MOD_CK2_1	227	233	PF00069	0.418
MOD_CK2_1	280	286	PF00069	0.531
MOD_CK2_1	399	405	PF00069	0.364
MOD_CK2_1	499	505	PF00069	0.326
MOD_CK2_1	633	639	PF00069	0.371
MOD_Cter_Amidation	213	216	PF01082	0.262
MOD_GlcNHglycan	176	179	PF01048	0.431
MOD_GlcNHglycan	226	229	PF01048	0.359
MOD_GlcNHglycan	460	463	PF01048	0.623
MOD_GlcNHglycan	476	480	PF01048	0.480
MOD_GlcNHglycan	593	596	PF01048	0.557
MOD_GlcNHglycan	706	709	PF01048	0.526
MOD_GSK3_1	11	18	PF00069	0.594
MOD_GSK3_1	133	140	PF00069	0.499
MOD_GSK3_1	220	227	PF00069	0.524
MOD_GSK3_1	257	264	PF00069	0.472
MOD_GSK3_1	304	311	PF00069	0.338
MOD_GSK3_1	376	383	PF00069	0.222
MOD_GSK3_1	400	407	PF00069	0.427
MOD_GSK3_1	466	473	PF00069	0.674
MOD_GSK3_1	475	482	PF00069	0.397
MOD_GSK3_1	521	528	PF00069	0.356
MOD_GSK3_1	532	539	PF00069	0.383
MOD_GSK3_1	59	66	PF00069	0.479
MOD_GSK3_1	608	615	PF00069	0.547
MOD_GSK3_1	633	640	PF00069	0.446
MOD_GSK3_1	721	728	PF00069	0.458
MOD_N-GLC_1	141	146	PF02516	0.524
MOD_N-GLC_1	305	310	PF02516	0.391
MOD_N-GLC_1	380	385	PF02516	0.176
MOD_NEK2_1	104	109	PF00069	0.505
MOD_NEK2_1	116	121	PF00069	0.459
MOD_NEK2_1	133	138	PF00069	0.387
MOD_NEK2_1	168	173	PF00069	0.350
MOD_NEK2_1	304	309	PF00069	0.356
MOD_NEK2_1	34	39	PF00069	0.489
MOD_NEK2_1	422	427	PF00069	0.371
MOD_NEK2_1	475	480	PF00069	0.324
MOD_NEK2_1	527	532	PF00069	0.257
MOD_NEK2_1	667	672	PF00069	0.280
MOD_NEK2_2	718	723	PF00069	0.341
MOD_OFUCOSY	188	195	PF10250	0.371
MOD_PIKK_1	217	223	PF00454	0.513
MOD_PIKK_1	317	323	PF00454	0.271
MOD_PIKK_1	405	411	PF00454	0.295
MOD_PIKK_1	99	105	PF00454	0.568
MOD_PK_1	147	153	PF00069	0.284
MOD_PKA_2	117	123	PF00069	0.456
MOD_PKA_2	174	180	PF00069	0.496
MOD_PKA_2	265	271	PF00069	0.494
MOD_PKA_2	290	296	PF00069	0.377
MOD_PKA_2	34	40	PF00069	0.524
MOD_PKA_2	673	679	PF00069	0.302
MOD_Plk_1	11	17	PF00069	0.571
MOD_Plk_1	116	122	PF00069	0.462
MOD_Plk_1	133	139	PF00069	0.534
MOD_Plk_1	141	147	PF00069	0.528
MOD_Plk_1	163	169	PF00069	0.489
MOD_Plk_1	232	238	PF00069	0.445
MOD_Plk_1	383	389	PF00069	0.193
MOD_Plk_1	427	433	PF00069	0.303
MOD_Plk_1	638	644	PF00069	0.367
MOD_Plk_4	117	123	PF00069	0.462
MOD_Plk_4	168	174	PF00069	0.380
MOD_Plk_4	251	257	PF00069	0.468
MOD_Plk_4	280	286	PF00069	0.497
MOD_Plk_4	308	314	PF00069	0.328
MOD_Plk_4	322	328	PF00069	0.328
MOD_Plk_4	427	433	PF00069	0.276
MOD_Plk_4	499	505	PF00069	0.403
MOD_Plk_4	638	644	PF00069	0.461
MOD_Plk_4	64	70	PF00069	0.422
MOD_Plk_4	667	673	PF00069	0.400
MOD_Plk_4	712	718	PF00069	0.448
MOD_ProDKin_1	245	251	PF00069	0.458
MOD_ProDKin_1	295	301	PF00069	0.176
MOD_ProDKin_1	400	406	PF00069	0.287
MOD_ProDKin_1	430	436	PF00069	0.348
MOD_ProDKin_1	466	472	PF00069	0.486
MOD_ProDKin_1	47	53	PF00069	0.538
MOD_ProDKin_1	633	639	PF00069	0.466
MOD_SUMO_rev_2	453	458	PF00179	0.559
TRG_DiLeu_BaEn_1	164	169	PF01217	0.460
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.337
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.503
TRG_DiLeu_BaLyEn_6	603	608	PF01217	0.313
TRG_ENDOCYTIC_2	148	151	PF00928	0.416
TRG_ENDOCYTIC_2	198	201	PF00928	0.393
TRG_ENDOCYTIC_2	327	330	PF00928	0.406
TRG_ENDOCYTIC_2	542	545	PF00928	0.323
TRG_ENDOCYTIC_2	697	700	PF00928	0.413
TRG_ER_diArg_1	128	130	PF00400	0.476
TRG_ER_diArg_1	215	217	PF00400	0.268
TRG_ER_diArg_1	414	416	PF00400	0.176
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	369	373	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1N0	Leptomonas seymouri	31%	99%
A0A0N1IKD7	Leptomonas seymouri	61%	97%
A0A0S4ITT3	Bodo saltans	31%	84%
A0A0S4J9Y4	Bodo saltans	32%	100%
A0A0S4JUS2	Bodo saltans	32%	100%
A0A1X0P2K1	Trypanosomatidae	33%	99%
A0A3Q8IF05	Leishmania donovani	32%	99%
A0A3S7X8U7	Leishmania donovani	79%	100%
A0A422N571	Trypanosoma rangeli	35%	100%
A4HCK9	Leishmania braziliensis	32%	100%
A4I027	Leishmania infantum	33%	93%
A4I5X4	Leishmania infantum	32%	99%
A4IAQ5	Leishmania infantum	79%	100%
A5D6R3	Danio rerio	29%	93%
E9AEI1	Leishmania major	79%	100%
E9B168	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	99%
E9B5P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
P10688	Rattus norvegicus	32%	96%
P40977	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	81%
P51178	Homo sapiens	30%	96%
Q15111	Homo sapiens	29%	67%
Q1RML2	Bos taurus	27%	100%
Q2VRL0	Gallus gallus	31%	100%
Q32NH8	Xenopus laevis	30%	96%
Q39032	Arabidopsis thaliana	27%	100%
Q3USB7	Mus musculus	29%	67%
Q4Q6Z7	Leishmania major	33%	100%
Q4QBH9	Leishmania major	31%	100%
Q56W08	Arabidopsis thaliana	29%	100%
Q5FX52	Rattus norvegicus	27%	100%
Q5RET0	Pongo abelii	30%	96%
Q62688	Rattus norvegicus	29%	67%
Q62711	Rattus norvegicus	31%	94%
Q7YRU3	Sus scrofa	27%	100%
Q86YW0	Homo sapiens	28%	100%
Q8GV43	Arabidopsis thaliana	28%	100%
Q8K2J0	Mus musculus	31%	93%
Q8K4D7	Mus musculus	29%	100%
Q8N3E9	Homo sapiens	32%	92%
Q8R3B1	Mus musculus	31%	96%
Q944C2	Arabidopsis thaliana	27%	100%
Q9BRC7	Homo sapiens	31%	96%