Pyruvate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Pyruvate kinase

Gene product:

pyruvate kinase, putative (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HM42_LEIBR

TriTrypDb:

LbrM.34.0070 , LBRM2903_340005600

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HM42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM42

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0000287	magnesium ion binding	5	2
GO:0003824	catalytic activity	1	2
GO:0004743	pyruvate kinase activity	5	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0030955	potassium ion binding	6	2
GO:0031420	alkali metal ion binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	8	12	PF00656	0.674
CLV_NRD_NRD_1	217	219	PF00675	0.620
CLV_PCSK_SKI1_1	96	100	PF00082	0.621
DOC_MAPK_gen_1	23	33	PF00069	0.661
DOC_MAPK_MEF2A_6	207	216	PF00069	0.808
DOC_MAPK_MEF2A_6	26	35	PF00069	0.657
DOC_MAPK_NFAT4_5	207	215	PF00069	0.700
DOC_WW_Pin1_4	102	107	PF00397	0.821
DOC_WW_Pin1_4	18	23	PF00397	0.680
LIG_14-3-3_CanoR_1	159	165	PF00244	0.700
LIG_14-3-3_CanoR_1	166	176	PF00244	0.612
LIG_14-3-3_CanoR_1	50	56	PF00244	0.500
LIG_14-3-3_CanoR_1	75	81	PF00244	0.835
LIG_14-3-3_CterR_2	218	220	PF00244	0.705
LIG_FHA_1	107	113	PF00498	0.823
LIG_FHA_1	123	129	PF00498	0.566
LIG_FHA_1	136	142	PF00498	0.537
LIG_FHA_1	146	152	PF00498	0.575
LIG_FHA_1	206	212	PF00498	0.700
LIG_FHA_1	55	61	PF00498	0.600
LIG_FHA_1	65	71	PF00498	0.425
LIG_FHA_1	76	82	PF00498	0.693
LIG_LIR_Gen_1	43	53	PF02991	0.627
LIG_LIR_Nem_3	127	132	PF02991	0.772
LIG_LIR_Nem_3	43	49	PF02991	0.627
LIG_Pex14_2	100	104	PF04695	0.820
LIG_SH2_STAT5	115	118	PF00017	0.804
LIG_SH2_STAT5	37	40	PF00017	0.650
LIG_SUMO_SIM_anti_2	54	61	PF11976	0.600
LIG_SUMO_SIM_par_1	124	130	PF11976	0.769
LIG_SUMO_SIM_par_1	56	61	PF11976	0.600
MOD_CDK_SPK_2	18	23	PF00069	0.680
MOD_CK1_1	102	108	PF00069	0.820
MOD_CK1_1	113	119	PF00069	0.668
MOD_CK1_1	147	153	PF00069	0.700
MOD_CK1_1	160	166	PF00069	0.537
MOD_CK1_1	170	176	PF00069	0.575
MOD_CK1_1	41	47	PF00069	0.628
MOD_CK1_1	54	60	PF00069	0.372
MOD_CK2_1	124	130	PF00069	0.769
MOD_GlcNHglycan	159	162	PF01048	0.500
MOD_GSK3_1	102	109	PF00069	0.820
MOD_GSK3_1	140	147	PF00069	0.700
MOD_GSK3_1	54	61	PF00069	0.600
MOD_N-GLC_1	122	127	PF02516	0.560
MOD_N-GLC_1	167	172	PF02516	0.500
MOD_N-GLC_1	39	44	PF02516	0.831
MOD_NEK2_1	124	129	PF00069	0.769
MOD_NEK2_1	157	162	PF00069	0.700
MOD_NEK2_1	167	172	PF00069	0.575
MOD_NEK2_1	58	63	PF00069	0.600
MOD_NEK2_1	99	104	PF00069	0.822
MOD_NEK2_2	110	115	PF00069	0.829
MOD_PIKK_1	104	110	PF00454	0.819
MOD_PIKK_1	115	121	PF00454	0.645
MOD_PIKK_1	145	151	PF00454	0.700
MOD_PKA_2	135	141	PF00069	0.700
MOD_PKA_2	74	80	PF00069	0.837
MOD_Plk_1	122	128	PF00069	0.763
MOD_Plk_4	110	116	PF00069	0.828
MOD_Plk_4	124	130	PF00069	0.594
MOD_Plk_4	41	47	PF00069	0.628
MOD_Plk_4	51	57	PF00069	0.375
MOD_Plk_4	58	64	PF00069	0.302
MOD_ProDKin_1	102	108	PF00069	0.820
MOD_ProDKin_1	18	24	PF00069	0.680
TRG_NES_CRM1_1	205	217	PF08389	0.700

Homologs


Protein	Taxonomy	Sequence identity	Coverage
B0B7Q0	CHLT2	54%	45%
B8BJ39	ORYSI	43%	42%
B8BM17	ORYSI	44%	42%
O08309	CLOAB	44%	47%
O44006	EIMTE	52%	41%
O51323	BORBU	42%	46%
O62619	DROME	56%	41%
O65595	ARATH	61%	44%
O94122	AGABI	48%	41%
P00548	CHICK	54%	42%
P00549	YEAST	49%	44%
P0AD61	ECOLI	52%	47%
P0AD62	ECO57	52%	47%
P0CE21	CHLTR	54%	45%
P11974	RABIT	55%	41%
P11979	FELCA	55%	41%
P11980	RAT	54%	41%
P12928	RAT	53%	38%
P14618	HUMAN	55%	41%
P19680	SPICI	46%	100%
P21599	ECOLI	49%	46%
P22200	SOLTU	58%	43%
P22360	EMENI	60%	42%
P30613	HUMAN	57%	38%
P30614	YARLI	54%	43%
P30615	TRYBB	83%	44%
P30616	TRYBB	83%	44%
P31865	HYPJE	66%	41%
P32044	THEAC	36%	40%
P34038	LACDE	47%	37%
P43924	HAEIN	47%	46%
P46614	CANAL	54%	44%
P47458	MYCGE	39%	43%
P51181	BACLI	62%	38%
P51182	SPOPS	54%	38%
P52480	MOUSE	54%	41%
P52489	YEAST	48%	43%
P53657	MOUSE	56%	38%
P57404	BUCAI	45%	46%
P70789	AGRVI	41%	46%
P73534	SYNY3	52%	37%
P77983	SALTY	52%	47%
P78031	MYCPN	33%	43%
P80885	BACSU	60%	38%
P94939	MYCIT	43%	47%
P9WKE4	MYCTO	40%	47%
P9WKE5	MYCTU	40%	47%
Q02499	GEOSE	60%	37%
Q04668	LEIBR	94%	100%
Q10208	SCHPO	57%	43%
Q12669	ASPNG	59%	42%
Q27686	LEIME	90%	44%
Q27788	TRYBO	64%	44%
Q29536	CANLF	56%	38%
Q2FG40	STAA3	59%	38%
Q2FXM9	STAA8	59%	38%
Q2QXR8	ORYSJ	44%	42%
Q2RAK2	ORYSJ	43%	42%
Q2YTE3	STAAB	59%	38%
Q40545	TOBAC	45%	37%
Q40546	TOBAC	53%	39%
Q42806	SOYBN	59%	43%
Q42954	TOBAC	62%	43%
Q43117	RICCO	47%	38%
Q44473	AGRVI	38%	46%
Q46078	CORGL	46%	46%
Q46289	CLOPE	48%	46%
Q49YC7	STAS1	56%	38%
Q4L739	STAHJ	60%	38%
Q54RF5	DICDI	58%	43%
Q55863	SYNY3	46%	46%
Q56301	THELN	47%	46%
Q5HF76	STAAC	59%	38%
Q5HNK7	STAEQ	58%	38%
Q5NVN0	PONAB	55%	41%
Q6BS75	DEBHA	55%	44%
Q6FIS9	CANGA	57%	44%
Q6FV12	CANGA	54%	43%
Q6G8M9	STAAS	59%	38%
Q6GG09	STAAR	59%	38%
Q759A9	ASHGO	58%	44%
Q7A0N4	STAAW	59%	38%
Q7A559	STAAN	59%	38%
Q7RVA8	NEUCR	62%	42%
Q875M9	KLULA	60%	44%
Q875S4	LACK1	58%	44%
Q875Z9	NAUCC	58%	44%
Q89AI8	BUCBP	44%	46%
Q8CS69	STAES	58%	38%
Q8FP04	COREF	45%	46%
Q8K9M3	BUCAP	42%	46%
Q8SQP0	ENCCU	57%	51%
Q8Z6K2	SALTI	52%	47%
Q8ZNW0	SALTY	49%	46%
Q92122	XENLA	59%	42%
Q93Z53	ARATH	55%	39%
Q99TG5	STAAM	59%	38%
Q9FLW9	ARATH	53%	38%
Q9LIK0	ARATH	45%	37%
Q9PK61	CHLMU	54%	46%
Q9WY51	THEMA	38%	47%
Q9YEU2	AERPE	38%	48%
Q9Z984	CHLPN	56%	45%