TATE DNA Transposon

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

TATE DNA Transposon

Gene product:

TATE DNA Transposon

Species:

Leishmania braziliensis

UniProt:

A4HM37_LEIBR

TriTrypDb:

LbrM.34.0020

Length:

908

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HM37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM37

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006310	DNA recombination	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015074	DNA integration	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003677	DNA binding	4	3
GO:0005488	binding	1	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.560
CLV_C14_Caspase3-7	519	523	PF00656	0.426
CLV_NRD_NRD_1	205	207	PF00675	0.588
CLV_NRD_NRD_1	248	250	PF00675	0.628
CLV_NRD_NRD_1	253	255	PF00675	0.595
CLV_NRD_NRD_1	414	416	PF00675	0.441
CLV_NRD_NRD_1	442	444	PF00675	0.418
CLV_NRD_NRD_1	764	766	PF00675	0.671
CLV_NRD_NRD_1	92	94	PF00675	0.567
CLV_PCSK_KEX2_1	204	206	PF00082	0.526
CLV_PCSK_KEX2_1	253	255	PF00082	0.670
CLV_PCSK_KEX2_1	317	319	PF00082	0.653
CLV_PCSK_KEX2_1	333	335	PF00082	0.364
CLV_PCSK_KEX2_1	338	340	PF00082	0.520
CLV_PCSK_KEX2_1	413	415	PF00082	0.447
CLV_PCSK_KEX2_1	442	444	PF00082	0.418
CLV_PCSK_KEX2_1	53	55	PF00082	0.548
CLV_PCSK_KEX2_1	763	765	PF00082	0.702
CLV_PCSK_KEX2_1	92	94	PF00082	0.549
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.526
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.653
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.364
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.520
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.548
CLV_PCSK_PC7_1	249	255	PF00082	0.650
CLV_PCSK_PC7_1	334	340	PF00082	0.616
CLV_PCSK_PC7_1	88	94	PF00082	0.549
CLV_PCSK_SKI1_1	172	176	PF00082	0.592
CLV_PCSK_SKI1_1	305	309	PF00082	0.632
CLV_PCSK_SKI1_1	338	342	PF00082	0.503
CLV_PCSK_SKI1_1	360	364	PF00082	0.530
CLV_PCSK_SKI1_1	415	419	PF00082	0.475
CLV_PCSK_SKI1_1	450	454	PF00082	0.378
CLV_PCSK_SKI1_1	473	477	PF00082	0.405
CLV_PCSK_SKI1_1	50	54	PF00082	0.546
CLV_PCSK_SKI1_1	604	608	PF00082	0.496
CLV_PCSK_SKI1_1	637	641	PF00082	0.581
CLV_PCSK_SKI1_1	813	817	PF00082	0.553
DEG_APCC_DBOX_1	557	565	PF00400	0.616
DOC_CKS1_1	511	516	PF01111	0.579
DOC_MAPK_gen_1	447	457	PF00069	0.406
DOC_MAPK_gen_1	643	653	PF00069	0.589
DOC_MAPK_MEF2A_6	450	457	PF00069	0.377
DOC_MAPK_MEF2A_6	598	607	PF00069	0.428
DOC_PP1_RVXF_1	648	654	PF00149	0.597
DOC_PP2B_LxvP_1	328	331	PF13499	0.642
DOC_PP4_FxxP_1	347	350	PF00568	0.583
DOC_PP4_FxxP_1	405	408	PF00568	0.607
DOC_PP4_FxxP_1	772	775	PF00568	0.788
DOC_PP4_FxxP_1	895	898	PF00568	0.530
DOC_USP7_MATH_1	264	268	PF00917	0.677
DOC_USP7_MATH_1	883	887	PF00917	0.569
DOC_USP7_UBL2_3	598	602	PF12436	0.432
DOC_WW_Pin1_4	317	322	PF00397	0.632
DOC_WW_Pin1_4	41	46	PF00397	0.502
DOC_WW_Pin1_4	510	515	PF00397	0.575
DOC_WW_Pin1_4	552	557	PF00397	0.448
LIG_14-3-3_CanoR_1	103	108	PF00244	0.554
LIG_14-3-3_CanoR_1	196	203	PF00244	0.589
LIG_14-3-3_CanoR_1	253	262	PF00244	0.644
LIG_14-3-3_CanoR_1	334	341	PF00244	0.551
LIG_14-3-3_CanoR_1	414	420	PF00244	0.436
LIG_14-3-3_CanoR_1	486	491	PF00244	0.419
LIG_14-3-3_CanoR_1	495	499	PF00244	0.415
LIG_14-3-3_CanoR_1	594	598	PF00244	0.576
LIG_14-3-3_CanoR_1	615	621	PF00244	0.414
LIG_14-3-3_CanoR_1	650	654	PF00244	0.608
LIG_14-3-3_CanoR_1	692	701	PF00244	0.636
LIG_14-3-3_CanoR_1	73	82	PF00244	0.510
LIG_14-3-3_CanoR_1	785	792	PF00244	0.497
LIG_Actin_WH2_2	341	359	PF00022	0.529
LIG_Actin_WH2_2	58	75	PF00022	0.501
LIG_Actin_WH2_2	590	606	PF00022	0.424
LIG_BIR_III_2	118	122	PF00653	0.593
LIG_BIR_III_2	462	466	PF00653	0.557
LIG_BIR_III_2	660	664	PF00653	0.613
LIG_BIR_III_4	160	164	PF00653	0.587
LIG_BIR_III_4	882	886	PF00653	0.592
LIG_BRCT_BRCA1_1	621	625	PF00533	0.553
LIG_BRCT_BRCA1_1	70	74	PF00533	0.542
LIG_BRCT_BRCA1_1	875	879	PF00533	0.453
LIG_deltaCOP1_diTrp_1	727	735	PF00928	0.595
LIG_eIF4E_1	840	846	PF01652	0.411
LIG_FHA_1	142	148	PF00498	0.655
LIG_FHA_1	196	202	PF00498	0.594
LIG_FHA_1	416	422	PF00498	0.532
LIG_FHA_1	503	509	PF00498	0.426
LIG_FHA_1	516	522	PF00498	0.454
LIG_FHA_1	575	581	PF00498	0.497
LIG_FHA_1	734	740	PF00498	0.679
LIG_FHA_1	82	88	PF00498	0.540
LIG_FHA_1	847	853	PF00498	0.396
LIG_FHA_1	882	888	PF00498	0.481
LIG_FHA_2	318	324	PF00498	0.609
LIG_FHA_2	366	372	PF00498	0.603
LIG_FHA_2	404	410	PF00498	0.485
LIG_FHA_2	505	511	PF00498	0.396
LIG_FHA_2	517	523	PF00498	0.420
LIG_FHA_2	693	699	PF00498	0.535
LIG_FHA_2	75	81	PF00498	0.509
LIG_Integrin_isoDGR_2	587	589	PF01839	0.629
LIG_LIR_Apic_2	144	148	PF02991	0.609
LIG_LIR_Apic_2	236	240	PF02991	0.544
LIG_LIR_Apic_2	893	898	PF02991	0.545
LIG_LIR_Gen_1	296	306	PF02991	0.632
LIG_LIR_Gen_1	458	468	PF02991	0.422
LIG_LIR_Gen_1	505	514	PF02991	0.446
LIG_LIR_Gen_1	698	709	PF02991	0.416
LIG_LIR_Nem_3	296	301	PF02991	0.624
LIG_LIR_Nem_3	351	356	PF02991	0.607
LIG_LIR_Nem_3	456	460	PF02991	0.457
LIG_LIR_Nem_3	481	487	PF02991	0.590
LIG_LIR_Nem_3	505	509	PF02991	0.428
LIG_LIR_Nem_3	622	628	PF02991	0.503
LIG_LIR_Nem_3	652	656	PF02991	0.606
LIG_LIR_Nem_3	698	704	PF02991	0.441
LIG_LIR_Nem_3	712	717	PF02991	0.389
LIG_LIR_Nem_3	859	865	PF02991	0.477
LIG_PCNA_yPIPBox_3	793	803	PF02747	0.589
LIG_Pex14_1	239	243	PF04695	0.558
LIG_Pex14_2	895	899	PF04695	0.529
LIG_SH2_CRK	353	357	PF00017	0.498
LIG_SH2_CRK	461	465	PF00017	0.385
LIG_SH2_CRK	645	649	PF00017	0.407
LIG_SH2_CRK	701	705	PF00017	0.440
LIG_SH2_NCK_1	461	465	PF00017	0.410
LIG_SH2_NCK_1	701	705	PF00017	0.590
LIG_SH2_SRC	664	667	PF00017	0.444
LIG_SH2_SRC	864	867	PF00017	0.504
LIG_SH2_STAP1	436	440	PF00017	0.553
LIG_SH2_STAP1	448	452	PF00017	0.332
LIG_SH2_STAP1	701	705	PF00017	0.590
LIG_SH2_STAP1	786	790	PF00017	0.659
LIG_SH2_STAP1	848	852	PF00017	0.392
LIG_SH2_STAP1	875	879	PF00017	0.550
LIG_SH2_STAT3	451	454	PF00017	0.394
LIG_SH2_STAT5	127	130	PF00017	0.682
LIG_SH2_STAT5	584	587	PF00017	0.578
LIG_SH2_STAT5	664	667	PF00017	0.444
LIG_SH2_STAT5	848	851	PF00017	0.395
LIG_SH2_STAT5	864	867	PF00017	0.407
LIG_SH3_3	390	396	PF00018	0.625
LIG_SH3_3	678	684	PF00018	0.440
LIG_SH3_3	83	89	PF00018	0.542
LIG_SUMO_SIM_anti_2	619	625	PF11976	0.404
LIG_SUMO_SIM_par_1	507	513	PF11976	0.409
LIG_SUMO_SIM_par_1	535	542	PF11976	0.562
LIG_TRAF2_1	284	287	PF00917	0.601
LIG_TRAF2_1	565	568	PF00917	0.534
LIG_TRAF2_1	672	675	PF00917	0.599
MOD_CAAXbox	905	908	PF01239	0.273
MOD_CDC14_SPxK_1	555	558	PF00782	0.464
MOD_CDK_SPxK_1	552	558	PF00069	0.447
MOD_CDK_SPxxK_3	41	48	PF00069	0.503
MOD_CK1_1	273	279	PF00069	0.695
MOD_CK1_1	46	52	PF00069	0.505
MOD_CK1_1	574	580	PF00069	0.589
MOD_CK1_1	596	602	PF00069	0.428
MOD_CK1_1	616	622	PF00069	0.415
MOD_CK2_1	365	371	PF00069	0.605
MOD_CK2_1	403	409	PF00069	0.480
MOD_CK2_1	562	568	PF00069	0.508
MOD_CK2_1	669	675	PF00069	0.547
MOD_CK2_1	692	698	PF00069	0.529
MOD_CK2_1	74	80	PF00069	0.508
MOD_Cter_Amidation	411	414	PF01082	0.461
MOD_Cter_Amidation	440	443	PF01082	0.582
MOD_GlcNHglycan	212	215	PF01048	0.637
MOD_GlcNHglycan	255	258	PF01048	0.658
MOD_GlcNHglycan	295	298	PF01048	0.528
MOD_GlcNHglycan	45	48	PF01048	0.493
MOD_GlcNHglycan	573	576	PF01048	0.581
MOD_GlcNHglycan	767	770	PF01048	0.774
MOD_GlcNHglycan	786	789	PF01048	0.350
MOD_GSK3_1	270	277	PF00069	0.702
MOD_GSK3_1	3	10	PF00069	0.527
MOD_GSK3_1	329	336	PF00069	0.637
MOD_GSK3_1	384	391	PF00069	0.678
MOD_GSK3_1	665	672	PF00069	0.600
MOD_GSK3_1	693	700	PF00069	0.643
MOD_GSK3_1	723	730	PF00069	0.521
MOD_NEK2_1	175	180	PF00069	0.590
MOD_NEK2_1	356	361	PF00069	0.468
MOD_NEK2_1	607	612	PF00069	0.621
MOD_NEK2_1	628	633	PF00069	0.427
MOD_NEK2_1	74	79	PF00069	0.508
MOD_NEK2_2	264	269	PF00069	0.674
MOD_NEK2_2	649	654	PF00069	0.607
MOD_NEK2_2	68	73	PF00069	0.504
MOD_PIKK_1	270	276	PF00454	0.702
MOD_PIKK_1	388	394	PF00454	0.449
MOD_PIKK_1	628	634	PF00454	0.576
MOD_PK_1	103	109	PF00069	0.559
MOD_PK_1	3	9	PF00069	0.526
MOD_PKA_1	253	259	PF00069	0.657
MOD_PKA_1	333	339	PF00069	0.626
MOD_PKA_2	102	108	PF00069	0.480
MOD_PKA_2	195	201	PF00069	0.600
MOD_PKA_2	253	259	PF00069	0.657
MOD_PKA_2	333	339	PF00069	0.626
MOD_PKA_2	356	362	PF00069	0.497
MOD_PKA_2	494	500	PF00069	0.411
MOD_PKA_2	593	599	PF00069	0.455
MOD_PKA_2	649	655	PF00069	0.611
MOD_PKA_2	733	739	PF00069	0.628
MOD_PKA_2	784	790	PF00069	0.521
MOD_PKA_2	87	93	PF00069	0.559
MOD_PKB_1	413	421	PF00069	0.469
MOD_PKB_1	763	771	PF00069	0.781
MOD_Plk_1	167	173	PF00069	0.591
MOD_Plk_1	582	588	PF00069	0.429
MOD_Plk_1	665	671	PF00069	0.604
MOD_Plk_1	697	703	PF00069	0.570
MOD_Plk_1	707	713	PF00069	0.545
MOD_Plk_1	846	852	PF00069	0.488
MOD_Plk_2-3	562	568	PF00069	0.484
MOD_Plk_2-3	697	703	PF00069	0.625
MOD_Plk_4	233	239	PF00069	0.692
MOD_Plk_4	264	270	PF00069	0.676
MOD_Plk_4	323	329	PF00069	0.634
MOD_Plk_4	348	354	PF00069	0.597
MOD_Plk_4	516	522	PF00069	0.429
MOD_Plk_4	574	580	PF00069	0.494
MOD_Plk_4	616	622	PF00069	0.415
MOD_ProDKin_1	317	323	PF00069	0.631
MOD_ProDKin_1	41	47	PF00069	0.501
MOD_ProDKin_1	510	516	PF00069	0.574
MOD_ProDKin_1	552	558	PF00069	0.447
TRG_DiLeu_BaEn_1	304	309	PF01217	0.634
TRG_DiLeu_BaEn_4	567	573	PF01217	0.532
TRG_DiLeu_BaLyEn_6	412	417	PF01217	0.478
TRG_DiLeu_BaLyEn_6	588	593	PF01217	0.588
TRG_ENDOCYTIC_2	353	356	PF00928	0.491
TRG_ENDOCYTIC_2	461	464	PF00928	0.376
TRG_ENDOCYTIC_2	484	487	PF00928	0.568
TRG_ENDOCYTIC_2	645	648	PF00928	0.402
TRG_ENDOCYTIC_2	701	704	PF00928	0.551
TRG_ER_diArg_1	224	227	PF00400	0.601
TRG_ER_diArg_1	413	415	PF00400	0.480
TRG_ER_diArg_1	442	445	PF00400	0.579
TRG_ER_diArg_1	476	479	PF00400	0.428
TRG_ER_diArg_1	48	51	PF00400	0.512
TRG_ER_diArg_1	485	488	PF00400	0.428
TRG_ER_diArg_1	731	734	PF00400	0.605
TRG_ER_diArg_1	762	765	PF00400	0.760
TRG_NES_CRM1_1	397	409	PF08389	0.599
TRG_NLS_MonoExtC_3	203	208	PF00514	0.539
TRG_NLS_MonoExtN_4	203	208	PF00514	0.539
TRG_Pf-PMV_PEXEL_1	414	419	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	671	675	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	741	746	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	800	804	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NZ81	Trypanosomatidae	48%	100%
A0A1X0NZU3	Trypanosomatidae	46%	100%
A0A1X0P2J1	Trypanosomatidae	49%	100%
A4H9A6	Leishmania braziliensis	99%	100%
A4HEK4	Leishmania braziliensis	95%	81%
A4HEK5	Leishmania braziliensis	99%	98%
A4HIQ7	Leishmania braziliensis	95%	100%
A4HIW1	Leishmania braziliensis	99%	100%
A4HIW3	Leishmania braziliensis	98%	68%
A4HJX9	Leishmania braziliensis	93%	100%