Delta-12 fatty acid desaturase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

delta-12 fatty acid desaturase

Species:

Leishmania braziliensis

UniProt:

A4HM35_LEIBR

TriTrypDb:

LbrM.33.3550 , LBRM2903_330044200

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

A4HM35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM35

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	18
GO:0008152	metabolic process	1	18
GO:0044238	primary metabolic process	2	18
GO:0071704	organic substance metabolic process	2	18

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004768	stearoyl-CoA 9-desaturase activity	6	6
GO:0016215	acyl-CoA desaturase activity	5	6
GO:0016491	oxidoreductase activity	2	7
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	6
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.574
CLV_NRD_NRD_1	215	217	PF00675	0.348
CLV_NRD_NRD_1	227	229	PF00675	0.306
CLV_PCSK_KEX2_1	215	217	PF00082	0.348
CLV_PCSK_KEX2_1	392	394	PF00082	0.476
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.476
CLV_PCSK_SKI1_1	2	6	PF00082	0.386
CLV_PCSK_SKI1_1	301	305	PF00082	0.214
CLV_PCSK_SKI1_1	349	353	PF00082	0.220
CLV_PCSK_SKI1_1	361	365	PF00082	0.278
DEG_APCC_DBOX_1	300	308	PF00400	0.420
DEG_APCC_DBOX_1	360	368	PF00400	0.483
DEG_Nend_UBRbox_1	1	4	PF02207	0.698
DOC_MAPK_gen_1	172	180	PF00069	0.334
DOC_PP1_RVXF_1	174	181	PF00149	0.205
DOC_PP4_FxxP_1	198	201	PF00568	0.323
DOC_USP7_MATH_1	126	130	PF00917	0.508
DOC_USP7_MATH_1	145	149	PF00917	0.332
DOC_USP7_MATH_2	379	385	PF00917	0.608
DOC_USP7_UBL2_3	2	6	PF12436	0.597
DOC_WW_Pin1_4	122	127	PF00397	0.448
DOC_WW_Pin1_4	181	186	PF00397	0.311
DOC_WW_Pin1_4	221	226	PF00397	0.532
LIG_14-3-3_CanoR_1	38	42	PF00244	0.409
LIG_APCC_ABBAyCdc20_2	6	12	PF00400	0.458
LIG_BRCT_BRCA1_1	223	227	PF00533	0.532
LIG_BRCT_BRCA1_2	223	229	PF00533	0.558
LIG_deltaCOP1_diTrp_1	295	299	PF00928	0.462
LIG_deltaCOP1_diTrp_1	83	87	PF00928	0.292
LIG_EH1_1	345	353	PF00400	0.574
LIG_EVH1_2	32	36	PF00568	0.412
LIG_FHA_1	158	164	PF00498	0.271
LIG_FHA_1	165	171	PF00498	0.266
LIG_FHA_1	182	188	PF00498	0.375
LIG_FHA_1	243	249	PF00498	0.202
LIG_FHA_1	370	376	PF00498	0.389
LIG_FHA_1	55	61	PF00498	0.186
LIG_FHA_2	368	374	PF00498	0.540
LIG_FHA_2	68	74	PF00498	0.285
LIG_GBD_Chelix_1	327	335	PF00786	0.296
LIG_HP1_1	185	189	PF01393	0.291
LIG_LIR_Apic_2	373	379	PF02991	0.508
LIG_LIR_Gen_1	295	305	PF02991	0.448
LIG_LIR_Gen_1	57	66	PF02991	0.280
LIG_LIR_Gen_1	86	95	PF02991	0.411
LIG_LIR_Nem_3	125	130	PF02991	0.521
LIG_LIR_Nem_3	253	259	PF02991	0.341
LIG_LIR_Nem_3	272	278	PF02991	0.269
LIG_LIR_Nem_3	295	300	PF02991	0.442
LIG_LIR_Nem_3	308	314	PF02991	0.480
LIG_LIR_Nem_3	384	389	PF02991	0.591
LIG_LIR_Nem_3	43	48	PF02991	0.562
LIG_LIR_Nem_3	86	90	PF02991	0.397
LIG_Pex14_2	196	200	PF04695	0.339
LIG_SH2_CRK	127	131	PF00017	0.556
LIG_SH2_CRK	311	315	PF00017	0.496
LIG_SH2_CRK	338	342	PF00017	0.427
LIG_SH2_CRK	62	66	PF00017	0.369
LIG_SH2_NCK_1	77	81	PF00017	0.292
LIG_SH2_PTP2	265	268	PF00017	0.444
LIG_SH2_PTP2	376	379	PF00017	0.512
LIG_SH2_SRC	254	257	PF00017	0.468
LIG_SH2_STAT5	203	206	PF00017	0.409
LIG_SH2_STAT5	265	268	PF00017	0.328
LIG_SH2_STAT5	269	272	PF00017	0.322
LIG_SH2_STAT5	278	281	PF00017	0.321
LIG_SH2_STAT5	35	38	PF00017	0.540
LIG_SH2_STAT5	356	359	PF00017	0.519
LIG_SH2_STAT5	376	379	PF00017	0.382
LIG_SH2_STAT5	46	49	PF00017	0.487
LIG_SH2_STAT5	58	61	PF00017	0.365
LIG_SH3_3	12	18	PF00018	0.521
LIG_SH3_3	165	171	PF00018	0.260
LIG_SH3_3	219	225	PF00018	0.471
LIG_SUMO_SIM_anti_2	245	250	PF11976	0.225
LIG_TYR_ITIM	60	65	PF00017	0.381
LIG_UBA3_1	363	369	PF00899	0.601
LIG_WW_1	32	35	PF00397	0.415
MOD_CDC14_SPxK_1	125	128	PF00782	0.448
MOD_CDK_SPxK_1	122	128	PF00069	0.448
MOD_CDK_SPxxK_3	221	228	PF00069	0.483
MOD_CK2_1	367	373	PF00069	0.523
MOD_CK2_1	67	73	PF00069	0.216
MOD_CMANNOS	84	87	PF00535	0.483
MOD_Cter_Amidation	213	216	PF01082	0.358
MOD_GlcNHglycan	139	142	PF01048	0.283
MOD_GlcNHglycan	18	21	PF01048	0.380
MOD_GlcNHglycan	90	93	PF01048	0.571
MOD_GSK3_1	122	129	PF00069	0.466
MOD_GSK3_1	145	152	PF00069	0.310
MOD_GSK3_1	157	164	PF00069	0.261
MOD_GSK3_1	16	23	PF00069	0.497
MOD_GSK3_1	36	43	PF00069	0.477
MOD_GSK3_1	377	384	PF00069	0.583
MOD_GSK3_1	67	74	PF00069	0.308
MOD_N-GLC_1	107	112	PF02516	0.248
MOD_N-GLC_1	322	327	PF02516	0.263
MOD_NEK2_1	107	112	PF00069	0.248
MOD_NEK2_1	36	41	PF00069	0.531
MOD_NEK2_1	367	372	PF00069	0.553
MOD_NEK2_1	54	59	PF00069	0.262
MOD_NEK2_2	20	25	PF00069	0.525
MOD_PIKK_1	207	213	PF00454	0.558
MOD_PIKK_1	330	336	PF00454	0.512
MOD_PKA_1	172	178	PF00069	0.311
MOD_PKA_2	149	155	PF00069	0.271
MOD_PKA_2	214	220	PF00069	0.522
MOD_PKA_2	37	43	PF00069	0.410
MOD_Plk_1	107	113	PF00069	0.275
MOD_Plk_1	20	26	PF00069	0.590
MOD_Plk_1	322	328	PF00069	0.463
MOD_Plk_1	36	42	PF00069	0.557
MOD_Plk_4	164	170	PF00069	0.311
MOD_Plk_4	244	250	PF00069	0.282
MOD_Plk_4	381	387	PF00069	0.578
MOD_Plk_4	54	60	PF00069	0.276
MOD_ProDKin_1	122	128	PF00069	0.448
MOD_ProDKin_1	181	187	PF00069	0.311
MOD_ProDKin_1	221	227	PF00069	0.532
TRG_DiLeu_BaEn_2	294	300	PF01217	0.504
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.570
TRG_ENDOCYTIC_2	127	130	PF00928	0.532
TRG_ENDOCYTIC_2	203	206	PF00928	0.445
TRG_ENDOCYTIC_2	259	262	PF00928	0.300
TRG_ENDOCYTIC_2	311	314	PF00928	0.493
TRG_ENDOCYTIC_2	338	341	PF00928	0.471
TRG_ENDOCYTIC_2	45	48	PF00928	0.521
TRG_ENDOCYTIC_2	58	61	PF00928	0.314
TRG_ENDOCYTIC_2	62	65	PF00928	0.307
TRG_ER_diLys_1	391	394	PF00400	0.662
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.282

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L0	Leptomonas seymouri	77%	100%
A0A0S4IVK0	Bodo saltans	54%	94%
A0A1X0NKF1	Trypanosomatidae	47%	85%
A0A3Q8I8P6	Leishmania donovani	74%	100%
A0A3S7X797	Leishmania donovani	83%	100%
A0A422MYL0	Trypanosoma rangeli	60%	94%
A3F5L2	Sorghum bicolor	35%	100%
A3F5L3	Sorghum bicolor	39%	100%
A4H5Y3	Leishmania braziliensis	74%	100%
A4H6C4	Leishmania braziliensis	73%	100%
A4HUP7	Leishmania infantum	74%	100%
A4I9G8	Leishmania infantum	82%	100%
B4YQU1	Claviceps purpurea	37%	83%
C9ZJ57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	97%
E9ANE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
E9B4G6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
G5EGA5	Caenorhabditis elegans	28%	100%
O34653	Bacillus subtilis (strain 168)	25%	100%
O81931	Crepis alpina	38%	100%
P20388	Synechocystis sp. (strain PCC 6803 / Kazusa)	24%	100%
P32291	Vigna radiata var. radiata	36%	100%
P46310	Arabidopsis thaliana	32%	88%
P46312	Arabidopsis thaliana	23%	88%
P46313	Arabidopsis thaliana	40%	100%
P48618	Brassica napus	35%	98%
P48619	Ricinus communis	32%	86%
P48620	Sesamum indicum	33%	88%
P48621	Glycine max	37%	87%
P48622	Arabidopsis thaliana	32%	91%
P48623	Arabidopsis thaliana	33%	100%
P48624	Brassica napus	34%	100%
P48625	Glycine max	39%	100%
P48626	Nicotiana tabacum	31%	100%
P48627	Brassica napus	24%	89%
P48628	Glycine max	24%	93%
P48630	Glycine max	40%	100%
P48631	Glycine max	39%	100%
P59668	Mortierella isabellina	42%	98%
Q39287	Brassica juncea	40%	100%
Q41131	Ricinus communis	40%	100%
Q4Q3K9	Leishmania major	83%	100%
Q4QH80	Leishmania major	74%	100%
Q56VS4	Helianthus annuus	37%	89%
Q594P3	Sorghum bicolor	37%	100%
Q59J82	Mortierella alpina	37%	98%
Q6RS95	Dimorphotheca sinuata	38%	100%
Q6RS96	Dimorphotheca sinuata	33%	100%
Q84UB8	Punica granatum	39%	100%
Q84UB9	Trichosanthes kirilowii	40%	100%
Q84UC0	Trichosanthes kirilowii	39%	100%
Q84VT2	Punica granatum	41%	100%
Q8GZC2	Vernicia fordii	39%	100%
Q8GZC3	Vernicia fordii	40%	100%
Q9AT72	Calendula officinalis	41%	100%
Q9FPP7	Calendula officinalis	36%	100%
Q9FPP8	Calendula officinalis	35%	100%
Q9NEQ0	Caenorhabditis elegans	32%	98%
Q9SCG2	Calendula officinalis	38%	100%
Q9SP61	Momordica charantia	37%	99%
Q9SP62	Impatiens balsamina	36%	100%
Q9Y8H5	Mortierella alpina	42%	98%
V5BA48	Trypanosoma cruzi	60%	96%