LeishMANIAdb
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ABC transporter family-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ABC transporter family-like protein
Gene product:
ABC transporter family-like protein
Species:
Leishmania braziliensis
UniProt:
A4HM34_LEIBR
TriTrypDb:
LbrM.33.3540 , LBRM2903_330044100 *
Length:
949

Annotations

LeishMANIAdb annotations

Publication identifier(s): 23716044
ABC superfamily protein. Involved in the efflux of toxic antimony species and porphyrin derivatives. Dimeric.. Most closely related to bacterial ABC transporters (e.g. A0A557ZZI4_9PSEU, A0A2Z6DZW4_HYDTE, G6XIG1_9PROT) with lipid flippase activity. Localization: Cell surface (experimental) / Mitochondrial (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7
GO:0005739 mitochondrion 5 1
GO:0005886 plasma membrane 3 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4HM34
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM34

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006811 monoatomic ion transport 4 1
GO:0006812 monoatomic cation transport 5 1
GO:0009987 cellular process 1 1
GO:0030001 metal ion transport 6 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0055085 transmembrane transport 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 9
GO:0005488 binding 1 9
GO:0005524 ATP binding 5 9
GO:0017076 purine nucleotide binding 4 9
GO:0030554 adenyl nucleotide binding 5 9
GO:0032553 ribonucleotide binding 3 9
GO:0032555 purine ribonucleotide binding 4 9
GO:0032559 adenyl ribonucleotide binding 5 9
GO:0035639 purine ribonucleoside triphosphate binding 4 9
GO:0036094 small molecule binding 2 9
GO:0043167 ion binding 2 9
GO:0043168 anion binding 3 9
GO:0097159 organic cyclic compound binding 2 9
GO:0097367 carbohydrate derivative binding 2 9
GO:1901265 nucleoside phosphate binding 3 9
GO:1901363 heterocyclic compound binding 2 9
GO:0005215 transporter activity 1 1
GO:0008324 monoatomic cation transmembrane transporter activity 4 1
GO:0015075 monoatomic ion transmembrane transporter activity 3 1
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 1
GO:0015399 primary active transmembrane transporter activity 4 1
GO:0022804 active transmembrane transporter activity 3 1
GO:0022857 transmembrane transporter activity 2 1
GO:0022890 inorganic cation transmembrane transporter activity 4 1
GO:0042626 ATPase-coupled transmembrane transporter activity 2 1
GO:0046873 metal ion transmembrane transporter activity 5 1
GO:0140657 ATP-dependent activity 1 1
GO:0003824 catalytic activity 1 1
GO:0016787 hydrolase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 114 118 PF00656 0.647
CLV_C14_Caspase3-7 499 503 PF00656 0.544
CLV_NRD_NRD_1 195 197 PF00675 0.460
CLV_NRD_NRD_1 31 33 PF00675 0.464
CLV_NRD_NRD_1 36 38 PF00675 0.467
CLV_NRD_NRD_1 436 438 PF00675 0.651
CLV_NRD_NRD_1 539 541 PF00675 0.773
CLV_NRD_NRD_1 777 779 PF00675 0.277
CLV_NRD_NRD_1 83 85 PF00675 0.449
CLV_NRD_NRD_1 891 893 PF00675 0.387
CLV_PCSK_KEX2_1 31 33 PF00082 0.506
CLV_PCSK_KEX2_1 36 38 PF00082 0.501
CLV_PCSK_KEX2_1 436 438 PF00082 0.641
CLV_PCSK_KEX2_1 539 541 PF00082 0.770
CLV_PCSK_KEX2_1 776 778 PF00082 0.277
CLV_PCSK_KEX2_1 83 85 PF00082 0.449
CLV_PCSK_KEX2_1 891 893 PF00082 0.435
CLV_PCSK_PC7_1 32 38 PF00082 0.380
CLV_PCSK_PC7_1 773 779 PF00082 0.277
CLV_PCSK_SKI1_1 188 192 PF00082 0.413
CLV_PCSK_SKI1_1 20 24 PF00082 0.424
CLV_PCSK_SKI1_1 206 210 PF00082 0.443
CLV_PCSK_SKI1_1 850 854 PF00082 0.390
CLV_Separin_Metazoa 506 510 PF03568 0.515
CLV_Separin_Metazoa 836 840 PF03568 0.575
DEG_APCC_DBOX_1 393 401 PF00400 0.519
DEG_COP1_1 244 253 PF00400 0.544
DEG_SPOP_SBC_1 242 246 PF00917 0.383
DEG_SPOP_SBC_1 282 286 PF00917 0.354
DOC_ANK_TNKS_1 539 546 PF00023 0.570
DOC_CKS1_1 683 688 PF01111 0.522
DOC_CYCLIN_RxL_1 185 193 PF00134 0.673
DOC_MAPK_FxFP_2 709 712 PF00069 0.394
DOC_MAPK_gen_1 376 385 PF00069 0.491
DOC_MAPK_MEF2A_6 206 214 PF00069 0.556
DOC_MAPK_MEF2A_6 445 454 PF00069 0.489
DOC_MAPK_MEF2A_6 742 749 PF00069 0.413
DOC_MAPK_NFAT4_5 742 750 PF00069 0.413
DOC_PP1_RVXF_1 699 705 PF00149 0.314
DOC_PP2B_LxvP_1 857 860 PF13499 0.412
DOC_PP4_FxxP_1 171 174 PF00568 0.526
DOC_PP4_FxxP_1 626 629 PF00568 0.464
DOC_PP4_FxxP_1 709 712 PF00568 0.394
DOC_PP4_FxxP_1 9 12 PF00568 0.459
DOC_USP7_MATH_1 137 141 PF00917 0.664
DOC_USP7_MATH_1 432 436 PF00917 0.591
DOC_USP7_MATH_1 458 462 PF00917 0.569
DOC_USP7_MATH_1 528 532 PF00917 0.422
DOC_USP7_MATH_1 636 640 PF00917 0.458
DOC_USP7_MATH_1 740 744 PF00917 0.391
DOC_USP7_MATH_1 807 811 PF00917 0.525
DOC_USP7_MATH_1 875 879 PF00917 0.497
DOC_WW_Pin1_4 182 187 PF00397 0.666
DOC_WW_Pin1_4 283 288 PF00397 0.353
DOC_WW_Pin1_4 456 461 PF00397 0.543
DOC_WW_Pin1_4 463 468 PF00397 0.565
DOC_WW_Pin1_4 518 523 PF00397 0.521
DOC_WW_Pin1_4 550 555 PF00397 0.463
DOC_WW_Pin1_4 590 595 PF00397 0.467
DOC_WW_Pin1_4 600 605 PF00397 0.426
DOC_WW_Pin1_4 632 637 PF00397 0.397
DOC_WW_Pin1_4 682 687 PF00397 0.528
LIG_14-3-3_CanoR_1 176 183 PF00244 0.589
LIG_14-3-3_CanoR_1 20 28 PF00244 0.459
LIG_14-3-3_CanoR_1 206 211 PF00244 0.582
LIG_14-3-3_CanoR_1 240 250 PF00244 0.544
LIG_14-3-3_CanoR_1 255 259 PF00244 0.365
LIG_14-3-3_CanoR_1 280 290 PF00244 0.477
LIG_14-3-3_CanoR_1 347 355 PF00244 0.522
LIG_14-3-3_CanoR_1 376 381 PF00244 0.501
LIG_14-3-3_CanoR_1 485 495 PF00244 0.516
LIG_14-3-3_CanoR_1 701 705 PF00244 0.308
LIG_14-3-3_CanoR_1 84 92 PF00244 0.590
LIG_14-3-3_CanoR_1 897 907 PF00244 0.543
LIG_14-3-3_CanoR_1 93 102 PF00244 0.632
LIG_14-3-3_CanoR_1 944 949 PF00244 0.530
LIG_APCC_ABBA_1 866 871 PF00400 0.502
LIG_BRCT_BRCA1_1 300 304 PF00533 0.486
LIG_BRCT_BRCA1_1 638 642 PF00533 0.544
LIG_Clathr_ClatBox_1 331 335 PF01394 0.374
LIG_CSL_BTD_1 633 636 PF09270 0.392
LIG_deltaCOP1_diTrp_1 398 404 PF00928 0.519
LIG_DLG_GKlike_1 91 99 PF00625 0.668
LIG_eIF4E_1 448 454 PF01652 0.542
LIG_FHA_1 16 22 PF00498 0.380
LIG_FHA_1 207 213 PF00498 0.556
LIG_FHA_1 216 222 PF00498 0.468
LIG_FHA_1 255 261 PF00498 0.506
LIG_FHA_1 293 299 PF00498 0.419
LIG_FHA_1 323 329 PF00498 0.510
LIG_FHA_1 409 415 PF00498 0.518
LIG_FHA_1 489 495 PF00498 0.527
LIG_FHA_1 533 539 PF00498 0.545
LIG_FHA_1 615 621 PF00498 0.430
LIG_FHA_1 644 650 PF00498 0.578
LIG_FHA_1 70 76 PF00498 0.682
LIG_FHA_1 721 727 PF00498 0.364
LIG_FHA_1 742 748 PF00498 0.325
LIG_FHA_1 787 793 PF00498 0.542
LIG_FHA_1 813 819 PF00498 0.575
LIG_FHA_1 871 877 PF00498 0.485
LIG_FHA_1 926 932 PF00498 0.573
LIG_FHA_2 112 118 PF00498 0.654
LIG_FHA_2 218 224 PF00498 0.267
LIG_FHA_2 243 249 PF00498 0.496
LIG_FHA_2 487 493 PF00498 0.383
LIG_FHA_2 712 718 PF00498 0.453
LIG_IRF3_LxIS_1 515 521 PF10401 0.390
LIG_LIR_Apic_2 169 174 PF02991 0.525
LIG_LIR_Apic_2 339 345 PF02991 0.499
LIG_LIR_Apic_2 379 384 PF02991 0.530
LIG_LIR_Gen_1 122 131 PF02991 0.537
LIG_LIR_Gen_1 209 217 PF02991 0.603
LIG_LIR_Gen_1 359 367 PF02991 0.532
LIG_LIR_Gen_1 703 712 PF02991 0.382
LIG_LIR_Gen_1 926 931 PF02991 0.547
LIG_LIR_Gen_1 936 945 PF02991 0.512
LIG_LIR_Nem_3 122 127 PF02991 0.536
LIG_LIR_Nem_3 209 214 PF02991 0.622
LIG_LIR_Nem_3 274 278 PF02991 0.454
LIG_LIR_Nem_3 359 363 PF02991 0.528
LIG_LIR_Nem_3 5 11 PF02991 0.298
LIG_LIR_Nem_3 577 582 PF02991 0.393
LIG_LIR_Nem_3 703 707 PF02991 0.313
LIG_LIR_Nem_3 926 930 PF02991 0.562
LIG_LIR_Nem_3 936 942 PF02991 0.550
LIG_NRBOX 225 231 PF00104 0.459
LIG_NRBOX 449 455 PF00104 0.468
LIG_NRBOX 744 750 PF00104 0.358
LIG_Pex14_1 700 704 PF04695 0.307
LIG_Pex14_2 704 708 PF04695 0.307
LIG_PTB_Apo_2 231 238 PF02174 0.661
LIG_PTB_Apo_2 354 361 PF02174 0.526
LIG_PTB_Phospho_1 231 237 PF10480 0.663
LIG_Rb_pABgroove_1 97 105 PF01858 0.659
LIG_REV1ctd_RIR_1 706 711 PF16727 0.315
LIG_RPA_C_Fungi 898 910 PF08784 0.448
LIG_SH2_CRK 349 353 PF00017 0.610
LIG_SH2_CRK 512 516 PF00017 0.676
LIG_SH2_CRK 683 687 PF00017 0.696
LIG_SH2_NCK_1 683 687 PF00017 0.696
LIG_SH2_STAP1 256 260 PF00017 0.664
LIG_SH2_STAP1 349 353 PF00017 0.429
LIG_SH2_STAP1 657 661 PF00017 0.664
LIG_SH2_STAT3 448 451 PF00017 0.697
LIG_SH2_STAT3 943 946 PF00017 0.509
LIG_SH2_STAT5 138 141 PF00017 0.523
LIG_SH2_STAT5 237 240 PF00017 0.706
LIG_SH2_STAT5 256 259 PF00017 0.382
LIG_SH2_STAT5 272 275 PF00017 0.541
LIG_SH3_1 436 442 PF00018 0.540
LIG_SH3_2 440 445 PF14604 0.520
LIG_SH3_3 436 442 PF00018 0.703
LIG_SH3_3 478 484 PF00018 0.598
LIG_SH3_3 599 605 PF00018 0.638
LIG_SH3_3 624 630 PF00018 0.652
LIG_SH3_3 749 755 PF00018 0.413
LIG_SUMO_SIM_anti_2 257 262 PF11976 0.610
LIG_SUMO_SIM_anti_2 325 333 PF11976 0.443
LIG_SUMO_SIM_anti_2 350 356 PF11976 0.431
LIG_SUMO_SIM_anti_2 743 750 PF11976 0.413
LIG_SUMO_SIM_anti_2 911 917 PF11976 0.360
LIG_SUMO_SIM_par_1 74 80 PF11976 0.434
LIG_SUMO_SIM_par_1 743 750 PF11976 0.413
LIG_TRAF2_1 522 525 PF00917 0.538
LIG_TYR_ITIM 801 806 PF00017 0.413
LIG_WRC_WIRS_1 410 415 PF05994 0.591
LIG_WRC_WIRS_1 576 581 PF05994 0.482
LIG_WRC_WIRS_1 637 642 PF05994 0.700
LIG_WW_3 185 189 PF00397 0.598
LIG_WW_3 770 774 PF00397 0.413
MOD_CDC14_SPxK_1 185 188 PF00782 0.367
MOD_CDC14_SPxK_1 286 289 PF00782 0.438
MOD_CDK_SPxK_1 182 188 PF00069 0.595
MOD_CDK_SPxK_1 283 289 PF00069 0.433
MOD_CDK_SPxK_1 590 596 PF00069 0.550
MOD_CK1_1 142 148 PF00069 0.528
MOD_CK1_1 149 155 PF00069 0.438
MOD_CK1_1 244 250 PF00069 0.660
MOD_CK1_1 465 471 PF00069 0.690
MOD_CK1_1 550 556 PF00069 0.614
MOD_CK1_1 603 609 PF00069 0.661
MOD_CK1_1 635 641 PF00069 0.561
MOD_CK1_1 660 666 PF00069 0.702
MOD_CK1_1 693 699 PF00069 0.420
MOD_CK1_1 841 847 PF00069 0.459
MOD_CK2_1 217 223 PF00069 0.267
MOD_CK2_1 242 248 PF00069 0.624
MOD_CK2_1 486 492 PF00069 0.471
MOD_CK2_1 518 524 PF00069 0.686
MOD_CK2_1 841 847 PF00069 0.288
MOD_CK2_1 875 881 PF00069 0.520
MOD_GlcNHglycan 139 142 PF01048 0.583
MOD_GlcNHglycan 144 147 PF01048 0.595
MOD_GlcNHglycan 178 181 PF01048 0.414
MOD_GlcNHglycan 251 254 PF01048 0.668
MOD_GlcNHglycan 349 352 PF01048 0.547
MOD_GlcNHglycan 460 463 PF01048 0.640
MOD_GlcNHglycan 467 470 PF01048 0.672
MOD_GlcNHglycan 610 613 PF01048 0.595
MOD_GlcNHglycan 621 624 PF01048 0.728
MOD_GlcNHglycan 692 695 PF01048 0.664
MOD_GlcNHglycan 696 699 PF01048 0.562
MOD_GlcNHglycan 737 740 PF01048 0.338
MOD_GlcNHglycan 842 846 PF01048 0.294
MOD_GSK3_1 142 149 PF00069 0.579
MOD_GSK3_1 172 179 PF00069 0.503
MOD_GSK3_1 200 207 PF00069 0.532
MOD_GSK3_1 242 249 PF00069 0.650
MOD_GSK3_1 298 305 PF00069 0.481
MOD_GSK3_1 458 465 PF00069 0.650
MOD_GSK3_1 528 535 PF00069 0.726
MOD_GSK3_1 57 64 PF00069 0.695
MOD_GSK3_1 632 639 PF00069 0.737
MOD_GSK3_1 65 72 PF00069 0.700
MOD_GSK3_1 653 660 PF00069 0.497
MOD_GSK3_1 667 674 PF00069 0.613
MOD_GSK3_1 690 697 PF00069 0.527
MOD_GSK3_1 91 98 PF00069 0.545
MOD_GSK3_1 934 941 PF00069 0.450
MOD_LATS_1 241 247 PF00433 0.468
MOD_LATS_1 89 95 PF00433 0.344
MOD_N-GLC_1 146 151 PF02516 0.580
MOD_N-GLC_1 233 238 PF02516 0.679
MOD_N-GLC_1 26 31 PF02516 0.637
MOD_N-GLC_1 356 361 PF02516 0.611
MOD_N-GLC_1 69 74 PF02516 0.558
MOD_N-GLC_1 893 898 PF02516 0.538
MOD_NEK2_1 215 220 PF00069 0.246
MOD_NEK2_1 290 295 PF00069 0.627
MOD_NEK2_1 319 324 PF00069 0.550
MOD_NEK2_1 409 414 PF00069 0.532
MOD_NEK2_1 532 537 PF00069 0.694
MOD_NEK2_1 547 552 PF00069 0.595
MOD_NEK2_1 747 752 PF00069 0.329
MOD_NEK2_1 938 943 PF00069 0.439
MOD_NEK2_1 95 100 PF00069 0.558
MOD_NEK2_2 534 539 PF00069 0.687
MOD_NEK2_2 786 791 PF00069 0.232
MOD_NEK2_2 934 939 PF00069 0.504
MOD_PIKK_1 925 931 PF00454 0.536
MOD_PK_1 903 909 PF00069 0.549
MOD_PKA_2 175 181 PF00069 0.426
MOD_PKA_2 242 248 PF00069 0.564
MOD_PKA_2 254 260 PF00069 0.627
MOD_PKA_2 700 706 PF00069 0.371
MOD_PKA_2 786 792 PF00069 0.459
MOD_PKA_2 838 844 PF00069 0.373
MOD_PKA_2 923 929 PF00069 0.493
MOD_PKB_1 91 99 PF00069 0.477
MOD_Plk_1 200 206 PF00069 0.466
MOD_Plk_1 233 239 PF00069 0.697
MOD_Plk_1 356 362 PF00069 0.606
MOD_Plk_1 475 481 PF00069 0.634
MOD_Plk_1 720 726 PF00069 0.388
MOD_Plk_1 893 899 PF00069 0.510
MOD_Plk_1 934 940 PF00069 0.532
MOD_Plk_2-3 793 799 PF00069 0.413
MOD_Plk_4 206 212 PF00069 0.570
MOD_Plk_4 324 330 PF00069 0.619
MOD_Plk_4 409 415 PF00069 0.552
MOD_Plk_4 45 51 PF00069 0.548
MOD_Plk_4 660 666 PF00069 0.712
MOD_Plk_4 685 691 PF00069 0.662
MOD_Plk_4 741 747 PF00069 0.346
MOD_Plk_4 934 940 PF00069 0.486
MOD_Plk_4 95 101 PF00069 0.448
MOD_ProDKin_1 182 188 PF00069 0.595
MOD_ProDKin_1 283 289 PF00069 0.433
MOD_ProDKin_1 456 462 PF00069 0.696
MOD_ProDKin_1 463 469 PF00069 0.723
MOD_ProDKin_1 518 524 PF00069 0.668
MOD_ProDKin_1 550 556 PF00069 0.583
MOD_ProDKin_1 590 596 PF00069 0.594
MOD_ProDKin_1 600 606 PF00069 0.524
MOD_ProDKin_1 632 638 PF00069 0.483
MOD_ProDKin_1 682 688 PF00069 0.668
MOD_SUMO_rev_2 877 885 PF00179 0.522
TRG_DiLeu_BaEn_1 847 852 PF01217 0.459
TRG_DiLeu_BaLyEn_6 210 215 PF01217 0.545
TRG_DiLeu_BaLyEn_6 362 367 PF01217 0.617
TRG_ENDOCYTIC_2 349 352 PF00928 0.620
TRG_ENDOCYTIC_2 512 515 PF00928 0.673
TRG_ENDOCYTIC_2 803 806 PF00928 0.413
TRG_ER_diArg_1 508 511 PF00400 0.683
TRG_ER_diArg_1 538 540 PF00400 0.744
TRG_ER_diArg_1 775 778 PF00400 0.323
TRG_ER_diArg_1 82 84 PF00400 0.602
TRG_Pf-PMV_PEXEL_1 188 193 PF00026 0.607

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I508 Leptomonas seymouri 44% 99%
A0A1X0NRF7 Trypanosomatidae 25% 94%
A0A3R7LPT9 Trypanosoma rangeli 28% 100%
A0A3S7X7B4 Leishmania donovani 77% 100%
A4I9G7 Leishmania infantum 78% 100%
E9B4G5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%
Q4Q3L0 Leishmania major 77% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS