Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM33_LEIBR

TriTrypDb:

LbrM.33.3530 , LBRM2903_330044000

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HM33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.700
CLV_NRD_NRD_1	163	165	PF00675	0.811
CLV_NRD_NRD_1	166	168	PF00675	0.744
CLV_NRD_NRD_1	29	31	PF00675	0.608
CLV_NRD_NRD_1	33	35	PF00675	0.640
CLV_PCSK_KEX2_1	163	165	PF00082	0.596
CLV_PCSK_KEX2_1	29	31	PF00082	0.492
CLV_PCSK_KEX2_1	33	35	PF00082	0.436
CLV_PCSK_PC7_1	29	35	PF00082	0.390
CLV_PCSK_SKI1_1	111	115	PF00082	0.486
CLV_PCSK_SKI1_1	167	171	PF00082	0.541
CLV_PCSK_SKI1_1	44	48	PF00082	0.566
DEG_Nend_UBRbox_2	1	3	PF02207	0.484
DEG_SCF_FBW7_1	311	316	PF00400	0.545
DEG_SPOP_SBC_1	158	162	PF00917	0.828
DEG_SPOP_SBC_1	182	186	PF00917	0.601
DOC_CKS1_1	177	182	PF01111	0.608
DOC_MAPK_gen_1	167	177	PF00069	0.543
DOC_USP7_MATH_1	157	161	PF00917	0.831
DOC_USP7_MATH_1	190	194	PF00917	0.578
DOC_USP7_MATH_1	201	205	PF00917	0.532
DOC_USP7_MATH_1	242	246	PF00917	0.817
DOC_USP7_MATH_1	263	267	PF00917	0.755
DOC_USP7_MATH_1	302	306	PF00917	0.787
DOC_USP7_MATH_1	320	324	PF00917	0.475
DOC_USP7_MATH_1	62	66	PF00917	0.427
DOC_USP7_MATH_1	8	12	PF00917	0.453
DOC_USP7_MATH_2	271	277	PF00917	0.477
DOC_WW_Pin1_4	176	181	PF00397	0.609
DOC_WW_Pin1_4	256	261	PF00397	0.800
DOC_WW_Pin1_4	307	312	PF00397	0.652
LIG_14-3-3_CanoR_1	167	177	PF00244	0.757
LIG_14-3-3_CanoR_1	22	28	PF00244	0.669
LIG_14-3-3_CanoR_1	291	295	PF00244	0.630
LIG_14-3-3_CanoR_1	94	104	PF00244	0.456
LIG_FHA_1	112	118	PF00498	0.724
LIG_FHA_1	169	175	PF00498	0.631
LIG_FHA_1	177	183	PF00498	0.593
LIG_FHA_1	184	190	PF00498	0.566
LIG_FHA_1	223	229	PF00498	0.619
LIG_FHA_1	291	297	PF00498	0.516
LIG_FHA_1	314	320	PF00498	0.719
LIG_FHA_2	241	247	PF00498	0.586
LIG_PDZ_Class_2	324	329	PF00595	0.759
LIG_PTAP_UEV_1	303	308	PF05743	0.562
LIG_SH2_STAT5	280	283	PF00017	0.436
LIG_SH3_3	254	260	PF00018	0.679
LIG_SH3_3	298	304	PF00018	0.546
LIG_SH3_3	308	314	PF00018	0.526
LIG_SUMO_SIM_anti_2	171	179	PF11976	0.544
LIG_SUMO_SIM_par_1	171	179	PF11976	0.544
LIG_TRAF2_1	18	21	PF00917	0.402
LIG_TRAF2_1	204	207	PF00917	0.663
LIG_TRAF2_1	236	239	PF00917	0.694
LIG_TRAF2_1	54	57	PF00917	0.425
LIG_UBA3_1	131	140	PF00899	0.440
LIG_WW_3	312	316	PF00397	0.543
MOD_CDK_SPxK_1	309	315	PF00069	0.553
MOD_CK1_1	162	168	PF00069	0.815
MOD_CK1_1	265	271	PF00069	0.532
MOD_CK1_1	309	315	PF00069	0.553
MOD_CK1_1	72	78	PF00069	0.426
MOD_CK2_1	182	188	PF00069	0.715
MOD_CK2_1	201	207	PF00069	0.507
MOD_CK2_1	240	246	PF00069	0.584
MOD_CK2_1	273	279	PF00069	0.730
MOD_CK2_1	95	101	PF00069	0.446
MOD_Cter_Amidation	165	168	PF01082	0.539
MOD_GlcNHglycan	164	167	PF01048	0.650
MOD_GlcNHglycan	218	221	PF01048	0.745
MOD_GlcNHglycan	265	268	PF01048	0.655
MOD_GlcNHglycan	275	278	PF01048	0.690
MOD_GlcNHglycan	304	307	PF01048	0.820
MOD_GlcNHglycan	63	67	PF01048	0.426
MOD_GSK3_1	153	160	PF00069	0.769
MOD_GSK3_1	222	229	PF00069	0.786
MOD_GSK3_1	302	309	PF00069	0.672
MOD_GSK3_1	92	99	PF00069	0.518
MOD_N-GLC_1	321	326	PF02516	0.619
MOD_NEK2_1	23	28	PF00069	0.666
MOD_NEK2_1	90	95	PF00069	0.436
MOD_PKA_2	162	168	PF00069	0.815
MOD_PKA_2	2	8	PF00069	0.471
MOD_PKA_2	290	296	PF00069	0.730
MOD_Plk_1	201	207	PF00069	0.566
MOD_Plk_1	72	78	PF00069	0.591
MOD_Plk_2-3	139	145	PF00069	0.502
MOD_Plk_2-3	69	75	PF00069	0.430
MOD_ProDKin_1	176	182	PF00069	0.609
MOD_ProDKin_1	256	262	PF00069	0.801
MOD_ProDKin_1	307	313	PF00069	0.649
MOD_SUMO_for_1	46	49	PF00179	0.616
MOD_SUMO_for_1	54	57	PF00179	0.503
MOD_SUMO_for_1	60	63	PF00179	0.525
MOD_SUMO_rev_2	265	274	PF00179	0.520
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.519
TRG_ER_diArg_1	29	31	PF00400	0.433
TRG_ER_diArg_1	76	79	PF00400	0.652
TRG_NLS_MonoExtC_3	33	39	PF00514	0.384
TRG_NLS_MonoExtN_4	164	171	PF00514	0.541
TRG_NLS_MonoExtN_4	33	38	PF00514	0.497
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IUB2	Leishmania donovani	53%	72%
A4I9G6	Leishmania infantum	53%	72%
E9B4G4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	85%
Q4Q3L1	Leishmania major	54%	100%