Putative 60S ribosomal protein L44

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L44

Species:

Leishmania braziliensis

UniProt:

A4HM31_LEIBR

TriTrypDb:

LbrM.33.3510 , LBRM2903_330043800

Length:

106

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	13
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	13
GO:0015934	large ribosomal subunit	4	1
GO:0022625	cytosolic large ribosomal subunit	5	1
GO:0044391	ribosomal subunit	3	1

Expansion

Sequence features

A4HM31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM31

PDB structure(s): 6az3_p

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	13
GO:0006518	peptide metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009058	biosynthetic process	2	13
GO:0009059	macromolecule biosynthetic process	4	13
GO:0009987	cellular process	1	13
GO:0019538	protein metabolic process	3	13
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	13
GO:0043043	peptide biosynthetic process	5	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043603	amide metabolic process	3	13
GO:0043604	amide biosynthetic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044249	cellular biosynthetic process	3	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0044271	cellular nitrogen compound biosynthetic process	4	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:1901566	organonitrogen compound biosynthetic process	4	13
GO:1901576	organic substance biosynthetic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	13
GO:0005198	structural molecule activity	1	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	41	43	PF00675	0.220
CLV_NRD_NRD_1	44	46	PF00675	0.222
CLV_PCSK_FUR_1	38	42	PF00082	0.224
CLV_PCSK_KEX2_1	40	42	PF00082	0.213
CLV_PCSK_KEX2_1	86	88	PF00082	0.213
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.213
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.213
CLV_PCSK_SKI1_1	21	25	PF00082	0.213
CLV_PCSK_SKI1_1	55	59	PF00082	0.219
CLV_PCSK_SKI1_1	60	64	PF00082	0.226
CLV_PCSK_SKI1_1	67	71	PF00082	0.247
DOC_MAPK_gen_1	60	70	PF00069	0.413
DOC_MAPK_MEF2A_6	63	72	PF00069	0.413
DOC_USP7_MATH_1	19	23	PF00917	0.252
DOC_USP7_UBL2_3	63	67	PF12436	0.433
DOC_USP7_UBL2_3	98	102	PF12436	0.482
LIG_FHA_1	52	58	PF00498	0.413
LIG_FHA_1	63	69	PF00498	0.413
LIG_LIR_Nem_3	22	26	PF02991	0.430
LIG_RPA_C_Fungi	29	41	PF08784	0.252
LIG_SH2_STAT3	50	53	PF00017	0.252
MOD_Cter_Amidation	38	41	PF01082	0.252
MOD_GlcNHglycan	47	50	PF01048	0.252
MOD_GlcNHglycan	74	77	PF01048	0.349
MOD_GSK3_1	72	79	PF00069	0.268
MOD_LATS_1	59	65	PF00433	0.268
MOD_NEK2_1	72	77	PF00069	0.252
MOD_NEK2_1	85	90	PF00069	0.252
MOD_NEK2_2	19	24	PF00069	0.252
MOD_NEK2_2	76	81	PF00069	0.393
MOD_PKA_1	45	51	PF00069	0.252
MOD_PKA_1	96	102	PF00069	0.484
MOD_SUMO_rev_2	92	99	PF00179	0.445
TRG_ER_diArg_1	41	43	PF00400	0.252
TRG_NLS_Bipartite_1	45	64	PF00514	0.252
TRG_NLS_MonoExtN_4	5	10	PF00514	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6J9	Leptomonas seymouri	95%	100%
A0A0S4KH49	Bodo saltans	88%	100%
A0A1D8PEV4	Candida albicans (strain SC5314 / ATCC MYA-2876)	65%	100%
A0A1X0NJJ1	Trypanosomatidae	92%	100%
A0A3Q8IKJ4	Leishmania donovani	99%	100%
A0A3R7KSA7	Trypanosoma rangeli	93%	100%
A4H7F7	Leishmania braziliensis	99%	100%
A4I9G4	Leishmania infantum	99%	100%
A8PCG3	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	62%	100%
A9L948	Papio anubis	58%	100%
B8D537	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	44%	100%
C9ZJT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	92%	100%
D0VWQ4	Canis lupus familiaris	61%	100%
E9APJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
F2L1X6	Thermoproteus uzoniensis (strain 768-20)	45%	100%
O23290	Arabidopsis thaliana	65%	100%
O59870	Phaffia rhodozyma	66%	100%
O97231	Plasmodium falciparum (isolate 3D7)	59%	100%
P0CQ50	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	64%	100%
P0CQ51	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	64%	100%
P0CX27	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	66%	100%
P0CX28	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	66%	100%
P17843	Trypanosoma brucei brucei	92%	100%
P27074	Candida maltosa	65%	100%
P27075	Candida tropicalis	66%	100%
P27076	Kluyveromyces marxianus	63%	100%
P31027	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	63%	100%
P31028	Schwanniomyces occidentalis	65%	100%
P31866	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	66%	100%
P48166	Caenorhabditis elegans	60%	100%
P49213	Chlamydomonas reinhardtii	65%	100%
P52809	Cyberlindnera jadinii	67%	100%
P61485	Danio rerio	61%	100%
P61486	Takifugu rubripes	61%	100%
P61487	Ictalurus punctatus	61%	100%
P83881	Homo sapiens	61%	100%
P83882	Mus musculus	61%	100%
P83883	Rattus norvegicus	61%	100%
P83884	Sus scrofa	61%	100%
P90702	Brugia malayi	58%	100%
Q00477	Candida maltosa	65%	100%
Q22X38	Tetrahymena thermophila (strain SB210)	50%	97%
Q3SZ59	Bos taurus	61%	100%
Q4PNY0	Pichia kudriavzevii	65%	100%
Q4Q3L3	Leishmania major	99%	100%
Q55CW5	Dictyostelium discoideum	66%	100%
Q5R9D2	Pongo abelii	59%	100%
Q6BLK0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	66%	100%
Q6CFS7	Yarrowia lipolytica (strain CLIB 122 / E 150)	64%	100%
Q754N8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	63%	100%
Q8SR18	Encephalitozoon cuniculi (strain GB-M1)	48%	100%
Q96499	Gossypium hirsutum	66%	100%
Q969Q0	Homo sapiens	60%	100%
Q9HIX1	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	35%	100%
Q9NB33	Ochlerotatus triseriatus	57%	100%
Q9UTI8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	61%	100%
Q9UVB8	Wickerhamomyces ciferrii (strain ATCC 14091 / BCRC 22168 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL Y-1031 F-60-10)	66%	100%
Q9UWE4	Coprinopsis cinerea	62%	100%
Q9YF00	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	45%	100%
V5BRN9	Trypanosoma cruzi	93%	100%