Coatomer subunit beta'

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta prime cop protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HM28_LEIBR

TriTrypDb:

LbrM.33.3480 , LBRM2903_330043400

Length:

904

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	11
GO:0012506	vesicle membrane	4	10
GO:0016020	membrane	2	11
GO:0030117	membrane coat	3	11
GO:0030659	cytoplasmic vesicle membrane	5	10
GO:0030660	Golgi-associated vesicle membrane	5	10
GO:0030662	coated vesicle membrane	5	10
GO:0030663	COPI-coated vesicle membrane	6	10
GO:0031090	organelle membrane	3	11
GO:0032991	protein-containing complex	1	11
GO:0098588	bounding membrane of organelle	4	11
GO:0098796	membrane protein complex	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0030120	vesicle coat	4	1
GO:0030126	COPI vesicle coat	5	1

Expansion

Sequence features

A4HM28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM28

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016192	vesicle-mediated transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	1
GO:0006891	intra-Golgi vesicle-mediated transport	6	1
GO:0048193	Golgi vesicle transport	5	1

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	335	339	PF00656	0.434
CLV_NRD_NRD_1	808	810	PF00675	0.635
CLV_PCSK_KEX2_1	282	284	PF00082	0.360
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.419
CLV_PCSK_SKI1_1	305	309	PF00082	0.393
CLV_PCSK_SKI1_1	357	361	PF00082	0.173
CLV_PCSK_SKI1_1	414	418	PF00082	0.228
CLV_PCSK_SKI1_1	422	426	PF00082	0.223
CLV_PCSK_SKI1_1	581	585	PF00082	0.226
CLV_PCSK_SKI1_1	629	633	PF00082	0.308
DEG_APCC_KENBOX_2	569	573	PF00400	0.444
DOC_CKS1_1	173	178	PF01111	0.384
DOC_CKS1_1	852	857	PF01111	0.475
DOC_CYCLIN_RxL_1	650	660	PF00134	0.484
DOC_CYCLIN_yCln2_LP_2	425	431	PF00134	0.358
DOC_CYCLIN_yCln2_LP_2	788	794	PF00134	0.500
DOC_MAPK_gen_1	282	289	PF00069	0.306
DOC_MAPK_gen_1	417	427	PF00069	0.411
DOC_MAPK_gen_1	809	818	PF00069	0.465
DOC_MAPK_HePTP_8	430	442	PF00069	0.489
DOC_MAPK_HePTP_8	626	638	PF00069	0.426
DOC_MAPK_MEF2A_6	433	442	PF00069	0.408
DOC_MAPK_MEF2A_6	629	638	PF00069	0.423
DOC_MAPK_MEF2A_6	645	652	PF00069	0.383
DOC_MAPK_MEF2A_6	813	820	PF00069	0.467
DOC_MAPK_RevD_3	795	810	PF00069	0.373
DOC_PP1_RVXF_1	524	531	PF00149	0.413
DOC_PP1_RVXF_1	60	67	PF00149	0.287
DOC_PP2B_LxvP_1	425	428	PF13499	0.508
DOC_PP2B_PxIxI_1	611	617	PF00149	0.459
DOC_PP4_FxxP_1	11	14	PF00568	0.253
DOC_PP4_FxxP_1	435	438	PF00568	0.413
DOC_SPAK_OSR1_1	587	591	PF12202	0.358
DOC_USP7_MATH_1	153	157	PF00917	0.432
DOC_USP7_MATH_1	158	162	PF00917	0.405
DOC_USP7_MATH_1	331	335	PF00917	0.479
DOC_USP7_MATH_1	504	508	PF00917	0.429
DOC_USP7_MATH_1	687	691	PF00917	0.459
DOC_USP7_MATH_1	782	786	PF00917	0.435
DOC_USP7_MATH_1	858	862	PF00917	0.593
DOC_WW_Pin1_4	172	177	PF00397	0.347
DOC_WW_Pin1_4	333	338	PF00397	0.563
DOC_WW_Pin1_4	462	467	PF00397	0.469
DOC_WW_Pin1_4	834	839	PF00397	0.518
DOC_WW_Pin1_4	851	856	PF00397	0.502
DOC_WW_Pin1_4	862	867	PF00397	0.491
LIG_14-3-3_CanoR_1	263	273	PF00244	0.335
LIG_14-3-3_CanoR_1	275	280	PF00244	0.271
LIG_14-3-3_CanoR_1	385	390	PF00244	0.426
LIG_14-3-3_CanoR_1	422	428	PF00244	0.426
LIG_14-3-3_CanoR_1	69	74	PF00244	0.288
LIG_14-3-3_CanoR_1	775	779	PF00244	0.472
LIG_14-3-3_CanoR_1	783	791	PF00244	0.406
LIG_BIR_II_1	1	5	PF00653	0.491
LIG_BIR_III_2	880	884	PF00653	0.530
LIG_BIR_III_4	311	315	PF00653	0.500
LIG_BRCT_BRCA1_1	155	159	PF00533	0.480
LIG_BRCT_BRCA1_1	234	238	PF00533	0.338
LIG_BRCT_BRCA1_1	446	450	PF00533	0.413
LIG_BRCT_BRCA1_1	483	487	PF00533	0.508
LIG_BRCT_BRCA1_1	584	588	PF00533	0.386
LIG_CtBP_PxDLS_1	817	821	PF00389	0.455
LIG_deltaCOP1_diTrp_1	128	133	PF00928	0.311
LIG_eIF4E_1	44	50	PF01652	0.467
LIG_EVH1_2	867	871	PF00568	0.452
LIG_FHA_1	132	138	PF00498	0.170
LIG_FHA_1	165	171	PF00498	0.409
LIG_FHA_1	209	215	PF00498	0.413
LIG_FHA_1	259	265	PF00498	0.336
LIG_FHA_1	283	289	PF00498	0.270
LIG_FHA_1	410	416	PF00498	0.426
LIG_FHA_1	44	50	PF00498	0.377
LIG_FHA_1	453	459	PF00498	0.469
LIG_FHA_1	472	478	PF00498	0.469
LIG_FHA_1	611	617	PF00498	0.459
LIG_FHA_2	115	121	PF00498	0.413
LIG_FHA_2	318	324	PF00498	0.370
LIG_FHA_2	503	509	PF00498	0.416
LIG_FHA_2	638	644	PF00498	0.392
LIG_FHA_2	852	858	PF00498	0.570
LIG_Integrin_isoDGR_2	313	315	PF01839	0.467
LIG_Integrin_RGD_1	197	199	PF01839	0.308
LIG_LIR_Apic_2	432	438	PF02991	0.354
LIG_LIR_Apic_2	8	14	PF02991	0.270
LIG_LIR_Gen_1	373	384	PF02991	0.432
LIG_LIR_Gen_1	401	408	PF02991	0.418
LIG_LIR_Gen_1	512	521	PF02991	0.413
LIG_LIR_Gen_1	870	877	PF02991	0.471
LIG_LIR_Nem_3	259	265	PF02991	0.469
LIG_LIR_Nem_3	373	379	PF02991	0.432
LIG_LIR_Nem_3	401	407	PF02991	0.431
LIG_LIR_Nem_3	452	456	PF02991	0.413
LIG_LIR_Nem_3	512	518	PF02991	0.413
LIG_LIR_Nem_3	571	577	PF02991	0.358
LIG_LIR_Nem_3	669	674	PF02991	0.508
LIG_LIR_Nem_3	696	700	PF02991	0.510
LIG_LIR_Nem_3	800	806	PF02991	0.403
LIG_LIR_Nem_3	870	874	PF02991	0.471
LIG_LYPXL_yS_3	794	797	PF13949	0.395
LIG_MYND_1	795	799	PF01753	0.393
LIG_PDZ_Class_1	899	904	PF00595	0.468
LIG_Pex14_2	487	491	PF04695	0.413
LIG_SH2_CRK	376	380	PF00017	0.426
LIG_SH2_CRK	704	708	PF00017	0.469
LIG_SH2_GRB2like	284	287	PF00017	0.254
LIG_SH2_GRB2like	537	540	PF00017	0.508
LIG_SH2_NCK_1	376	380	PF00017	0.508
LIG_SH2_STAP1	284	288	PF00017	0.245
LIG_SH2_STAP1	758	762	PF00017	0.498
LIG_SH2_STAT3	42	45	PF00017	0.432
LIG_SH2_STAT3	499	502	PF00017	0.508
LIG_SH2_STAT3	537	540	PF00017	0.508
LIG_SH2_STAT5	102	105	PF00017	0.413
LIG_SH2_STAT5	202	205	PF00017	0.413
LIG_SH2_STAT5	284	287	PF00017	0.274
LIG_SH2_STAT5	376	379	PF00017	0.433
LIG_SH2_STAT5	499	502	PF00017	0.444
LIG_SH2_STAT5	537	540	PF00017	0.434
LIG_SH2_STAT5	547	550	PF00017	0.395
LIG_SH2_STAT5	563	566	PF00017	0.413
LIG_SH2_STAT5	567	570	PF00017	0.326
LIG_SH2_STAT5	683	686	PF00017	0.443
LIG_SH2_STAT5	762	765	PF00017	0.412
LIG_SH3_3	22	28	PF00018	0.337
LIG_SH3_3	237	243	PF00018	0.301
LIG_SH3_3	300	306	PF00018	0.440
LIG_SH3_3	393	399	PF00018	0.426
LIG_SH3_3	860	866	PF00018	0.669
LIG_SUMO_SIM_anti_2	455	460	PF11976	0.508
LIG_SUMO_SIM_anti_2	698	704	PF11976	0.474
LIG_SUMO_SIM_anti_2	741	747	PF11976	0.414
LIG_SUMO_SIM_par_1	112	117	PF11976	0.414
LIG_SUMO_SIM_par_1	315	320	PF11976	0.237
LIG_SUMO_SIM_par_1	340	346	PF11976	0.360
LIG_SUMO_SIM_par_1	438	444	PF11976	0.496
LIG_SUMO_SIM_par_1	476	484	PF11976	0.428
LIG_SUMO_SIM_par_1	612	617	PF11976	0.459
LIG_TYR_ITIM	702	707	PF00017	0.469
LIG_TYR_ITIM	801	806	PF00017	0.380
LIG_UBA3_1	378	387	PF00899	0.426
LIG_UBA3_1	564	570	PF00899	0.426
LIG_UBA3_1	700	705	PF00899	0.422
LIG_WRC_WIRS_1	225	230	PF05994	0.372
LIG_WRC_WIRS_1	416	421	PF05994	0.358
LIG_WRC_WIRS_1	50	55	PF05994	0.317
LIG_WRC_WIRS_1	70	75	PF05994	0.155
MOD_CDK_SPxK_1	834	840	PF00069	0.625
MOD_CK1_1	2	8	PF00069	0.516
MOD_CK1_1	258	264	PF00069	0.461
MOD_CK1_1	343	349	PF00069	0.377
MOD_CK1_1	380	386	PF00069	0.420
MOD_CK1_1	409	415	PF00069	0.358
MOD_CK1_1	52	58	PF00069	0.433
MOD_CK1_1	777	783	PF00069	0.509
MOD_CK1_1	859	865	PF00069	0.616
MOD_CK2_1	244	250	PF00069	0.245
MOD_CK2_1	317	323	PF00069	0.471
MOD_CK2_1	637	643	PF00069	0.437
MOD_CK2_1	805	811	PF00069	0.630
MOD_CK2_1	816	822	PF00069	0.497
MOD_CK2_1	851	857	PF00069	0.564
MOD_GlcNHglycan	1	4	PF01048	0.563
MOD_GlcNHglycan	155	159	PF01048	0.312
MOD_GlcNHglycan	160	163	PF01048	0.305
MOD_GlcNHglycan	204	207	PF01048	0.213
MOD_GlcNHglycan	35	38	PF01048	0.294
MOD_GlcNHglycan	379	382	PF01048	0.236
MOD_GlcNHglycan	400	403	PF01048	0.308
MOD_GlcNHglycan	483	486	PF01048	0.200
MOD_GlcNHglycan	696	700	PF01048	0.269
MOD_GlcNHglycan	722	725	PF01048	0.337
MOD_GlcNHglycan	831	834	PF01048	0.626
MOD_GlcNHglycan	900	904	PF01048	0.666
MOD_GSK3_1	127	134	PF00069	0.509
MOD_GSK3_1	154	161	PF00069	0.413
MOD_GSK3_1	204	211	PF00069	0.527
MOD_GSK3_1	244	251	PF00069	0.380
MOD_GSK3_1	264	271	PF00069	0.201
MOD_GSK3_1	5	12	PF00069	0.393
MOD_GSK3_1	610	617	PF00069	0.439
MOD_GSK3_1	858	865	PF00069	0.545
MOD_GSK3_1	86	93	PF00069	0.325
MOD_N-GLC_1	374	379	PF02516	0.220
MOD_N-GLC_1	444	449	PF02516	0.295
MOD_N-GLC_1	471	476	PF02516	0.259
MOD_N-GLC_1	502	507	PF02516	0.259
MOD_N-GLC_1	581	586	PF02516	0.201
MOD_NEK2_1	114	119	PF00069	0.508
MOD_NEK2_1	164	169	PF00069	0.413
MOD_NEK2_1	264	269	PF00069	0.459
MOD_NEK2_1	317	322	PF00069	0.427
MOD_NEK2_1	407	412	PF00069	0.444
MOD_NEK2_1	480	485	PF00069	0.537
MOD_NEK2_1	625	630	PF00069	0.469
MOD_NEK2_1	728	733	PF00069	0.445
MOD_NEK2_1	746	751	PF00069	0.364
MOD_NEK2_1	856	861	PF00069	0.515
MOD_NEK2_1	90	95	PF00069	0.332
MOD_PIKK_1	12	18	PF00454	0.466
MOD_PIKK_1	43	49	PF00454	0.327
MOD_PIKK_1	733	739	PF00454	0.459
MOD_PIKK_1	782	788	PF00454	0.503
MOD_PIKK_1	856	862	PF00454	0.493
MOD_PKA_1	282	288	PF00069	0.356
MOD_PKA_2	282	288	PF00069	0.374
MOD_PKA_2	774	780	PF00069	0.474
MOD_PKA_2	782	788	PF00069	0.420
MOD_Plk_1	120	126	PF00069	0.413
MOD_Plk_1	154	160	PF00069	0.444
MOD_Plk_1	164	170	PF00069	0.383
MOD_Plk_1	208	214	PF00069	0.419
MOD_Plk_1	322	328	PF00069	0.426
MOD_Plk_1	374	380	PF00069	0.411
MOD_Plk_1	444	450	PF00069	0.449
MOD_Plk_1	511	517	PF00069	0.486
MOD_Plk_1	581	587	PF00069	0.412
MOD_Plk_1	614	620	PF00069	0.459
MOD_Plk_2-3	637	643	PF00069	0.390
MOD_Plk_4	232	238	PF00069	0.339
MOD_Plk_4	374	380	PF00069	0.424
MOD_Plk_4	444	450	PF00069	0.446
MOD_Plk_4	69	75	PF00069	0.302
MOD_Plk_4	859	865	PF00069	0.488
MOD_ProDKin_1	172	178	PF00069	0.345
MOD_ProDKin_1	333	339	PF00069	0.563
MOD_ProDKin_1	462	468	PF00069	0.469
MOD_ProDKin_1	834	840	PF00069	0.523
MOD_ProDKin_1	851	857	PF00069	0.505
MOD_ProDKin_1	862	868	PF00069	0.488
MOD_SUMO_rev_2	323	332	PF00179	0.413
MOD_SUMO_rev_2	516	525	PF00179	0.508
MOD_SUMO_rev_2	805	814	PF00179	0.446
TRG_DiLeu_BaEn_1	260	265	PF01217	0.422
TRG_DiLeu_BaEn_1	627	632	PF01217	0.508
TRG_DiLeu_BaEn_1	741	746	PF01217	0.508
TRG_DiLeu_BaEn_1	894	899	PF01217	0.473
TRG_DiLeu_BaLyEn_6	435	440	PF01217	0.426
TRG_DiLeu_LyEn_5	260	265	PF01217	0.422
TRG_ENDOCYTIC_2	284	287	PF00928	0.254
TRG_ENDOCYTIC_2	376	379	PF00928	0.433
TRG_ENDOCYTIC_2	404	407	PF00928	0.420
TRG_ENDOCYTIC_2	683	686	PF00928	0.443
TRG_ENDOCYTIC_2	704	707	PF00928	0.444
TRG_ENDOCYTIC_2	794	797	PF00928	0.395
TRG_ENDOCYTIC_2	803	806	PF00928	0.480
TRG_ENDOCYTIC_2	87	90	PF00928	0.322
TRG_NES_CRM1_1	647	660	PF08389	0.401
TRG_Pf-PMV_PEXEL_1	460	464	PF00026	0.213
TRG_Pf-PMV_PEXEL_1	629	633	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R6	Leptomonas seymouri	24%	76%
A0A0N1HWQ8	Leptomonas seymouri	85%	100%
A0A0S4IPS1	Bodo saltans	24%	75%
A0A0S4J4T7	Bodo saltans	42%	91%
A0A1X0NT50	Trypanosomatidae	61%	95%
A0A1X0PA85	Trypanosomatidae	22%	76%
A0A3Q8IGV8	Leishmania donovani	84%	100%
A0A3S7X8J8	Leishmania donovani	24%	76%
A0A422N6J5	Trypanosoma rangeli	57%	98%
A4HBF3	Leishmania braziliensis	23%	76%
A4I9G2	Leishmania infantum	84%	100%
A4IAK2	Leishmania infantum	24%	76%
C9ZJT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9B4G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9B5M6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	76%
O35142	Rattus norvegicus	41%	100%
O42937	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
O55029	Mus musculus	41%	100%
O62621	Drosophila melanogaster	40%	99%
P35605	Bos taurus	41%	100%
P35606	Homo sapiens	41%	100%
P41811	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
P53621	Homo sapiens	24%	74%
P53622	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	75%
Q0J3D9	Oryza sativa subsp. japonica	25%	74%
Q20168	Caenorhabditis elegans	37%	90%
Q27954	Bos taurus	24%	74%
Q4Q2B0	Leishmania major	24%	76%
Q4Q3L5	Leishmania major	84%	98%
Q4R4I8	Macaca fascicularis	41%	100%
Q54YD8	Dictyostelium discoideum	42%	90%
Q55FR9	Dictyostelium discoideum	23%	74%
Q5R664	Pongo abelii	42%	100%
Q5VQ78	Oryza sativa subsp. japonica	42%	100%
Q6H8D5	Oryza sativa subsp. japonica	43%	99%
Q6H8D6	Oryza sativa subsp. japonica	43%	99%
Q8CIE6	Mus musculus	24%	74%
Q8L828	Arabidopsis thaliana	42%	99%
Q94A40	Arabidopsis thaliana	25%	74%
Q96WV5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	75%
Q9AUR7	Oryza sativa subsp. japonica	24%	74%
Q9AUR8	Oryza sativa subsp. japonica	25%	74%
Q9C827	Arabidopsis thaliana	42%	98%
Q9CAA0	Arabidopsis thaliana	43%	98%
Q9SJT9	Arabidopsis thaliana	25%	74%
V5AUU0	Trypanosoma cruzi	56%	99%