Putative cation transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cation transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4HM27_LEIBR

TriTrypDb:

LbrM.33.3470 , LBRM2903_330043300

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 31
NetGPI	no	yes: 0, no: 31

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	4
GO:0016020	membrane	2	32
GO:0110165	cellular anatomical entity	1	32

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Expansion

Sequence features

A4HM27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM27

Function

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Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	4
GO:0006810	transport	3	4
GO:0006811	monoatomic ion transport	4	4
GO:0006812	monoatomic cation transport	5	4
GO:0006829	zinc ion transport	8	4
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0006882	intracellular zinc ion homeostasis	7	1
GO:0009987	cellular process	1	4
GO:0019725	cellular homeostasis	2	1

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	32
GO:0005381	iron ion transmembrane transporter activity	7	1
GO:0005385	zinc ion transmembrane transporter activity	7	4
GO:0008324	monoatomic cation transmembrane transporter activity	4	32
GO:0015075	monoatomic ion transmembrane transporter activity	3	32
GO:0015093	ferrous iron transmembrane transporter activity	8	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	32
GO:0022857	transmembrane transporter activity	2	32
GO:0022890	inorganic cation transmembrane transporter activity	4	32
GO:0046873	metal ion transmembrane transporter activity	5	32

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	47	49	PF00082	0.251
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.251
CLV_PCSK_SKI1_1	142	146	PF00082	0.256
DEG_Nend_UBRbox_2	1	3	PF02207	0.322
DOC_CYCLIN_yClb5_NLxxxL_5	96	102	PF00134	0.142
DOC_CYCLIN_yCln2_LP_2	98	104	PF00134	0.149
DOC_PP2B_LxvP_1	243	246	PF13499	0.445
DOC_PP4_FxxP_1	155	158	PF00568	0.342
DOC_PP4_FxxP_1	52	55	PF00568	0.524
DOC_USP7_MATH_1	135	139	PF00917	0.442

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E9	Leptomonas seymouri	35%	100%
A0A0N0P5K7	Leptomonas seymouri	59%	100%
A0A1X0NR51	Trypanosomatidae	38%	90%
A0A1X0NSB9	Trypanosomatidae	31%	82%
A0A1X0NSI7	Trypanosomatidae	31%	88%
A0A3R7LZX6	Trypanosoma rangeli	35%	95%
A0A3S7X1N7	Leishmania donovani	33%	72%
A0A3S7X501	Leishmania donovani	32%	77%
A0A3S7X7B0	Leishmania donovani	76%	100%
A0A422MUI2	Trypanosoma rangeli	32%	90%

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