Putative cation transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cation transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4HM27_LEIBR

TriTrypDb:

LbrM.33.3470 , LBRM2903_330043300

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 31
NetGPI	no	yes: 0, no: 31

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	32
GO:0110165	cellular anatomical entity	1	32
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	4

Expansion

Sequence features

A4HM27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM27

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	4
GO:0006810	transport	3	4
GO:0006811	monoatomic ion transport	4	4
GO:0006812	monoatomic cation transport	5	4
GO:0006829	zinc ion transport	8	4
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0006882	intracellular zinc ion homeostasis	7	1
GO:0009987	cellular process	1	4
GO:0019725	cellular homeostasis	2	1
GO:0030001	metal ion transport	6	4
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0034220	monoatomic ion transmembrane transport	3	4
GO:0042592	homeostatic process	3	1
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055069	obsolete zinc ion homeostasis	8	1
GO:0055076	obsolete transition metal ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0055085	transmembrane transport	2	4
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071577	zinc ion transmembrane transport	6	4
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	1
GO:0072507	obsolete divalent inorganic cation homeostasis	7	1
GO:0098655	monoatomic cation transmembrane transport	4	4
GO:0098660	inorganic ion transmembrane transport	4	4
GO:0098662	inorganic cation transmembrane transport	5	4
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	32
GO:0008324	monoatomic cation transmembrane transporter activity	4	32
GO:0015075	monoatomic ion transmembrane transporter activity	3	32
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	32
GO:0022857	transmembrane transporter activity	2	32
GO:0022890	inorganic cation transmembrane transporter activity	4	32
GO:0046873	metal ion transmembrane transporter activity	5	32
GO:0005385	zinc ion transmembrane transporter activity	7	4
GO:0046915	transition metal ion transmembrane transporter activity	6	4
GO:0005381	iron ion transmembrane transporter activity	7	1
GO:0015093	ferrous iron transmembrane transporter activity	8	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	47	49	PF00082	0.251
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.251
CLV_PCSK_SKI1_1	142	146	PF00082	0.256
DEG_Nend_UBRbox_2	1	3	PF02207	0.322
DOC_CYCLIN_yClb5_NLxxxL_5	96	102	PF00134	0.142
DOC_CYCLIN_yCln2_LP_2	98	104	PF00134	0.149
DOC_PP2B_LxvP_1	243	246	PF13499	0.445
DOC_PP4_FxxP_1	155	158	PF00568	0.342
DOC_PP4_FxxP_1	52	55	PF00568	0.524
DOC_USP7_MATH_1	135	139	PF00917	0.442
DOC_USP7_MATH_1	219	223	PF00917	0.311
DOC_USP7_MATH_1	322	326	PF00917	0.212
DOC_USP7_MATH_1	82	86	PF00917	0.303
DOC_WW_Pin1_4	131	136	PF00397	0.388
DOC_WW_Pin1_4	3	8	PF00397	0.362
DOC_WW_Pin1_4	305	310	PF00397	0.520
LIG_14-3-3_CanoR_1	48	53	PF00244	0.383
LIG_Actin_WH2_2	66	82	PF00022	0.451
LIG_APCC_ABBA_1	229	234	PF00400	0.342
LIG_BRCT_BRCA1_1	243	247	PF00533	0.315
LIG_CSL_BTD_1	7	10	PF09270	0.332
LIG_eIF4E_1	285	291	PF01652	0.290
LIG_FHA_1	103	109	PF00498	0.177
LIG_FHA_1	191	197	PF00498	0.223
LIG_FHA_1	231	237	PF00498	0.556
LIG_FHA_1	269	275	PF00498	0.264
LIG_FHA_1	49	55	PF00498	0.483
LIG_FHA_1	65	71	PF00498	0.341
LIG_FHA_2	135	141	PF00498	0.456
LIG_HCF-1_HBM_1	293	296	PF13415	0.342
LIG_LIR_Apic_2	152	158	PF02991	0.364
LIG_LIR_Apic_2	50	55	PF02991	0.370
LIG_LIR_Gen_1	201	211	PF02991	0.243
LIG_LIR_Gen_1	21	32	PF02991	0.185
LIG_LIR_Gen_1	233	243	PF02991	0.402
LIG_LIR_Gen_1	293	303	PF02991	0.492
LIG_LIR_Nem_3	187	192	PF02991	0.313
LIG_LIR_Nem_3	21	27	PF02991	0.232
LIG_LIR_Nem_3	210	214	PF02991	0.278
LIG_LIR_Nem_3	233	238	PF02991	0.414
LIG_LIR_Nem_3	293	299	PF02991	0.383
LIG_PCNA_PIPBox_1	289	298	PF02747	0.212
LIG_PCNA_yPIPBox_3	289	300	PF02747	0.158
LIG_Pex14_2	211	215	PF04695	0.340
LIG_Pex14_2	237	241	PF04695	0.239
LIG_SH2_PTP2	235	238	PF00017	0.148
LIG_SH2_SRC	57	60	PF00017	0.474
LIG_SH2_STAP1	104	108	PF00017	0.163
LIG_SH2_STAP1	20	24	PF00017	0.341
LIG_SH2_STAP1	57	61	PF00017	0.388
LIG_SH2_STAT5	104	107	PF00017	0.315
LIG_SH2_STAT5	203	206	PF00017	0.300
LIG_SH2_STAT5	235	238	PF00017	0.410
LIG_SH2_STAT5	268	271	PF00017	0.281
LIG_SH2_STAT5	285	288	PF00017	0.264
LIG_SH2_STAT5	296	299	PF00017	0.439
LIG_SH3_1	4	10	PF00018	0.305
LIG_SH3_3	154	160	PF00018	0.530
LIG_SH3_3	303	309	PF00018	0.472
LIG_SH3_3	4	10	PF00018	0.536
LIG_SH3_4	80	87	PF00018	0.142
LIG_SUMO_SIM_anti_2	110	116	PF11976	0.148
LIG_SUMO_SIM_anti_2	325	330	PF11976	0.172
LIG_TRAF2_1	137	140	PF00917	0.349
LIG_TYR_ITSM	231	238	PF00017	0.342
LIG_UBA3_1	75	80	PF00899	0.439
MOD_CK1_1	134	140	PF00069	0.408
MOD_CK1_1	184	190	PF00069	0.310
MOD_CK1_1	230	236	PF00069	0.422
MOD_CK1_1	305	311	PF00069	0.380
MOD_CK1_1	64	70	PF00069	0.374
MOD_CK1_1	85	91	PF00069	0.250
MOD_CK2_1	134	140	PF00069	0.375
MOD_Cter_Amidation	45	48	PF01082	0.300
MOD_GlcNHglycan	127	131	PF01048	0.196
MOD_GlcNHglycan	145	148	PF01048	0.275
MOD_GlcNHglycan	174	177	PF01048	0.303
MOD_GlcNHglycan	243	246	PF01048	0.320
MOD_GlcNHglycan	92	95	PF01048	0.551
MOD_GSK3_1	131	138	PF00069	0.418
MOD_GSK3_1	14	21	PF00069	0.363
MOD_GSK3_1	260	267	PF00069	0.219
MOD_GSK3_1	294	301	PF00069	0.415
MOD_GSK3_1	33	40	PF00069	0.269
MOD_N-GLC_1	82	87	PF02516	0.565
MOD_N-GLC_1	96	101	PF02516	0.487
MOD_NEK2_1	102	107	PF00069	0.307
MOD_NEK2_1	181	186	PF00069	0.301
MOD_NEK2_1	241	246	PF00069	0.301
MOD_NEK2_1	33	38	PF00069	0.287
MOD_NEK2_2	207	212	PF00069	0.452
MOD_PIKK_1	268	274	PF00454	0.246
MOD_PKA_1	47	53	PF00069	0.370
MOD_PKA_2	47	53	PF00069	0.370
MOD_Plk_1	126	132	PF00069	0.516
MOD_Plk_1	82	88	PF00069	0.218
MOD_Plk_4	184	190	PF00069	0.291
MOD_Plk_4	201	207	PF00069	0.282
MOD_Plk_4	264	270	PF00069	0.287
MOD_Plk_4	322	328	PF00069	0.274
MOD_Plk_4	33	39	PF00069	0.297
MOD_ProDKin_1	131	137	PF00069	0.388
MOD_ProDKin_1	3	9	PF00069	0.361
MOD_ProDKin_1	305	311	PF00069	0.520
MOD_SUMO_for_1	15	18	PF00179	0.264
MOD_SUMO_rev_2	134	144	PF00179	0.478
TRG_DiLeu_BaEn_1	140	145	PF01217	0.388
TRG_DiLeu_BaEn_1	201	206	PF01217	0.206
TRG_ENDOCYTIC_2	203	206	PF00928	0.289
TRG_ENDOCYTIC_2	235	238	PF00928	0.161
TRG_ENDOCYTIC_2	285	288	PF00928	0.294
TRG_ENDOCYTIC_2	296	299	PF00928	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E9	Leptomonas seymouri	35%	100%
A0A0N0P5K7	Leptomonas seymouri	59%	100%
A0A1X0NR51	Trypanosomatidae	38%	90%
A0A1X0NSB9	Trypanosomatidae	31%	82%
A0A1X0NSI7	Trypanosomatidae	31%	88%
A0A3R7LZX6	Trypanosoma rangeli	35%	95%
A0A3S7X1N7	Leishmania donovani	33%	72%
A0A3S7X501	Leishmania donovani	32%	77%
A0A3S7X7B0	Leishmania donovani	76%	100%
A0A422MUI2	Trypanosoma rangeli	32%	90%
A4HGP7	Leishmania braziliensis	34%	99%
A4HJU9	Leishmania braziliensis	30%	100%
A4HJV0	Leishmania braziliensis	31%	100%
A4I3R9	Leishmania infantum	33%	72%
A4I7B1	Leishmania infantum	32%	77%
A4I9G1	Leishmania infantum	76%	100%
D0A885	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	85%
D0A886	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	85%
D0A887	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	85%
D0A888	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	85%
D0A889	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	87%
E9B012	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	74%
E9B4F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
O23039	Arabidopsis thaliana	24%	93%
O64738	Arabidopsis thaliana	26%	98%
O81123	Arabidopsis thaliana	27%	94%
O81850	Arabidopsis thaliana	24%	95%
O94639	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	82%
P32804	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	89%
Q38856	Arabidopsis thaliana	26%	96%
Q3SYU3	Bos taurus	25%	100%
Q4Q3L6	Leishmania major	74%	100%
Q4Q5V0	Leishmania major	31%	100%
Q4Q5V1	Leishmania major	31%	100%
Q4Q873	Leishmania major	32%	100%
Q6L8G0	Oryza sativa subsp. japonica	28%	95%
Q6L8G1	Oryza sativa subsp. japonica	25%	90%
Q6ZJ91	Oryza sativa subsp. japonica	23%	84%
Q75HB1	Oryza sativa subsp. japonica	26%	89%
Q7XLD4	Oryza sativa subsp. japonica	26%	92%
Q852F6	Oryza sativa subsp. japonica	24%	93%
Q8S3W4	Arabidopsis thaliana	26%	96%
Q8W245	Arabidopsis thaliana	26%	92%
Q8W246	Arabidopsis thaliana	26%	92%
Q9FIS2	Arabidopsis thaliana	26%	94%
Q9NY26	Homo sapiens	27%	100%
Q9QZ03	Mus musculus	27%	100%
Q9SLG3	Arabidopsis thaliana	25%	99%
V5AWN3	Trypanosoma cruzi	33%	90%
V5BC34	Trypanosoma cruzi	31%	90%
V5DCU2	Trypanosoma cruzi	40%	90%