Small nuclear ribonucleoprotein Sm D2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small nuclear ribonucleoprotein SmD2

Species:

Leishmania braziliensis

UniProt:

A4HM26_LEIBR

TriTrypDb:

LbrM.33.3460 , LBRM2903_330043200

Length:

103

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	12
GO:0030532	small nuclear ribonucleoprotein complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0110165	cellular anatomical entity	1	12
GO:0120114	Sm-like protein family complex	2	12
GO:0140513	nuclear protein-containing complex	2	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005681	spliceosomal complex	3	1
GO:0005682	U5 snRNP	5	1
GO:0005685	U1 snRNP	5	1
GO:0005686	U2 snRNP	5	1
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	1
GO:0071011	precatalytic spliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0097526	spliceosomal tri-snRNP complex	5	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HM26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM26

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000387	spliceosomal snRNP assembly	7	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.510
CLV_PCSK_KEX2_1	40	42	PF00082	0.365
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.360
CLV_PCSK_SKI1_1	17	21	PF00082	0.519
CLV_PCSK_SKI1_1	40	44	PF00082	0.365
CLV_PCSK_SKI1_1	50	54	PF00082	0.367
CLV_Separin_Metazoa	18	22	PF03568	0.575
DEG_APCC_KENBOX_2	36	40	PF00400	0.202
DEG_Nend_UBRbox_2	1	3	PF02207	0.721
DOC_CYCLIN_RxL_1	11	23	PF00134	0.580
DOC_MAPK_gen_1	82	91	PF00069	0.446
LIG_14-3-3_CanoR_1	21	25	PF00244	0.554
LIG_BRCT_BRCA1_1	94	98	PF00533	0.457
LIG_FHA_1	14	20	PF00498	0.628
LIG_FHA_2	21	27	PF00498	0.542
LIG_LIR_Gen_1	26	36	PF02991	0.431
LIG_LIR_Gen_1	60	70	PF02991	0.446
LIG_LIR_Nem_3	26	32	PF02991	0.445
LIG_LIR_Nem_3	60	66	PF02991	0.446
LIG_PCNA_PIPBox_1	83	92	PF02747	0.549
LIG_PCNA_yPIPBox_3	82	90	PF02747	0.549
LIG_Pex14_2	59	63	PF04695	0.446
LIG_SH3_3	97	103	PF00018	0.457
MOD_CK1_1	76	82	PF00069	0.565
MOD_CK2_1	32	38	PF00069	0.335
MOD_GSK3_1	27	34	PF00069	0.393
MOD_GSK3_1	9	16	PF00069	0.585
MOD_NEK2_1	19	24	PF00069	0.497
MOD_NEK2_1	31	36	PF00069	0.404
MOD_PK_1	92	98	PF00069	0.457
MOD_PKA_2	20	26	PF00069	0.559
MOD_PKA_2	46	52	PF00069	0.549
MOD_Plk_1	32	38	PF00069	0.440
MOD_Plk_4	92	98	PF00069	0.446
MOD_SUMO_rev_2	33	42	PF00179	0.426
TRG_DiLeu_BaEn_2	93	99	PF01217	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3M6	Leptomonas seymouri	93%	100%
A0A0S4J4L5	Bodo saltans	50%	96%
A0A1X0NRD5	Trypanosomatidae	58%	93%
A0A3S7X782	Leishmania donovani	96%	100%
A0A422MRQ5	Trypanosoma rangeli	57%	93%
A4I9G0	Leishmania infantum	96%	100%
C9ZJS5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	93%
E9B4F8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O14036	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	90%
P62316	Homo sapiens	43%	87%
P62317	Mus musculus	43%	87%
Q06217	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	94%
Q18786	Caenorhabditis elegans	46%	87%
Q3SZF8	Bos taurus	43%	87%
Q4Q3L7	Leishmania major	96%	100%
Q54NC5	Dictyostelium discoideum	42%	92%
Q9VI10	Drosophila melanogaster	43%	87%
V5B7X1	Trypanosoma cruzi	56%	93%