Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM25_LEIBR

TriTrypDb:

LbrM.33.3450 , LBRM2903_330043100

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 4
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HM25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.678
CLV_C14_Caspase3-7	461	465	PF00656	0.675
CLV_C14_Caspase3-7	529	533	PF00656	0.759
CLV_C14_Caspase3-7	57	61	PF00656	0.336
CLV_NRD_NRD_1	352	354	PF00675	0.486
CLV_PCSK_KEX2_1	351	353	PF00082	0.490
CLV_PCSK_KEX2_1	475	477	PF00082	0.447
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.447
CLV_PCSK_SKI1_1	2	6	PF00082	0.576
CLV_PCSK_SKI1_1	257	261	PF00082	0.638
CLV_PCSK_SKI1_1	364	368	PF00082	0.419
DEG_Nend_UBRbox_1	1	4	PF02207	0.785
DEG_SCF_FBW7_1	152	159	PF00400	0.298
DEG_SPOP_SBC_1	101	105	PF00917	0.306
DEG_SPOP_SBC_1	38	42	PF00917	0.498
DEG_SPOP_SBC_1	458	462	PF00917	0.676
DOC_CKS1_1	153	158	PF01111	0.295
DOC_CKS1_1	600	605	PF01111	0.678
DOC_CKS1_1	74	79	PF01111	0.286
DOC_CYCLIN_yCln2_LP_2	311	317	PF00134	0.387
DOC_MAPK_gen_1	286	295	PF00069	0.542
DOC_MAPK_MEF2A_6	216	225	PF00069	0.456
DOC_PP4_FxxP_1	178	181	PF00568	0.360
DOC_USP7_MATH_1	156	160	PF00917	0.284
DOC_USP7_MATH_1	170	174	PF00917	0.313
DOC_USP7_MATH_1	400	404	PF00917	0.753
DOC_USP7_MATH_1	452	456	PF00917	0.736
DOC_USP7_MATH_1	46	50	PF00917	0.462
DOC_USP7_MATH_1	535	539	PF00917	0.672
DOC_WW_Pin1_4	13	18	PF00397	0.591
DOC_WW_Pin1_4	152	157	PF00397	0.302
DOC_WW_Pin1_4	194	199	PF00397	0.361
DOC_WW_Pin1_4	260	265	PF00397	0.350
DOC_WW_Pin1_4	414	419	PF00397	0.775
DOC_WW_Pin1_4	599	604	PF00397	0.675
DOC_WW_Pin1_4	73	78	PF00397	0.381
LIG_14-3-3_CanoR_1	100	110	PF00244	0.397
LIG_14-3-3_CanoR_1	144	153	PF00244	0.466
LIG_14-3-3_CanoR_1	172	178	PF00244	0.472
LIG_14-3-3_CanoR_1	2	11	PF00244	0.775
LIG_14-3-3_CanoR_1	277	285	PF00244	0.442
LIG_APCC_ABBA_1	586	591	PF00400	0.637
LIG_BIR_III_2	507	511	PF00653	0.686
LIG_BIR_III_4	370	374	PF00653	0.834
LIG_BIR_III_4	536	540	PF00653	0.677
LIG_BIR_III_4	581	585	PF00653	0.674
LIG_eIF4E_1	319	325	PF01652	0.261
LIG_EVH1_2	378	382	PF00568	0.850
LIG_FHA_1	103	109	PF00498	0.418
LIG_FHA_1	190	196	PF00498	0.356
LIG_FHA_1	218	224	PF00498	0.300
LIG_FHA_1	46	52	PF00498	0.416
LIG_FHA_1	494	500	PF00498	0.693
LIG_FHA_1	556	562	PF00498	0.666
LIG_FHA_1	583	589	PF00498	0.836
LIG_FHA_1	67	73	PF00498	0.416
LIG_FHA_1	74	80	PF00498	0.322
LIG_FHA_1	86	92	PF00498	0.413
LIG_FHA_2	156	162	PF00498	0.286
LIG_FHA_2	233	239	PF00498	0.291
LIG_FHA_2	365	371	PF00498	0.637
LIG_FHA_2	390	396	PF00498	0.613
LIG_FHA_2	418	424	PF00498	0.661
LIG_FHA_2	459	465	PF00498	0.731
LIG_FHA_2	468	474	PF00498	0.631
LIG_FHA_2	485	491	PF00498	0.693
LIG_FHA_2	514	520	PF00498	0.772
LIG_FHA_2	527	533	PF00498	0.769
LIG_FHA_2	53	59	PF00498	0.298
LIG_FHA_2	555	561	PF00498	0.824
LIG_GBD_Chelix_1	21	29	PF00786	0.290
LIG_LIR_Apic_2	176	181	PF02991	0.487
LIG_LIR_Apic_2	420	424	PF02991	0.656
LIG_LIR_Apic_2	469	474	PF02991	0.744
LIG_LIR_Gen_1	231	242	PF02991	0.413
LIG_LIR_Gen_1	428	438	PF02991	0.658
LIG_LIR_Gen_1	549	555	PF02991	0.646
LIG_LIR_Gen_1	92	101	PF02991	0.287
LIG_LIR_Nem_3	123	127	PF02991	0.395
LIG_LIR_Nem_3	161	166	PF02991	0.453
LIG_LIR_Nem_3	174	180	PF02991	0.479
LIG_LIR_Nem_3	231	237	PF02991	0.415
LIG_LIR_Nem_3	316	322	PF02991	0.513
LIG_LIR_Nem_3	428	433	PF02991	0.652
LIG_LIR_Nem_3	549	554	PF02991	0.650
LIG_LIR_Nem_3	92	98	PF02991	0.286
LIG_PCNA_yPIPBox_3	286	294	PF02747	0.368
LIG_Pex14_2	118	122	PF04695	0.317
LIG_Pex14_2	335	339	PF04695	0.622
LIG_SH2_CRK	167	171	PF00017	0.429
LIG_SH2_CRK	95	99	PF00017	0.276
LIG_SH2_NCK_1	234	238	PF00017	0.383
LIG_SH2_NCK_1	528	532	PF00017	0.844
LIG_SH2_NCK_1	580	584	PF00017	0.675
LIG_SH2_NCK_1	600	604	PF00017	0.774
LIG_SH2_PTP2	421	424	PF00017	0.732
LIG_SH2_PTP2	589	592	PF00017	0.743
LIG_SH2_SRC	179	182	PF00017	0.529
LIG_SH2_SRC	421	424	PF00017	0.690
LIG_SH2_SRC	430	433	PF00017	0.625
LIG_SH2_SRC	471	474	PF00017	0.740
LIG_SH2_SRC	540	543	PF00017	0.842
LIG_SH2_SRC	551	554	PF00017	0.729
LIG_SH2_SRC	562	565	PF00017	0.754
LIG_SH2_SRC	589	592	PF00017	0.743
LIG_SH2_STAP1	405	409	PF00017	0.698
LIG_SH2_STAP1	468	472	PF00017	0.709
LIG_SH2_STAP1	482	486	PF00017	0.633
LIG_SH2_STAP1	521	525	PF00017	0.696
LIG_SH2_STAP1	564	568	PF00017	0.771
LIG_SH2_STAP1	95	99	PF00017	0.276
LIG_SH2_STAT3	553	556	PF00017	0.645
LIG_SH2_STAT3	564	567	PF00017	0.630
LIG_SH2_STAT5	167	170	PF00017	0.400
LIG_SH2_STAT5	177	180	PF00017	0.506
LIG_SH2_STAT5	194	197	PF00017	0.304
LIG_SH2_STAT5	205	208	PF00017	0.390
LIG_SH2_STAT5	209	212	PF00017	0.404
LIG_SH2_STAT5	234	237	PF00017	0.462
LIG_SH2_STAT5	252	255	PF00017	0.407
LIG_SH2_STAT5	421	424	PF00017	0.772
LIG_SH2_STAT5	432	435	PF00017	0.722
LIG_SH2_STAT5	482	485	PF00017	0.703
LIG_SH2_STAT5	521	524	PF00017	0.760
LIG_SH2_STAT5	528	531	PF00017	0.776
LIG_SH2_STAT5	553	556	PF00017	0.753
LIG_SH2_STAT5	589	592	PF00017	0.743
LIG_SH3_3	222	228	PF00018	0.482
LIG_SH3_3	264	270	PF00018	0.391
LIG_SH3_3	60	66	PF00018	0.336
LIG_SH3_3	71	77	PF00018	0.271
LIG_SUMO_SIM_anti_2	19	25	PF11976	0.325
LIG_SUMO_SIM_par_1	111	116	PF11976	0.301
LIG_SUMO_SIM_par_1	235	240	PF11976	0.319
LIG_TRAF2_1	489	492	PF00917	0.853
LIG_TRAF2_1	576	579	PF00917	0.754
LIG_TRFH_1	194	198	PF08558	0.465
MOD_CDC14_SPxK_1	263	266	PF00782	0.372
MOD_CDK_SPxK_1	260	266	PF00069	0.358
MOD_CK1_1	102	108	PF00069	0.417
MOD_CK1_1	111	117	PF00069	0.393
MOD_CK1_1	13	19	PF00069	0.438
MOD_CK1_1	173	179	PF00069	0.473
MOD_CK1_1	197	203	PF00069	0.453
MOD_CK1_1	229	235	PF00069	0.440
MOD_CK1_1	300	306	PF00069	0.517
MOD_CK1_1	390	396	PF00069	0.613
MOD_CK1_1	459	465	PF00069	0.861
MOD_CK1_1	85	91	PF00069	0.452
MOD_CK2_1	232	238	PF00069	0.297
MOD_CK2_1	293	299	PF00069	0.496
MOD_CK2_1	389	395	PF00069	0.620
MOD_CK2_1	52	58	PF00069	0.396
MOD_CK2_1	554	560	PF00069	0.824
MOD_GlcNHglycan	146	149	PF01048	0.593
MOD_GlcNHglycan	18	21	PF01048	0.397
MOD_GlcNHglycan	206	209	PF01048	0.583
MOD_GlcNHglycan	32	35	PF01048	0.612
MOD_GlcNHglycan	367	370	PF01048	0.534
MOD_GlcNHglycan	383	387	PF01048	0.492
MOD_GlcNHglycan	438	441	PF01048	0.528
MOD_GlcNHglycan	536	540	PF01048	0.477
MOD_GSK3_1	132	139	PF00069	0.444
MOD_GSK3_1	140	147	PF00069	0.415
MOD_GSK3_1	148	155	PF00069	0.372
MOD_GSK3_1	228	235	PF00069	0.383
MOD_GSK3_1	293	300	PF00069	0.452
MOD_GSK3_1	30	37	PF00069	0.577
MOD_GSK3_1	38	45	PF00069	0.527
MOD_GSK3_1	452	459	PF00069	0.834
MOD_GSK3_1	480	487	PF00069	0.799
MOD_GSK3_1	75	82	PF00069	0.297
MOD_GSK3_1	85	92	PF00069	0.366
MOD_N-GLC_1	120	125	PF02516	0.684
MOD_N-GLC_1	300	305	PF02516	0.653
MOD_N-GLC_1	400	405	PF02516	0.403
MOD_N-GLC_1	52	57	PF02516	0.579
MOD_N-GLC_1	79	84	PF02516	0.630
MOD_NEK2_1	108	113	PF00069	0.425
MOD_NEK2_1	136	141	PF00069	0.352
MOD_NEK2_1	217	222	PF00069	0.317
MOD_NEK2_1	382	387	PF00069	0.768
MOD_NEK2_1	52	57	PF00069	0.387
MOD_NEK2_2	189	194	PF00069	0.453
MOD_PIKK_1	125	131	PF00454	0.397
MOD_PIKK_1	229	235	PF00454	0.326
MOD_PIKK_1	452	458	PF00454	0.831
MOD_PIKK_1	563	569	PF00454	0.663
MOD_PKA_2	143	149	PF00069	0.464
MOD_PKA_2	171	177	PF00069	0.535
MOD_PKA_2	276	282	PF00069	0.420
MOD_PKA_2	99	105	PF00069	0.478
MOD_Plk_1	120	126	PF00069	0.481
MOD_Plk_1	34	40	PF00069	0.563
MOD_Plk_1	52	58	PF00069	0.289
MOD_Plk_1	79	85	PF00069	0.451
MOD_Plk_2-3	519	525	PF00069	0.692
MOD_Plk_4	108	114	PF00069	0.444
MOD_Plk_4	137	143	PF00069	0.319
MOD_Plk_4	148	154	PF00069	0.270
MOD_Plk_4	173	179	PF00069	0.482
MOD_Plk_4	189	195	PF00069	0.398
MOD_Plk_4	232	238	PF00069	0.360
MOD_Plk_4	400	406	PF00069	0.599
MOD_Plk_4	417	423	PF00069	0.662
MOD_ProDKin_1	13	19	PF00069	0.591
MOD_ProDKin_1	152	158	PF00069	0.296
MOD_ProDKin_1	194	200	PF00069	0.370
MOD_ProDKin_1	260	266	PF00069	0.358
MOD_ProDKin_1	414	420	PF00069	0.774
MOD_ProDKin_1	599	605	PF00069	0.677
MOD_ProDKin_1	73	79	PF00069	0.375
MOD_SUMO_for_1	309	312	PF00179	0.419
MOD_SUMO_rev_2	197	204	PF00179	0.304
TRG_ENDOCYTIC_2	124	127	PF00928	0.398
TRG_ENDOCYTIC_2	177	180	PF00928	0.484
TRG_ENDOCYTIC_2	234	237	PF00928	0.389
TRG_ENDOCYTIC_2	319	322	PF00928	0.513
TRG_ENDOCYTIC_2	430	433	PF00928	0.653
TRG_ENDOCYTIC_2	551	554	PF00928	0.714
TRG_ENDOCYTIC_2	95	98	PF00928	0.275
TRG_ER_diArg_1	11	14	PF00400	0.625
TRG_ER_diArg_1	285	288	PF00400	0.352
TRG_ER_diArg_1	340	343	PF00400	0.655
TRG_ER_diArg_1	351	353	PF00400	0.690
TRG_ER_FFAT_2	524	534	PF00635	0.657
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Z7	Leptomonas seymouri	38%	99%
A0A3S7X786	Leishmania donovani	62%	99%
A4I9F9	Leishmania infantum	61%	99%
E9B4F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	75%
Q4Q3L8	Leishmania major	62%	99%