Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM24_LEIBR

TriTrypDb:

LbrM.33.3440 , LBRM2903_330043000

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HM24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.514
CLV_NRD_NRD_1	122	124	PF00675	0.537
CLV_NRD_NRD_1	263	265	PF00675	0.575
CLV_NRD_NRD_1	514	516	PF00675	0.603
CLV_PCSK_KEX2_1	122	124	PF00082	0.568
CLV_PCSK_KEX2_1	291	293	PF00082	0.505
CLV_PCSK_KEX2_1	302	304	PF00082	0.605
CLV_PCSK_KEX2_1	514	516	PF00082	0.633
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.584
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.605
CLV_PCSK_PC7_1	287	293	PF00082	0.568
CLV_PCSK_SKI1_1	122	126	PF00082	0.644
CLV_PCSK_SKI1_1	132	136	PF00082	0.610
CLV_PCSK_SKI1_1	171	175	PF00082	0.602
CLV_PCSK_SKI1_1	227	231	PF00082	0.479
CLV_PCSK_SKI1_1	232	236	PF00082	0.494
CLV_PCSK_SKI1_1	287	291	PF00082	0.511
CLV_PCSK_SKI1_1	345	349	PF00082	0.522
CLV_PCSK_SKI1_1	357	361	PF00082	0.372
CLV_PCSK_SKI1_1	51	55	PF00082	0.415
CLV_PCSK_SKI1_1	62	66	PF00082	0.398
CLV_PCSK_SKI1_1	98	102	PF00082	0.458
DEG_APCC_DBOX_1	356	364	PF00400	0.468
DEG_Nend_Nbox_1	1	3	PF02207	0.503
DEG_SPOP_SBC_1	102	106	PF00917	0.465
DOC_CYCLIN_RxL_1	119	129	PF00134	0.610
DOC_CYCLIN_RxL_1	59	66	PF00134	0.370
DOC_CYCLIN_yCln2_LP_2	317	323	PF00134	0.655
DOC_MAPK_MEF2A_6	219	226	PF00069	0.536
DOC_PP2B_LxvP_1	317	320	PF13499	0.649
DOC_PP2B_LxvP_1	416	419	PF13499	0.550
DOC_USP7_MATH_1	146	150	PF00917	0.470
DOC_USP7_MATH_1	169	173	PF00917	0.633
DOC_USP7_MATH_1	374	378	PF00917	0.596
DOC_USP7_MATH_1	488	492	PF00917	0.736
DOC_USP7_MATH_1	506	510	PF00917	0.447
DOC_USP7_MATH_2	524	530	PF00917	0.463
DOC_USP7_UBL2_3	290	294	PF12436	0.566
DOC_USP7_UBL2_3	461	465	PF12436	0.546
DOC_WW_Pin1_4	217	222	PF00397	0.627
DOC_WW_Pin1_4	431	436	PF00397	0.610
DOC_WW_Pin1_4	482	487	PF00397	0.743
DOC_WW_Pin1_4	495	500	PF00397	0.553
LIG_14-3-3_CanoR_1	171	177	PF00244	0.527
LIG_14-3-3_CanoR_1	237	242	PF00244	0.568
LIG_14-3-3_CanoR_1	390	394	PF00244	0.676
LIG_14-3-3_CanoR_1	4	14	PF00244	0.652
LIG_14-3-3_CanoR_1	430	435	PF00244	0.765
LIG_14-3-3_CanoR_1	515	521	PF00244	0.722
LIG_14-3-3_CanoR_1	527	532	PF00244	0.587
LIG_14-3-3_CanoR_1	62	68	PF00244	0.536
LIG_Actin_WH2_2	21	39	PF00022	0.355
LIG_BRCT_BRCA1_1	245	249	PF00533	0.589
LIG_CaM_IQ_9	279	294	PF13499	0.643
LIG_Clathr_ClatBox_1	13	17	PF01394	0.655
LIG_EH1_1	210	218	PF00400	0.434
LIG_FHA_1	109	115	PF00498	0.628
LIG_FHA_1	137	143	PF00498	0.633
LIG_FHA_1	16	22	PF00498	0.536
LIG_FHA_1	172	178	PF00498	0.576
LIG_FHA_1	233	239	PF00498	0.586
LIG_FHA_1	265	271	PF00498	0.702
LIG_FHA_1	274	280	PF00498	0.513
LIG_FHA_1	52	58	PF00498	0.478
LIG_FHA_1	73	79	PF00498	0.484
LIG_FHA_2	102	108	PF00498	0.622
LIG_FHA_2	131	137	PF00498	0.398
LIG_FHA_2	181	187	PF00498	0.622
LIG_FHA_2	327	333	PF00498	0.459
LIG_FHA_2	457	463	PF00498	0.791
LIG_FHA_2	85	91	PF00498	0.544
LIG_LIR_Gen_1	304	314	PF02991	0.553
LIG_LIR_Nem_3	304	309	PF02991	0.548
LIG_LIR_Nem_3	355	359	PF02991	0.449
LIG_MYND_1	414	418	PF01753	0.538
LIG_MYND_1	482	486	PF01753	0.539
LIG_NRBOX	130	136	PF00104	0.396
LIG_PCNA_yPIPBox_3	122	135	PF02747	0.389
LIG_PTB_Apo_2	407	414	PF02174	0.515
LIG_SH2_NCK_1	525	529	PF00017	0.577
LIG_SH2_STAP1	504	508	PF00017	0.572
LIG_SH2_STAT3	67	70	PF00017	0.371
LIG_SH2_STAT5	507	510	PF00017	0.433
LIG_SH3_1	408	414	PF00018	0.515
LIG_SH3_3	362	368	PF00018	0.387
LIG_SH3_3	390	396	PF00018	0.602
LIG_SH3_3	408	414	PF00018	0.620
LIG_SH3_3	423	429	PF00018	0.789
LIG_SH3_3	518	524	PF00018	0.557
LIG_SUMO_SIM_anti_2	195	201	PF11976	0.524
LIG_SUMO_SIM_par_1	220	225	PF11976	0.599
LIG_TRAF2_1	420	423	PF00917	0.760
MOD_CK1_1	172	178	PF00069	0.516
MOD_CK1_1	189	195	PF00069	0.627
MOD_CK1_1	201	207	PF00069	0.705
MOD_CK1_1	383	389	PF00069	0.584
MOD_CK1_1	445	451	PF00069	0.708
MOD_CK1_1	5	11	PF00069	0.717
MOD_CK1_1	84	90	PF00069	0.540
MOD_CK2_1	101	107	PF00069	0.638
MOD_CK2_1	130	136	PF00069	0.396
MOD_CK2_1	16	22	PF00069	0.535
MOD_CK2_1	326	332	PF00069	0.555
MOD_CK2_1	417	423	PF00069	0.757
MOD_CK2_1	456	462	PF00069	0.786
MOD_CK2_1	5	11	PF00069	0.663
MOD_GlcNHglycan	136	139	PF01048	0.629
MOD_GlcNHglycan	148	151	PF01048	0.631
MOD_GlcNHglycan	166	169	PF01048	0.660
MOD_GlcNHglycan	200	203	PF01048	0.701
MOD_GlcNHglycan	4	7	PF01048	0.692
MOD_GlcNHglycan	447	450	PF01048	0.677
MOD_GlcNHglycan	456	459	PF01048	0.719
MOD_GlcNHglycan	486	489	PF01048	0.730
MOD_GlcNHglycan	82	86	PF01048	0.720
MOD_GSK3_1	130	137	PF00069	0.611
MOD_GSK3_1	140	147	PF00069	0.669
MOD_GSK3_1	160	167	PF00069	0.564
MOD_GSK3_1	194	201	PF00069	0.664
MOD_GSK3_1	232	239	PF00069	0.565
MOD_GSK3_1	326	333	PF00069	0.532
MOD_GSK3_1	441	448	PF00069	0.633
MOD_GSK3_1	484	491	PF00069	0.756
MOD_GSK3_1	506	513	PF00069	0.691
MOD_GSK3_1	98	105	PF00069	0.625
MOD_LATS_1	428	434	PF00433	0.659
MOD_N-GLC_1	324	329	PF02516	0.522
MOD_N-GLC_2	185	187	PF02516	0.497
MOD_NEK2_1	134	139	PF00069	0.435
MOD_NEK2_1	16	21	PF00069	0.423
MOD_NEK2_1	180	185	PF00069	0.642
MOD_NEK2_1	198	203	PF00069	0.754
MOD_NEK2_1	2	7	PF00069	0.686
MOD_NEK2_1	222	227	PF00069	0.580
MOD_NEK2_1	249	254	PF00069	0.516
MOD_NEK2_1	282	287	PF00069	0.596
MOD_NEK2_1	359	364	PF00069	0.613
MOD_NEK2_1	63	68	PF00069	0.565
MOD_NEK2_1	72	77	PF00069	0.541
MOD_PIKK_1	161	167	PF00454	0.538
MOD_PIKK_1	180	186	PF00454	0.399
MOD_PIKK_1	380	386	PF00454	0.615
MOD_PIKK_1	456	462	PF00454	0.785
MOD_PIKK_1	497	503	PF00454	0.611
MOD_PK_1	237	243	PF00069	0.590
MOD_PKA_1	264	270	PF00069	0.458
MOD_PKA_2	144	150	PF00069	0.720
MOD_PKA_2	236	242	PF00069	0.506
MOD_PKA_2	389	395	PF00069	0.759
MOD_PKA_2	474	480	PF00069	0.762
MOD_PKA_2	526	532	PF00069	0.475
MOD_PKB_1	262	270	PF00069	0.447
MOD_PKB_1	40	48	PF00069	0.526
MOD_Plk_1	16	22	PF00069	0.604
MOD_Plk_1	194	200	PF00069	0.520
MOD_Plk_1	204	210	PF00069	0.652
MOD_Plk_1	304	310	PF00069	0.429
MOD_Plk_1	324	330	PF00069	0.330
MOD_Plk_2-3	209	215	PF00069	0.700
MOD_Plk_2-3	324	330	PF00069	0.408
MOD_Plk_4	16	22	PF00069	0.518
MOD_Plk_4	172	178	PF00069	0.479
MOD_Plk_4	194	200	PF00069	0.773
MOD_Plk_4	237	243	PF00069	0.499
MOD_Plk_4	305	311	PF00069	0.569
MOD_Plk_4	313	319	PF00069	0.607
MOD_Plk_4	389	395	PF00069	0.694
MOD_Plk_4	488	494	PF00069	0.729
MOD_ProDKin_1	217	223	PF00069	0.622
MOD_ProDKin_1	431	437	PF00069	0.608
MOD_ProDKin_1	482	488	PF00069	0.738
MOD_ProDKin_1	495	501	PF00069	0.549
MOD_SUMO_rev_2	31	39	PF00179	0.385
TRG_DiLeu_BaEn_1	305	310	PF01217	0.537
TRG_DiLeu_BaEn_1	355	360	PF01217	0.562
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.604
TRG_DiLeu_BaLyEn_6	218	223	PF01217	0.578
TRG_DiLeu_BaLyEn_6	91	96	PF01217	0.427
TRG_ER_diArg_1	122	124	PF00400	0.532
TRG_ER_diArg_1	39	42	PF00400	0.355
TRG_NLS_MonoExtC_3	289	294	PF00514	0.383
TRG_NLS_MonoExtN_4	287	294	PF00514	0.383
TRG_Pf-PMV_PEXEL_1	122	127	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5K5	Leptomonas seymouri	44%	97%
A0A1X0NRF9	Trypanosomatidae	27%	94%
A0A3Q8IMT0	Leishmania donovani	66%	100%
A0A422N0Y7	Trypanosoma rangeli	26%	100%
A4I9F8	Leishmania infantum	66%	100%
C9ZJT2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B4F6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4Q3L9	Leishmania major	65%	100%