Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM23_LEIBR

TriTrypDb:

LbrM.33.3430 , LBRM2903_330042900

Length:

486

Annotations

LeishMANIAdb annotations

A protein with very uncertain structure. However, it does not appear to be transmembrane.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HM23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.555
CLV_C14_Caspase3-7	277	281	PF00656	0.434
CLV_C14_Caspase3-7	406	410	PF00656	0.359
CLV_NRD_NRD_1	11	13	PF00675	0.536
CLV_NRD_NRD_1	160	162	PF00675	0.482
CLV_NRD_NRD_1	2	4	PF00675	0.541
CLV_NRD_NRD_1	273	275	PF00675	0.645
CLV_NRD_NRD_1	286	288	PF00675	0.606
CLV_NRD_NRD_1	387	389	PF00675	0.640
CLV_NRD_NRD_1	453	455	PF00675	0.627
CLV_NRD_NRD_1	46	48	PF00675	0.461
CLV_PCSK_KEX2_1	11	13	PF00082	0.536
CLV_PCSK_KEX2_1	120	122	PF00082	0.452
CLV_PCSK_KEX2_1	160	162	PF00082	0.437
CLV_PCSK_KEX2_1	2	4	PF00082	0.541
CLV_PCSK_KEX2_1	273	275	PF00082	0.598
CLV_PCSK_KEX2_1	286	288	PF00082	0.585
CLV_PCSK_KEX2_1	386	388	PF00082	0.658
CLV_PCSK_KEX2_1	453	455	PF00082	0.627
CLV_PCSK_KEX2_1	46	48	PF00082	0.475
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.452
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.437
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.615
CLV_PCSK_PC7_1	382	388	PF00082	0.554
CLV_PCSK_SKI1_1	202	206	PF00082	0.393
CLV_PCSK_SKI1_1	232	236	PF00082	0.355
CLV_PCSK_SKI1_1	293	297	PF00082	0.639
CLV_PCSK_SKI1_1	453	457	PF00082	0.635
DEG_APCC_DBOX_1	302	310	PF00400	0.486
DEG_Nend_UBRbox_1	1	4	PF02207	0.703
DOC_CKS1_1	151	156	PF01111	0.629
DOC_CKS1_1	98	103	PF01111	0.715
DOC_CYCLIN_RxL_1	450	461	PF00134	0.431
DOC_MAPK_gen_1	11	21	PF00069	0.607
DOC_MAPK_MEF2A_6	176	184	PF00069	0.597
DOC_MAPK_RevD_3	146	162	PF00069	0.546
DOC_PP1_RVXF_1	118	125	PF00149	0.658
DOC_PP4_FxxP_1	124	127	PF00568	0.685
DOC_PP4_FxxP_1	60	63	PF00568	0.712
DOC_USP7_MATH_1	105	109	PF00917	0.763
DOC_USP7_MATH_1	331	335	PF00917	0.568
DOC_USP7_MATH_1	359	363	PF00917	0.543
DOC_USP7_MATH_1	369	373	PF00917	0.563
DOC_USP7_MATH_1	441	445	PF00917	0.357
DOC_USP7_UBL2_3	162	166	PF12436	0.666
DOC_USP7_UBL2_3	275	279	PF12436	0.336
DOC_USP7_UBL2_3	289	293	PF12436	0.455
DOC_USP7_UBL2_3	31	35	PF12436	0.680
DOC_WW_Pin1_4	150	155	PF00397	0.659
DOC_WW_Pin1_4	439	444	PF00397	0.443
DOC_WW_Pin1_4	97	102	PF00397	0.698
LIG_14-3-3_CanoR_1	11	19	PF00244	0.723
LIG_14-3-3_CanoR_1	2	6	PF00244	0.705
LIG_14-3-3_CanoR_1	250	260	PF00244	0.456
LIG_14-3-3_CanoR_1	46	55	PF00244	0.664
LIG_14-3-3_CanoR_1	89	99	PF00244	0.576
LIG_BRCT_BRCA1_1	56	60	PF00533	0.740
LIG_Clathr_ClatBox_1	181	185	PF01394	0.581
LIG_deltaCOP1_diTrp_1	218	223	PF00928	0.658
LIG_deltaCOP1_diTrp_1	409	416	PF00928	0.520
LIG_EH1_1	224	232	PF00400	0.349
LIG_eIF4E_1	225	231	PF01652	0.385
LIG_FHA_1	11	17	PF00498	0.768
LIG_FHA_1	226	232	PF00498	0.355
LIG_FHA_1	94	100	PF00498	0.704
LIG_FHA_2	194	200	PF00498	0.583
LIG_FHA_2	351	357	PF00498	0.582
LIG_FHA_2	375	381	PF00498	0.463
LIG_FHA_2	81	87	PF00498	0.664
LIG_IRF3_LxIS_1	16	22	PF10401	0.604
LIG_LIR_Apic_2	479	485	PF02991	0.462
LIG_LIR_Apic_2	57	63	PF02991	0.743
LIG_LIR_Gen_1	177	186	PF02991	0.581
LIG_LIR_Gen_1	235	243	PF02991	0.357
LIG_LIR_Gen_1	254	263	PF02991	0.391
LIG_LIR_Gen_1	409	419	PF02991	0.465
LIG_LIR_Gen_1	92	101	PF02991	0.744
LIG_LIR_Nem_3	177	182	PF02991	0.584
LIG_LIR_Nem_3	220	226	PF02991	0.487
LIG_LIR_Nem_3	254	259	PF02991	0.395
LIG_LIR_Nem_3	291	295	PF02991	0.397
LIG_LIR_Nem_3	409	415	PF02991	0.454
LIG_LIR_Nem_3	83	88	PF02991	0.653
LIG_LIR_Nem_3	92	98	PF02991	0.669
LIG_NRBOX	229	235	PF00104	0.480
LIG_PCNA_PIPBox_1	240	249	PF02747	0.463
LIG_Pex14_1	219	223	PF04695	0.659
LIG_Pex14_2	124	128	PF04695	0.580
LIG_RPA_C_Fungi	343	355	PF08784	0.483
LIG_SH2_CRK	226	230	PF00017	0.335
LIG_SH2_SRC	482	485	PF00017	0.713
LIG_SH2_STAP1	247	251	PF00017	0.455
LIG_SH2_STAP1	256	260	PF00017	0.448
LIG_SH2_STAP1	437	441	PF00017	0.580
LIG_SH2_STAT5	131	134	PF00017	0.600
LIG_SH2_STAT5	338	341	PF00017	0.480
LIG_SH3_3	124	130	PF00018	0.636
LIG_SH3_3	148	154	PF00018	0.428
LIG_SH3_3	363	369	PF00018	0.683
LIG_SH3_4	289	296	PF00018	0.630
LIG_SUMO_SIM_par_1	180	185	PF11976	0.476
LIG_SxIP_EBH_1	439	453	PF03271	0.687
LIG_TRAF2_1	196	199	PF00917	0.508
LIG_TRAF2_1	281	284	PF00917	0.606
LIG_TRAF2_1	313	316	PF00917	0.622
LIG_TRAF2_1	378	381	PF00917	0.643
LIG_UBA3_1	180	188	PF00899	0.524
LIG_UBA3_1	55	61	PF00899	0.429
MOD_CDK_SPxxK_3	150	157	PF00069	0.546
MOD_CK1_1	4	10	PF00069	0.682
MOD_CK1_1	442	448	PF00069	0.531
MOD_CK1_1	97	103	PF00069	0.660
MOD_CK2_1	171	177	PF00069	0.509
MOD_CK2_1	193	199	PF00069	0.500
MOD_CK2_1	21	27	PF00069	0.670
MOD_CK2_1	291	297	PF00069	0.573
MOD_CK2_1	350	356	PF00069	0.651
MOD_CK2_1	374	380	PF00069	0.582
MOD_GlcNHglycan	107	110	PF01048	0.705
MOD_GlcNHglycan	133	136	PF01048	0.474
MOD_GlcNHglycan	173	176	PF01048	0.636
MOD_GlcNHglycan	331	334	PF01048	0.674
MOD_GlcNHglycan	361	364	PF01048	0.705
MOD_GlcNHglycan	369	372	PF01048	0.640
MOD_GlcNHglycan	405	408	PF01048	0.710
MOD_GlcNHglycan	48	51	PF01048	0.563
MOD_GlcNHglycan	66	69	PF01048	0.595
MOD_GSK3_1	129	136	PF00069	0.598
MOD_GSK3_1	15	22	PF00069	0.680
MOD_GSK3_1	322	329	PF00069	0.534
MOD_GSK3_1	435	442	PF00069	0.558
MOD_GSK3_1	6	13	PF00069	0.735
MOD_GSK3_1	89	96	PF00069	0.581
MOD_N-GLC_1	202	207	PF02516	0.464
MOD_NEK2_1	1	6	PF00069	0.686
MOD_NEK2_1	19	24	PF00069	0.716
MOD_NEK2_1	239	244	PF00069	0.506
MOD_NEK2_1	251	256	PF00069	0.511
MOD_NEK2_2	6	11	PF00069	0.548
MOD_PIKK_1	54	60	PF00454	0.687
MOD_PKA_1	46	52	PF00069	0.474
MOD_PKA_2	1	7	PF00069	0.652
MOD_PKA_2	10	16	PF00069	0.683
MOD_PKA_2	302	308	PF00069	0.539
MOD_PKA_2	329	335	PF00069	0.688
MOD_PKA_2	417	423	PF00069	0.568
MOD_PKA_2	46	52	PF00069	0.489
MOD_PKA_2	88	94	PF00069	0.598
MOD_Plk_1	375	381	PF00069	0.721
MOD_Plk_1	93	99	PF00069	0.704
MOD_Plk_2-3	291	297	PF00069	0.587
MOD_Plk_2-3	302	308	PF00069	0.416
MOD_Plk_2-3	322	328	PF00069	0.714
MOD_Plk_4	133	139	PF00069	0.617
MOD_Plk_4	225	231	PF00069	0.353
MOD_Plk_4	232	238	PF00069	0.331
MOD_Plk_4	291	297	PF00069	0.597
MOD_Plk_4	94	100	PF00069	0.715
MOD_ProDKin_1	150	156	PF00069	0.578
MOD_ProDKin_1	439	445	PF00069	0.554
MOD_ProDKin_1	97	103	PF00069	0.640
MOD_SUMO_for_1	30	33	PF00179	0.648
MOD_SUMO_rev_2	22	30	PF00179	0.686
MOD_SUMO_rev_2	271	281	PF00179	0.448
MOD_SUMO_rev_2	302	311	PF00179	0.431
MOD_SUMO_rev_2	362	369	PF00179	0.733
TRG_DiLeu_BaEn_1	177	182	PF01217	0.485
TRG_ENDOCYTIC_2	224	227	PF00928	0.335
TRG_ENDOCYTIC_2	256	259	PF00928	0.456
TRG_ER_diArg_1	1	3	PF00400	0.697
TRG_ER_diArg_1	10	12	PF00400	0.690
TRG_ER_diArg_1	121	124	PF00400	0.606
TRG_ER_diArg_1	285	287	PF00400	0.585
TRG_ER_diArg_1	386	388	PF00400	0.566
TRG_ER_diArg_1	452	454	PF00400	0.542
TRG_Pf-PMV_PEXEL_1	53	58	PF00026	0.674

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE42	Leptomonas seymouri	64%	100%
A0A0S4JAR7	Bodo saltans	37%	86%
A0A3R7N841	Trypanosoma rangeli	47%	95%
A0A3S5H7V5	Leishmania donovani	80%	99%
A4I9F7	Leishmania infantum	80%	99%
C9ZJT1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	93%
E9B4F5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q4Q3M0	Leishmania major	80%	100%
V5B2X5	Trypanosoma cruzi	45%	100%