Proteasome assembly chaperone 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Trypsin-like peptidase domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HM21_LEIBR

TriTrypDb:

LbrM.33.3410 , LBRM2903_330042600

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HM21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM21

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004252	serine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008236	serine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0017171	serine hydrolase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.739
CLV_NRD_NRD_1	20	22	PF00675	0.565
CLV_PCSK_KEX2_1	20	22	PF00082	0.565
CLV_PCSK_SKI1_1	210	214	PF00082	0.701
CLV_PCSK_SKI1_1	36	40	PF00082	0.495
DOC_CKS1_1	51	56	PF01111	0.706
DOC_CYCLIN_RxL_1	36	47	PF00134	0.636
DOC_MAPK_DCC_7	20	30	PF00069	0.454
DOC_MAPK_gen_1	20	27	PF00069	0.589
DOC_MAPK_gen_1	223	233	PF00069	0.739
DOC_MAPK_JIP1_4	39	45	PF00069	0.636
DOC_MAPK_MEF2A_6	21	30	PF00069	0.644
DOC_MAPK_MEF2A_6	36	45	PF00069	0.501
DOC_MAPK_MEF2A_6	63	72	PF00069	0.553
DOC_PP2B_LxvP_1	31	34	PF13499	0.560
DOC_PP2B_LxvP_1	91	94	PF13499	0.587
DOC_PP4_FxxP_1	51	54	PF00568	0.601
DOC_SPAK_OSR1_1	101	105	PF12202	0.627
DOC_USP7_MATH_1	15	19	PF00917	0.621
DOC_USP7_MATH_1	175	179	PF00917	0.679
DOC_USP7_MATH_1	229	233	PF00917	0.654
DOC_USP7_MATH_1	66	70	PF00917	0.727
DOC_USP7_MATH_1	75	79	PF00917	0.650
DOC_WW_Pin1_4	50	55	PF00397	0.707
DOC_WW_Pin1_4	64	69	PF00397	0.606
LIG_14-3-3_CanoR_1	115	124	PF00244	0.550
LIG_14-3-3_CanoR_1	150	156	PF00244	0.502
LIG_14-3-3_CanoR_1	226	232	PF00244	0.740
LIG_BIR_II_1	1	5	PF00653	0.770
LIG_BIR_III_4	235	239	PF00653	0.738
LIG_Clathr_ClatBox_1	137	141	PF01394	0.698
LIG_FHA_1	117	123	PF00498	0.546
LIG_FHA_1	155	161	PF00498	0.613
LIG_FHA_1	226	232	PF00498	0.677
LIG_FHA_1	9	15	PF00498	0.591
LIG_FHA_2	108	114	PF00498	0.730
LIG_LIR_Apic_2	144	148	PF02991	0.543
LIG_LIR_Gen_1	29	38	PF02991	0.575
LIG_LIR_Nem_3	29	33	PF02991	0.584
LIG_Rb_LxCxE_1	165	179	PF01857	0.457
LIG_SH2_STAP1	84	88	PF00017	0.736
LIG_SH2_STAT5	84	87	PF00017	0.656
LIG_SUMO_SIM_anti_2	134	139	PF11976	0.595
LIG_SUMO_SIM_anti_2	230	235	PF11976	0.717
LIG_SUMO_SIM_anti_2	69	74	PF11976	0.467
LIG_SUMO_SIM_par_1	136	141	PF11976	0.664
LIG_SUMO_SIM_par_1	228	235	PF11976	0.742
LIG_SUMO_SIM_par_1	69	74	PF11976	0.467
LIG_UBA3_1	27	36	PF00899	0.690
LIG_WRC_WIRS_1	27	32	PF05994	0.612
LIG_WW_1	94	97	PF00397	0.444
MOD_CDK_SPK_2	50	55	PF00069	0.468
MOD_GlcNHglycan	60	63	PF01048	0.633
MOD_GSK3_1	116	123	PF00069	0.549
MOD_GSK3_1	193	200	PF00069	0.658
MOD_GSK3_1	225	232	PF00069	0.679
MOD_GSK3_1	4	11	PF00069	0.641
MOD_GSK3_1	71	78	PF00069	0.573
MOD_GSK3_1	82	89	PF00069	0.539
MOD_N-GLC_1	4	9	PF02516	0.598
MOD_N-GLC_1	82	87	PF02516	0.475
MOD_NEK2_1	44	49	PF00069	0.579
MOD_NEK2_1	71	76	PF00069	0.583
MOD_PIKK_1	15	21	PF00454	0.720
MOD_PIKK_1	86	92	PF00454	0.711
MOD_PKA_2	149	155	PF00069	0.506
MOD_PKA_2	225	231	PF00069	0.717
MOD_Plk_1	4	10	PF00069	0.487
MOD_Plk_1	86	92	PF00069	0.711
MOD_Plk_2-3	193	199	PF00069	0.643
MOD_Plk_4	163	169	PF00069	0.699
MOD_Plk_4	197	203	PF00069	0.670
MOD_Plk_4	229	235	PF00069	0.682
MOD_Plk_4	26	32	PF00069	0.574
MOD_Plk_4	66	72	PF00069	0.686
MOD_ProDKin_1	50	56	PF00069	0.706
MOD_ProDKin_1	64	70	PF00069	0.607
MOD_SUMO_rev_2	216	225	PF00179	0.610
TRG_DiLeu_BaEn_1	209	214	PF01217	0.661
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.715
TRG_ENDOCYTIC_2	250	253	PF00928	0.592
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6J2	Leptomonas seymouri	56%	85%
A0A0S4J2F7	Bodo saltans	40%	84%
A0A0S4JI53	Bodo saltans	40%	86%
A0A1X0NRD6	Trypanosomatidae	43%	83%
A0A3Q8IHS3	Leishmania donovani	80%	83%
A4I9F4	Leishmania infantum	80%	83%
C9ZJS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	83%
E9B4F2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	83%
Q4Q3M3	Leishmania major	81%	100%
V5D3Q6	Trypanosoma cruzi	46%	90%