Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM20_LEIBR

TriTrypDb:

LbrM.33.3400 , LBRM2903_330042500

Length:

947

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HM20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	507	511	PF00656	0.409
CLV_NRD_NRD_1	161	163	PF00675	0.578
CLV_NRD_NRD_1	270	272	PF00675	0.424
CLV_NRD_NRD_1	369	371	PF00675	0.523
CLV_NRD_NRD_1	396	398	PF00675	0.539
CLV_NRD_NRD_1	908	910	PF00675	0.737
CLV_PCSK_KEX2_1	163	165	PF00082	0.580
CLV_PCSK_KEX2_1	369	371	PF00082	0.523
CLV_PCSK_KEX2_1	396	398	PF00082	0.539
CLV_PCSK_KEX2_1	908	910	PF00082	0.737
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.526
CLV_PCSK_PC7_1	904	910	PF00082	0.724
CLV_PCSK_SKI1_1	163	167	PF00082	0.532
CLV_PCSK_SKI1_1	232	236	PF00082	0.695
CLV_PCSK_SKI1_1	244	248	PF00082	0.378
CLV_PCSK_SKI1_1	396	400	PF00082	0.519
CLV_PCSK_SKI1_1	711	715	PF00082	0.433
CLV_PCSK_SKI1_1	844	848	PF00082	0.465
DEG_APCC_DBOX_1	161	169	PF00400	0.519
DEG_APCC_DBOX_1	594	602	PF00400	0.503
DEG_APCC_DBOX_1	604	612	PF00400	0.496
DEG_Nend_UBRbox_2	1	3	PF02207	0.646
DEG_SPOP_SBC_1	458	462	PF00917	0.500
DEG_SPOP_SBC_1	784	788	PF00917	0.439
DOC_ANK_TNKS_1	104	111	PF00023	0.423
DOC_CDC14_PxL_1	72	80	PF14671	0.598
DOC_CYCLIN_RxL_1	391	404	PF00134	0.529
DOC_CYCLIN_yCln2_LP_2	175	181	PF00134	0.619
DOC_MAPK_DCC_7	171	181	PF00069	0.397
DOC_MAPK_DCC_7	879	887	PF00069	0.487
DOC_MAPK_gen_1	162	168	PF00069	0.527
DOC_MAPK_gen_1	171	181	PF00069	0.437
DOC_MAPK_MEF2A_6	171	179	PF00069	0.403
DOC_MAPK_MEF2A_6	256	264	PF00069	0.582
DOC_MAPK_MEF2A_6	879	887	PF00069	0.703
DOC_MAPK_RevD_3	354	370	PF00069	0.580
DOC_PP1_RVXF_1	378	385	PF00149	0.544
DOC_PP1_RVXF_1	871	877	PF00149	0.565
DOC_PP2B_LxvP_1	175	178	PF13499	0.632
DOC_PP2B_LxvP_1	400	403	PF13499	0.458
DOC_USP7_MATH_1	136	140	PF00917	0.652
DOC_USP7_MATH_1	512	516	PF00917	0.493
DOC_USP7_MATH_1	617	621	PF00917	0.351
DOC_USP7_MATH_1	689	693	PF00917	0.486
DOC_USP7_MATH_1	903	907	PF00917	0.713
DOC_USP7_UBL2_3	232	236	PF12436	0.479
DOC_USP7_UBL2_3	422	426	PF12436	0.601
DOC_WW_Pin1_4	221	226	PF00397	0.516
DOC_WW_Pin1_4	301	306	PF00397	0.413
DOC_WW_Pin1_4	508	513	PF00397	0.448
DOC_WW_Pin1_4	764	769	PF00397	0.651
DOC_WW_Pin1_4	787	792	PF00397	0.531
LIG_14-3-3_CanoR_1	105	113	PF00244	0.490
LIG_14-3-3_CanoR_1	216	223	PF00244	0.583
LIG_14-3-3_CanoR_1	49	54	PF00244	0.581
LIG_14-3-3_CanoR_1	557	561	PF00244	0.554
LIG_14-3-3_CanoR_1	572	576	PF00244	0.299
LIG_14-3-3_CanoR_1	676	686	PF00244	0.595
LIG_14-3-3_CanoR_1	776	781	PF00244	0.416
LIG_14-3-3_CanoR_1	783	793	PF00244	0.442
LIG_14-3-3_CanoR_1	808	814	PF00244	0.502
LIG_14-3-3_CanoR_1	904	908	PF00244	0.720
LIG_Actin_RPEL_3	249	268	PF02755	0.403
LIG_Actin_WH2_2	89	107	PF00022	0.486
LIG_BRCT_BRCA1_1	785	789	PF00533	0.436
LIG_CaM_NSCaTE_8	542	549	PF13499	0.325
LIG_Clathr_ClatBox_1	142	146	PF01394	0.586
LIG_Clathr_ClatBox_1	798	802	PF01394	0.566
LIG_deltaCOP1_diTrp_1	92	100	PF00928	0.369
LIG_FHA_1	312	318	PF00498	0.502
LIG_FHA_1	373	379	PF00498	0.442
LIG_FHA_1	393	399	PF00498	0.302
LIG_FHA_1	459	465	PF00498	0.559
LIG_FHA_1	678	684	PF00498	0.420
LIG_FHA_1	788	794	PF00498	0.583
LIG_FHA_1	795	801	PF00498	0.454
LIG_FHA_1	813	819	PF00498	0.348
LIG_FHA_1	914	920	PF00498	0.616
LIG_FHA_2	113	119	PF00498	0.563
LIG_FHA_2	314	320	PF00498	0.474
LIG_FHA_2	387	393	PF00498	0.631
LIG_FHA_2	505	511	PF00498	0.388
LIG_GBD_Chelix_1	309	317	PF00786	0.565
LIG_LIR_Gen_1	121	131	PF02991	0.484
LIG_LIR_Gen_1	212	222	PF02991	0.535
LIG_LIR_Gen_1	345	354	PF02991	0.556
LIG_LIR_Gen_1	435	444	PF02991	0.535
LIG_LIR_Gen_1	498	503	PF02991	0.478
LIG_LIR_Gen_1	539	550	PF02991	0.459
LIG_LIR_Gen_1	860	867	PF02991	0.476
LIG_LIR_Gen_1	92	100	PF02991	0.488
LIG_LIR_Nem_3	121	127	PF02991	0.466
LIG_LIR_Nem_3	345	349	PF02991	0.436
LIG_LIR_Nem_3	383	387	PF02991	0.328
LIG_LIR_Nem_3	435	441	PF02991	0.530
LIG_LIR_Nem_3	498	502	PF02991	0.475
LIG_LIR_Nem_3	539	545	PF02991	0.475
LIG_LIR_Nem_3	625	630	PF02991	0.616
LIG_LIR_Nem_3	660	665	PF02991	0.618
LIG_LIR_Nem_3	840	846	PF02991	0.536
LIG_LIR_Nem_3	860	864	PF02991	0.355
LIG_LIR_Nem_3	92	97	PF02991	0.492
LIG_LYPXL_yS_3	6	9	PF13949	0.631
LIG_LYPXL_yS_3	627	630	PF13949	0.397
LIG_LYPXL_yS_3	662	665	PF13949	0.446
LIG_NRBOX	143	149	PF00104	0.458
LIG_NRBOX	362	368	PF00104	0.470
LIG_NRBOX	794	800	PF00104	0.351
LIG_PCNA_PIPBox_1	348	357	PF02747	0.534
LIG_PCNA_yPIPBox_3	343	355	PF02747	0.422
LIG_Pex14_2	17	21	PF04695	0.724
LIG_Rb_pABgroove_1	716	724	PF01858	0.539
LIG_RPA_C_Fungi	365	377	PF08784	0.573
LIG_SH2_CRK	346	350	PF00017	0.603
LIG_SH2_STAP1	915	919	PF00017	0.631
LIG_SH2_STAT5	346	349	PF00017	0.449
LIG_SH2_STAT5	584	587	PF00017	0.544
LIG_SH2_STAT5	915	918	PF00017	0.621
LIG_SH3_3	220	226	PF00018	0.517
LIG_SH3_3	287	293	PF00018	0.606
LIG_SH3_3	299	305	PF00018	0.430
LIG_SH3_3	735	741	PF00018	0.464
LIG_SH3_3	757	763	PF00018	0.463
LIG_Sin3_3	682	689	PF02671	0.569
LIG_SUMO_SIM_anti_2	541	547	PF11976	0.552
LIG_SUMO_SIM_anti_2	797	804	PF11976	0.351
LIG_SUMO_SIM_anti_2	8	14	PF11976	0.511
LIG_SUMO_SIM_par_1	141	146	PF11976	0.495
LIG_SUMO_SIM_par_1	614	620	PF11976	0.334
LIG_SUMO_SIM_par_1	796	804	PF11976	0.472
LIG_TRAF2_1	119	122	PF00917	0.569
LIG_TRAF2_1	194	197	PF00917	0.464
LIG_TRAF2_1	633	636	PF00917	0.376
LIG_TRAF2_1	769	772	PF00917	0.416
LIG_TRAF2_1	886	889	PF00917	0.502
LIG_UBA3_1	165	171	PF00899	0.359
LIG_UBA3_1	20	29	PF00899	0.521
LIG_WRC_WIRS_1	113	118	PF05994	0.341
LIG_WRC_WIRS_1	267	272	PF05994	0.374
LIG_WRC_WIRS_1	537	542	PF05994	0.573
LIG_WRC_WIRS_1	79	84	PF05994	0.410
LIG_WRC_WIRS_1	858	863	PF05994	0.464
MOD_CDK_SPK_2	301	306	PF00069	0.413
MOD_CK1_1	112	118	PF00069	0.565
MOD_CK1_1	221	227	PF00069	0.519
MOD_CK1_1	357	363	PF00069	0.451
MOD_CK1_1	460	466	PF00069	0.561
MOD_CK1_1	787	793	PF00069	0.521
MOD_CK1_1	806	812	PF00069	0.583
MOD_CK2_1	112	118	PF00069	0.565
MOD_GlcNHglycan	106	109	PF01048	0.594
MOD_GlcNHglycan	148	151	PF01048	0.489
MOD_GlcNHglycan	157	160	PF01048	0.466
MOD_GlcNHglycan	21	24	PF01048	0.494
MOD_GlcNHglycan	220	223	PF01048	0.737
MOD_GlcNHglycan	356	359	PF01048	0.477
MOD_GlcNHglycan	363	366	PF01048	0.466
MOD_GlcNHglycan	514	517	PF01048	0.432
MOD_GlcNHglycan	527	530	PF01048	0.489
MOD_GlcNHglycan	576	580	PF01048	0.392
MOD_GlcNHglycan	671	676	PF01048	0.456
MOD_GlcNHglycan	748	751	PF01048	0.427
MOD_GlcNHglycan	861	864	PF01048	0.570
MOD_GlcNHglycan	929	932	PF01048	0.675
MOD_GSK3_1	112	119	PF00069	0.570
MOD_GSK3_1	327	334	PF00069	0.554
MOD_GSK3_1	357	364	PF00069	0.571
MOD_GSK3_1	387	394	PF00069	0.526
MOD_GSK3_1	453	460	PF00069	0.475
MOD_GSK3_1	49	56	PF00069	0.654
MOD_GSK3_1	504	511	PF00069	0.430
MOD_GSK3_1	571	578	PF00069	0.532
MOD_GSK3_1	607	614	PF00069	0.346
MOD_GSK3_1	671	678	PF00069	0.526
MOD_GSK3_1	712	719	PF00069	0.614
MOD_GSK3_1	742	749	PF00069	0.555
MOD_GSK3_1	758	765	PF00069	0.408
MOD_GSK3_1	783	790	PF00069	0.662
MOD_GSK3_1	808	815	PF00069	0.690
MOD_GSK3_1	822	829	PF00069	0.390
MOD_N-GLC_1	453	458	PF02516	0.572
MOD_N-GLC_2	57	59	PF02516	0.567
MOD_NEK2_1	104	109	PF00069	0.475
MOD_NEK2_1	19	24	PF00069	0.715
MOD_NEK2_1	252	257	PF00069	0.623
MOD_NEK2_1	354	359	PF00069	0.488
MOD_NEK2_1	453	458	PF00069	0.475
MOD_NEK2_1	459	464	PF00069	0.465
MOD_NEK2_1	491	496	PF00069	0.465
MOD_NEK2_1	546	551	PF00069	0.363
MOD_NEK2_1	657	662	PF00069	0.511
MOD_NEK2_1	664	669	PF00069	0.675
MOD_NEK2_1	758	763	PF00069	0.530
MOD_NEK2_1	78	83	PF00069	0.455
MOD_NEK2_1	857	862	PF00069	0.575
MOD_NEK2_1	893	898	PF00069	0.559
MOD_NEK2_2	903	908	PF00069	0.717
MOD_PIKK_1	215	221	PF00454	0.704
MOD_PIKK_1	244	250	PF00454	0.382
MOD_PIKK_1	344	350	PF00454	0.399
MOD_PIKK_1	631	637	PF00454	0.378
MOD_PIKK_1	644	650	PF00454	0.304
MOD_PK_1	49	55	PF00069	0.463
MOD_PK_1	776	782	PF00069	0.388
MOD_PKA_2	104	110	PF00069	0.486
MOD_PKA_2	215	221	PF00069	0.635
MOD_PKA_2	556	562	PF00069	0.461
MOD_PKA_2	571	577	PF00069	0.520
MOD_PKA_2	675	681	PF00069	0.572
MOD_PKA_2	775	781	PF00069	0.392
MOD_PKA_2	903	909	PF00069	0.721
MOD_Plk_1	447	453	PF00069	0.466
MOD_Plk_2-3	504	510	PF00069	0.387
MOD_Plk_2-3	836	842	PF00069	0.452
MOD_Plk_4	112	118	PF00069	0.565
MOD_Plk_4	448	454	PF00069	0.479
MOD_Plk_4	460	466	PF00069	0.465
MOD_Plk_4	5	11	PF00069	0.607
MOD_Plk_4	533	539	PF00069	0.372
MOD_Plk_4	607	613	PF00069	0.475
MOD_Plk_4	776	782	PF00069	0.545
MOD_Plk_4	794	800	PF00069	0.351
MOD_Plk_4	893	899	PF00069	0.634
MOD_ProDKin_1	221	227	PF00069	0.519
MOD_ProDKin_1	301	307	PF00069	0.408
MOD_ProDKin_1	508	514	PF00069	0.451
MOD_ProDKin_1	764	770	PF00069	0.644
MOD_ProDKin_1	787	793	PF00069	0.521
MOD_SUMO_for_1	235	238	PF00179	0.474
MOD_SUMO_for_1	421	424	PF00179	0.498
MOD_SUMO_for_1	601	604	PF00179	0.626
TRG_DiLeu_BaEn_1	122	127	PF01217	0.548
TRG_DiLeu_BaEn_1	889	894	PF01217	0.721
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.731
TRG_DiLeu_BaLyEn_6	161	166	PF01217	0.521
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.590
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.535
TRG_DiLeu_BaLyEn_6	660	665	PF01217	0.425
TRG_DiLeu_BaLyEn_6	750	755	PF01217	0.462
TRG_ENDOCYTIC_2	346	349	PF00928	0.613
TRG_ENDOCYTIC_2	6	9	PF00928	0.600
TRG_ENDOCYTIC_2	627	630	PF00928	0.627
TRG_ENDOCYTIC_2	662	665	PF00928	0.602
TRG_ER_diArg_1	161	164	PF00400	0.577
TRG_ER_diArg_1	396	398	PF00400	0.539
TRG_ER_diArg_1	48	51	PF00400	0.567
TRG_ER_diArg_1	907	909	PF00400	0.737
TRG_NES_CRM1_1	856	868	PF08389	0.465
TRG_NLS_MonoExtC_3	270	276	PF00514	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKS9	Leptomonas seymouri	43%	91%
A0A3Q8II36	Leishmania donovani	70%	93%
A4I9F3	Leishmania infantum	70%	100%
E9B4F1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%