Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM19_LEIBR

TriTrypDb:

LbrM.33.3390 , LBRM2903_330042400

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HM19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	379	383	PF00656	0.563
CLV_C14_Caspase3-7	386	390	PF00656	0.487
CLV_C14_Caspase3-7	401	405	PF00656	0.530
CLV_NRD_NRD_1	170	172	PF00675	0.472
CLV_NRD_NRD_1	259	261	PF00675	0.617
CLV_NRD_NRD_1	3	5	PF00675	0.630
CLV_NRD_NRD_1	444	446	PF00675	0.553
CLV_PCSK_KEX2_1	170	172	PF00082	0.521
CLV_PCSK_KEX2_1	250	252	PF00082	0.573
CLV_PCSK_KEX2_1	258	260	PF00082	0.668
CLV_PCSK_KEX2_1	3	5	PF00082	0.640
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.503
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.528
CLV_PCSK_SKI1_1	307	311	PF00082	0.645
CLV_PCSK_SKI1_1	33	37	PF00082	0.269
CLV_PCSK_SKI1_1	4	8	PF00082	0.574
CLV_PCSK_SKI1_1	69	73	PF00082	0.400
CLV_PCSK_SKI1_1	83	87	PF00082	0.427
DEG_APCC_DBOX_1	2	10	PF00400	0.573
DEG_Nend_Nbox_1	1	3	PF02207	0.577
DEG_SCF_FBW7_1	278	284	PF00400	0.713
DOC_CDC14_PxL_1	113	121	PF14671	0.480
DOC_CKS1_1	278	283	PF01111	0.723
DOC_MAPK_gen_1	170	176	PF00069	0.493
DOC_MAPK_gen_1	3	9	PF00069	0.634
DOC_MAPK_JIP1_4	291	297	PF00069	0.432
DOC_MAPK_MEF2A_6	213	222	PF00069	0.412
DOC_MAPK_MEF2A_6	69	78	PF00069	0.473
DOC_PP2B_LxvP_1	273	276	PF13499	0.773
DOC_USP7_MATH_1	15	19	PF00917	0.374
DOC_USP7_MATH_1	300	304	PF00917	0.603
DOC_USP7_UBL2_3	411	415	PF12436	0.429
DOC_USP7_UBL2_3	452	456	PF12436	0.517
DOC_USP7_UBL2_3	89	93	PF12436	0.599
DOC_WW_Pin1_4	102	107	PF00397	0.357
DOC_WW_Pin1_4	277	282	PF00397	0.679
DOC_WW_Pin1_4	62	67	PF00397	0.461
LIG_14-3-3_CanoR_1	11	20	PF00244	0.560
LIG_14-3-3_CanoR_1	219	223	PF00244	0.341
LIG_14-3-3_CanoR_1	33	39	PF00244	0.401
LIG_CSL_BTD_1	103	106	PF09270	0.370
LIG_CtBP_PxDLS_1	437	441	PF00389	0.643
LIG_deltaCOP1_diTrp_1	187	194	PF00928	0.374
LIG_FHA_1	124	130	PF00498	0.374
LIG_FHA_1	146	152	PF00498	0.495
LIG_FHA_1	201	207	PF00498	0.390
LIG_FHA_1	278	284	PF00498	0.709
LIG_FHA_1	420	426	PF00498	0.634
LIG_FHA_2	157	163	PF00498	0.378
LIG_FHA_2	283	289	PF00498	0.750
LIG_FHA_2	329	335	PF00498	0.645
LIG_FHA_2	63	69	PF00498	0.483
LIG_FHA_2	79	85	PF00498	0.338
LIG_LIR_Gen_1	148	156	PF02991	0.402
LIG_LIR_Gen_1	347	358	PF02991	0.353
LIG_LIR_Gen_1	397	407	PF02991	0.463
LIG_LIR_Gen_1	42	52	PF02991	0.428
LIG_LIR_Nem_3	148	153	PF02991	0.406
LIG_LIR_Nem_3	30	35	PF02991	0.456
LIG_LIR_Nem_3	347	353	PF02991	0.474
LIG_LIR_Nem_3	397	403	PF02991	0.468
LIG_LIR_Nem_3	42	48	PF02991	0.381
LIG_LIR_Nem_3	82	88	PF02991	0.447
LIG_MAD2	110	118	PF02301	0.479
LIG_Pex14_1	190	194	PF04695	0.402
LIG_SH2_CRK	350	354	PF00017	0.563
LIG_SH2_GRB2like	152	155	PF00017	0.377
LIG_SH2_STAP1	137	141	PF00017	0.426
LIG_SH2_STAT3	342	345	PF00017	0.500
LIG_SH2_STAT5	152	155	PF00017	0.328
LIG_SH2_STAT5	204	207	PF00017	0.488
LIG_SH2_STAT5	75	78	PF00017	0.343
LIG_SH3_3	112	118	PF00018	0.439
LIG_SH3_3	138	144	PF00018	0.536
LIG_SH3_3	17	23	PF00018	0.396
LIG_SH3_3	171	177	PF00018	0.381
LIG_SH3_3	275	281	PF00018	0.756
LIG_SH3_3	286	292	PF00018	0.656
LIG_SUMO_SIM_par_1	34	42	PF11976	0.476
LIG_TYR_ITIM	43	48	PF00017	0.400
LIG_UBA3_1	352	357	PF00899	0.512
MOD_CDK_SPxxK_3	62	69	PF00069	0.455
MOD_CK1_1	18	24	PF00069	0.421
MOD_CK1_1	282	288	PF00069	0.576
MOD_CK2_1	34	40	PF00069	0.393
MOD_CK2_1	391	397	PF00069	0.616
MOD_CK2_1	61	67	PF00069	0.525
MOD_CK2_1	78	84	PF00069	0.322
MOD_Cter_Amidation	168	171	PF01082	0.550
MOD_GlcNHglycan	13	16	PF01048	0.382
MOD_GlcNHglycan	184	187	PF01048	0.386
MOD_GlcNHglycan	304	307	PF01048	0.716
MOD_GlcNHglycan	322	325	PF01048	0.763
MOD_GlcNHglycan	361	364	PF01048	0.596
MOD_GSK3_1	11	18	PF00069	0.469
MOD_GSK3_1	277	284	PF00069	0.720
MOD_GSK3_1	373	380	PF00069	0.626
MOD_GSK3_1	457	464	PF00069	0.620
MOD_N-GLC_1	207	212	PF02516	0.572
MOD_NEK2_1	156	161	PF00069	0.476
MOD_NEK2_1	218	223	PF00069	0.342
MOD_NEK2_1	359	364	PF00069	0.566
MOD_NEK2_1	424	429	PF00069	0.614
MOD_NEK2_1	440	445	PF00069	0.496
MOD_PIKK_1	430	436	PF00454	0.615
MOD_PKA_1	250	256	PF00069	0.361
MOD_PKA_2	218	224	PF00069	0.330
MOD_PKA_2	250	256	PF00069	0.361
MOD_PKA_2	440	446	PF00069	0.636
MOD_PKA_2	61	67	PF00069	0.356
MOD_Plk_1	15	21	PF00069	0.400
MOD_Plk_1	241	247	PF00069	0.464
MOD_Plk_1	376	382	PF00069	0.610
MOD_Plk_1	396	402	PF00069	0.393
MOD_Plk_2-3	377	383	PF00069	0.555
MOD_Plk_4	104	110	PF00069	0.335
MOD_Plk_4	15	21	PF00069	0.333
MOD_Plk_4	156	162	PF00069	0.410
MOD_Plk_4	200	206	PF00069	0.436
MOD_Plk_4	56	62	PF00069	0.478
MOD_ProDKin_1	102	108	PF00069	0.352
MOD_ProDKin_1	277	283	PF00069	0.683
MOD_ProDKin_1	62	68	PF00069	0.457
MOD_SUMO_rev_2	398	407	PF00179	0.481
MOD_SUMO_rev_2	64	71	PF00179	0.524
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.372
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.604
TRG_ENDOCYTIC_2	152	155	PF00928	0.298
TRG_ENDOCYTIC_2	350	353	PF00928	0.561
TRG_ENDOCYTIC_2	45	48	PF00928	0.482
TRG_ENDOCYTIC_2	75	78	PF00928	0.351
TRG_ER_diArg_1	2	4	PF00400	0.648
TRG_Pf-PMV_PEXEL_1	11	16	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD27	Leptomonas seymouri	75%	99%
A0A0S4JDR9	Bodo saltans	40%	75%
A0A1X0NSW5	Trypanosomatidae	52%	100%
A0A3S7X787	Leishmania donovani	88%	100%
A4I9F2	Leishmania infantum	88%	100%
C9ZJS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	90%
E9B4F0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q3M6	Leishmania major	86%	100%
V5AFA6	Trypanosoma cruzi	53%	100%