Putative tyrosyl-DNA phosphodiesterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tyrosyl-DNA phosphodiesterase, putative

Species:

Leishmania braziliensis

UniProt:

A4HM15_LEIBR

TriTrypDb:

LbrM.33.3330 , LBRM2903_330041700

Length:

680

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0020023	kinetoplast	2	1

Expansion

Sequence features

A4HM15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM15

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006281	DNA repair	5	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0006950	response to stress	2	11
GO:0006974	DNA damage response	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0033554	cellular response to stress	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0050896	response to stimulus	1	11
GO:0051716	cellular response to stimulus	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000012	single strand break repair	6	1
GO:0006302	double-strand break repair	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004518	nuclease activity	4	11
GO:0008081	phosphoric diester hydrolase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0003697	single-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0017005	3'-tyrosyl-DNA phosphodiesterase activity	5	1
GO:0070259	tyrosyl-DNA phosphodiesterase activity	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.411
CLV_C14_Caspase3-7	451	455	PF00656	0.505
CLV_NRD_NRD_1	320	322	PF00675	0.291
CLV_NRD_NRD_1	602	604	PF00675	0.411
CLV_PCSK_KEX2_1	320	322	PF00082	0.282
CLV_PCSK_KEX2_1	517	519	PF00082	0.238
CLV_PCSK_KEX2_1	602	604	PF00082	0.413
CLV_PCSK_KEX2_1	675	677	PF00082	0.556
CLV_PCSK_PC1ET2_1	517	519	PF00082	0.157
CLV_PCSK_PC1ET2_1	675	677	PF00082	0.582
CLV_PCSK_PC7_1	671	677	PF00082	0.452
CLV_PCSK_SKI1_1	163	167	PF00082	0.271
CLV_PCSK_SKI1_1	375	379	PF00082	0.157
CLV_PCSK_SKI1_1	44	48	PF00082	0.305
CLV_PCSK_SKI1_1	494	498	PF00082	0.335
CLV_PCSK_SKI1_1	563	567	PF00082	0.507
CLV_PCSK_SKI1_1	71	75	PF00082	0.299
CLV_Separin_Metazoa	317	321	PF03568	0.509
DEG_APCC_DBOX_1	142	150	PF00400	0.469
DEG_APCC_DBOX_1	308	316	PF00400	0.509
DEG_APCC_DBOX_1	562	570	PF00400	0.279
DEG_APCC_DBOX_1	70	78	PF00400	0.417
DEG_Nend_Nbox_1	1	3	PF02207	0.456
DEG_SCF_FBW7_1	587	594	PF00400	0.390
DEG_SPOP_SBC_1	131	135	PF00917	0.481
DOC_CDC14_PxL_1	74	82	PF14671	0.446
DOC_CKS1_1	580	585	PF01111	0.295
DOC_CKS1_1	588	593	PF01111	0.267
DOC_CYCLIN_yCln2_LP_2	149	155	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	267	273	PF00134	0.357
DOC_CYCLIN_yCln2_LP_2	580	586	PF00134	0.334
DOC_MAPK_gen_1	372	380	PF00069	0.390
DOC_MAPK_MEF2A_6	395	404	PF00069	0.446
DOC_PP1_RVXF_1	233	240	PF00149	0.357
DOC_PP2B_LxvP_1	149	152	PF13499	0.425
DOC_PP2B_LxvP_1	626	629	PF13499	0.516
DOC_PP4_FxxP_1	475	478	PF00568	0.469
DOC_USP7_MATH_1	106	110	PF00917	0.357
DOC_USP7_MATH_1	12	16	PF00917	0.289
DOC_USP7_MATH_1	205	209	PF00917	0.442
DOC_USP7_MATH_1	25	29	PF00917	0.506
DOC_USP7_MATH_1	257	261	PF00917	0.475
DOC_USP7_MATH_1	263	267	PF00917	0.481
DOC_USP7_MATH_1	36	40	PF00917	0.395
DOC_USP7_MATH_1	440	444	PF00917	0.478
DOC_USP7_MATH_1	461	465	PF00917	0.361
DOC_USP7_MATH_1	507	511	PF00917	0.418
DOC_USP7_MATH_1	559	563	PF00917	0.498
DOC_USP7_MATH_1	591	595	PF00917	0.355
DOC_USP7_MATH_1	611	615	PF00917	0.472
DOC_USP7_MATH_1	643	647	PF00917	0.598
DOC_USP7_UBL2_3	202	206	PF12436	0.357
DOC_WW_Pin1_4	111	116	PF00397	0.535
DOC_WW_Pin1_4	302	307	PF00397	0.357
DOC_WW_Pin1_4	319	324	PF00397	0.351
DOC_WW_Pin1_4	326	331	PF00397	0.486
DOC_WW_Pin1_4	579	584	PF00397	0.454
DOC_WW_Pin1_4	587	592	PF00397	0.509
LIG_14-3-3_CanoR_1	100	107	PF00244	0.417
LIG_14-3-3_CanoR_1	321	327	PF00244	0.526
LIG_14-3-3_CanoR_1	388	392	PF00244	0.471
LIG_Actin_WH2_2	161	176	PF00022	0.538
LIG_Actin_WH2_2	60	77	PF00022	0.357
LIG_AP2alpha_2	24	26	PF02296	0.312
LIG_BIR_III_4	634	638	PF00653	0.416
LIG_BRCT_BRCA1_1	14	18	PF00533	0.431
LIG_BRCT_BRCA1_1	225	229	PF00533	0.433
LIG_BRCT_BRCA1_1	542	546	PF00533	0.421
LIG_deltaCOP1_diTrp_1	184	189	PF00928	0.486
LIG_EH_1	120	124	PF12763	0.509
LIG_eIF4E_1	581	587	PF01652	0.367
LIG_FHA_1	111	117	PF00498	0.552
LIG_FHA_1	132	138	PF00498	0.469
LIG_FHA_1	177	183	PF00498	0.473
LIG_FHA_1	18	24	PF00498	0.256
LIG_FHA_1	274	280	PF00498	0.475
LIG_FHA_1	460	466	PF00498	0.426
LIG_FHA_1	593	599	PF00498	0.366
LIG_FHA_1	662	668	PF00498	0.649
LIG_FHA_1	82	88	PF00498	0.496
LIG_FHA_1	94	100	PF00498	0.503
LIG_FHA_2	100	106	PF00498	0.469
LIG_FHA_2	361	367	PF00498	0.357
LIG_FHA_2	381	387	PF00498	0.428
LIG_FHA_2	74	80	PF00498	0.530
LIG_LIR_Gen_1	24	34	PF02991	0.480
LIG_LIR_Gen_1	482	488	PF02991	0.415
LIG_LIR_Gen_1	543	554	PF02991	0.419
LIG_LIR_Gen_1	55	66	PF02991	0.424
LIG_LIR_Gen_1	582	592	PF02991	0.305
LIG_LIR_LC3C_4	376	380	PF02991	0.357
LIG_LIR_LC3C_4	84	89	PF02991	0.417
LIG_LIR_Nem_3	226	232	PF02991	0.357
LIG_LIR_Nem_3	24	29	PF02991	0.460
LIG_LIR_Nem_3	482	486	PF02991	0.422
LIG_LIR_Nem_3	543	549	PF02991	0.464
LIG_LIR_Nem_3	55	61	PF02991	0.424
LIG_LIR_Nem_3	582	587	PF02991	0.403
LIG_LIR_Nem_3	68	73	PF02991	0.471
LIG_Pex14_2	274	278	PF04695	0.509
LIG_Rb_pABgroove_1	528	536	PF01858	0.503
LIG_SH2_CRK	483	487	PF00017	0.435
LIG_SH2_CRK	584	588	PF00017	0.347
LIG_SH2_NCK_1	483	487	PF00017	0.469
LIG_SH2_NCK_1	567	571	PF00017	0.373
LIG_SH2_PTP2	60	63	PF00017	0.369
LIG_SH2_STAP1	483	487	PF00017	0.469
LIG_SH2_STAP1	592	596	PF00017	0.402
LIG_SH2_STAT3	246	249	PF00017	0.491
LIG_SH2_STAT3	339	342	PF00017	0.471
LIG_SH2_STAT5	110	113	PF00017	0.516
LIG_SH2_STAT5	195	198	PF00017	0.415
LIG_SH2_STAT5	246	249	PF00017	0.457
LIG_SH2_STAT5	581	584	PF00017	0.363
LIG_SH2_STAT5	60	63	PF00017	0.417
LIG_SH3_3	145	151	PF00018	0.445
LIG_SH3_3	376	382	PF00018	0.446
LIG_SH3_3	645	651	PF00018	0.457
LIG_SUMO_SIM_anti_2	144	150	PF11976	0.509
LIG_SUMO_SIM_anti_2	332	337	PF11976	0.357
LIG_SUMO_SIM_anti_2	360	367	PF11976	0.417
LIG_SUMO_SIM_anti_2	376	381	PF11976	0.357
LIG_SUMO_SIM_par_1	86	91	PF11976	0.482
LIG_TRAF2_1	382	385	PF00917	0.469
LIG_WW_2	151	154	PF00397	0.471
MOD_CDK_SPxxK_3	302	309	PF00069	0.357
MOD_CK1_1	176	182	PF00069	0.488
MOD_CK1_1	204	210	PF00069	0.486
MOD_CK1_1	227	233	PF00069	0.473
MOD_CK1_1	322	328	PF00069	0.469
MOD_CK1_1	341	347	PF00069	0.458
MOD_CK1_1	65	71	PF00069	0.486
MOD_CK1_1	81	87	PF00069	0.509
MOD_CK2_1	123	129	PF00069	0.348
MOD_CK2_1	360	366	PF00069	0.467
MOD_CK2_1	380	386	PF00069	0.428
MOD_CK2_1	417	423	PF00069	0.426
MOD_CK2_1	73	79	PF00069	0.516
MOD_CK2_1	99	105	PF00069	0.407
MOD_CMANNOS	391	394	PF00535	0.269
MOD_GlcNHglycan	134	137	PF01048	0.351
MOD_GlcNHglycan	203	206	PF01048	0.257
MOD_GlcNHglycan	229	232	PF01048	0.157
MOD_GlcNHglycan	283	287	PF01048	0.242
MOD_GlcNHglycan	3	6	PF01048	0.450
MOD_GlcNHglycan	366	369	PF01048	0.288
MOD_GlcNHglycan	499	502	PF01048	0.224
MOD_GlcNHglycan	511	514	PF01048	0.228
MOD_GlcNHglycan	537	540	PF01048	0.310
MOD_GlcNHglycan	551	554	PF01048	0.422
MOD_GlcNHglycan	7	10	PF01048	0.612
MOD_GlcNHglycan	79	83	PF01048	0.256
MOD_GlcNHglycan	90	93	PF01048	0.180
MOD_GSK3_1	1	8	PF00069	0.648
MOD_GSK3_1	106	113	PF00069	0.482
MOD_GSK3_1	132	139	PF00069	0.533
MOD_GSK3_1	200	207	PF00069	0.454
MOD_GSK3_1	209	216	PF00069	0.476
MOD_GSK3_1	218	225	PF00069	0.540
MOD_GSK3_1	273	280	PF00069	0.499
MOD_GSK3_1	291	298	PF00069	0.361
MOD_GSK3_1	322	329	PF00069	0.478
MOD_GSK3_1	337	344	PF00069	0.461
MOD_GSK3_1	345	352	PF00069	0.348
MOD_GSK3_1	360	367	PF00069	0.367
MOD_GSK3_1	461	468	PF00069	0.472
MOD_GSK3_1	497	504	PF00069	0.422
MOD_GSK3_1	540	547	PF00069	0.459
MOD_GSK3_1	555	562	PF00069	0.486
MOD_GSK3_1	587	594	PF00069	0.518
MOD_GSK3_1	61	68	PF00069	0.483
MOD_GSK3_1	95	102	PF00069	0.488
MOD_N-GLC_1	227	232	PF02516	0.269
MOD_N-GLC_1	345	350	PF02516	0.157
MOD_N-GLC_1	501	506	PF02516	0.215
MOD_NEK2_1	1	6	PF00069	0.624
MOD_NEK2_1	123	128	PF00069	0.425
MOD_NEK2_1	173	178	PF00069	0.469
MOD_NEK2_1	213	218	PF00069	0.433
MOD_NEK2_1	291	296	PF00069	0.465
MOD_NEK2_1	345	350	PF00069	0.501
MOD_NEK2_1	465	470	PF00069	0.469
MOD_NEK2_1	496	501	PF00069	0.472
MOD_NEK2_1	533	538	PF00069	0.452
MOD_NEK2_1	62	67	PF00069	0.513
MOD_NEK2_1	644	649	PF00069	0.455
MOD_NEK2_1	73	78	PF00069	0.437
MOD_NEK2_1	99	104	PF00069	0.560
MOD_NEK2_2	257	262	PF00069	0.357
MOD_NEK2_2	95	100	PF00069	0.509
MOD_OFUCOSY	32	38	PF10250	0.346
MOD_PIKK_1	188	194	PF00454	0.431
MOD_PIKK_1	338	344	PF00454	0.415
MOD_PIKK_1	429	435	PF00454	0.357
MOD_PIKK_1	501	507	PF00454	0.465
MOD_PKA_1	602	608	PF00069	0.404
MOD_PKA_2	173	179	PF00069	0.509
MOD_PKA_2	387	393	PF00069	0.446
MOD_PKA_2	602	608	PF00069	0.412
MOD_PKA_2	99	105	PF00069	0.488
MOD_Plk_1	12	18	PF00069	0.267
MOD_Plk_1	345	351	PF00069	0.451
MOD_Plk_1	488	494	PF00069	0.509
MOD_Plk_1	644	650	PF00069	0.363
MOD_Plk_1	78	84	PF00069	0.509
MOD_Plk_2-3	360	366	PF00069	0.374
MOD_Plk_4	136	142	PF00069	0.357
MOD_Plk_4	173	179	PF00069	0.452
MOD_Plk_4	345	351	PF00069	0.449
MOD_Plk_4	36	42	PF00069	0.446
MOD_Plk_4	360	366	PF00069	0.420
MOD_Plk_4	461	467	PF00069	0.497
MOD_Plk_4	540	546	PF00069	0.355
MOD_Plk_4	62	68	PF00069	0.505
MOD_Plk_4	663	669	PF00069	0.551
MOD_ProDKin_1	111	117	PF00069	0.535
MOD_ProDKin_1	302	308	PF00069	0.357
MOD_ProDKin_1	319	325	PF00069	0.351
MOD_ProDKin_1	326	332	PF00069	0.520
MOD_ProDKin_1	579	585	PF00069	0.458
MOD_ProDKin_1	587	593	PF00069	0.512
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.357
TRG_ENDOCYTIC_2	472	475	PF00928	0.451
TRG_ENDOCYTIC_2	483	486	PF00928	0.391
TRG_ENDOCYTIC_2	584	587	PF00928	0.312
TRG_ENDOCYTIC_2	60	63	PF00928	0.369
TRG_ER_diArg_1	319	321	PF00400	0.469
TRG_ER_diArg_1	41	44	PF00400	0.469
TRG_ER_diArg_1	602	604	PF00400	0.559
TRG_ER_diArg_1	668	671	PF00400	0.582
TRG_NES_CRM1_1	79	93	PF08389	0.509
TRG_NLS_MonoExtN_4	514	520	PF00514	0.357
TRG_Pf-PMV_PEXEL_1	518	522	PF00026	0.157

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C9	Leptomonas seymouri	51%	98%
A0A0S4JE96	Bodo saltans	30%	96%
A0A1X0NRE8	Trypanosomatidae	35%	100%
A0A3Q8IMS2	Leishmania donovani	75%	100%
A0A3R7RCR4	Trypanosoma rangeli	34%	100%
A4I9E7	Leishmania infantum	75%	100%
C9ZJR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B4E6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q3N1	Leishmania major	73%	100%
Q8H1D9	Arabidopsis thaliana	27%	100%