Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HM13_LEIBR

TriTrypDb:

LbrM.33.3310 , LBRM2903_330041500

Length:

987

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HM13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.670
CLV_C14_Caspase3-7	175	179	PF00656	0.539
CLV_C14_Caspase3-7	266	270	PF00656	0.519
CLV_C14_Caspase3-7	865	869	PF00656	0.579
CLV_NRD_NRD_1	193	195	PF00675	0.706
CLV_NRD_NRD_1	222	224	PF00675	0.662
CLV_NRD_NRD_1	606	608	PF00675	0.567
CLV_NRD_NRD_1	647	649	PF00675	0.725
CLV_NRD_NRD_1	707	709	PF00675	0.694
CLV_NRD_NRD_1	856	858	PF00675	0.618
CLV_NRD_NRD_1	866	868	PF00675	0.605
CLV_NRD_NRD_1	934	936	PF00675	0.544
CLV_NRD_NRD_1	962	964	PF00675	0.599
CLV_NRD_NRD_1	983	985	PF00675	0.601
CLV_PCSK_KEX2_1	193	195	PF00082	0.706
CLV_PCSK_KEX2_1	222	224	PF00082	0.631
CLV_PCSK_KEX2_1	464	466	PF00082	0.454
CLV_PCSK_KEX2_1	553	555	PF00082	0.733
CLV_PCSK_KEX2_1	606	608	PF00082	0.567
CLV_PCSK_KEX2_1	647	649	PF00082	0.703
CLV_PCSK_KEX2_1	709	711	PF00082	0.698
CLV_PCSK_KEX2_1	722	724	PF00082	0.567
CLV_PCSK_KEX2_1	853	855	PF00082	0.720
CLV_PCSK_KEX2_1	866	868	PF00082	0.573
CLV_PCSK_KEX2_1	934	936	PF00082	0.603
CLV_PCSK_KEX2_1	961	963	PF00082	0.592
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.410
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.733
CLV_PCSK_PC1ET2_1	709	711	PF00082	0.698
CLV_PCSK_PC1ET2_1	722	724	PF00082	0.567
CLV_PCSK_PC1ET2_1	853	855	PF00082	0.720
CLV_PCSK_PC1ET2_1	961	963	PF00082	0.535
CLV_PCSK_PC7_1	957	963	PF00082	0.535
CLV_PCSK_SKI1_1	237	241	PF00082	0.553
CLV_PCSK_SKI1_1	557	561	PF00082	0.664
CLV_PCSK_SKI1_1	665	669	PF00082	0.600
CLV_PCSK_SKI1_1	867	871	PF00082	0.551
CLV_PCSK_SKI1_1	934	938	PF00082	0.523
CLV_Separin_Metazoa	425	429	PF03568	0.518
DEG_APCC_DBOX_1	707	715	PF00400	0.548
DEG_ODPH_VHL_1	759	772	PF01847	0.522
DEG_SCF_FBW7_2	22	29	PF00400	0.564
DEG_SPOP_SBC_1	489	493	PF00917	0.559
DEG_SPOP_SBC_1	835	839	PF00917	0.540
DEG_SPOP_SBC_1	84	88	PF00917	0.587
DEG_SPOP_SBC_1	99	103	PF00917	0.631
DOC_CKS1_1	656	661	PF01111	0.636
DOC_CKS1_1	893	898	PF01111	0.552
DOC_MAPK_DCC_7	590	600	PF00069	0.548
DOC_MAPK_gen_1	300	310	PF00069	0.537
DOC_MAPK_gen_1	365	374	PF00069	0.559
DOC_MAPK_gen_1	550	560	PF00069	0.635
DOC_MAPK_gen_1	590	600	PF00069	0.589
DOC_MAPK_MEF2A_6	303	312	PF00069	0.523
DOC_MAPK_MEF2A_6	391	400	PF00069	0.540
DOC_MAPK_MEF2A_6	635	642	PF00069	0.560
DOC_PP1_RVXF_1	554	561	PF00149	0.703
DOC_PP2B_LxvP_1	629	632	PF13499	0.551
DOC_PP2B_LxvP_1	759	762	PF13499	0.659
DOC_PP2B_LxvP_1	926	929	PF13499	0.507
DOC_PP4_FxxP_1	112	115	PF00568	0.696
DOC_PP4_FxxP_1	343	346	PF00568	0.530
DOC_PP4_FxxP_1	811	814	PF00568	0.622
DOC_PP4_MxPP_1	927	930	PF00568	0.504
DOC_USP7_MATH_1	204	208	PF00917	0.532
DOC_USP7_MATH_1	325	329	PF00917	0.664
DOC_USP7_MATH_1	413	417	PF00917	0.557
DOC_USP7_MATH_1	512	516	PF00917	0.597
DOC_USP7_MATH_1	579	583	PF00917	0.576
DOC_USP7_MATH_1	788	792	PF00917	0.661
DOC_USP7_MATH_1	912	916	PF00917	0.542
DOC_USP7_MATH_1	956	960	PF00917	0.565
DOC_USP7_MATH_1	967	971	PF00917	0.527
DOC_USP7_MATH_1	979	983	PF00917	0.633
DOC_USP7_MATH_2	906	912	PF00917	0.697
DOC_USP7_UBL2_3	552	556	PF12436	0.676
DOC_USP7_UBL2_3	860	864	PF12436	0.627
DOC_WW_Pin1_4	17	22	PF00397	0.578
DOC_WW_Pin1_4	200	205	PF00397	0.730
DOC_WW_Pin1_4	321	326	PF00397	0.809
DOC_WW_Pin1_4	36	41	PF00397	0.697
DOC_WW_Pin1_4	416	421	PF00397	0.543
DOC_WW_Pin1_4	527	532	PF00397	0.725
DOC_WW_Pin1_4	593	598	PF00397	0.764
DOC_WW_Pin1_4	605	610	PF00397	0.623
DOC_WW_Pin1_4	642	647	PF00397	0.650
DOC_WW_Pin1_4	655	660	PF00397	0.625
DOC_WW_Pin1_4	7	12	PF00397	0.614
DOC_WW_Pin1_4	71	76	PF00397	0.793
DOC_WW_Pin1_4	793	798	PF00397	0.676
DOC_WW_Pin1_4	810	815	PF00397	0.489
DOC_WW_Pin1_4	892	897	PF00397	0.619
DOC_WW_Pin1_4	902	907	PF00397	0.673
LIG_14-3-3_CanoR_1	121	129	PF00244	0.537
LIG_14-3-3_CanoR_1	137	143	PF00244	0.526
LIG_14-3-3_CanoR_1	237	242	PF00244	0.562
LIG_14-3-3_CanoR_1	607	617	PF00244	0.638
LIG_14-3-3_CanoR_1	67	76	PF00244	0.556
LIG_14-3-3_CanoR_1	708	717	PF00244	0.597
LIG_14-3-3_CanoR_1	742	748	PF00244	0.599
LIG_14-3-3_CanoR_1	753	762	PF00244	0.714
LIG_14-3-3_CanoR_1	806	814	PF00244	0.662
LIG_14-3-3_CanoR_1	971	975	PF00244	0.580
LIG_Actin_WH2_2	290	307	PF00022	0.596
LIG_APCC_ABBA_1	589	594	PF00400	0.565
LIG_BIR_II_1	1	5	PF00653	0.533
LIG_BIR_III_4	737	741	PF00653	0.534
LIG_BRCT_BRCA1_1	294	298	PF00533	0.715
LIG_BRCT_BRCA1_1	743	747	PF00533	0.688
LIG_BRCT_BRCA1_2	294	300	PF00533	0.713
LIG_FHA_1	144	150	PF00498	0.541
LIG_FHA_1	37	43	PF00498	0.747
LIG_FHA_1	388	394	PF00498	0.533
LIG_FHA_1	491	497	PF00498	0.780
LIG_FHA_1	656	662	PF00498	0.691
LIG_FHA_1	682	688	PF00498	0.603
LIG_FHA_1	71	77	PF00498	0.677
LIG_FHA_1	816	822	PF00498	0.582
LIG_FHA_1	835	841	PF00498	0.494
LIG_FHA_1	86	92	PF00498	0.690
LIG_FHA_1	893	899	PF00498	0.554
LIG_FHA_1	970	976	PF00498	0.612
LIG_FHA_2	150	156	PF00498	0.823
LIG_FHA_2	166	172	PF00498	0.557
LIG_FHA_2	58	64	PF00498	0.729
LIG_FHA_2	943	949	PF00498	0.530
LIG_LIR_Apic_2	109	115	PF02991	0.538
LIG_LIR_Apic_2	808	814	PF02991	0.623
LIG_LIR_Gen_1	269	279	PF02991	0.536
LIG_LIR_Gen_1	317	325	PF02991	0.535
LIG_LIR_Gen_1	421	431	PF02991	0.680
LIG_LIR_Nem_3	235	241	PF02991	0.601
LIG_LIR_Nem_3	269	274	PF02991	0.533
LIG_LIR_Nem_3	317	322	PF02991	0.624
LIG_LIR_Nem_3	421	427	PF02991	0.688
LIG_LIR_Nem_3	874	880	PF02991	0.686
LIG_MYND_1	40	44	PF01753	0.713
LIG_NRP_CendR_1	984	987	PF00754	0.572
LIG_SH2_CRK	319	323	PF00017	0.540
LIG_SH2_CRK	97	101	PF00017	0.703
LIG_SH2_STAT5	238	241	PF00017	0.664
LIG_SH2_STAT5	70	73	PF00017	0.707
LIG_SH3_1	887	893	PF00018	0.540
LIG_SH3_3	108	114	PF00018	0.542
LIG_SH3_3	319	325	PF00018	0.590
LIG_SH3_3	332	338	PF00018	0.663
LIG_SH3_3	41	47	PF00018	0.731
LIG_SH3_3	424	430	PF00018	0.722
LIG_SH3_3	519	525	PF00018	0.559
LIG_SH3_3	53	59	PF00018	0.567
LIG_SH3_3	653	659	PF00018	0.645
LIG_SH3_3	683	689	PF00018	0.702
LIG_SH3_3	767	773	PF00018	0.685
LIG_SH3_3	828	834	PF00018	0.684
LIG_SH3_3	887	893	PF00018	0.702
LIG_SH3_3	972	978	PF00018	0.555
LIG_Sin3_3	949	956	PF02671	0.535
LIG_SUMO_SIM_anti_2	922	928	PF11976	0.615
LIG_SUMO_SIM_par_1	124	131	PF11976	0.532
LIG_SUMO_SIM_par_1	837	844	PF11976	0.545
LIG_TRAF2_1	27	30	PF00917	0.564
LIG_TRAF2_1	443	446	PF00917	0.697
LIG_UBA3_1	183	188	PF00899	0.535
LIG_WRC_WIRS_1	268	273	PF05994	0.519
LIG_WRC_WIRS_1	916	921	PF05994	0.530
MOD_CDK_SPK_2	642	647	PF00069	0.635
MOD_CDK_SPK_2	660	665	PF00069	0.517
MOD_CDK_SPK_2	902	907	PF00069	0.686
MOD_CDK_SPxK_1	642	648	PF00069	0.670
MOD_CDK_SPxxK_3	527	534	PF00069	0.552
MOD_CDK_SPxxK_3	7	14	PF00069	0.620
MOD_CDK_SPxxK_3	71	78	PF00069	0.707
MOD_CDK_SPxxK_3	793	800	PF00069	0.573
MOD_CDK_SPxxK_3	892	899	PF00069	0.554
MOD_CK1_1	105	111	PF00069	0.631
MOD_CK1_1	200	206	PF00069	0.807
MOD_CK1_1	227	233	PF00069	0.726
MOD_CK1_1	242	248	PF00069	0.559
MOD_CK1_1	263	269	PF00069	0.598
MOD_CK1_1	292	298	PF00069	0.716
MOD_CK1_1	321	327	PF00069	0.769
MOD_CK1_1	416	422	PF00069	0.654
MOD_CK1_1	492	498	PF00069	0.741
MOD_CK1_1	663	669	PF00069	0.578
MOD_CK1_1	718	724	PF00069	0.727
MOD_CK1_1	749	755	PF00069	0.711
MOD_CK1_1	791	797	PF00069	0.652
MOD_CK1_1	815	821	PF00069	0.616
MOD_CK1_1	829	835	PF00069	0.507
MOD_CK1_1	873	879	PF00069	0.664
MOD_CK1_1	915	921	PF00069	0.598
MOD_CK1_1	939	945	PF00069	0.538
MOD_CK1_1	970	976	PF00069	0.656
MOD_CK2_1	125	131	PF00069	0.703
MOD_CK2_1	149	155	PF00069	0.779
MOD_CK2_1	24	30	PF00069	0.562
MOD_CK2_1	242	248	PF00069	0.744
MOD_CK2_1	321	327	PF00069	0.699
MOD_CK2_1	616	622	PF00069	0.640
MOD_CK2_1	763	769	PF00069	0.622
MOD_CK2_1	775	781	PF00069	0.561
MOD_CK2_1	902	908	PF00069	0.688
MOD_CK2_1	917	923	PF00069	0.515
MOD_CK2_1	942	948	PF00069	0.529
MOD_Cter_Amidation	554	557	PF01082	0.528
MOD_GlcNHglycan	1	4	PF01048	0.551
MOD_GlcNHglycan	199	202	PF01048	0.643
MOD_GlcNHglycan	224	227	PF01048	0.762
MOD_GlcNHglycan	234	237	PF01048	0.541
MOD_GlcNHglycan	282	285	PF01048	0.625
MOD_GlcNHglycan	331	334	PF01048	0.699
MOD_GlcNHglycan	343	346	PF01048	0.575
MOD_GlcNHglycan	481	485	PF01048	0.721
MOD_GlcNHglycan	665	668	PF01048	0.714
MOD_GlcNHglycan	677	680	PF01048	0.572
MOD_GlcNHglycan	692	695	PF01048	0.525
MOD_GlcNHglycan	793	796	PF01048	0.655
MOD_GlcNHglycan	808	811	PF01048	0.519
MOD_GlcNHglycan	828	831	PF01048	0.498
MOD_GlcNHglycan	910	913	PF01048	0.592
MOD_GlcNHglycan	919	922	PF01048	0.636
MOD_GlcNHglycan	941	944	PF01048	0.586
MOD_GlcNHglycan	954	957	PF01048	0.551
MOD_GSK3_1	121	128	PF00069	0.706
MOD_GSK3_1	133	140	PF00069	0.687
MOD_GSK3_1	145	152	PF00069	0.613
MOD_GSK3_1	200	207	PF00069	0.567
MOD_GSK3_1	213	220	PF00069	0.526
MOD_GSK3_1	237	244	PF00069	0.772
MOD_GSK3_1	260	267	PF00069	0.641
MOD_GSK3_1	288	295	PF00069	0.737
MOD_GSK3_1	314	321	PF00069	0.753
MOD_GSK3_1	325	332	PF00069	0.670
MOD_GSK3_1	414	421	PF00069	0.746
MOD_GSK3_1	488	495	PF00069	0.758
MOD_GSK3_1	579	586	PF00069	0.723
MOD_GSK3_1	636	643	PF00069	0.645
MOD_GSK3_1	721	728	PF00069	0.626
MOD_GSK3_1	742	749	PF00069	0.601
MOD_GSK3_1	789	796	PF00069	0.602
MOD_GSK3_1	806	813	PF00069	0.496
MOD_GSK3_1	834	841	PF00069	0.637
MOD_GSK3_1	867	874	PF00069	0.650
MOD_GSK3_1	908	915	PF00069	0.628
MOD_GSK3_1	935	942	PF00069	0.633
MOD_GSK3_1	952	959	PF00069	0.564
MOD_GSK3_1	98	105	PF00069	0.544
MOD_N-GLC_1	149	154	PF02516	0.712
MOD_N-GLC_1	227	232	PF02516	0.785
MOD_N-GLC_1	264	269	PF02516	0.602
MOD_N-GLC_1	341	346	PF02516	0.720
MOD_N-GLC_2	377	379	PF02516	0.541
MOD_NEK2_1	239	244	PF00069	0.762
MOD_NEK2_1	280	285	PF00069	0.682
MOD_NEK2_1	289	294	PF00069	0.629
MOD_NEK2_1	298	303	PF00069	0.591
MOD_NEK2_1	341	346	PF00069	0.695
MOD_NEK2_1	357	362	PF00069	0.547
MOD_NEK2_1	414	419	PF00069	0.714
MOD_NEK2_1	640	645	PF00069	0.596
MOD_NEK2_1	68	73	PF00069	0.711
MOD_NEK2_1	681	686	PF00069	0.544
MOD_NEK2_1	741	746	PF00069	0.536
MOD_NEK2_1	840	845	PF00069	0.631
MOD_NEK2_1	936	941	PF00069	0.538
MOD_NEK2_1	98	103	PF00069	0.672
MOD_NEK2_2	138	143	PF00069	0.656
MOD_NEK2_2	697	702	PF00069	0.546
MOD_NEK2_2	956	961	PF00069	0.533
MOD_PIKK_1	239	245	PF00454	0.777
MOD_PIKK_1	292	298	PF00454	0.716
MOD_PIKK_1	326	332	PF00454	0.538
MOD_PIKK_1	499	505	PF00454	0.649
MOD_PIKK_1	780	786	PF00454	0.613
MOD_PIKK_1	829	835	PF00454	0.542
MOD_PK_1	318	324	PF00069	0.538
MOD_PK_1	710	716	PF00069	0.556
MOD_PKA_1	222	228	PF00069	0.568
MOD_PKA_1	709	715	PF00069	0.553
MOD_PKA_1	962	968	PF00069	0.533
MOD_PKA_2	165	171	PF00069	0.564
MOD_PKA_2	222	228	PF00069	0.568
MOD_PKA_2	709	715	PF00069	0.603
MOD_PKA_2	741	747	PF00069	0.535
MOD_PKA_2	789	795	PF00069	0.655
MOD_PKA_2	805	811	PF00069	0.625
MOD_PKA_2	956	962	PF00069	0.545
MOD_PKA_2	970	976	PF00069	0.605
MOD_PKB_1	211	219	PF00069	0.540
MOD_PKB_1	708	716	PF00069	0.690
MOD_Plk_1	149	155	PF00069	0.825
MOD_Plk_1	264	270	PF00069	0.598
MOD_Plk_1	289	295	PF00069	0.720
MOD_Plk_1	326	332	PF00069	0.566
MOD_Plk_1	922	928	PF00069	0.590
MOD_Plk_2-3	125	131	PF00069	0.533
MOD_Plk_2-3	165	171	PF00069	0.602
MOD_Plk_4	106	112	PF00069	0.559
MOD_Plk_4	149	155	PF00069	0.747
MOD_Plk_4	204	210	PF00069	0.548
MOD_Plk_4	336	342	PF00069	0.697
MOD_Plk_4	492	498	PF00069	0.561
MOD_Plk_4	542	548	PF00069	0.648
MOD_Plk_4	665	671	PF00069	0.602
MOD_Plk_4	697	703	PF00069	0.610
MOD_Plk_4	922	928	PF00069	0.615
MOD_Plk_4	942	948	PF00069	0.480
MOD_Plk_4	970	976	PF00069	0.553
MOD_ProDKin_1	17	23	PF00069	0.579
MOD_ProDKin_1	200	206	PF00069	0.728
MOD_ProDKin_1	321	327	PF00069	0.811
MOD_ProDKin_1	36	42	PF00069	0.699
MOD_ProDKin_1	416	422	PF00069	0.542
MOD_ProDKin_1	527	533	PF00069	0.724
MOD_ProDKin_1	593	599	PF00069	0.763
MOD_ProDKin_1	605	611	PF00069	0.624
MOD_ProDKin_1	642	648	PF00069	0.649
MOD_ProDKin_1	655	661	PF00069	0.624
MOD_ProDKin_1	7	13	PF00069	0.617
MOD_ProDKin_1	71	77	PF00069	0.793
MOD_ProDKin_1	793	799	PF00069	0.675
MOD_ProDKin_1	810	816	PF00069	0.490
MOD_ProDKin_1	892	898	PF00069	0.621
MOD_ProDKin_1	902	908	PF00069	0.669
MOD_SUMO_rev_2	125	135	PF00179	0.622
TRG_DiLeu_BaLyEn_6	656	661	PF01217	0.576
TRG_ENDOCYTIC_2	238	241	PF00928	0.764
TRG_ENDOCYTIC_2	319	322	PF00928	0.535
TRG_ENDOCYTIC_2	4	7	PF00928	0.691
TRG_ENDOCYTIC_2	97	100	PF00928	0.705
TRG_ER_diArg_1	192	194	PF00400	0.704
TRG_ER_diArg_1	210	213	PF00400	0.521
TRG_ER_diArg_1	646	648	PF00400	0.704
TRG_ER_diArg_1	707	710	PF00400	0.677
TRG_ER_diArg_1	934	936	PF00400	0.544
TRG_NLS_Bipartite_1	853	867	PF00514	0.564
TRG_NLS_MonoCore_2	960	965	PF00514	0.529
TRG_NLS_MonoExtC_3	551	556	PF00514	0.693
TRG_NLS_MonoExtC_3	862	867	PF00514	0.567
TRG_NLS_MonoExtC_3	960	966	PF00514	0.531
TRG_NLS_MonoExtN_4	550	557	PF00514	0.591
TRG_NLS_MonoExtN_4	707	712	PF00514	0.682
TRG_NLS_MonoExtN_4	860	867	PF00514	0.567
TRG_Pf-PMV_PEXEL_1	456	461	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X777	Leishmania donovani	53%	92%
A4I9E5	Leishmania infantum	53%	92%
E9B4E4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	96%
Q4Q3N3	Leishmania major	51%	100%