Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HM12_LEIBR

TriTrypDb:

LbrM.33.3300 , LBRM2903_330041200

Length:

950

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HM12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	430	434	PF00656	0.635
CLV_C14_Caspase3-7	83	87	PF00656	0.721
CLV_NRD_NRD_1	172	174	PF00675	0.685
CLV_NRD_NRD_1	29	31	PF00675	0.544
CLV_NRD_NRD_1	293	295	PF00675	0.595
CLV_NRD_NRD_1	566	568	PF00675	0.662
CLV_NRD_NRD_1	656	658	PF00675	0.677
CLV_NRD_NRD_1	769	771	PF00675	0.626
CLV_NRD_NRD_1	870	872	PF00675	0.733
CLV_NRD_NRD_1	885	887	PF00675	0.563
CLV_NRD_NRD_1	899	901	PF00675	0.678
CLV_PCSK_KEX2_1	172	174	PF00082	0.685
CLV_PCSK_KEX2_1	28	30	PF00082	0.571
CLV_PCSK_KEX2_1	293	295	PF00082	0.567
CLV_PCSK_KEX2_1	333	335	PF00082	0.721
CLV_PCSK_KEX2_1	384	386	PF00082	0.605
CLV_PCSK_KEX2_1	422	424	PF00082	0.574
CLV_PCSK_KEX2_1	565	567	PF00082	0.678
CLV_PCSK_KEX2_1	652	654	PF00082	0.604
CLV_PCSK_KEX2_1	769	771	PF00082	0.608
CLV_PCSK_KEX2_1	870	872	PF00082	0.733
CLV_PCSK_KEX2_1	899	901	PF00082	0.654
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.685
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.605
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.552
CLV_PCSK_PC1ET2_1	652	654	PF00082	0.604
CLV_PCSK_SKI1_1	33	37	PF00082	0.636
CLV_PCSK_SKI1_1	797	801	PF00082	0.740
CLV_PCSK_SKI1_1	870	874	PF00082	0.729
CLV_Separin_Metazoa	413	417	PF03568	0.576
DEG_MDM2_SWIB_1	612	619	PF02201	0.521
DEG_SCF_TRCP1_1	700	706	PF00400	0.549
DEG_SPOP_SBC_1	245	249	PF00917	0.763
DEG_SPOP_SBC_1	260	264	PF00917	0.589
DEG_SPOP_SBC_1	459	463	PF00917	0.550
DOC_CKS1_1	776	781	PF01111	0.565
DOC_CKS1_1	819	824	PF01111	0.547
DOC_CYCLIN_yCln2_LP_2	255	261	PF00134	0.514
DOC_MAPK_FxFP_2	7	10	PF00069	0.508
DOC_MAPK_gen_1	172	180	PF00069	0.552
DOC_MAPK_gen_1	565	574	PF00069	0.542
DOC_MAPK_gen_1	769	776	PF00069	0.553
DOC_MAPK_MEF2A_6	173	182	PF00069	0.552
DOC_MAPK_MEF2A_6	567	576	PF00069	0.538
DOC_MAPK_MEF2A_6	908	915	PF00069	0.533
DOC_PP1_RVXF_1	615	622	PF00149	0.670
DOC_PP2B_LxvP_1	255	258	PF13499	0.505
DOC_PP2B_LxvP_1	271	274	PF13499	0.484
DOC_PP2B_LxvP_1	913	916	PF13499	0.503
DOC_PP4_FxxP_1	7	10	PF00568	0.508
DOC_PP4_MxPP_1	241	244	PF00568	0.674
DOC_USP7_MATH_1	212	216	PF00917	0.608
DOC_USP7_MATH_1	234	238	PF00917	0.731
DOC_USP7_MATH_1	300	304	PF00917	0.664
DOC_USP7_MATH_1	386	390	PF00917	0.692
DOC_USP7_MATH_1	451	455	PF00917	0.628
DOC_USP7_MATH_1	459	463	PF00917	0.581
DOC_USP7_MATH_1	585	589	PF00917	0.667
DOC_USP7_MATH_1	605	609	PF00917	0.619
DOC_USP7_MATH_1	733	737	PF00917	0.586
DOC_USP7_MATH_1	804	808	PF00917	0.568
DOC_USP7_MATH_1	863	867	PF00917	0.665
DOC_USP7_MATH_1	89	93	PF00917	0.577
DOC_USP7_MATH_2	585	591	PF00917	0.611
DOC_USP7_UBL2_3	640	644	PF12436	0.705
DOC_USP7_UBL2_3	647	651	PF12436	0.637
DOC_WW_Pin1_4	187	192	PF00397	0.612
DOC_WW_Pin1_4	348	353	PF00397	0.559
DOC_WW_Pin1_4	443	448	PF00397	0.547
DOC_WW_Pin1_4	463	468	PF00397	0.643
DOC_WW_Pin1_4	476	481	PF00397	0.540
DOC_WW_Pin1_4	53	58	PF00397	0.532
DOC_WW_Pin1_4	599	604	PF00397	0.562
DOC_WW_Pin1_4	701	706	PF00397	0.675
DOC_WW_Pin1_4	775	780	PF00397	0.703
DOC_WW_Pin1_4	799	804	PF00397	0.708
DOC_WW_Pin1_4	818	823	PF00397	0.550
DOC_WW_Pin1_4	861	866	PF00397	0.711
LIG_14-3-3_CanoR_1	112	118	PF00244	0.561
LIG_14-3-3_CanoR_1	132	137	PF00244	0.571
LIG_14-3-3_CanoR_1	334	343	PF00244	0.697
LIG_14-3-3_CanoR_1	385	389	PF00244	0.547
LIG_14-3-3_CanoR_1	50	59	PF00244	0.553
LIG_14-3-3_CanoR_1	523	532	PF00244	0.690
LIG_14-3-3_CanoR_1	553	560	PF00244	0.653
LIG_14-3-3_CanoR_1	593	600	PF00244	0.602
LIG_14-3-3_CanoR_1	617	622	PF00244	0.673
LIG_14-3-3_CanoR_1	769	773	PF00244	0.552
LIG_14-3-3_CanoR_1	870	875	PF00244	0.731
LIG_14-3-3_CanoR_1	902	911	PF00244	0.621
LIG_Actin_WH2_2	760	777	PF00022	0.551
LIG_BIR_III_4	561	565	PF00653	0.564
LIG_BRCT_BRCA1_1	215	219	PF00533	0.516
LIG_BRCT_BRCA1_1	263	267	PF00533	0.503
LIG_BRCT_BRCA1_1	499	503	PF00533	0.525
LIG_FHA_1	246	252	PF00498	0.697
LIG_FHA_1	324	330	PF00498	0.547
LIG_FHA_1	335	341	PF00498	0.544
LIG_FHA_1	34	40	PF00498	0.693
LIG_FHA_1	769	775	PF00498	0.553
LIG_FHA_1	803	809	PF00498	0.692
LIG_FHA_1	905	911	PF00498	0.542
LIG_FHA_1	96	102	PF00498	0.622
LIG_FHA_2	126	132	PF00498	0.705
LIG_FHA_2	133	139	PF00498	0.589
LIG_FHA_2	20	26	PF00498	0.663
LIG_FHA_2	428	434	PF00498	0.676
LIG_FHA_2	628	634	PF00498	0.711
LIG_FHA_2	74	80	PF00498	0.640
LIG_FHA_2	88	94	PF00498	0.559
LIG_Integrin_isoDGR_2	551	553	PF01839	0.580
LIG_Integrin_RGD_1	488	490	PF01839	0.656
LIG_LIR_Apic_2	726	730	PF02991	0.571
LIG_LIR_Gen_1	216	223	PF02991	0.528
LIG_LIR_Gen_1	470	480	PF02991	0.525
LIG_LIR_Gen_1	626	636	PF02991	0.548
LIG_LIR_Gen_1	852	862	PF02991	0.709
LIG_LIR_Nem_3	216	222	PF02991	0.525
LIG_LIR_Nem_3	393	398	PF02991	0.594
LIG_LIR_Nem_3	470	475	PF02991	0.537
LIG_LIR_Nem_3	626	632	PF02991	0.543
LIG_LIR_Nem_3	852	857	PF02991	0.709
LIG_MAD2	908	916	PF02301	0.524
LIG_MLH1_MIPbox_1	499	503	PF16413	0.525
LIG_PCNA_PIPBox_1	1	10	PF02747	0.509
LIG_PCNA_yPIPBox_3	61	72	PF02747	0.520
LIG_Pex14_2	398	402	PF04695	0.522
LIG_Pex14_2	612	616	PF04695	0.521
LIG_PTB_Apo_2	266	273	PF02174	0.509
LIG_PTB_Apo_2	436	443	PF02174	0.554
LIG_PTB_Phospho_1	436	442	PF10480	0.554
LIG_RPA_C_Fungi	561	573	PF08784	0.549
LIG_SH2_CRK	727	731	PF00017	0.558
LIG_SH2_NCK_1	727	731	PF00017	0.558
LIG_SH2_STAT5	12	15	PF00017	0.512
LIG_SH2_STAT5	246	249	PF00017	0.671
LIG_SH2_STAT5	259	262	PF00017	0.529
LIG_SH2_STAT5	310	313	PF00017	0.659
LIG_SH2_STAT5	401	404	PF00017	0.535
LIG_SH2_STAT5	531	534	PF00017	0.567
LIG_SH2_STAT5	648	651	PF00017	0.567
LIG_SH3_1	727	733	PF00018	0.553
LIG_SH3_2	403	408	PF14604	0.533
LIG_SH3_3	400	406	PF00018	0.530
LIG_SH3_3	597	603	PF00018	0.656
LIG_SH3_3	727	733	PF00018	0.710
LIG_SH3_3	773	779	PF00018	0.601
LIG_SH3_3	816	822	PF00018	0.625
LIG_SH3_3	859	865	PF00018	0.665
LIG_TRAF2_1	143	146	PF00917	0.680
LIG_TRAF2_1	410	413	PF00917	0.567
LIG_WRC_WIRS_1	206	211	PF05994	0.525
LIG_WRC_WIRS_1	395	400	PF05994	0.634
LIG_WRC_WIRS_1	618	623	PF05994	0.676
LIG_WW_1	243	246	PF00397	0.543
LIG_WW_3	405	409	PF00397	0.542
MOD_CDC14_SPxK_1	446	449	PF00782	0.537
MOD_CDK_SPxK_1	443	449	PF00069	0.545
MOD_CDK_SPxxK_3	348	355	PF00069	0.564
MOD_CDK_SPxxK_3	799	806	PF00069	0.568
MOD_CK1_1	103	109	PF00069	0.594
MOD_CK1_1	111	117	PF00069	0.637
MOD_CK1_1	125	131	PF00069	0.526
MOD_CK1_1	185	191	PF00069	0.607
MOD_CK1_1	201	207	PF00069	0.685
MOD_CK1_1	217	223	PF00069	0.616
MOD_CK1_1	237	243	PF00069	0.723
MOD_CK1_1	287	293	PF00069	0.591
MOD_CK1_1	369	375	PF00069	0.534
MOD_CK1_1	394	400	PF00069	0.502
MOD_CK1_1	443	449	PF00069	0.701
MOD_CK1_1	454	460	PF00069	0.607
MOD_CK1_1	463	469	PF00069	0.494
MOD_CK1_1	497	503	PF00069	0.708
MOD_CK1_1	526	532	PF00069	0.564
MOD_CK1_1	594	600	PF00069	0.651
MOD_CK1_1	701	707	PF00069	0.630
MOD_CK1_1	728	734	PF00069	0.581
MOD_CK1_1	745	751	PF00069	0.589
MOD_CK1_1	811	817	PF00069	0.812
MOD_CK1_1	87	93	PF00069	0.619
MOD_CK1_1	876	882	PF00069	0.719
MOD_CK1_1	889	895	PF00069	0.556
MOD_CK1_1	95	101	PF00069	0.615
MOD_CK2_1	132	138	PF00069	0.712
MOD_CK2_1	140	146	PF00069	0.676
MOD_CK2_1	19	25	PF00069	0.665
MOD_CK2_1	35	41	PF00069	0.550
MOD_CK2_1	511	517	PF00069	0.723
MOD_CK2_1	617	623	PF00069	0.674
MOD_CK2_1	627	633	PF00069	0.601
MOD_CK2_1	745	751	PF00069	0.696
MOD_CK2_1	77	83	PF00069	0.590
MOD_CK2_1	87	93	PF00069	0.607
MOD_Cter_Amidation	420	423	PF01082	0.562
MOD_Cter_Amidation	563	566	PF01082	0.624
MOD_Cter_Amidation	868	871	PF01082	0.575
MOD_Cter_Amidation	884	887	PF01082	0.509
MOD_DYRK1A_RPxSP_1	476	480	PF00069	0.510
MOD_DYRK1A_RPxSP_1	775	779	PF00069	0.565
MOD_GlcNHglycan	102	105	PF01048	0.624
MOD_GlcNHglycan	117	120	PF01048	0.597
MOD_GlcNHglycan	234	237	PF01048	0.718
MOD_GlcNHglycan	285	289	PF01048	0.614
MOD_GlcNHglycan	296	299	PF01048	0.616
MOD_GlcNHglycan	302	305	PF01048	0.500
MOD_GlcNHglycan	379	382	PF01048	0.600
MOD_GlcNHglycan	430	433	PF01048	0.700
MOD_GlcNHglycan	462	465	PF01048	0.589
MOD_GlcNHglycan	525	528	PF01048	0.562
MOD_GlcNHglycan	561	565	PF01048	0.673
MOD_GlcNHglycan	568	571	PF01048	0.574
MOD_GlcNHglycan	596	599	PF01048	0.797
MOD_GlcNHglycan	700	703	PF01048	0.728
MOD_GlcNHglycan	727	730	PF01048	0.581
MOD_GlcNHglycan	735	738	PF01048	0.645
MOD_GlcNHglycan	744	747	PF01048	0.569
MOD_GlcNHglycan	865	868	PF01048	0.723
MOD_GlcNHglycan	875	878	PF01048	0.656
MOD_GlcNHglycan	883	886	PF01048	0.540
MOD_GlcNHglycan	888	891	PF01048	0.554
MOD_GlcNHglycan	895	898	PF01048	0.579
MOD_GlcNHglycan	904	907	PF01048	0.540
MOD_GSK3_1	108	115	PF00069	0.601
MOD_GSK3_1	122	129	PF00069	0.582
MOD_GSK3_1	198	205	PF00069	0.640
MOD_GSK3_1	213	220	PF00069	0.677
MOD_GSK3_1	259	266	PF00069	0.702
MOD_GSK3_1	300	307	PF00069	0.702
MOD_GSK3_1	365	372	PF00069	0.596
MOD_GSK3_1	423	430	PF00069	0.692
MOD_GSK3_1	454	461	PF00069	0.601
MOD_GSK3_1	53	60	PF00069	0.529
MOD_GSK3_1	585	592	PF00069	0.672
MOD_GSK3_1	716	723	PF00069	0.681
MOD_GSK3_1	73	80	PF00069	0.564
MOD_GSK3_1	733	740	PF00069	0.635
MOD_GSK3_1	795	802	PF00069	0.657
MOD_GSK3_1	804	811	PF00069	0.794
MOD_GSK3_1	84	91	PF00069	0.694
MOD_GSK3_1	861	868	PF00069	0.760
MOD_GSK3_1	876	883	PF00069	0.632
MOD_GSK3_1	889	896	PF00069	0.637
MOD_GSK3_1	92	99	PF00069	0.614
MOD_LATS_1	130	136	PF00433	0.568
MOD_LATS_1	508	514	PF00433	0.709
MOD_LATS_1	645	651	PF00433	0.569
MOD_N-GLC_1	348	353	PF02516	0.559
MOD_N-GLC_1	57	62	PF02516	0.614
MOD_NEK2_1	14	19	PF00069	0.677
MOD_NEK2_1	182	187	PF00069	0.681
MOD_NEK2_1	24	29	PF00069	0.588
MOD_NEK2_1	35	40	PF00069	0.584
MOD_NEK2_1	415	420	PF00069	0.568
MOD_NEK2_1	427	432	PF00069	0.528
MOD_NEK2_1	572	577	PF00069	0.577
MOD_NEK2_1	589	594	PF00069	0.631
MOD_PIKK_1	304	310	PF00454	0.679
MOD_PIKK_1	57	63	PF00454	0.674
MOD_PIKK_1	605	611	PF00454	0.680
MOD_PIKK_1	70	76	PF00454	0.554
MOD_PIKK_1	737	743	PF00454	0.556
MOD_PIKK_1	768	774	PF00454	0.549
MOD_PIKK_1	808	814	PF00454	0.564
MOD_PK_1	384	390	PF00069	0.544
MOD_PKA_1	33	39	PF00069	0.539
MOD_PKA_1	384	390	PF00069	0.544
MOD_PKA_1	566	572	PF00069	0.699
MOD_PKA_1	646	652	PF00069	0.668
MOD_PKA_1	870	876	PF00069	0.729
MOD_PKA_1	886	892	PF00069	0.528
MOD_PKA_2	111	117	PF00069	0.558
MOD_PKA_2	131	137	PF00069	0.568
MOD_PKA_2	185	191	PF00069	0.655
MOD_PKA_2	384	390	PF00069	0.544
MOD_PKA_2	415	421	PF00069	0.565
MOD_PKA_2	552	558	PF00069	0.637
MOD_PKA_2	566	572	PF00069	0.651
MOD_PKA_2	656	662	PF00069	0.590
MOD_PKA_2	698	704	PF00069	0.661
MOD_PKA_2	768	774	PF00069	0.549
MOD_PKA_2	870	876	PF00069	0.729
MOD_PKB_1	523	531	PF00069	0.544
MOD_PKB_1	900	908	PF00069	0.543
MOD_Plk_1	359	365	PF00069	0.672
MOD_Plk_1	494	500	PF00069	0.669
MOD_Plk_1	511	517	PF00069	0.544
MOD_Plk_1	57	63	PF00069	0.674
MOD_Plk_1	624	630	PF00069	0.533
MOD_Plk_1	92	98	PF00069	0.582
MOD_Plk_2-3	140	146	PF00069	0.575
MOD_Plk_2-3	147	153	PF00069	0.557
MOD_Plk_4	132	138	PF00069	0.692
MOD_Plk_4	237	243	PF00069	0.689
MOD_Plk_4	336	342	PF00069	0.706
MOD_Plk_4	35	41	PF00069	0.667
MOD_Plk_4	359	365	PF00069	0.611
MOD_Plk_4	366	372	PF00069	0.570
MOD_Plk_4	394	400	PF00069	0.659
MOD_Plk_4	572	578	PF00069	0.537
MOD_Plk_4	624	630	PF00069	0.560
MOD_ProDKin_1	187	193	PF00069	0.615
MOD_ProDKin_1	348	354	PF00069	0.561
MOD_ProDKin_1	443	449	PF00069	0.545
MOD_ProDKin_1	463	469	PF00069	0.643
MOD_ProDKin_1	476	482	PF00069	0.539
MOD_ProDKin_1	53	59	PF00069	0.530
MOD_ProDKin_1	599	605	PF00069	0.562
MOD_ProDKin_1	701	707	PF00069	0.677
MOD_ProDKin_1	775	781	PF00069	0.704
MOD_ProDKin_1	799	805	PF00069	0.707
MOD_ProDKin_1	818	824	PF00069	0.548
MOD_ProDKin_1	861	867	PF00069	0.713
MOD_SUMO_rev_2	225	231	PF00179	0.537
MOD_SUMO_rev_2	320	325	PF00179	0.537
MOD_SUMO_rev_2	339	347	PF00179	0.554
MOD_SUMO_rev_2	369	378	PF00179	0.661
MOD_SUMO_rev_2	512	521	PF00179	0.653
TRG_DiLeu_BaEn_3	151	157	PF01217	0.628
TRG_DiLeu_BaLyEn_6	614	619	PF01217	0.671
TRG_DiLeu_BaLyEn_6	826	831	PF01217	0.533
TRG_ENDOCYTIC_2	925	928	PF00928	0.798
TRG_ER_diArg_1	28	30	PF00400	0.553
TRG_ER_diArg_1	293	295	PF00400	0.676
TRG_ER_diArg_1	522	525	PF00400	0.551
TRG_ER_diArg_1	565	567	PF00400	0.675
TRG_ER_diArg_1	768	770	PF00400	0.602
TRG_ER_diArg_1	870	872	PF00400	0.725
TRG_ER_diArg_1	898	900	PF00400	0.638
TRG_NLS_Bipartite_1	642	661	PF00514	0.678
TRG_NLS_MonoExtC_3	641	646	PF00514	0.694
TRG_NLS_MonoExtC_3	650	655	PF00514	0.635
TRG_NLS_MonoExtN_4	640	647	PF00514	0.711
TRG_NLS_MonoExtN_4	651	656	PF00514	0.583
TRG_Pf-PMV_PEXEL_1	485	490	PF00026	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7V4	Leishmania donovani	47%	98%
A4I9E3	Leishmania infantum	48%	98%
E9B4E3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	98%
Q4Q3N4	Leishmania major	47%	100%