J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM11_LEIBR

TriTrypDb:

LbrM.33.3290 , LBRM2903_330041100

Length:

1103

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HM11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.720
CLV_C14_Caspase3-7	612	616	PF00656	0.650
CLV_C14_Caspase3-7	754	758	PF00656	0.562
CLV_C14_Caspase3-7	763	767	PF00656	0.468
CLV_NRD_NRD_1	1007	1009	PF00675	0.553
CLV_NRD_NRD_1	1071	1073	PF00675	0.539
CLV_NRD_NRD_1	110	112	PF00675	0.589
CLV_NRD_NRD_1	197	199	PF00675	0.800
CLV_NRD_NRD_1	270	272	PF00675	0.583
CLV_NRD_NRD_1	444	446	PF00675	0.612
CLV_NRD_NRD_1	479	481	PF00675	0.623
CLV_NRD_NRD_1	487	489	PF00675	0.523
CLV_NRD_NRD_1	521	523	PF00675	0.698
CLV_NRD_NRD_1	568	570	PF00675	0.728
CLV_NRD_NRD_1	628	630	PF00675	0.732
CLV_NRD_NRD_1	637	639	PF00675	0.618
CLV_NRD_NRD_1	96	98	PF00675	0.670
CLV_PCSK_FUR_1	477	481	PF00082	0.450
CLV_PCSK_KEX2_1	1045	1047	PF00082	0.558
CLV_PCSK_KEX2_1	110	112	PF00082	0.588
CLV_PCSK_KEX2_1	197	199	PF00082	0.757
CLV_PCSK_KEX2_1	298	300	PF00082	0.579
CLV_PCSK_KEX2_1	444	446	PF00082	0.612
CLV_PCSK_KEX2_1	477	479	PF00082	0.603
CLV_PCSK_KEX2_1	489	491	PF00082	0.491
CLV_PCSK_KEX2_1	502	504	PF00082	0.575
CLV_PCSK_KEX2_1	520	522	PF00082	0.464
CLV_PCSK_KEX2_1	527	529	PF00082	0.534
CLV_PCSK_KEX2_1	568	570	PF00082	0.728
CLV_PCSK_KEX2_1	637	639	PF00082	0.575
CLV_PCSK_KEX2_1	648	650	PF00082	0.564
CLV_PCSK_KEX2_1	96	98	PF00082	0.670
CLV_PCSK_PC1ET2_1	1045	1047	PF00082	0.491
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.579
CLV_PCSK_PC1ET2_1	489	491	PF00082	0.507
CLV_PCSK_PC1ET2_1	502	504	PF00082	0.571
CLV_PCSK_PC1ET2_1	520	522	PF00082	0.414
CLV_PCSK_PC1ET2_1	527	529	PF00082	0.504
CLV_PCSK_PC1ET2_1	648	650	PF00082	0.591
CLV_PCSK_PC7_1	440	446	PF00082	0.609
CLV_PCSK_PC7_1	564	570	PF00082	0.735
CLV_PCSK_SKI1_1	1046	1050	PF00082	0.574
CLV_PCSK_SKI1_1	432	436	PF00082	0.481
CLV_PCSK_SKI1_1	836	840	PF00082	0.535
CLV_PCSK_SKI1_1	868	872	PF00082	0.471
DEG_APCC_DBOX_1	95	103	PF00400	0.669
DEG_Nend_Nbox_1	1	3	PF02207	0.591
DEG_SPOP_SBC_1	350	354	PF00917	0.589
DEG_SPOP_SBC_1	378	382	PF00917	0.641
DEG_SPOP_SBC_1	912	916	PF00917	0.501
DOC_CDC14_PxL_1	313	321	PF14671	0.729
DOC_CKS1_1	651	656	PF01111	0.560
DOC_CYCLIN_RxL_1	1020	1030	PF00134	0.315
DOC_CYCLIN_RxL_1	741	754	PF00134	0.526
DOC_CYCLIN_RxL_1	833	843	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	603	609	PF00134	0.570
DOC_MAPK_DCC_7	667	677	PF00069	0.579
DOC_MAPK_gen_1	1045	1053	PF00069	0.493
DOC_PP2B_LxvP_1	876	879	PF13499	0.428
DOC_PP4_FxxP_1	823	826	PF00568	0.484
DOC_USP7_MATH_1	1010	1014	PF00917	0.505
DOC_USP7_MATH_1	133	137	PF00917	0.716
DOC_USP7_MATH_1	214	218	PF00917	0.666
DOC_USP7_MATH_1	233	237	PF00917	0.735
DOC_USP7_MATH_1	345	349	PF00917	0.620
DOC_USP7_MATH_1	378	382	PF00917	0.682
DOC_USP7_MATH_1	40	44	PF00917	0.511
DOC_USP7_MATH_1	558	562	PF00917	0.666
DOC_USP7_MATH_1	59	63	PF00917	0.547
DOC_USP7_MATH_1	625	629	PF00917	0.602
DOC_USP7_MATH_1	662	666	PF00917	0.763
DOC_USP7_MATH_1	704	708	PF00917	0.680
DOC_USP7_MATH_1	734	738	PF00917	0.617
DOC_USP7_MATH_1	802	806	PF00917	0.470
DOC_USP7_MATH_1	968	972	PF00917	0.489
DOC_USP7_MATH_2	725	731	PF00917	0.672
DOC_USP7_UBL2_3	1045	1049	PF12436	0.492
DOC_USP7_UBL2_3	209	213	PF12436	0.732
DOC_USP7_UBL2_3	553	557	PF12436	0.562
DOC_USP7_UBL2_3	864	868	PF12436	0.490
DOC_WW_Pin1_4	337	342	PF00397	0.641
DOC_WW_Pin1_4	351	356	PF00397	0.604
DOC_WW_Pin1_4	640	645	PF00397	0.833
DOC_WW_Pin1_4	650	655	PF00397	0.659
DOC_WW_Pin1_4	667	672	PF00397	0.560
DOC_WW_Pin1_4	699	704	PF00397	0.693
DOC_WW_Pin1_4	708	713	PF00397	0.792
DOC_WW_Pin1_4	822	827	PF00397	0.478
DOC_WW_Pin1_4	885	890	PF00397	0.471
LIG_14-3-3_CanoR_1	101	108	PF00244	0.659
LIG_14-3-3_CanoR_1	190	196	PF00244	0.609
LIG_14-3-3_CanoR_1	299	307	PF00244	0.629
LIG_14-3-3_CanoR_1	403	408	PF00244	0.720
LIG_14-3-3_CanoR_1	564	570	PF00244	0.572
LIG_14-3-3_CanoR_1	637	643	PF00244	0.683
LIG_14-3-3_CanoR_1	664	673	PF00244	0.609
LIG_14-3-3_CanoR_1	721	725	PF00244	0.647
LIG_14-3-3_CanoR_1	833	839	PF00244	0.559
LIG_14-3-3_CanoR_1	919	926	PF00244	0.527
LIG_Actin_WH2_2	1024	1042	PF00022	0.479
LIG_APCC_ABBA_1	607	612	PF00400	0.575
LIG_APCC_ABBA_1	675	680	PF00400	0.580
LIG_BIR_III_2	700	704	PF00653	0.578
LIG_BRCT_BRCA1_1	108	112	PF00533	0.656
LIG_BRCT_BRCA1_1	905	909	PF00533	0.335
LIG_Clathr_ClatBox_1	749	753	PF01394	0.487
LIG_CtBP_PxDLS_1	586	590	PF00389	0.549
LIG_FHA_1	238	244	PF00498	0.577
LIG_FHA_1	396	402	PF00498	0.628
LIG_FHA_1	746	752	PF00498	0.558
LIG_FHA_1	773	779	PF00498	0.544
LIG_FHA_1	912	918	PF00498	0.592
LIG_FHA_2	352	358	PF00498	0.579
LIG_FHA_2	595	601	PF00498	0.728
LIG_FHA_2	685	691	PF00498	0.637
LIG_FHA_2	761	767	PF00498	0.497
LIG_FHA_2	781	787	PF00498	0.552
LIG_FHA_2	872	878	PF00498	0.546
LIG_FHA_2	974	980	PF00498	0.388
LIG_LIR_Apic_2	69	74	PF02991	0.613
LIG_LIR_Gen_1	825	835	PF02991	0.458
LIG_LIR_Gen_1	877	887	PF02991	0.521
LIG_LIR_Gen_1	899	908	PF02991	0.503
LIG_LIR_Gen_1	979	988	PF02991	0.470
LIG_LIR_LC3C_4	955	959	PF02991	0.449
LIG_LIR_Nem_3	1087	1092	PF02991	0.488
LIG_LIR_Nem_3	113	119	PF02991	0.634
LIG_LIR_Nem_3	825	831	PF02991	0.456
LIG_LIR_Nem_3	877	883	PF02991	0.533
LIG_LIR_Nem_3	899	903	PF02991	0.608
LIG_LIR_Nem_3	906	912	PF02991	0.499
LIG_LIR_Nem_3	979	983	PF02991	0.475
LIG_PDZ_Class_3	1098	1103	PF00595	0.493
LIG_Pex14_2	108	112	PF04695	0.656
LIG_PTB_Apo_2	894	901	PF02174	0.493
LIG_PTB_Phospho_1	894	900	PF10480	0.492
LIG_Rb_LxCxE_1	1094	1103	PF01857	0.446
LIG_RPA_C_Fungi	1050	1062	PF08784	0.345
LIG_SH2_CRK	1089	1093	PF00017	0.500
LIG_SH2_CRK	71	75	PF00017	0.533
LIG_SH2_CRK	980	984	PF00017	0.506
LIG_SH2_NCK_1	900	904	PF00017	0.499
LIG_SH2_NCK_1	980	984	PF00017	0.467
LIG_SH2_PTP2	1050	1053	PF00017	0.495
LIG_SH2_STAP1	980	984	PF00017	0.506
LIG_SH2_STAT3	2	5	PF00017	0.573
LIG_SH2_STAT3	771	774	PF00017	0.546
LIG_SH2_STAT5	1050	1053	PF00017	0.495
LIG_SH2_STAT5	1077	1080	PF00017	0.502
LIG_SH2_STAT5	119	122	PF00017	0.499
LIG_SH2_STAT5	41	44	PF00017	0.565
LIG_SH2_STAT5	861	864	PF00017	0.460
LIG_SH2_STAT5	953	956	PF00017	0.468
LIG_SH3_1	333	339	PF00018	0.683
LIG_SH3_1	648	654	PF00018	0.568
LIG_SH3_2	651	656	PF14604	0.560
LIG_SH3_2	679	684	PF14604	0.568
LIG_SH3_3	333	339	PF00018	0.691
LIG_SH3_3	394	400	PF00018	0.736
LIG_SH3_3	407	413	PF00018	0.769
LIG_SH3_3	580	586	PF00018	0.817
LIG_SH3_3	603	609	PF00018	0.655
LIG_SH3_3	648	654	PF00018	0.568
LIG_SH3_3	676	682	PF00018	0.592
LIG_SH3_3	700	706	PF00018	0.748
LIG_SH3_3	811	817	PF00018	0.463
LIG_SH3_4	209	216	PF00018	0.700
LIG_SUMO_SIM_anti_2	748	754	PF11976	0.496
LIG_SUMO_SIM_par_1	136	142	PF11976	0.540
LIG_SUMO_SIM_par_1	314	322	PF11976	0.565
LIG_SUMO_SIM_par_1	747	754	PF11976	0.499
LIG_SUMO_SIM_par_1	774	780	PF11976	0.530
LIG_SUMO_SIM_par_1	810	815	PF11976	0.569
LIG_TRAF2_1	1016	1019	PF00917	0.507
LIG_TRAF2_1	175	178	PF00917	0.629
LIG_TRAF2_1	783	786	PF00917	0.391
LIG_TRAF2_2	583	588	PF00917	0.711
LIG_TYR_ITIM	1048	1053	PF00017	0.495
LIG_TYR_ITIM	898	903	PF00017	0.603
LIG_WW_3	653	657	PF00397	0.571
MOD_CDK_SPK_2	337	342	PF00069	0.582
MOD_CDK_SPxK_1	650	656	PF00069	0.564
MOD_CK1_1	1013	1019	PF00069	0.491
MOD_CK1_1	1030	1036	PF00069	0.382
MOD_CK1_1	145	151	PF00069	0.670
MOD_CK1_1	208	214	PF00069	0.728
MOD_CK1_1	235	241	PF00069	0.661
MOD_CK1_1	246	252	PF00069	0.682
MOD_CK1_1	402	408	PF00069	0.738
MOD_CK1_1	563	569	PF00069	0.656
MOD_CK1_1	616	622	PF00069	0.682
MOD_CK1_1	665	671	PF00069	0.758
MOD_CK1_1	702	708	PF00069	0.694
MOD_CK1_1	714	720	PF00069	0.607
MOD_CK1_1	730	736	PF00069	0.619
MOD_CK1_1	737	743	PF00069	0.503
MOD_CK1_1	918	924	PF00069	0.571
MOD_CK1_1	971	977	PF00069	0.568
MOD_CK2_1	1013	1019	PF00069	0.589
MOD_CK2_1	1095	1101	PF00069	0.403
MOD_CK2_1	172	178	PF00069	0.677
MOD_CK2_1	235	241	PF00069	0.738
MOD_CK2_1	298	304	PF00069	0.584
MOD_CK2_1	351	357	PF00069	0.578
MOD_CK2_1	544	550	PF00069	0.547
MOD_CK2_1	780	786	PF00069	0.609
MOD_CK2_1	871	877	PF00069	0.540
MOD_CK2_1	925	931	PF00069	0.491
MOD_CK2_1	973	979	PF00069	0.549
MOD_DYRK1A_RPxSP_1	667	671	PF00069	0.748
MOD_GlcNHglycan	103	106	PF01048	0.701
MOD_GlcNHglycan	1040	1043	PF01048	0.442
MOD_GlcNHglycan	130	133	PF01048	0.749
MOD_GlcNHglycan	144	147	PF01048	0.567
MOD_GlcNHglycan	174	177	PF01048	0.646
MOD_GlcNHglycan	199	202	PF01048	0.839
MOD_GlcNHglycan	216	219	PF01048	0.795
MOD_GlcNHglycan	237	240	PF01048	0.625
MOD_GlcNHglycan	300	303	PF01048	0.586
MOD_GlcNHglycan	372	375	PF01048	0.566
MOD_GlcNHglycan	42	45	PF01048	0.505
MOD_GlcNHglycan	509	512	PF01048	0.449
MOD_GlcNHglycan	560	563	PF01048	0.706
MOD_GlcNHglycan	66	69	PF01048	0.529
MOD_GlcNHglycan	732	735	PF01048	0.709
MOD_GlcNHglycan	736	739	PF01048	0.637
MOD_GlcNHglycan	804	807	PF01048	0.580
MOD_GlcNHglycan	905	908	PF01048	0.465
MOD_GlcNHglycan	970	973	PF01048	0.479
MOD_GSK3_1	111	118	PF00069	0.641
MOD_GSK3_1	138	145	PF00069	0.624
MOD_GSK3_1	197	204	PF00069	0.611
MOD_GSK3_1	205	212	PF00069	0.552
MOD_GSK3_1	233	240	PF00069	0.715
MOD_GSK3_1	246	253	PF00069	0.612
MOD_GSK3_1	262	269	PF00069	0.579
MOD_GSK3_1	298	305	PF00069	0.679
MOD_GSK3_1	345	352	PF00069	0.640
MOD_GSK3_1	391	398	PF00069	0.714
MOD_GSK3_1	399	406	PF00069	0.743
MOD_GSK3_1	560	567	PF00069	0.820
MOD_GSK3_1	569	576	PF00069	0.617
MOD_GSK3_1	60	67	PF00069	0.626
MOD_GSK3_1	640	647	PF00069	0.647
MOD_GSK3_1	695	702	PF00069	0.710
MOD_GSK3_1	704	711	PF00069	0.613
MOD_GSK3_1	728	735	PF00069	0.709
MOD_GSK3_1	772	779	PF00069	0.579
MOD_GSK3_1	822	829	PF00069	0.464
MOD_GSK3_1	87	94	PF00069	0.615
MOD_GSK3_1	911	918	PF00069	0.506
MOD_LATS_1	389	395	PF00433	0.583
MOD_N-GLC_1	1095	1100	PF02516	0.374
MOD_N-GLC_1	221	226	PF02516	0.636
MOD_N-GLC_1	227	232	PF02516	0.585
MOD_N-GLC_1	32	37	PF02516	0.570
MOD_N-GLC_1	708	713	PF02516	0.629
MOD_N-GLC_1	896	901	PF02516	0.499
MOD_N-GLC_2	150	152	PF02516	0.539
MOD_NEK2_1	1027	1032	PF00069	0.341
MOD_NEK2_1	1053	1058	PF00069	0.407
MOD_NEK2_1	144	149	PF00069	0.654
MOD_NEK2_1	32	37	PF00069	0.495
MOD_NEK2_1	594	599	PF00069	0.618
MOD_NEK2_1	64	69	PF00069	0.604
MOD_NEK2_1	732	737	PF00069	0.632
MOD_NEK2_1	745	750	PF00069	0.571
MOD_NEK2_1	853	858	PF00069	0.473
MOD_NEK2_1	913	918	PF00069	0.501
MOD_NEK2_1	92	97	PF00069	0.555
MOD_NEK2_2	60	65	PF00069	0.687
MOD_NEK2_2	66	71	PF00069	0.632
MOD_NEK2_2	991	996	PF00069	0.436
MOD_PIKK_1	233	239	PF00454	0.629
MOD_PIKK_1	262	268	PF00454	0.749
MOD_PIKK_1	616	622	PF00454	0.593
MOD_PIKK_1	662	668	PF00454	0.755
MOD_PIKK_1	711	717	PF00454	0.772
MOD_PIKK_1	720	726	PF00454	0.690
MOD_PK_1	1040	1046	PF00069	0.476
MOD_PK_1	250	256	PF00069	0.570
MOD_PK_1	638	644	PF00069	0.570
MOD_PKA_1	197	203	PF00069	0.639
MOD_PKA_1	298	304	PF00069	0.580
MOD_PKA_1	490	496	PF00069	0.443
MOD_PKA_2	142	148	PF00069	0.583
MOD_PKA_2	197	203	PF00069	0.747
MOD_PKA_2	298	304	PF00069	0.630
MOD_PKA_2	402	408	PF00069	0.721
MOD_PKA_2	544	550	PF00069	0.482
MOD_PKA_2	563	569	PF00069	0.692
MOD_PKA_2	613	619	PF00069	0.623
MOD_PKA_2	720	726	PF00069	0.589
MOD_PKA_2	755	761	PF00069	0.559
MOD_PKA_2	893	899	PF00069	0.493
MOD_PKA_2	918	924	PF00069	0.520
MOD_PKA_2	943	949	PF00069	0.537
MOD_PKB_1	393	401	PF00069	0.634
MOD_PKB_1	488	496	PF00069	0.444
MOD_Plk_1	177	183	PF00069	0.560
MOD_Plk_1	250	256	PF00069	0.570
MOD_Plk_1	32	38	PF00069	0.532
MOD_Plk_1	727	733	PF00069	0.697
MOD_Plk_1	765	771	PF00069	0.460
MOD_Plk_1	896	902	PF00069	0.427
MOD_Plk_1	922	928	PF00069	0.444
MOD_Plk_4	133	139	PF00069	0.647
MOD_Plk_4	405	411	PF00069	0.828
MOD_Plk_4	594	600	PF00069	0.563
MOD_Plk_4	60	66	PF00069	0.687
MOD_Plk_4	745	751	PF00069	0.497
MOD_Plk_4	75	81	PF00069	0.494
MOD_Plk_4	791	797	PF00069	0.595
MOD_Plk_4	953	959	PF00069	0.457
MOD_Plk_4	979	985	PF00069	0.589
MOD_ProDKin_1	337	343	PF00069	0.643
MOD_ProDKin_1	351	357	PF00069	0.607
MOD_ProDKin_1	640	646	PF00069	0.833
MOD_ProDKin_1	650	656	PF00069	0.665
MOD_ProDKin_1	667	673	PF00069	0.554
MOD_ProDKin_1	699	705	PF00069	0.693
MOD_ProDKin_1	708	714	PF00069	0.791
MOD_ProDKin_1	822	828	PF00069	0.475
MOD_ProDKin_1	885	891	PF00069	0.471
MOD_SUMO_for_1	332	335	PF00179	0.621
MOD_SUMO_rev_2	165	174	PF00179	0.572
MOD_SUMO_rev_2	175	181	PF00179	0.538
MOD_SUMO_rev_2	246	252	PF00179	0.588
MOD_SUMO_rev_2	253	261	PF00179	0.624
MOD_SUMO_rev_2	264	274	PF00179	0.691
MOD_SUMO_rev_2	301	307	PF00179	0.642
MOD_SUMO_rev_2	429	437	PF00179	0.486
MOD_SUMO_rev_2	519	529	PF00179	0.602
MOD_SUMO_rev_2	530	535	PF00179	0.474
MOD_SUMO_rev_2	641	650	PF00179	0.575
MOD_SUMO_rev_2	723	731	PF00179	0.749
MOD_SUMO_rev_2	777	783	PF00179	0.529
MOD_SUMO_rev_2	945	950	PF00179	0.547
TRG_DiLeu_BaEn_1	1080	1085	PF01217	0.481
TRG_DiLeu_BaLyEn_6	1087	1092	PF01217	0.488
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.729
TRG_DiLeu_LyEn_5	1080	1085	PF01217	0.481
TRG_ENDOCYTIC_2	1050	1053	PF00928	0.495
TRG_ENDOCYTIC_2	1089	1092	PF00928	0.489
TRG_ENDOCYTIC_2	900	903	PF00928	0.603
TRG_ENDOCYTIC_2	980	983	PF00928	0.509
TRG_ER_diArg_1	110	112	PF00400	0.733
TRG_ER_diArg_1	392	395	PF00400	0.740
TRG_ER_diArg_1	477	480	PF00400	0.583
TRG_ER_diArg_1	521	523	PF00400	0.720
TRG_ER_diArg_1	568	570	PF00400	0.711
TRG_ER_diArg_1	655	658	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	1076	1080	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	1083	1087	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	1090	1094	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	836	841	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X763	Leishmania donovani	68%	100%
A4I9E2	Leishmania infantum	68%	99%
E9B4E2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q3N5	Leishmania major	71%	99%