MIF4G domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HM10_LEIBR

TriTrypDb:

LbrM.33.3280 , LBRM2903_330041000

Length:

964

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HM10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.602
CLV_NRD_NRD_1	223	225	PF00675	0.579
CLV_NRD_NRD_1	24	26	PF00675	0.737
CLV_NRD_NRD_1	3	5	PF00675	0.816
CLV_NRD_NRD_1	330	332	PF00675	0.560
CLV_NRD_NRD_1	506	508	PF00675	0.437
CLV_NRD_NRD_1	553	555	PF00675	0.495
CLV_NRD_NRD_1	611	613	PF00675	0.437
CLV_NRD_NRD_1	73	75	PF00675	0.831
CLV_NRD_NRD_1	751	753	PF00675	0.570
CLV_NRD_NRD_1	878	880	PF00675	0.695
CLV_NRD_NRD_1	886	888	PF00675	0.484
CLV_NRD_NRD_1	961	963	PF00675	0.553
CLV_PCSK_KEX2_1	223	225	PF00082	0.579
CLV_PCSK_KEX2_1	23	25	PF00082	0.521
CLV_PCSK_KEX2_1	3	5	PF00082	0.816
CLV_PCSK_KEX2_1	553	555	PF00082	0.495
CLV_PCSK_KEX2_1	611	613	PF00082	0.430
CLV_PCSK_KEX2_1	73	75	PF00082	0.793
CLV_PCSK_KEX2_1	772	774	PF00082	0.728
CLV_PCSK_KEX2_1	878	880	PF00082	0.695
CLV_PCSK_KEX2_1	886	888	PF00082	0.484
CLV_PCSK_KEX2_1	923	925	PF00082	0.430
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.624
CLV_PCSK_PC1ET2_1	772	774	PF00082	0.728
CLV_PCSK_PC1ET2_1	923	925	PF00082	0.410
CLV_PCSK_SKI1_1	288	292	PF00082	0.540
CLV_PCSK_SKI1_1	508	512	PF00082	0.684
CLV_PCSK_SKI1_1	611	615	PF00082	0.475
CLV_PCSK_SKI1_1	704	708	PF00082	0.369
CLV_PCSK_SKI1_1	893	897	PF00082	0.632
CLV_PCSK_SKI1_1	915	919	PF00082	0.542
DEG_Kelch_Keap1_1	414	419	PF01344	0.591
DOC_ANK_TNKS_1	189	196	PF00023	0.621
DOC_CDC14_PxL_1	147	155	PF14671	0.594
DOC_CKS1_1	156	161	PF01111	0.815
DOC_MAPK_gen_1	602	609	PF00069	0.319
DOC_MAPK_gen_1	752	759	PF00069	0.613
DOC_MAPK_RevD_3	495	508	PF00069	0.363
DOC_PP1_SILK_1	263	268	PF00149	0.606
DOC_PP4_FxxP_1	105	108	PF00568	0.608
DOC_PP4_FxxP_1	843	846	PF00568	0.618
DOC_PP4_FxxP_1	92	95	PF00568	0.629
DOC_PP4_MxPP_1	163	166	PF00568	0.810
DOC_USP7_MATH_1	194	198	PF00917	0.820
DOC_USP7_MATH_1	212	216	PF00917	0.566
DOC_USP7_MATH_1	375	379	PF00917	0.699
DOC_USP7_MATH_1	392	396	PF00917	0.558
DOC_USP7_MATH_1	593	597	PF00917	0.587
DOC_USP7_MATH_1	696	700	PF00917	0.569
DOC_USP7_MATH_1	793	797	PF00917	0.763
DOC_USP7_MATH_1	800	804	PF00917	0.559
DOC_USP7_MATH_1	816	820	PF00917	0.345
DOC_USP7_MATH_1	86	90	PF00917	0.599
DOC_USP7_UBL2_3	284	288	PF12436	0.567
DOC_USP7_UBL2_3	585	589	PF12436	0.516
DOC_WW_Pin1_4	106	111	PF00397	0.831
DOC_WW_Pin1_4	155	160	PF00397	0.831
DOC_WW_Pin1_4	343	348	PF00397	0.763
DOC_WW_Pin1_4	411	416	PF00397	0.851
DOC_WW_Pin1_4	417	422	PF00397	0.740
DOC_WW_Pin1_4	91	96	PF00397	0.703
LIG_14-3-3_CanoR_1	25	35	PF00244	0.611
LIG_14-3-3_CanoR_1	250	259	PF00244	0.619
LIG_14-3-3_CanoR_1	493	498	PF00244	0.380
LIG_14-3-3_CanoR_1	505	511	PF00244	0.529
LIG_14-3-3_CanoR_1	695	703	PF00244	0.611
LIG_14-3-3_CterR_2	962	964	PF00244	0.551
LIG_Actin_WH2_2	519	534	PF00022	0.548
LIG_BRCT_BRCA1_1	394	398	PF00533	0.608
LIG_BRCT_BRCA1_1	625	629	PF00533	0.528
LIG_BRCT_BRCA1_1	88	92	PF00533	0.607
LIG_BRCT_BRCA1_2	394	400	PF00533	0.609
LIG_CtBP_PxDLS_1	339	343	PF00389	0.590
LIG_EH1_1	404	412	PF00400	0.600
LIG_EH1_1	661	669	PF00400	0.587
LIG_eIF4E_1	662	668	PF01652	0.577
LIG_EVH1_1	150	154	PF00568	0.797
LIG_FHA_1	232	238	PF00498	0.776
LIG_FHA_1	391	397	PF00498	0.721
LIG_FHA_1	5	11	PF00498	0.603
LIG_FHA_1	528	534	PF00498	0.516
LIG_FHA_1	659	665	PF00498	0.377
LIG_FHA_1	744	750	PF00498	0.579
LIG_FHA_1	752	758	PF00498	0.525
LIG_FHA_1	847	853	PF00498	0.587
LIG_FHA_1	894	900	PF00498	0.635
LIG_FHA_2	243	249	PF00498	0.646
LIG_FHA_2	441	447	PF00498	0.596
LIG_FHA_2	538	544	PF00498	0.661
LIG_FHA_2	555	561	PF00498	0.376
LIG_FHA_2	856	862	PF00498	0.547
LIG_Integrin_isoDGR_2	450	452	PF01839	0.601
LIG_LIR_Apic_2	840	846	PF02991	0.616
LIG_LIR_Apic_2	89	95	PF02991	0.635
LIG_LIR_Gen_1	635	642	PF02991	0.559
LIG_LIR_Gen_1	88	96	PF02991	0.593
LIG_LIR_Gen_1	948	959	PF02991	0.557
LIG_LIR_Nem_3	112	116	PF02991	0.612
LIG_LIR_Nem_3	635	639	PF02991	0.546
LIG_LIR_Nem_3	661	665	PF02991	0.341
LIG_LIR_Nem_3	693	697	PF02991	0.588
LIG_LIR_Nem_3	70	75	PF02991	0.626
LIG_LIR_Nem_3	700	706	PF02991	0.501
LIG_LIR_Nem_3	88	93	PF02991	0.608
LIG_LIR_Nem_3	948	954	PF02991	0.554
LIG_PCNA_yPIPBox_3	602	610	PF02747	0.360
LIG_PCNA_yPIPBox_3	738	752	PF02747	0.573
LIG_Pex14_2	630	634	PF04695	0.559
LIG_Pex14_2	839	843	PF04695	0.613
LIG_SH2_CRK	694	698	PF00017	0.604
LIG_SH2_CRK	848	852	PF00017	0.587
LIG_SH2_SRC	500	503	PF00017	0.575
LIG_SH2_STAP1	575	579	PF00017	0.571
LIG_SH2_STAP1	620	624	PF00017	0.692
LIG_SH2_STAP1	848	852	PF00017	0.587
LIG_SH2_STAT3	104	107	PF00017	0.783
LIG_SH2_STAT3	116	119	PF00017	0.607
LIG_SH2_STAT5	104	107	PF00017	0.620
LIG_SH2_STAT5	129	132	PF00017	0.741
LIG_SH2_STAT5	169	172	PF00017	0.630
LIG_SH2_STAT5	848	851	PF00017	0.588
LIG_SH2_STAT5	87	90	PF00017	0.608
LIG_SH2_STAT5	894	897	PF00017	0.392
LIG_SH3_1	148	154	PF00018	0.799
LIG_SH3_1	3	9	PF00018	0.604
LIG_SH3_3	125	131	PF00018	0.828
LIG_SH3_3	148	154	PF00018	0.774
LIG_SH3_3	156	162	PF00018	0.615
LIG_SH3_3	174	180	PF00018	0.799
LIG_SH3_3	243	249	PF00018	0.606
LIG_SH3_3	3	9	PF00018	0.604
LIG_SH3_3	386	392	PF00018	0.608
LIG_SH3_3	90	96	PF00018	0.788
LIG_SUMO_SIM_par_1	578	584	PF11976	0.562
LIG_SUMO_SIM_par_1	754	761	PF11976	0.426
LIG_SUMO_SIM_par_1	848	854	PF11976	0.586
LIG_TRAF2_1	758	761	PF00917	0.671
LIG_TYR_ITIM	692	697	PF00017	0.586
LIG_UBA3_1	606	614	PF00899	0.459
LIG_UBA3_1	851	859	PF00899	0.556
LIG_WRC_WIRS_1	87	92	PF05994	0.608
LIG_WRC_WIRS_1	935	940	PF05994	0.431
LIG_WW_1	166	169	PF00397	0.612
LIG_WW_2	151	154	PF00397	0.795
MOD_CDK_SPK_2	343	348	PF00069	0.763
MOD_CK1_1	109	115	PF00069	0.613
MOD_CK1_1	118	124	PF00069	0.646
MOD_CK1_1	316	322	PF00069	0.483
MOD_CK1_1	360	366	PF00069	0.723
MOD_CK1_1	384	390	PF00069	0.830
MOD_CK1_1	399	405	PF00069	0.635
MOD_CK1_1	414	420	PF00069	0.669
MOD_CK1_1	578	584	PF00069	0.562
MOD_CK1_1	59	65	PF00069	0.715
MOD_CK1_1	618	624	PF00069	0.684
MOD_CK1_1	654	660	PF00069	0.482
MOD_CK1_1	801	807	PF00069	0.630
MOD_CK1_1	870	876	PF00069	0.572
MOD_CK1_1	937	943	PF00069	0.470
MOD_CK1_1	946	952	PF00069	0.505
MOD_CK2_1	316	322	PF00069	0.483
MOD_CK2_1	360	366	PF00069	0.768
MOD_CK2_1	413	419	PF00069	0.596
MOD_CK2_1	537	543	PF00069	0.676
MOD_CK2_1	554	560	PF00069	0.382
MOD_CK2_1	696	702	PF00069	0.617
MOD_CK2_1	755	761	PF00069	0.673
MOD_CK2_1	779	785	PF00069	0.791
MOD_CK2_1	855	861	PF00069	0.626
MOD_CK2_1	927	933	PF00069	0.480
MOD_Cter_Amidation	1	4	PF01082	0.828
MOD_GlcNHglycan	19	22	PF01048	0.702
MOD_GlcNHglycan	208	211	PF01048	0.603
MOD_GlcNHglycan	214	217	PF01048	0.574
MOD_GlcNHglycan	317	321	PF01048	0.485
MOD_GlcNHglycan	359	362	PF01048	0.778
MOD_GlcNHglycan	40	43	PF01048	0.722
MOD_GlcNHglycan	416	419	PF01048	0.594
MOD_GlcNHglycan	45	49	PF01048	0.670
MOD_GlcNHglycan	455	458	PF01048	0.812
MOD_GlcNHglycan	474	477	PF01048	0.567
MOD_GlcNHglycan	575	578	PF01048	0.575
MOD_GlcNHglycan	591	594	PF01048	0.327
MOD_GlcNHglycan	595	598	PF01048	0.256
MOD_GlcNHglycan	625	628	PF01048	0.459
MOD_GlcNHglycan	708	711	PF01048	0.606
MOD_GlcNHglycan	800	803	PF01048	0.690
MOD_GlcNHglycan	861	864	PF01048	0.647
MOD_GlcNHglycan	869	872	PF01048	0.497
MOD_GlcNHglycan	883	886	PF01048	0.377
MOD_GlcNHglycan	903	906	PF01048	0.357
MOD_GlcNHglycan	945	948	PF01048	0.763
MOD_GSK3_1	114	121	PF00069	0.727
MOD_GSK3_1	223	230	PF00069	0.717
MOD_GSK3_1	250	257	PF00069	0.651
MOD_GSK3_1	26	33	PF00069	0.814
MOD_GSK3_1	360	367	PF00069	0.745
MOD_GSK3_1	376	383	PF00069	0.654
MOD_GSK3_1	392	399	PF00069	0.634
MOD_GSK3_1	413	420	PF00069	0.783
MOD_GSK3_1	472	479	PF00069	0.609
MOD_GSK3_1	527	534	PF00069	0.383
MOD_GSK3_1	535	542	PF00069	0.408
MOD_GSK3_1	554	561	PF00069	0.576
MOD_GSK3_1	589	596	PF00069	0.406
MOD_GSK3_1	650	657	PF00069	0.710
MOD_GSK3_1	702	709	PF00069	0.366
MOD_GSK3_1	743	750	PF00069	0.579
MOD_GSK3_1	751	758	PF00069	0.517
MOD_GSK3_1	785	792	PF00069	0.651
MOD_GSK3_1	851	858	PF00069	0.559
MOD_GSK3_1	889	896	PF00069	0.620
MOD_GSK3_1	903	910	PF00069	0.459
MOD_GSK3_1	933	940	PF00069	0.588
MOD_GSK3_1	941	948	PF00069	0.709
MOD_LATS_1	552	558	PF00433	0.492
MOD_N-GLC_1	343	348	PF02516	0.621
MOD_N-GLC_1	440	445	PF02516	0.603
MOD_N-GLC_1	650	655	PF02516	0.559
MOD_N-GLC_1	67	72	PF02516	0.720
MOD_N-GLC_1	881	886	PF02516	0.629
MOD_NEK2_1	227	232	PF00069	0.599
MOD_NEK2_1	266	271	PF00069	0.608
MOD_NEK2_1	526	531	PF00069	0.638
MOD_NEK2_1	587	592	PF00069	0.378
MOD_NEK2_1	838	843	PF00069	0.587
MOD_NEK2_1	881	886	PF00069	0.629
MOD_NEK2_1	903	908	PF00069	0.513
MOD_NEK2_1	943	948	PF00069	0.760
MOD_NEK2_2	506	511	PF00069	0.453
MOD_NEK2_2	615	620	PF00069	0.394
MOD_PIKK_1	115	121	PF00454	0.813
MOD_PIKK_1	376	382	PF00454	0.597
MOD_PIKK_1	399	405	PF00454	0.647
MOD_PIKK_1	4	10	PF00454	0.602
MOD_PIKK_1	535	541	PF00454	0.432
MOD_PIKK_1	641	647	PF00454	0.450
MOD_PIKK_1	865	871	PF00454	0.631
MOD_PK_1	261	267	PF00069	0.855
MOD_PKA_1	223	229	PF00069	0.592
MOD_PKA_1	24	30	PF00069	0.678
MOD_PKA_1	4	10	PF00069	0.617
MOD_PKA_1	553	559	PF00069	0.492
MOD_PKA_1	640	646	PF00069	0.494
MOD_PKA_2	223	229	PF00069	0.603
MOD_PKA_2	24	30	PF00069	0.802
MOD_PKA_2	257	263	PF00069	0.736
MOD_PKA_2	390	396	PF00069	0.636
MOD_PKA_2	506	512	PF00069	0.460
MOD_PKA_2	531	537	PF00069	0.389
MOD_PKA_2	553	559	PF00069	0.492
MOD_PKA_2	751	757	PF00069	0.400
MOD_Plk_1	288	294	PF00069	0.532
MOD_Plk_1	440	446	PF00069	0.602
MOD_Plk_1	650	656	PF00069	0.464
MOD_Plk_2-3	440	446	PF00069	0.602
MOD_Plk_4	223	229	PF00069	0.765
MOD_Plk_4	242	248	PF00069	0.595
MOD_Plk_4	261	267	PF00069	0.855
MOD_Plk_4	440	446	PF00069	0.602
MOD_Plk_4	575	581	PF00069	0.566
MOD_Plk_4	615	621	PF00069	0.400
MOD_Plk_4	670	676	PF00069	0.430
MOD_Plk_4	702	708	PF00069	0.364
MOD_Plk_4	737	743	PF00069	0.616
MOD_Plk_4	846	852	PF00069	0.445
MOD_ProDKin_1	106	112	PF00069	0.831
MOD_ProDKin_1	155	161	PF00069	0.821
MOD_ProDKin_1	343	349	PF00069	0.763
MOD_ProDKin_1	411	417	PF00069	0.848
MOD_ProDKin_1	91	97	PF00069	0.704
MOD_SUMO_for_1	917	920	PF00179	0.421
MOD_SUMO_rev_2	513	523	PF00179	0.429
MOD_SUMO_rev_2	578	587	PF00179	0.462
MOD_SUMO_rev_2	699	706	PF00179	0.368
MOD_SUMO_rev_2	910	919	PF00179	0.517
TRG_DiLeu_BaLyEn_6	601	606	PF01217	0.481
TRG_ENDOCYTIC_2	136	139	PF00928	0.793
TRG_ENDOCYTIC_2	662	665	PF00928	0.581
TRG_ENDOCYTIC_2	694	697	PF00928	0.590
TRG_ENDOCYTIC_2	848	851	PF00928	0.588
TRG_ENDOCYTIC_2	87	90	PF00928	0.608
TRG_ER_diArg_1	223	225	PF00400	0.582
TRG_ER_diArg_1	303	306	PF00400	0.735
TRG_ER_diArg_1	504	507	PF00400	0.435
TRG_ER_diArg_1	610	612	PF00400	0.436
TRG_ER_diArg_1	72	74	PF00400	0.799
TRG_ER_diArg_1	878	880	PF00400	0.695
TRG_ER_diArg_1	886	888	PF00400	0.484
TRG_ER_FFAT_1	626	635	PF00635	0.461
TRG_Pf-PMV_PEXEL_1	695	700	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	915	920	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IF45	Leishmania donovani	58%	92%
A4I9E4	Leishmania infantum	58%	92%
E9B4E1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	91%
Q4Q3N6	Leishmania major	57%	100%