Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HM09_LEIBR

TriTrypDb:

LbrM.33.3270 , LBRM2903_330040900

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HM09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM09

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	302	304	PF00675	0.587
CLV_NRD_NRD_1	308	310	PF00675	0.583
CLV_PCSK_KEX2_1	302	304	PF00082	0.566
CLV_PCSK_KEX2_1	308	310	PF00082	0.550
CLV_PCSK_KEX2_1	322	324	PF00082	0.463
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.614
CLV_PCSK_SKI1_1	178	182	PF00082	0.385
DEG_Nend_UBRbox_3	1	3	PF02207	0.726
DOC_CYCLIN_RxL_1	201	212	PF00134	0.408
DOC_CYCLIN_yCln2_LP_2	228	234	PF00134	0.454
DOC_MAPK_DCC_7	248	258	PF00069	0.555
DOC_PP1_RVXF_1	176	183	PF00149	0.389
DOC_PP2B_LxvP_1	181	184	PF13499	0.356
DOC_PP2B_LxvP_1	251	254	PF13499	0.551
DOC_USP7_MATH_1	32	36	PF00917	0.713
DOC_USP7_MATH_1	64	68	PF00917	0.554
DOC_USP7_MATH_1	97	101	PF00917	0.560
DOC_USP7_UBL2_3	244	248	PF12436	0.633
DOC_WW_Pin1_4	262	267	PF00397	0.551
LIG_14-3-3_CanoR_1	302	308	PF00244	0.678
LIG_BRCT_BRCA1_1	29	33	PF00533	0.548
LIG_FHA_1	103	109	PF00498	0.643
LIG_LIR_Gen_1	147	158	PF02991	0.465
LIG_LIR_Nem_3	147	153	PF02991	0.506
LIG_LIR_Nem_3	157	162	PF02991	0.475
LIG_LIR_Nem_3	212	217	PF02991	0.415
LIG_LIR_Nem_3	219	224	PF02991	0.420
LIG_LYPXL_yS_3	210	213	PF13949	0.419
LIG_MYND_1	179	183	PF01753	0.370
LIG_NRP_CendR_1	328	330	PF00754	0.561
LIG_Pex14_2	139	143	PF04695	0.577
LIG_Pex14_2	155	159	PF04695	0.529
LIG_SH2_CRK	203	207	PF00017	0.392
LIG_SH2_CRK	89	93	PF00017	0.702
LIG_SH2_GRB2like	89	92	PF00017	0.540
LIG_SH2_STAT3	195	198	PF00017	0.432
LIG_SH2_STAT5	217	220	PF00017	0.524
LIG_SH3_1	230	236	PF00018	0.438
LIG_SH3_2	233	238	PF14604	0.466
LIG_SH3_3	159	165	PF00018	0.606
LIG_SH3_3	230	236	PF00018	0.454
LIG_SH3_3	240	246	PF00018	0.587
LIG_SH3_3	257	263	PF00018	0.663
LIG_SH3_3	266	272	PF00018	0.625
LIG_TRFH_1	38	42	PF08558	0.618
LIG_TYR_ITIM	200	205	PF00017	0.450
LIG_TYR_ITIM	208	213	PF00017	0.374
LIG_WW_1	192	195	PF00397	0.441
MOD_CK1_1	289	295	PF00069	0.636
MOD_GlcNHglycan	146	150	PF01048	0.609
MOD_GlcNHglycan	291	294	PF01048	0.667
MOD_GlcNHglycan	99	102	PF01048	0.653
MOD_GSK3_1	145	152	PF00069	0.564
MOD_GSK3_1	289	296	PF00069	0.601
MOD_N-GLC_1	137	142	PF02516	0.587
MOD_N-GLC_1	289	294	PF02516	0.620
MOD_NEK2_1	125	130	PF00069	0.599
MOD_NEK2_1	297	302	PF00069	0.618
MOD_PIKK_1	128	134	PF00454	0.550
MOD_PIKK_1	27	33	PF00454	0.552
MOD_Plk_4	154	160	PF00069	0.433
MOD_ProDKin_1	262	268	PF00069	0.551
MOD_SUMO_for_1	315	318	PF00179	0.590
MOD_SUMO_rev_2	175	180	PF00179	0.529
TRG_DiLeu_BaLyEn_6	176	181	PF01217	0.407
TRG_DiLeu_BaLyEn_6	201	206	PF01217	0.508
TRG_ENDOCYTIC_2	202	205	PF00928	0.466
TRG_ENDOCYTIC_2	210	213	PF00928	0.419
TRG_ENDOCYTIC_2	220	223	PF00928	0.415
TRG_ENDOCYTIC_2	225	228	PF00928	0.453
TRG_ER_diArg_1	301	303	PF00400	0.591
TRG_ER_diArg_1	307	309	PF00400	0.585
TRG_ER_diArg_1	327	330	PF00400	0.489
TRG_Pf-PMV_PEXEL_1	204	209	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I737	Leptomonas seymouri	46%	96%
A0A3Q8IHR4	Leishmania donovani	60%	99%
A4I9E1	Leishmania infantum	62%	100%
E9B4E0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	68%
Q4Q3N7	Leishmania major	56%	97%