VWFA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM06_LEIBR

TriTrypDb:

LbrM.33.3240 , LBRM2903_330040600

Length:

651

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HM06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM06

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.694
CLV_C14_Caspase3-7	217	221	PF00656	0.669
CLV_C14_Caspase3-7	265	269	PF00656	0.496
CLV_C14_Caspase3-7	288	292	PF00656	0.547
CLV_C14_Caspase3-7	293	297	PF00656	0.767
CLV_C14_Caspase3-7	298	302	PF00656	0.706
CLV_C14_Caspase3-7	303	307	PF00656	0.711
CLV_NRD_NRD_1	178	180	PF00675	0.591
CLV_NRD_NRD_1	341	343	PF00675	0.350
CLV_NRD_NRD_1	504	506	PF00675	0.421
CLV_PCSK_KEX2_1	178	180	PF00082	0.595
CLV_PCSK_KEX2_1	274	276	PF00082	0.520
CLV_PCSK_KEX2_1	592	594	PF00082	0.549
CLV_PCSK_KEX2_1	626	628	PF00082	0.515
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.520
CLV_PCSK_PC1ET2_1	592	594	PF00082	0.570
CLV_PCSK_PC1ET2_1	626	628	PF00082	0.515
CLV_PCSK_SKI1_1	206	210	PF00082	0.662
CLV_PCSK_SKI1_1	224	228	PF00082	0.504
CLV_PCSK_SKI1_1	244	248	PF00082	0.640
CLV_PCSK_SKI1_1	275	279	PF00082	0.615
CLV_PCSK_SKI1_1	336	340	PF00082	0.502
CLV_PCSK_SKI1_1	440	444	PF00082	0.382
CLV_PCSK_SKI1_1	640	644	PF00082	0.578
DEG_Nend_UBRbox_2	1	3	PF02207	0.488
DEG_SPOP_SBC_1	609	613	PF00917	0.554
DOC_CYCLIN_RxL_1	323	334	PF00134	0.418
DOC_MAPK_gen_1	218	228	PF00069	0.568
DOC_MAPK_gen_1	353	363	PF00069	0.530
DOC_MAPK_gen_1	626	632	PF00069	0.482
DOC_PP4_FxxP_1	33	36	PF00568	0.622
DOC_USP7_MATH_1	106	110	PF00917	0.595
DOC_USP7_MATH_1	126	130	PF00917	0.665
DOC_USP7_MATH_1	136	140	PF00917	0.742
DOC_USP7_MATH_1	143	147	PF00917	0.665
DOC_USP7_MATH_1	195	199	PF00917	0.713
DOC_USP7_MATH_1	86	90	PF00917	0.635
DOC_USP7_MATH_1	96	100	PF00917	0.593
DOC_USP7_UBL2_3	214	218	PF12436	0.796
DOC_USP7_UBL2_3	232	236	PF12436	0.628
DOC_USP7_UBL2_3	239	243	PF12436	0.723
DOC_USP7_UBL2_3	262	266	PF12436	0.641
DOC_USP7_UBL2_3	274	278	PF12436	0.625
DOC_USP7_UBL2_3	280	284	PF12436	0.559
DOC_USP7_UBL2_3	290	294	PF12436	0.708
DOC_USP7_UBL2_3	295	299	PF12436	0.740
DOC_USP7_UBL2_3	300	304	PF12436	0.719
DOC_USP7_UBL2_3	339	343	PF12436	0.467
DOC_USP7_UBL2_3	502	506	PF12436	0.470
DOC_USP7_UBL2_3	600	604	PF12436	0.394
DOC_WW_Pin1_4	454	459	PF00397	0.460
LIG_14-3-3_CanoR_1	398	406	PF00244	0.518
LIG_14-3-3_CanoR_1	505	514	PF00244	0.427
LIG_14-3-3_CanoR_1	546	550	PF00244	0.442
LIG_eIF4E_1	111	117	PF01652	0.454
LIG_FHA_1	387	393	PF00498	0.495
LIG_FHA_1	398	404	PF00498	0.525
LIG_FHA_1	412	418	PF00498	0.393
LIG_FHA_1	553	559	PF00498	0.521
LIG_FHA_2	353	359	PF00498	0.399
LIG_FHA_2	429	435	PF00498	0.499
LIG_FHA_2	466	472	PF00498	0.495
LIG_FHA_2	475	481	PF00498	0.497
LIG_FHA_2	596	602	PF00498	0.473
LIG_LIR_Gen_1	425	433	PF02991	0.321
LIG_LIR_Gen_1	448	455	PF02991	0.457
LIG_LIR_Nem_3	420	426	PF02991	0.420
LIG_LIR_Nem_3	448	452	PF02991	0.395
LIG_LIR_Nem_3	497	501	PF02991	0.453
LIG_PCNA_PIPBox_1	150	159	PF02747	0.562
LIG_SH2_CRK	169	173	PF00017	0.627
LIG_SH2_GRB2like	38	41	PF00017	0.460
LIG_SH2_STAP1	621	625	PF00017	0.473
LIG_SH2_STAT5	38	41	PF00017	0.460
LIG_SH2_STAT5	409	412	PF00017	0.456
LIG_SH2_STAT5	423	426	PF00017	0.439
LIG_SH2_STAT5	427	430	PF00017	0.437
LIG_SH2_STAT5	498	501	PF00017	0.416
LIG_SH2_STAT5	514	517	PF00017	0.266
LIG_SH2_STAT5	597	600	PF00017	0.539
LIG_SH3_2	538	543	PF14604	0.424
LIG_SH3_3	308	314	PF00018	0.635
LIG_SH3_3	363	369	PF00018	0.498
LIG_SH3_3	456	462	PF00018	0.471
LIG_SH3_3	535	541	PF00018	0.476
LIG_SUMO_SIM_anti_2	327	332	PF11976	0.458
LIG_SUMO_SIM_par_1	388	395	PF11976	0.472
LIG_TRAF2_1	477	480	PF00917	0.346
LIG_TRAF2_1	612	615	PF00917	0.511
LIG_UBA3_1	624	633	PF00899	0.515
MOD_CK1_1	394	400	PF00069	0.595
MOD_CK1_1	411	417	PF00069	0.305
MOD_CK2_1	331	337	PF00069	0.466
MOD_CK2_1	428	434	PF00069	0.424
MOD_CK2_1	465	471	PF00069	0.509
MOD_CK2_1	474	480	PF00069	0.506
MOD_CK2_1	595	601	PF00069	0.468
MOD_CK2_1	608	614	PF00069	0.476
MOD_GlcNHglycan	15	18	PF01048	0.679
MOD_GlcNHglycan	251	254	PF01048	0.781
MOD_GlcNHglycan	320	323	PF01048	0.527
MOD_GlcNHglycan	333	336	PF01048	0.370
MOD_GlcNHglycan	383	386	PF01048	0.387
MOD_GlcNHglycan	419	422	PF01048	0.430
MOD_GlcNHglycan	507	510	PF01048	0.440
MOD_GlcNHglycan	563	569	PF01048	0.443
MOD_GlcNHglycan	587	590	PF01048	0.456
MOD_GSK3_1	112	119	PF00069	0.517
MOD_GSK3_1	13	20	PF00069	0.657
MOD_GSK3_1	174	181	PF00069	0.755
MOD_GSK3_1	320	327	PF00069	0.422
MOD_GSK3_1	422	429	PF00069	0.382
MOD_GSK3_1	450	457	PF00069	0.411
MOD_GSK3_1	514	521	PF00069	0.401
MOD_GSK3_1	559	566	PF00069	0.334
MOD_GSK3_1	581	588	PF00069	0.444
MOD_GSK3_1	609	616	PF00069	0.519
MOD_N-GLC_1	386	391	PF02516	0.420
MOD_N-GLC_1	465	470	PF02516	0.517
MOD_N-GLC_1	518	523	PF02516	0.454
MOD_NEK2_1	116	121	PF00069	0.569
MOD_NEK2_1	318	323	PF00069	0.532
MOD_NEK2_1	518	523	PF00069	0.405
MOD_NEK2_2	106	111	PF00069	0.537
MOD_NEK2_2	126	131	PF00069	0.629
MOD_NEK2_2	143	148	PF00069	0.607
MOD_NEK2_2	152	157	PF00069	0.538
MOD_NEK2_2	160	165	PF00069	0.539
MOD_NEK2_2	86	91	PF00069	0.594
MOD_NEK2_2	96	101	PF00069	0.468
MOD_PIKK_1	397	403	PF00454	0.565
MOD_PKA_1	178	184	PF00069	0.655
MOD_PKA_1	249	255	PF00069	0.657
MOD_PKA_1	289	295	PF00069	0.738
MOD_PKA_1	505	511	PF00069	0.529
MOD_PKA_2	178	184	PF00069	0.658
MOD_PKA_2	397	403	PF00069	0.414
MOD_PKA_2	504	510	PF00069	0.529
MOD_PKA_2	545	551	PF00069	0.435
MOD_Plk_1	386	392	PF00069	0.413
MOD_Plk_1	465	471	PF00069	0.334
MOD_Plk_1	518	524	PF00069	0.420
MOD_Plk_2-3	445	451	PF00069	0.321
MOD_Plk_4	106	112	PF00069	0.615
MOD_Plk_4	116	122	PF00069	0.615
MOD_Plk_4	126	132	PF00069	0.604
MOD_Plk_4	136	142	PF00069	0.626
MOD_Plk_4	143	149	PF00069	0.606
MOD_Plk_4	152	158	PF00069	0.538
MOD_Plk_4	160	166	PF00069	0.518
MOD_Plk_4	168	174	PF00069	0.536
MOD_Plk_4	178	184	PF00069	0.578
MOD_Plk_4	344	350	PF00069	0.552
MOD_Plk_4	386	392	PF00069	0.420
MOD_Plk_4	494	500	PF00069	0.383
MOD_Plk_4	620	626	PF00069	0.526
MOD_Plk_4	86	92	PF00069	0.596
MOD_Plk_4	96	102	PF00069	0.497
MOD_ProDKin_1	454	460	PF00069	0.459
MOD_SUMO_for_1	226	229	PF00179	0.658
MOD_SUMO_rev_2	187	196	PF00179	0.672
MOD_SUMO_rev_2	215	223	PF00179	0.748
MOD_SUMO_rev_2	225	233	PF00179	0.547
MOD_SUMO_rev_2	234	241	PF00179	0.721
MOD_SUMO_rev_2	242	252	PF00179	0.688
MOD_SUMO_rev_2	254	264	PF00179	0.729
MOD_SUMO_rev_2	283	292	PF00179	0.644
MOD_SUMO_rev_2	334	341	PF00179	0.446
MOD_SUMO_rev_2	346	355	PF00179	0.529
MOD_SUMO_rev_2	359	369	PF00179	0.456
MOD_SUMO_rev_2	611	619	PF00179	0.557
MOD_SUMO_rev_2	636	645	PF00179	0.512
TRG_DiLeu_BaEn_4	539	545	PF01217	0.495
TRG_ENDOCYTIC_2	169	172	PF00928	0.683
TRG_ENDOCYTIC_2	18	21	PF00928	0.668
TRG_ENDOCYTIC_2	42	45	PF00928	0.719
TRG_ENDOCYTIC_2	423	426	PF00928	0.439
TRG_ENDOCYTIC_2	427	430	PF00928	0.437
TRG_ENDOCYTIC_2	498	501	PF00928	0.437
TRG_ENDOCYTIC_2	621	624	PF00928	0.448
TRG_ENDOCYTIC_2	69	72	PF00928	0.686
TRG_Pf-PMV_PEXEL_1	440	445	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0D6	Leptomonas seymouri	57%	75%
A0A1X0NRB5	Trypanosomatidae	33%	76%
A0A1X0NST4	Trypanosomatidae	28%	79%
A0A3Q8II25	Leishmania donovani	76%	100%
A0A3S7X791	Leishmania donovani	33%	100%
A4HM05	Leishmania braziliensis	33%	94%
A4I9D8	Leishmania infantum	77%	83%
E9B4D6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B4D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q3P0	Leishmania major	74%	100%
Q4Q3P1	Leishmania major	34%	100%
V5BC36	Trypanosoma cruzi	23%	100%