J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM05_LEIBR

TriTrypDb:

LbrM.33.3230 , LBRM2903_330040400

Length:

630

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HM05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM05

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	340	344	PF00656	0.513
CLV_NRD_NRD_1	235	237	PF00675	0.641
CLV_NRD_NRD_1	382	384	PF00675	0.422
CLV_NRD_NRD_1	552	554	PF00675	0.409
CLV_PCSK_KEX2_1	206	208	PF00082	0.675
CLV_PCSK_KEX2_1	235	237	PF00082	0.733
CLV_PCSK_KEX2_1	569	571	PF00082	0.486
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.664
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.560
CLV_PCSK_SKI1_1	463	467	PF00082	0.490
CLV_PCSK_SKI1_1	479	483	PF00082	0.252
CLV_PCSK_SKI1_1	556	560	PF00082	0.402
CLV_PCSK_SKI1_1	609	613	PF00082	0.605
CLV_Separin_Metazoa	578	582	PF03568	0.406
DEG_SCF_FBW7_2	586	593	PF00400	0.361
DOC_AGCK_PIF_1	571	576	PF00069	0.510
DOC_ANK_TNKS_1	522	529	PF00023	0.473
DOC_MAPK_gen_1	235	242	PF00069	0.612
DOC_MAPK_gen_1	391	400	PF00069	0.428
DOC_MAPK_gen_1	463	473	PF00069	0.522
DOC_MAPK_gen_1	581	588	PF00069	0.559
DOC_MAPK_gen_1	594	601	PF00069	0.552
DOC_MAPK_MEF2A_6	466	475	PF00069	0.360
DOC_PP1_RVXF_1	583	589	PF00149	0.525
DOC_USP7_MATH_1	120	124	PF00917	0.644
DOC_USP7_MATH_1	130	134	PF00917	0.469
DOC_USP7_MATH_1	247	251	PF00917	0.724
DOC_USP7_MATH_1	265	269	PF00917	0.727
DOC_USP7_MATH_1	274	278	PF00917	0.660
DOC_USP7_MATH_1	76	80	PF00917	0.701
DOC_USP7_UBL2_3	282	286	PF12436	0.573
DOC_USP7_UBL2_3	320	324	PF12436	0.546
DOC_USP7_UBL2_3	479	483	PF12436	0.399
DOC_WW_Pin1_4	266	271	PF00397	0.699
DOC_WW_Pin1_4	430	435	PF00397	0.434
DOC_WW_Pin1_4	514	519	PF00397	0.525
DOC_WW_Pin1_4	586	591	PF00397	0.352
DOC_WW_Pin1_4	614	619	PF00397	0.424
LIG_14-3-3_CanoR_1	166	176	PF00244	0.644
LIG_14-3-3_CanoR_1	235	242	PF00244	0.629
LIG_14-3-3_CanoR_1	3	8	PF00244	0.658
LIG_14-3-3_CanoR_1	624	629	PF00244	0.338
LIG_Actin_WH2_2	395	412	PF00022	0.483
LIG_BRCT_BRCA1_1	492	496	PF00533	0.270
LIG_CaM_IQ_9	371	386	PF13499	0.511
LIG_Clathr_ClatBox_1	296	300	PF01394	0.342
LIG_Clathr_ClatBox_1	440	444	PF01394	0.502
LIG_DLG_GKlike_1	3	11	PF00625	0.608
LIG_EH1_1	290	298	PF00400	0.373
LIG_eIF4E_1	291	297	PF01652	0.370
LIG_FHA_1	103	109	PF00498	0.473
LIG_FHA_1	140	146	PF00498	0.637
LIG_FHA_1	303	309	PF00498	0.390
LIG_FHA_1	324	330	PF00498	0.475
LIG_FHA_1	372	378	PF00498	0.478
LIG_FHA_1	594	600	PF00498	0.405
LIG_FHA_2	179	185	PF00498	0.577
LIG_FHA_2	301	307	PF00498	0.531
LIG_FHA_2	448	454	PF00498	0.479
LIG_FHA_2	482	488	PF00498	0.491
LIG_FHA_2	49	55	PF00498	0.472
LIG_FHA_2	573	579	PF00498	0.454
LIG_LIR_Gen_1	422	430	PF02991	0.424
LIG_LIR_Gen_1	493	504	PF02991	0.320
LIG_LIR_Nem_3	170	176	PF02991	0.742
LIG_LIR_Nem_3	422	428	PF02991	0.576
LIG_LIR_Nem_3	493	499	PF02991	0.384
LIG_LIR_Nem_3	573	579	PF02991	0.510
LIG_PCNA_yPIPBox_3	284	297	PF02747	0.414
LIG_SH2_CRK	524	528	PF00017	0.391
LIG_SH2_NCK_1	524	528	PF00017	0.244
LIG_SH2_STAP1	425	429	PF00017	0.387
LIG_SH2_STAT5	574	577	PF00017	0.592
LIG_SH3_3	307	313	PF00018	0.406
LIG_SH3_3	432	438	PF00018	0.406
LIG_SUMO_SIM_anti_2	295	300	PF11976	0.408
LIG_SUMO_SIM_par_1	295	300	PF11976	0.326
LIG_SUMO_SIM_par_1	439	445	PF11976	0.364
LIG_TRAF2_1	465	468	PF00917	0.593
LIG_TRAF2_1	486	489	PF00917	0.507
LIG_UBA3_1	440	446	PF00899	0.448
LIG_UBA3_1	477	483	PF00899	0.241
LIG_WRC_WIRS_1	192	197	PF05994	0.678
LIG_WRC_WIRS_1	455	460	PF05994	0.373
LIG_WW_3	561	565	PF00397	0.408
MOD_CDC14_SPxK_1	517	520	PF00782	0.496
MOD_CDK_SPxK_1	514	520	PF00069	0.518
MOD_CDK_SPxxK_3	266	273	PF00069	0.526
MOD_CK1_1	167	173	PF00069	0.718
MOD_CK1_1	178	184	PF00069	0.737
MOD_CK1_1	227	233	PF00069	0.637
MOD_CK1_1	238	244	PF00069	0.569
MOD_CK1_1	250	256	PF00069	0.739
MOD_CK1_1	266	272	PF00069	0.714
MOD_CK1_1	29	35	PF00069	0.553
MOD_CK1_1	421	427	PF00069	0.349
MOD_CK1_1	617	623	PF00069	0.502
MOD_CK2_1	120	126	PF00069	0.466
MOD_CK2_1	252	258	PF00069	0.698
MOD_CK2_1	300	306	PF00069	0.560
MOD_CK2_1	447	453	PF00069	0.408
MOD_CK2_1	537	543	PF00069	0.470
MOD_CK2_1	572	578	PF00069	0.453
MOD_Cter_Amidation	204	207	PF01082	0.659
MOD_Cter_Amidation	321	324	PF01082	0.544
MOD_GlcNHglycan	166	169	PF01048	0.778
MOD_GlcNHglycan	170	173	PF01048	0.791
MOD_GlcNHglycan	203	206	PF01048	0.586
MOD_GlcNHglycan	229	232	PF01048	0.693
MOD_GlcNHglycan	243	246	PF01048	0.817
MOD_GlcNHglycan	276	279	PF01048	0.637
MOD_GlcNHglycan	336	339	PF01048	0.565
MOD_GlcNHglycan	359	362	PF01048	0.398
MOD_GlcNHglycan	533	536	PF01048	0.382
MOD_GlcNHglycan	56	59	PF01048	0.649
MOD_GlcNHglycan	564	567	PF01048	0.449
MOD_GlcNHglycan	74	77	PF01048	0.725
MOD_GSK3_1	164	171	PF00069	0.690
MOD_GSK3_1	247	254	PF00069	0.717
MOD_GSK3_1	25	32	PF00069	0.643
MOD_GSK3_1	265	272	PF00069	0.647
MOD_GSK3_1	3	10	PF00069	0.730
MOD_GSK3_1	302	309	PF00069	0.448
MOD_GSK3_1	341	348	PF00069	0.403
MOD_GSK3_1	37	44	PF00069	0.713
MOD_GSK3_1	477	484	PF00069	0.481
MOD_GSK3_1	614	621	PF00069	0.503
MOD_GSK3_1	72	79	PF00069	0.655
MOD_GSK3_1	98	105	PF00069	0.597
MOD_N-GLC_1	153	158	PF02516	0.678
MOD_N-GLC_1	164	169	PF02516	0.583
MOD_N-GLC_1	227	232	PF02516	0.640
MOD_N-GLC_1	250	255	PF02516	0.745
MOD_N-GLC_1	7	12	PF02516	0.462
MOD_NEK2_1	37	42	PF00069	0.577
MOD_NEK2_1	400	405	PF00069	0.365
MOD_NEK2_1	7	12	PF00069	0.476
MOD_NEK2_1	87	92	PF00069	0.689
MOD_NEK2_2	120	125	PF00069	0.702
MOD_NEK2_2	130	135	PF00069	0.538
MOD_PIKK_1	159	165	PF00454	0.785
MOD_PIKK_1	371	377	PF00454	0.486
MOD_PKA_1	235	241	PF00069	0.702
MOD_PKA_1	323	329	PF00069	0.474
MOD_PKA_2	159	165	PF00069	0.627
MOD_PKA_2	235	241	PF00069	0.643
MOD_Plk_1	153	159	PF00069	0.713
MOD_Plk_1	178	184	PF00069	0.758
MOD_Plk_1	227	233	PF00069	0.794
MOD_Plk_1	238	244	PF00069	0.723
MOD_Plk_1	400	406	PF00069	0.358
MOD_Plk_1	421	427	PF00069	0.440
MOD_Plk_1	572	578	PF00069	0.513
MOD_Plk_1	618	624	PF00069	0.319
MOD_Plk_4	104	110	PF00069	0.647
MOD_Plk_4	113	119	PF00069	0.644
MOD_Plk_4	120	126	PF00069	0.672
MOD_Plk_4	130	136	PF00069	0.568
MOD_Plk_4	292	298	PF00069	0.354
MOD_Plk_4	312	318	PF00069	0.537
MOD_Plk_4	341	347	PF00069	0.354
MOD_Plk_4	402	408	PF00069	0.450
MOD_Plk_4	491	497	PF00069	0.453
MOD_Plk_4	7	13	PF00069	0.498
MOD_ProDKin_1	266	272	PF00069	0.699
MOD_ProDKin_1	430	436	PF00069	0.433
MOD_ProDKin_1	514	520	PF00069	0.528
MOD_ProDKin_1	586	592	PF00069	0.359
MOD_ProDKin_1	614	620	PF00069	0.430
MOD_SUMO_for_1	465	468	PF00179	0.565
MOD_SUMO_rev_2	442	447	PF00179	0.343
MOD_SUMO_rev_2	547	555	PF00179	0.443
MOD_SUMO_rev_2	587	596	PF00179	0.561
MOD_SUMO_rev_2	605	614	PF00179	0.329
TRG_ENDOCYTIC_2	12	15	PF00928	0.707
TRG_ENDOCYTIC_2	173	176	PF00928	0.758
TRG_ENDOCYTIC_2	30	33	PF00928	0.625
TRG_ENDOCYTIC_2	425	428	PF00928	0.388
TRG_ENDOCYTIC_2	49	52	PF00928	0.696
TRG_ENDOCYTIC_2	524	527	PF00928	0.391
TRG_ENDOCYTIC_2	576	579	PF00928	0.505
TRG_ENDOCYTIC_2	63	66	PF00928	0.565
TRG_ENDOCYTIC_2	77	80	PF00928	0.726
TRG_ENDOCYTIC_2	88	91	PF00928	0.614
TRG_ER_diArg_1	234	236	PF00400	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF45	Leptomonas seymouri	62%	73%
A0A1X0NRD1	Trypanosomatidae	40%	77%
A0A1X0NST4	Trypanosomatidae	31%	76%
A0A3Q8II25	Leishmania donovani	34%	100%
A0A3S7X791	Leishmania donovani	78%	96%
A4HM06	Leishmania braziliensis	33%	97%
A4I9D6	Leishmania infantum	78%	96%
A4I9D8	Leishmania infantum	34%	100%
C9ZJQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	82%
E9B4D6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	97%
E9B4D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q4Q3P0	Leishmania major	35%	100%
Q4Q3P1	Leishmania major	79%	100%
V5B7N5	Trypanosoma cruzi	22%	100%
V5BC36	Trypanosoma cruzi	29%	100%
V5D844	Trypanosoma cruzi	35%	100%