Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM03_LEIBR

TriTrypDb:

LbrM.33.3210 , LBRM2903_330040100

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HM03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM03

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.522
CLV_C14_Caspase3-7	79	83	PF00656	0.529
CLV_NRD_NRD_1	173	175	PF00675	0.572
CLV_NRD_NRD_1	178	180	PF00675	0.595
CLV_NRD_NRD_1	203	205	PF00675	0.601
CLV_NRD_NRD_1	208	210	PF00675	0.615
CLV_NRD_NRD_1	225	227	PF00675	0.564
CLV_PCSK_KEX2_1	173	175	PF00082	0.622
CLV_PCSK_KEX2_1	178	180	PF00082	0.678
CLV_PCSK_KEX2_1	203	205	PF00082	0.601
CLV_PCSK_KEX2_1	208	210	PF00082	0.615
CLV_PCSK_KEX2_1	225	227	PF00082	0.564
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.564
CLV_PCSK_PC7_1	174	180	PF00082	0.683
CLV_PCSK_PC7_1	204	210	PF00082	0.613
CLV_PCSK_SKI1_1	203	207	PF00082	0.704
CLV_PCSK_SKI1_1	214	218	PF00082	0.585
CLV_PCSK_SKI1_1	92	96	PF00082	0.682
DEG_Nend_Nbox_1	1	3	PF02207	0.502
DEG_SPOP_SBC_1	241	245	PF00917	0.583
DOC_ANK_TNKS_1	207	214	PF00023	0.634
DOC_MAPK_gen_1	137	145	PF00069	0.608
DOC_PP4_FxxP_1	94	97	PF00568	0.580
DOC_USP7_MATH_1	108	112	PF00917	0.662
DOC_USP7_MATH_1	113	117	PF00917	0.685
DOC_USP7_MATH_1	185	189	PF00917	0.685
DOC_WW_Pin1_4	276	281	PF00397	0.557
LIG_14-3-3_CanoR_1	148	154	PF00244	0.594
LIG_14-3-3_CanoR_1	84	88	PF00244	0.753
LIG_BIR_III_4	307	311	PF00653	0.531
LIG_BRCT_BRCA1_1	297	301	PF00533	0.613
LIG_BRCT_BRCA1_1	90	94	PF00533	0.696
LIG_FHA_1	269	275	PF00498	0.546
LIG_FHA_2	157	163	PF00498	0.533
LIG_Integrin_RGD_1	190	192	PF01839	0.583
LIG_LIR_Apic_2	26	30	PF02991	0.535
LIG_LIR_Apic_2	72	78	PF02991	0.532
LIG_LIR_Apic_2	91	97	PF02991	0.583
LIG_LIR_Gen_1	293	301	PF02991	0.591
LIG_LIR_Nem_3	217	222	PF02991	0.568
LIG_LIR_Nem_3	234	239	PF02991	0.452
LIG_SH2_CRK	219	223	PF00017	0.567
LIG_SH2_CRK	27	31	PF00017	0.537
LIG_SH2_CRK	52	56	PF00017	0.521
LIG_SH2_GRB2like	294	297	PF00017	0.586
LIG_SH2_GRB2like	71	74	PF00017	0.539
LIG_SH2_NCK_1	52	56	PF00017	0.521
LIG_SH2_NCK_1	75	79	PF00017	0.557
LIG_SH2_SRC	71	74	PF00017	0.626
LIG_SH2_STAT3	259	262	PF00017	0.544
LIG_SH2_STAT3	29	32	PF00017	0.624
LIG_SH2_STAT3	46	49	PF00017	0.658
LIG_SH3_3	196	202	PF00018	0.601
LIG_SH3_3	277	283	PF00018	0.545
LIG_TRAF2_1	36	39	PF00917	0.539
LIG_TYR_ITSM	215	222	PF00017	0.572
MOD_CK1_1	116	122	PF00069	0.633
MOD_CK1_1	144	150	PF00069	0.508
MOD_CK1_1	295	301	PF00069	0.595
MOD_CK1_1	90	96	PF00069	0.605
MOD_CK2_1	156	162	PF00069	0.537
MOD_GlcNHglycan	106	109	PF01048	0.640
MOD_GlcNHglycan	214	217	PF01048	0.749
MOD_GlcNHglycan	266	269	PF01048	0.564
MOD_GSK3_1	104	111	PF00069	0.651
MOD_GSK3_1	264	271	PF00069	0.627
MOD_GSK3_1	295	302	PF00069	0.621
MOD_GSK3_1	83	90	PF00069	0.618
MOD_N-GLC_1	128	133	PF02516	0.512
MOD_N-GLC_1	295	300	PF02516	0.601
MOD_NEK2_1	104	109	PF00069	0.585
MOD_NEK2_1	255	260	PF00069	0.543
MOD_NEK2_1	264	269	PF00069	0.545
MOD_NEK2_1	88	93	PF00069	0.639
MOD_NEK2_2	149	154	PF00069	0.590
MOD_PIKK_1	138	144	PF00454	0.610
MOD_PK_1	128	134	PF00069	0.595
MOD_PKA_1	203	209	PF00069	0.612
MOD_PKA_2	138	144	PF00069	0.610
MOD_PKA_2	203	209	PF00069	0.612
MOD_PKA_2	241	247	PF00069	0.532
MOD_PKA_2	83	89	PF00069	0.533
MOD_Plk_1	255	261	PF00069	0.544
MOD_Plk_1	6	12	PF00069	0.504
MOD_Plk_2-3	299	305	PF00069	0.709
MOD_Plk_4	128	134	PF00069	0.595
MOD_Plk_4	83	89	PF00069	0.598
MOD_ProDKin_1	276	282	PF00069	0.557
TRG_ENDOCYTIC_2	168	171	PF00928	0.562
TRG_ENDOCYTIC_2	219	222	PF00928	0.566
TRG_ENDOCYTIC_2	294	297	PF00928	0.596
TRG_ER_diArg_1	110	113	PF00400	0.539
TRG_ER_diArg_1	178	180	PF00400	0.692
TRG_ER_diArg_1	202	204	PF00400	0.607
TRG_NLS_Bipartite_1	208	229	PF00514	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYS4	Leptomonas seymouri	54%	100%
A0A3S7X783	Leishmania donovani	66%	100%
A4I9D4	Leishmania infantum	66%	100%
E9B4D4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4Q3P3	Leishmania major	66%	99%