Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLZ9_LEIBR

TriTrypDb:

LbrM.33.3170 , LBRM2903_330039600

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLZ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.576
CLV_C14_Caspase3-7	75	79	PF00656	0.522
CLV_NRD_NRD_1	111	113	PF00675	0.706
CLV_NRD_NRD_1	137	139	PF00675	0.630
CLV_NRD_NRD_1	186	188	PF00675	0.554
CLV_NRD_NRD_1	228	230	PF00675	0.680
CLV_NRD_NRD_1	25	27	PF00675	0.633
CLV_NRD_NRD_1	318	320	PF00675	0.725
CLV_NRD_NRD_1	384	386	PF00675	0.678
CLV_NRD_NRD_1	387	389	PF00675	0.712
CLV_NRD_NRD_1	390	392	PF00675	0.728
CLV_PCSK_FUR_1	228	232	PF00082	0.647
CLV_PCSK_FUR_1	381	385	PF00082	0.663
CLV_PCSK_FUR_1	388	392	PF00082	0.717
CLV_PCSK_KEX2_1	137	139	PF00082	0.630
CLV_PCSK_KEX2_1	195	197	PF00082	0.693
CLV_PCSK_KEX2_1	228	230	PF00082	0.677
CLV_PCSK_KEX2_1	318	320	PF00082	0.707
CLV_PCSK_KEX2_1	335	337	PF00082	0.404
CLV_PCSK_KEX2_1	383	385	PF00082	0.672
CLV_PCSK_KEX2_1	387	389	PF00082	0.712
CLV_PCSK_KEX2_1	390	392	PF00082	0.728
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.693
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.663
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.583
CLV_PCSK_PC7_1	383	389	PF00082	0.691
CLV_PCSK_SKI1_1	187	191	PF00082	0.562
CLV_PCSK_SKI1_1	192	196	PF00082	0.538
CLV_PCSK_SKI1_1	262	266	PF00082	0.638
CLV_Separin_Metazoa	263	267	PF03568	0.672
DEG_SPOP_SBC_1	10	14	PF00917	0.557
DEG_SPOP_SBC_1	79	83	PF00917	0.537
DOC_ANK_TNKS_1	180	187	PF00023	0.554
DOC_PP1_RVXF_1	333	340	PF00149	0.671
DOC_PP4_FxxP_1	386	389	PF00568	0.808
DOC_USP7_MATH_1	194	198	PF00917	0.760
DOC_USP7_MATH_1	2	6	PF00917	0.808
DOC_USP7_MATH_1	317	321	PF00917	0.675
DOC_USP7_MATH_1	356	360	PF00917	0.703
DOC_USP7_MATH_1	64	68	PF00917	0.711
DOC_USP7_MATH_1	79	83	PF00917	0.580
DOC_USP7_UBL2_3	188	192	PF12436	0.746
DOC_WW_Pin1_4	11	16	PF00397	0.801
DOC_WW_Pin1_4	255	260	PF00397	0.503
DOC_WW_Pin1_4	92	97	PF00397	0.753
LIG_14-3-3_CanoR_1	112	121	PF00244	0.671
LIG_14-3-3_CanoR_1	127	135	PF00244	0.625
LIG_14-3-3_CanoR_1	217	224	PF00244	0.508
LIG_14-3-3_CanoR_1	269	275	PF00244	0.528
LIG_14-3-3_CanoR_1	299	304	PF00244	0.562
LIG_14-3-3_CanoR_1	86	92	PF00244	0.530
LIG_BIR_II_1	1	5	PF00653	0.710
LIG_BIR_III_3	1	5	PF00653	0.807
LIG_BIR_III_4	147	151	PF00653	0.617
LIG_DLG_GKlike_1	299	307	PF00625	0.492
LIG_FHA_1	115	121	PF00498	0.592
LIG_FHA_1	131	137	PF00498	0.620
LIG_FHA_1	213	219	PF00498	0.554
LIG_FHA_1	303	309	PF00498	0.696
LIG_FHA_1	86	92	PF00498	0.695
LIG_FHA_2	217	223	PF00498	0.569
LIG_FHA_2	243	249	PF00498	0.657
LIG_FHA_2	256	262	PF00498	0.647
LIG_FHA_2	43	49	PF00498	0.513
LIG_LIR_Gen_1	67	77	PF02991	0.646
LIG_LIR_Nem_3	159	165	PF02991	0.603
LIG_LIR_Nem_3	57	62	PF02991	0.631
LIG_LIR_Nem_3	67	72	PF02991	0.632
LIG_LIR_Nem_3	95	100	PF02991	0.650
LIG_LYPXL_yS_3	59	62	PF13949	0.627
LIG_PCNA_PIPBox_1	327	336	PF02747	0.593
LIG_PCNA_yPIPBox_3	327	338	PF02747	0.606
LIG_SH2_CRK	69	73	PF00017	0.635
LIG_SH2_GRB2like	37	40	PF00017	0.498
LIG_SH2_NCK_1	105	109	PF00017	0.681
LIG_SH2_NCK_1	254	258	PF00017	0.694
LIG_SH2_NCK_1	37	41	PF00017	0.754
LIG_SH2_NCK_1	69	73	PF00017	0.514
LIG_SH2_SRC	105	108	PF00017	0.677
LIG_SH2_SRC	37	40	PF00017	0.498
LIG_SH2_STAT5	244	247	PF00017	0.662
LIG_SH2_STAT5	333	336	PF00017	0.579
LIG_SH3_3	154	160	PF00018	0.613
LIG_SH3_3	276	282	PF00018	0.577
LIG_Sin3_3	141	148	PF02671	0.612
LIG_SUMO_SIM_par_1	298	307	PF11976	0.608
LIG_TRAF2_1	258	261	PF00917	0.652
LIG_TRAF2_1	291	294	PF00917	0.796
LIG_TRAF2_1	320	323	PF00917	0.764
LIG_ULM_U2AF65_1	335	340	PF00076	0.574
LIG_WW_3	14	18	PF00397	0.784
MOD_CDC14_SPxK_1	14	17	PF00782	0.786
MOD_CDK_SPxK_1	11	17	PF00069	0.797
MOD_CDK_SPxxK_3	255	262	PF00069	0.498
MOD_CK1_1	126	132	PF00069	0.690
MOD_CK1_1	255	261	PF00069	0.653
MOD_CK1_1	273	279	PF00069	0.689
MOD_CK1_1	292	298	PF00069	0.650
MOD_CK1_1	302	308	PF00069	0.636
MOD_CK1_1	345	351	PF00069	0.635
MOD_CK1_1	359	365	PF00069	0.607
MOD_CK2_1	242	248	PF00069	0.660
MOD_CK2_1	255	261	PF00069	0.653
MOD_CK2_1	317	323	PF00069	0.776
MOD_CK2_1	42	48	PF00069	0.517
MOD_Cter_Amidation	185	188	PF01082	0.557
MOD_GlcNHglycan	123	126	PF01048	0.679
MOD_GlcNHglycan	171	174	PF01048	0.551
MOD_GlcNHglycan	254	257	PF01048	0.664
MOD_GlcNHglycan	274	278	PF01048	0.461
MOD_GlcNHglycan	358	361	PF01048	0.744
MOD_GlcNHglycan	4	7	PF01048	0.787
MOD_GSK3_1	126	133	PF00069	0.705
MOD_GSK3_1	212	219	PF00069	0.557
MOD_GSK3_1	242	249	PF00069	0.612
MOD_GSK3_1	265	272	PF00069	0.618
MOD_GSK3_1	295	302	PF00069	0.536
MOD_GSK3_1	339	346	PF00069	0.582
MOD_GSK3_1	44	51	PF00069	0.663
MOD_N-GLC_1	2	7	PF02516	0.556
MOD_N-GLC_1	212	217	PF02516	0.780
MOD_NEK2_1	169	174	PF00069	0.473
MOD_NEK2_1	252	257	PF00069	0.623
MOD_NEK2_1	265	270	PF00069	0.670
MOD_NEK2_1	303	308	PF00069	0.515
MOD_NEK2_1	376	381	PF00069	0.548
MOD_NEK2_1	85	90	PF00069	0.754
MOD_NEK2_2	64	69	PF00069	0.719
MOD_PIKK_1	289	295	PF00454	0.795
MOD_PIKK_1	339	345	PF00454	0.576
MOD_PIKK_1	376	382	PF00454	0.548
MOD_PK_1	246	252	PF00069	0.601
MOD_PKA_2	126	132	PF00069	0.531
MOD_PKA_2	216	222	PF00069	0.579
MOD_PKA_2	265	271	PF00069	0.646
MOD_PKA_2	317	323	PF00069	0.786
MOD_PKA_2	85	91	PF00069	0.537
MOD_Plk_1	212	218	PF00069	0.719
MOD_Plk_1	42	48	PF00069	0.517
MOD_Plk_4	246	252	PF00069	0.638
MOD_Plk_4	299	305	PF00069	0.633
MOD_ProDKin_1	11	17	PF00069	0.797
MOD_ProDKin_1	255	261	PF00069	0.502
MOD_ProDKin_1	92	98	PF00069	0.754
MOD_SUMO_for_1	372	375	PF00179	0.625
MOD_SUMO_rev_2	255	264	PF00179	0.653
TRG_DiLeu_BaEn_4	260	266	PF01217	0.659
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.631
TRG_ENDOCYTIC_2	105	108	PF00928	0.677
TRG_ENDOCYTIC_2	244	247	PF00928	0.662
TRG_ENDOCYTIC_2	37	40	PF00928	0.649
TRG_ENDOCYTIC_2	59	62	PF00928	0.627
TRG_ENDOCYTIC_2	69	72	PF00928	0.636
TRG_ER_diArg_1	136	138	PF00400	0.548
TRG_ER_diArg_1	181	184	PF00400	0.558
TRG_ER_diArg_1	227	229	PF00400	0.668
TRG_ER_diArg_1	336	339	PF00400	0.518
TRG_ER_diArg_1	381	384	PF00400	0.655
TRG_ER_diArg_1	386	388	PF00400	0.703
TRG_ER_diArg_1	389	391	PF00400	0.723
TRG_NLS_Bipartite_1	318	339	PF00514	0.717
TRG_NLS_MonoExtN_4	228	233	PF00514	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L6	Leptomonas seymouri	56%	100%
A0A3S7X784	Leishmania donovani	79%	99%
A4I9C9	Leishmania infantum	79%	99%
E9B4C9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%
Q4Q3P7	Leishmania major	76%	100%