LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HLZ8_LEIBR
TriTrypDb:
LbrM.33.3160 , LBRM2903_330039500
Length:
115

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLZ8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLZ8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 82 88 PF00089 0.606
CLV_NRD_NRD_1 78 80 PF00675 0.630
CLV_PCSK_KEX2_1 78 80 PF00082 0.630
CLV_PCSK_SKI1_1 27 31 PF00082 0.602
DEG_APCC_DBOX_1 7 15 PF00400 0.604
DEG_MDM2_SWIB_1 97 104 PF02201 0.483
DEG_SPOP_SBC_1 107 111 PF00917 0.593
DOC_CYCLIN_RxL_1 24 33 PF00134 0.603
DOC_PP1_RVXF_1 25 31 PF00149 0.594
DOC_PP4_FxxP_1 32 35 PF00568 0.535
DOC_USP7_MATH_1 42 46 PF00917 0.480
LIG_BIR_II_1 1 5 PF00653 0.583
LIG_Clathr_ClatBox_1 29 33 PF01394 0.537
LIG_FHA_1 75 81 PF00498 0.476
LIG_FHA_2 109 115 PF00498 0.713
LIG_FXI_DFP_1 29 33 PF00024 0.537
LIG_LIR_Apic_2 31 35 PF02991 0.536
LIG_LIR_Gen_1 99 108 PF02991 0.657
LIG_LIR_Nem_3 99 104 PF02991 0.600
LIG_PDZ_Class_3 110 115 PF00595 0.674
LIG_Pex14_2 97 101 PF04695 0.482
LIG_Rb_pABgroove_1 24 32 PF01858 0.595
LIG_SH2_NCK_1 93 97 PF00017 0.472
LIG_SH2_SRC 93 96 PF00017 0.629
LIG_SH2_STAT3 38 41 PF00017 0.598
LIG_SH2_STAT3 7 10 PF00017 0.545
LIG_SH3_3 101 107 PF00018 0.644
LIG_SH3_3 57 63 PF00018 0.655
LIG_SH3_3 68 74 PF00018 0.664
LIG_TRFH_1 38 42 PF08558 0.598
MOD_CK1_1 2 8 PF00069 0.532
MOD_CK2_1 107 113 PF00069 0.714
MOD_GSK3_1 15 22 PF00069 0.606
MOD_N-GLC_1 42 47 PF02516 0.526
MOD_NEK2_1 19 24 PF00069 0.603
MOD_NEK2_1 56 61 PF00069 0.628
MOD_PIKK_1 19 25 PF00454 0.590
MOD_PIKK_1 33 39 PF00454 0.600
MOD_PK_1 85 91 PF00069 0.520
MOD_PKA_2 50 56 PF00069 0.529
MOD_Plk_4 2 8 PF00069 0.573
MOD_Plk_4 42 48 PF00069 0.443
TRG_ER_diArg_1 78 80 PF00400 0.627

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IGP1 Leptomonas seymouri 77% 100%
A0A3S7X781 Leishmania donovani 88% 100%
A4I9C8 Leishmania infantum 88% 100%
E9B4C8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q3P8 Leishmania major 87% 100%
V5AV52 Trypanosoma cruzi 24% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS