Peptidase C51 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLZ7_LEIBR

TriTrypDb:

LbrM.33.3150 , LBRM2903_330039400

Length:

471

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HLZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLZ7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	43	47	PF00656	0.419
CLV_NRD_NRD_1	181	183	PF00675	0.314
CLV_NRD_NRD_1	426	428	PF00675	0.560
CLV_PCSK_FUR_1	424	428	PF00082	0.437
CLV_PCSK_KEX2_1	181	183	PF00082	0.314
CLV_PCSK_KEX2_1	424	426	PF00082	0.539
CLV_PCSK_SKI1_1	187	191	PF00082	0.330
CLV_PCSK_SKI1_1	352	356	PF00082	0.477
CLV_PCSK_SKI1_1	438	442	PF00082	0.394
DOC_CKS1_1	1	6	PF01111	0.464
DOC_CYCLIN_RxL_1	181	191	PF00134	0.520
DOC_CYCLIN_RxL_1	434	446	PF00134	0.586
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.628
DOC_CYCLIN_yCln2_LP_2	269	275	PF00134	0.462
DOC_MAPK_DCC_7	22	32	PF00069	0.547
DOC_MAPK_gen_1	156	165	PF00069	0.549
DOC_MAPK_gen_1	181	188	PF00069	0.450
DOC_MAPK_gen_1	214	224	PF00069	0.636
DOC_MAPK_gen_1	24	32	PF00069	0.541
DOC_MAPK_gen_1	71	80	PF00069	0.401
DOC_MAPK_MEF2A_6	156	165	PF00069	0.564
DOC_PP1_RVXF_1	306	313	PF00149	0.616
DOC_PP2B_LxvP_1	119	122	PF13499	0.629
DOC_PP2B_LxvP_1	230	233	PF13499	0.588
DOC_PP2B_PxIxI_1	86	92	PF00149	0.476
DOC_USP7_MATH_1	131	135	PF00917	0.607
DOC_USP7_MATH_1	279	283	PF00917	0.669
DOC_USP7_MATH_1	299	303	PF00917	0.446
DOC_USP7_UBL2_3	263	267	PF12436	0.507
DOC_WW_Pin1_4	127	132	PF00397	0.582
DOC_WW_Pin1_4	408	413	PF00397	0.594
DOC_WW_Pin1_4	83	88	PF00397	0.484
LIG_14-3-3_CanoR_1	159	164	PF00244	0.491
LIG_14-3-3_CanoR_1	167	174	PF00244	0.467
LIG_14-3-3_CanoR_1	217	222	PF00244	0.680
LIG_14-3-3_CanoR_1	425	433	PF00244	0.663
LIG_14-3-3_CanoR_1	65	73	PF00244	0.521
LIG_BIR_II_1	1	5	PF00653	0.613
LIG_BRCT_BRCA1_1	168	172	PF00533	0.588
LIG_deltaCOP1_diTrp_1	126	132	PF00928	0.492
LIG_deltaCOP1_diTrp_1	394	402	PF00928	0.549
LIG_eIF4E_1	436	442	PF01652	0.491
LIG_EVH1_1	192	196	PF00568	0.478
LIG_FHA_1	103	109	PF00498	0.415
LIG_FHA_1	435	441	PF00498	0.636
LIG_FHA_1	67	73	PF00498	0.429
LIG_FHA_2	353	359	PF00498	0.744
LIG_FHA_2	38	44	PF00498	0.441
LIG_FHA_2	415	421	PF00498	0.713
LIG_GBD_Chelix_1	100	108	PF00786	0.398
LIG_LIR_Apic_2	444	448	PF02991	0.604
LIG_LIR_Gen_1	158	168	PF02991	0.602
LIG_LIR_Gen_1	198	207	PF02991	0.518
LIG_LIR_Gen_1	225	235	PF02991	0.596
LIG_LIR_Gen_1	400	408	PF02991	0.683
LIG_LIR_Nem_3	112	117	PF02991	0.402
LIG_LIR_Nem_3	130	135	PF02991	0.555
LIG_LIR_Nem_3	158	163	PF02991	0.569
LIG_LIR_Nem_3	191	195	PF02991	0.507
LIG_LIR_Nem_3	198	203	PF02991	0.544
LIG_LIR_Nem_3	225	230	PF02991	0.608
LIG_LIR_Nem_3	309	315	PF02991	0.639
LIG_LIR_Nem_3	35	41	PF02991	0.579
LIG_LIR_Nem_3	384	390	PF02991	0.569
LIG_LIR_Nem_3	400	405	PF02991	0.618
LIG_NRBOX	185	191	PF00104	0.609
LIG_NRBOX	99	105	PF00104	0.443
LIG_PCNA_yPIPBox_3	458	471	PF02747	0.578
LIG_Pex14_1	184	188	PF04695	0.458
LIG_Pex14_1	397	401	PF04695	0.568
LIG_Pex14_2	113	117	PF04695	0.475
LIG_Pex14_2	188	192	PF04695	0.479
LIG_SH2_CRK	227	231	PF00017	0.612
LIG_SH2_CRK	273	277	PF00017	0.449
LIG_SH2_CRK	38	42	PF00017	0.513
LIG_SH2_CRK	436	440	PF00017	0.554
LIG_SH2_CRK	445	449	PF00017	0.635
LIG_SH2_GRB2like	145	148	PF00017	0.593
LIG_SH2_GRB2like	227	230	PF00017	0.531
LIG_SH2_GRB2like	445	448	PF00017	0.652
LIG_SH2_PTP2	200	203	PF00017	0.466
LIG_SH2_SRC	273	276	PF00017	0.451
LIG_SH2_STAP1	179	183	PF00017	0.542
LIG_SH2_STAP1	227	231	PF00017	0.571
LIG_SH2_STAP1	273	277	PF00017	0.449
LIG_SH2_STAP1	436	440	PF00017	0.495
LIG_SH2_STAT5	114	117	PF00017	0.398
LIG_SH2_STAT5	200	203	PF00017	0.511
LIG_SH2_STAT5	407	410	PF00017	0.766
LIG_SH2_STAT5	436	439	PF00017	0.477
LIG_SH3_3	190	196	PF00018	0.576
LIG_SH3_3	293	299	PF00018	0.581
LIG_SH3_3	322	328	PF00018	0.709
LIG_SH3_3	345	351	PF00018	0.708
LIG_SH3_3	81	87	PF00018	0.408
LIG_SH3_5	196	200	PF00018	0.489
LIG_SH3_CIN85_PxpxPR_1	29	34	PF14604	0.553
LIG_SUMO_SIM_anti_2	105	110	PF11976	0.455
LIG_SUMO_SIM_anti_2	437	444	PF11976	0.575
LIG_SUMO_SIM_par_1	437	444	PF11976	0.575
LIG_TYR_ITIM	385	390	PF00017	0.563
LIG_WRC_WIRS_1	110	115	PF05994	0.497
LIG_WW_2	193	196	PF00397	0.487
MOD_CK1_1	356	362	PF00069	0.627
MOD_CK1_1	363	369	PF00069	0.613
MOD_CK1_1	381	387	PF00069	0.460
MOD_CK1_1	406	412	PF00069	0.695
MOD_CK1_1	58	64	PF00069	0.487
MOD_CK1_1	66	72	PF00069	0.569
MOD_CK1_1	82	88	PF00069	0.407
MOD_CK2_1	363	369	PF00069	0.732
MOD_CK2_1	414	420	PF00069	0.643
MOD_GlcNHglycan	119	122	PF01048	0.429
MOD_GlcNHglycan	138	142	PF01048	0.272
MOD_GlcNHglycan	256	259	PF01048	0.495
MOD_GlcNHglycan	286	289	PF01048	0.480
MOD_GlcNHglycan	362	365	PF01048	0.549
MOD_GlcNHglycan	371	374	PF01048	0.603
MOD_GlcNHglycan	380	383	PF01048	0.334
MOD_GlcNHglycan	51	54	PF01048	0.768
MOD_GlcNHglycan	60	63	PF01048	0.801
MOD_GlcNHglycan	65	68	PF01048	0.707
MOD_GSK3_1	127	134	PF00069	0.546
MOD_GSK3_1	352	359	PF00069	0.766
MOD_GSK3_1	397	404	PF00069	0.585
MOD_GSK3_1	79	86	PF00069	0.473
MOD_N-GLC_1	238	243	PF02516	0.529
MOD_N-GLC_1	254	259	PF02516	0.314
MOD_N-GLC_1	316	321	PF02516	0.476
MOD_N-GLC_1	344	349	PF02516	0.491
MOD_N-GLC_1	352	357	PF02516	0.525
MOD_N-GLC_1	369	374	PF02516	0.465
MOD_N-GLC_1	414	419	PF02516	0.523
MOD_N-GLC_1	434	439	PF02516	0.415
MOD_NEK2_1	109	114	PF00069	0.372
MOD_NEK2_1	117	122	PF00069	0.445
MOD_NEK2_1	136	141	PF00069	0.582
MOD_NEK2_1	188	193	PF00069	0.501
MOD_NEK2_1	237	242	PF00069	0.602
MOD_NEK2_1	256	261	PF00069	0.665
MOD_NEK2_1	453	458	PF00069	0.600
MOD_NEK2_1	63	68	PF00069	0.507
MOD_NEK2_2	37	42	PF00069	0.431
MOD_PIKK_1	238	244	PF00454	0.605
MOD_PIKK_1	335	341	PF00454	0.722
MOD_PK_1	159	165	PF00069	0.497
MOD_PK_1	217	223	PF00069	0.676
MOD_PKA_1	426	432	PF00069	0.647
MOD_PKA_2	166	172	PF00069	0.473
MOD_PKA_2	216	222	PF00069	0.678
MOD_PKA_2	426	432	PF00069	0.615
MOD_PKA_2	465	471	PF00069	0.614
MOD_PKA_2	58	64	PF00069	0.567
MOD_PKB_1	424	432	PF00069	0.673
MOD_Plk_1	316	322	PF00069	0.700
MOD_Plk_1	344	350	PF00069	0.617
MOD_Plk_1	352	358	PF00069	0.597
MOD_Plk_1	397	403	PF00069	0.573
MOD_Plk_1	434	440	PF00069	0.640
MOD_Plk_4	102	108	PF00069	0.409
MOD_Plk_4	109	115	PF00069	0.393
MOD_Plk_4	131	137	PF00069	0.535
MOD_Plk_4	217	223	PF00069	0.633
MOD_Plk_4	231	237	PF00069	0.541
MOD_Plk_4	299	305	PF00069	0.511
MOD_Plk_4	381	387	PF00069	0.609
MOD_Plk_4	397	403	PF00069	0.595
MOD_ProDKin_1	127	133	PF00069	0.583
MOD_ProDKin_1	408	414	PF00069	0.596
MOD_ProDKin_1	83	89	PF00069	0.484
TRG_DiLeu_BaEn_2	308	314	PF01217	0.679
TRG_ENDOCYTIC_2	114	117	PF00928	0.398
TRG_ENDOCYTIC_2	183	186	PF00928	0.553
TRG_ENDOCYTIC_2	200	203	PF00928	0.421
TRG_ENDOCYTIC_2	227	230	PF00928	0.564
TRG_ENDOCYTIC_2	273	276	PF00928	0.462
TRG_ENDOCYTIC_2	38	41	PF00928	0.540
TRG_ENDOCYTIC_2	387	390	PF00928	0.558
TRG_ENDOCYTIC_2	436	439	PF00928	0.488
TRG_ER_diArg_1	181	183	PF00400	0.514
TRG_ER_diArg_1	24	27	PF00400	0.531
TRG_ER_diArg_1	424	427	PF00400	0.651
TRG_NES_CRM1_1	155	166	PF08389	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRT1	Leptomonas seymouri	49%	100%
A0A3S7X756	Leishmania donovani	71%	97%
A4HLZ4	Leishmania braziliensis	26%	100%
A4I9C7	Leishmania infantum	71%	97%
E9B4C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	97%
Q4Q3P9	Leishmania major	71%	100%