D-alanyl-glycyl endopeptidase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cysteine peptidase, Clan CA, family C51, putative

Species:

Leishmania braziliensis

UniProt:

A4HLZ6_LEIBR

TriTrypDb:

LbrM.33.3140 , LBRM2903_330039300

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	15
GO:0005737	cytoplasm	2	2

Expansion

Sequence features

A4HLZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLZ6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.305
CLV_C14_Caspase3-7	187	191	PF00656	0.458
CLV_C14_Caspase3-7	243	247	PF00656	0.341
CLV_C14_Caspase3-7	303	307	PF00656	0.405
CLV_C14_Caspase3-7	69	73	PF00656	0.506
CLV_NRD_NRD_1	212	214	PF00675	0.449
CLV_NRD_NRD_1	321	323	PF00675	0.513
CLV_NRD_NRD_1	4	6	PF00675	0.430
CLV_NRD_NRD_1	47	49	PF00675	0.500
CLV_NRD_NRD_1	77	79	PF00675	0.439
CLV_PCSK_FUR_1	2	6	PF00082	0.433
CLV_PCSK_FUR_1	319	323	PF00082	0.450
CLV_PCSK_FUR_1	75	79	PF00082	0.346
CLV_PCSK_KEX2_1	212	214	PF00082	0.454
CLV_PCSK_KEX2_1	321	323	PF00082	0.513
CLV_PCSK_KEX2_1	4	6	PF00082	0.430
CLV_PCSK_KEX2_1	77	79	PF00082	0.429
CLV_PCSK_SKI1_1	197	201	PF00082	0.620
DEG_APCC_DBOX_1	320	328	PF00400	0.276
DEG_Nend_UBRbox_1	1	4	PF02207	0.677
DEG_SPOP_SBC_1	117	121	PF00917	0.427
DOC_CYCLIN_RxL_1	342	354	PF00134	0.349
DOC_MAPK_gen_1	319	327	PF00069	0.337
DOC_MAPK_MEF2A_6	248	256	PF00069	0.185
DOC_MAPK_MEF2A_6	346	353	PF00069	0.305
DOC_PP2B_LxvP_1	189	192	PF13499	0.471
DOC_PP2B_PxIxI_1	86	92	PF00149	0.300
DOC_USP7_MATH_1	118	122	PF00917	0.489
DOC_USP7_MATH_1	304	308	PF00917	0.526
DOC_USP7_MATH_1	32	36	PF00917	0.720
DOC_USP7_UBL2_3	200	204	PF12436	0.197
DOC_WW_Pin1_4	219	224	PF00397	0.269
DOC_WW_Pin1_4	25	30	PF00397	0.648
DOC_WW_Pin1_4	83	88	PF00397	0.498
LIG_14-3-3_CanoR_1	186	190	PF00244	0.481
LIG_14-3-3_CanoR_1	75	81	PF00244	0.592
LIG_Actin_WH2_2	100	115	PF00022	0.470
LIG_BRCT_BRCA1_1	144	148	PF00533	0.307
LIG_BRCT_BRCA1_1	240	244	PF00533	0.179
LIG_Clathr_ClatBox_1	350	354	PF01394	0.300
LIG_deltaCOP1_diTrp_1	329	337	PF00928	0.324
LIG_FHA_1	220	226	PF00498	0.380
LIG_FHA_1	248	254	PF00498	0.291
LIG_FHA_1	96	102	PF00498	0.479
LIG_FHA_2	103	109	PF00498	0.593
LIG_FHA_2	185	191	PF00498	0.456
LIG_FHA_2	241	247	PF00498	0.321
LIG_FHA_2	307	313	PF00498	0.376
LIG_FHA_2	362	368	PF00498	0.354
LIG_HP1_1	349	353	PF01393	0.305
LIG_LIR_Apic_2	334	340	PF02991	0.416
LIG_LIR_Gen_1	234	244	PF02991	0.275
LIG_LIR_Gen_1	329	340	PF02991	0.403
LIG_LIR_LC3C_4	347	352	PF02991	0.303
LIG_LIR_LC3C_4	98	103	PF02991	0.300
LIG_LIR_Nem_3	145	151	PF02991	0.316
LIG_LIR_Nem_3	234	239	PF02991	0.267
LIG_LIR_Nem_3	329	335	PF02991	0.359
LIG_LIR_Nem_3	366	372	PF02991	0.294
LIG_LIR_Nem_3	79	83	PF02991	0.558
LIG_NRBOX	89	95	PF00104	0.333
LIG_Pex14_1	337	341	PF04695	0.349
LIG_PTB_Apo_2	281	288	PF02174	0.185
LIG_SH2_GRB2like	161	164	PF00017	0.365
LIG_SH2_GRB2like	341	344	PF00017	0.358
LIG_SH2_NCK_1	308	312	PF00017	0.352
LIG_SH2_NCK_1	378	382	PF00017	0.294
LIG_SH2_SRC	378	381	PF00017	0.302
LIG_SH2_STAP1	210	214	PF00017	0.220
LIG_SH2_STAP1	344	348	PF00017	0.320
LIG_SH2_STAP1	62	66	PF00017	0.653
LIG_SH2_STAT5	104	107	PF00017	0.303
LIG_SH2_STAT5	308	311	PF00017	0.555
LIG_SH2_STAT5	326	329	PF00017	0.394
LIG_SH2_STAT5	363	366	PF00017	0.391
LIG_SH3_3	177	183	PF00018	0.421
LIG_SH3_3	26	32	PF00018	0.657
LIG_SH3_3	293	299	PF00018	0.236
LIG_SH3_3	332	338	PF00018	0.282
LIG_SUMO_SIM_par_1	347	355	PF11976	0.306
LIG_TYR_ITIM	102	107	PF00017	0.474
LIG_WRC_WIRS_1	107	112	PF05994	0.351
MOD_CK1_1	122	128	PF00069	0.452
MOD_CK1_1	185	191	PF00069	0.307
MOD_CK1_1	238	244	PF00069	0.238
MOD_CK1_1	3	9	PF00069	0.729
MOD_CK1_1	30	36	PF00069	0.722
MOD_CK1_1	51	57	PF00069	0.657
MOD_CK2_1	118	124	PF00069	0.511
MOD_CK2_1	168	174	PF00069	0.247
MOD_CK2_1	306	312	PF00069	0.378
MOD_DYRK1A_RPxSP_1	27	31	PF00069	0.596
MOD_GlcNHglycan	121	124	PF01048	0.724
MOD_GlcNHglycan	266	269	PF01048	0.467
MOD_GlcNHglycan	32	35	PF01048	0.578
MOD_GlcNHglycan	354	357	PF01048	0.527
MOD_GlcNHglycan	40	43	PF01048	0.455
MOD_GlcNHglycan	7	10	PF01048	0.567
MOD_GSK3_1	102	109	PF00069	0.645
MOD_GSK3_1	118	125	PF00069	0.506
MOD_GSK3_1	159	166	PF00069	0.362
MOD_GSK3_1	30	37	PF00069	0.697
MOD_GSK3_1	361	368	PF00069	0.424
MOD_N-GLC_1	246	251	PF02516	0.506
MOD_N-GLC_1	304	309	PF02516	0.588
MOD_N-GLC_1	342	347	PF02516	0.546
MOD_N-GLC_2	167	169	PF02516	0.457
MOD_NEK2_1	159	164	PF00069	0.334
MOD_NEK2_1	225	230	PF00069	0.258
MOD_NEK2_1	38	43	PF00069	0.701
MOD_OFUCOSY	164	169	PF10250	0.531
MOD_PIKK_1	125	131	PF00454	0.386
MOD_PKA_1	48	54	PF00069	0.637
MOD_PKA_2	185	191	PF00069	0.422
MOD_PKA_2	278	284	PF00069	0.390
MOD_PKA_2	3	9	PF00069	0.656
MOD_PKA_2	76	82	PF00069	0.574
MOD_Plk_1	304	310	PF00069	0.466
MOD_Plk_1	365	371	PF00069	0.383
MOD_Plk_2-3	306	312	PF00069	0.353
MOD_Plk_4	225	231	PF00069	0.339
MOD_Plk_4	240	246	PF00069	0.295
MOD_Plk_4	34	40	PF00069	0.594
MOD_Plk_4	85	91	PF00069	0.409
MOD_ProDKin_1	219	225	PF00069	0.269
MOD_ProDKin_1	25	31	PF00069	0.647
MOD_ProDKin_1	83	89	PF00069	0.498
MOD_SUMO_rev_2	241	250	PF00179	0.277
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.298
TRG_ENDOCYTIC_2	104	107	PF00928	0.468
TRG_ENDOCYTIC_2	214	217	PF00928	0.276
TRG_ENDOCYTIC_2	378	381	PF00928	0.372
TRG_ENDOCYTIC_2	80	83	PF00928	0.665
TRG_ER_diArg_1	1	4	PF00400	0.751
TRG_ER_diArg_1	212	214	PF00400	0.253
TRG_ER_diArg_1	318	321	PF00400	0.403
TRG_ER_diArg_1	64	67	PF00400	0.705
TRG_ER_diArg_1	76	78	PF00400	0.669

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB04	Leptomonas seymouri	57%	100%
A0A1X0NR96	Trypanosomatidae	43%	100%
A0A3S5IRC8	Trypanosoma rangeli	40%	100%
A0A3S7WZA9	Leishmania donovani	29%	100%
A0A3S7X774	Leishmania donovani	68%	95%
A0A422NKH5	Trypanosoma rangeli	30%	100%
A4HLZ4	Leishmania braziliensis	39%	100%
A4I1M7	Leishmania infantum	29%	100%
A4I9C6	Leishmania infantum	68%	95%
C9ZJ94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AXR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B4C6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	99%
Q4Q3Q0	Leishmania major	69%	100%
Q4Q9R0	Leishmania major	29%	100%
V5BF57	Trypanosoma cruzi	31%	100%