Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HLZ5_LEIBR

TriTrypDb:

LbrM.33.3120 , LBRM2903_330039200

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 1
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HLZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLZ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.461
CLV_C14_Caspase3-7	192	196	PF00656	0.411
CLV_C14_Caspase3-7	87	91	PF00656	0.464
CLV_NRD_NRD_1	329	331	PF00675	0.547
CLV_PCSK_SKI1_1	260	264	PF00082	0.450
DEG_SCF_FBW7_2	384	389	PF00400	0.638
DEG_SCF_TRCP1_1	282	288	PF00400	0.635
DEG_SPOP_SBC_1	105	109	PF00917	0.478
DEG_SPOP_SBC_1	135	139	PF00917	0.548
DEG_SPOP_SBC_1	177	181	PF00917	0.453
DEG_SPOP_SBC_1	347	351	PF00917	0.655
DOC_CKS1_1	377	382	PF01111	0.644
DOC_MAPK_MEF2A_6	234	243	PF00069	0.646
DOC_USP7_MATH_1	105	109	PF00917	0.620
DOC_USP7_MATH_1	127	131	PF00917	0.535
DOC_USP7_MATH_1	135	139	PF00917	0.531
DOC_USP7_MATH_1	186	190	PF00917	0.460
DOC_USP7_MATH_1	285	289	PF00917	0.707
DOC_USP7_MATH_1	303	307	PF00917	0.606
DOC_USP7_MATH_1	61	65	PF00917	0.459
DOC_USP7_UBL2_3	323	327	PF12436	0.716
DOC_WW_Pin1_4	173	178	PF00397	0.494
DOC_WW_Pin1_4	182	187	PF00397	0.477
DOC_WW_Pin1_4	32	37	PF00397	0.481
DOC_WW_Pin1_4	341	346	PF00397	0.738
DOC_WW_Pin1_4	357	362	PF00397	0.613
DOC_WW_Pin1_4	376	381	PF00397	0.659
DOC_WW_Pin1_4	382	387	PF00397	0.667
LIG_14-3-3_CanoR_1	15	19	PF00244	0.345
LIG_14-3-3_CanoR_1	334	342	PF00244	0.659
LIG_14-3-3_CanoR_1	370	374	PF00244	0.655
LIG_14-3-3_CanoR_1	51	60	PF00244	0.422
LIG_14-3-3_CanoR_1	7	14	PF00244	0.669
LIG_APCC_ABBAyCdc20_2	74	80	PF00400	0.455
LIG_BRCT_BRCA1_1	287	291	PF00533	0.692
LIG_BRCT_BRCA1_1	305	309	PF00533	0.613
LIG_deltaCOP1_diTrp_1	389	394	PF00928	0.827
LIG_FHA_1	14	20	PF00498	0.428
LIG_FHA_1	164	170	PF00498	0.461
LIG_FHA_1	337	343	PF00498	0.677
LIG_FHA_1	349	355	PF00498	0.638
LIG_FHA_1	372	378	PF00498	0.641
LIG_FHA_1	383	389	PF00498	0.618
LIG_FHA_2	190	196	PF00498	0.477
LIG_FHA_2	81	87	PF00498	0.520
LIG_LIR_Gen_1	150	159	PF02991	0.455
LIG_LIR_Gen_1	261	270	PF02991	0.840
LIG_LIR_Gen_1	287	297	PF02991	0.715
LIG_LIR_Nem_3	150	155	PF02991	0.457
LIG_LIR_Nem_3	287	292	PF02991	0.632
LIG_Pex14_2	205	209	PF04695	0.334
LIG_SH2_CRK	250	254	PF00017	0.754
LIG_SH2_GRB2like	250	253	PF00017	0.754
LIG_SH2_NCK_1	69	73	PF00017	0.445
LIG_SH2_STAT5	250	253	PF00017	0.754
LIG_SH2_STAT5	373	376	PF00017	0.651
LIG_SH3_3	110	116	PF00018	0.459
LIG_SH3_3	297	303	PF00018	0.635
LIG_SH3_3	339	345	PF00018	0.699
LIG_SH3_5	226	230	PF00018	0.621
LIG_Sin3_3	24	31	PF02671	0.240
LIG_SUMO_SIM_par_1	93	101	PF11976	0.457
LIG_UBA3_1	262	269	PF00899	0.746
LIG_WRC_WIRS_1	286	291	PF05994	0.635
MOD_CDK_SPK_2	382	387	PF00069	0.678
MOD_CDK_SPxK_1	32	38	PF00069	0.454
MOD_CDK_SPxxK_3	376	383	PF00069	0.695
MOD_CK1_1	109	115	PF00069	0.566
MOD_CK1_1	122	128	PF00069	0.460
MOD_CK1_1	130	136	PF00069	0.484
MOD_CK1_1	137	143	PF00069	0.531
MOD_CK1_1	144	150	PF00069	0.519
MOD_CK1_1	161	167	PF00069	0.517
MOD_CK1_1	171	177	PF00069	0.522
MOD_CK1_1	178	184	PF00069	0.459
MOD_CK1_1	189	195	PF00069	0.400
MOD_CK1_1	307	313	PF00069	0.736
MOD_CK1_1	325	331	PF00069	0.626
MOD_CK1_1	371	377	PF00069	0.641
MOD_CK1_1	88	94	PF00069	0.550
MOD_CK2_1	105	111	PF00069	0.487
MOD_CK2_1	136	142	PF00069	0.503
MOD_CK2_1	148	154	PF00069	0.530
MOD_CK2_1	80	86	PF00069	0.542
MOD_GlcNHglycan	102	105	PF01048	0.826
MOD_GlcNHglycan	129	132	PF01048	0.730
MOD_GlcNHglycan	163	166	PF01048	0.701
MOD_GlcNHglycan	216	219	PF01048	0.473
MOD_GlcNHglycan	236	239	PF01048	0.524
MOD_GlcNHglycan	276	279	PF01048	0.558
MOD_GlcNHglycan	282	285	PF01048	0.486
MOD_GlcNHglycan	306	309	PF01048	0.620
MOD_GlcNHglycan	63	66	PF01048	0.652
MOD_GSK3_1	105	112	PF00069	0.492
MOD_GSK3_1	115	122	PF00069	0.432
MOD_GSK3_1	126	133	PF00069	0.507
MOD_GSK3_1	134	141	PF00069	0.510
MOD_GSK3_1	144	151	PF00069	0.498
MOD_GSK3_1	164	171	PF00069	0.427
MOD_GSK3_1	172	179	PF00069	0.484
MOD_GSK3_1	180	187	PF00069	0.438
MOD_GSK3_1	303	310	PF00069	0.732
MOD_GSK3_1	318	325	PF00069	0.650
MOD_GSK3_1	336	343	PF00069	0.648
MOD_GSK3_1	346	353	PF00069	0.703
MOD_GSK3_1	362	369	PF00069	0.644
MOD_GSK3_1	371	378	PF00069	0.657
MOD_GSK3_1	80	87	PF00069	0.561
MOD_GSK3_1	88	95	PF00069	0.589
MOD_GSK3_1	96	103	PF00069	0.558
MOD_N-GLC_1	135	140	PF02516	0.665
MOD_N-GLC_1	161	166	PF02516	0.682
MOD_N-GLC_1	51	56	PF02516	0.620
MOD_NEK2_1	274	279	PF00069	0.665
MOD_NEK2_1	304	309	PF00069	0.734
MOD_NEK2_1	322	327	PF00069	0.627
MOD_NEK2_1	362	367	PF00069	0.726
MOD_PIKK_1	130	136	PF00454	0.488
MOD_PIKK_1	2	8	PF00454	0.676
MOD_PIKK_1	268	274	PF00454	0.648
MOD_PIKK_1	80	86	PF00454	0.503
MOD_PIKK_1	98	104	PF00454	0.420
MOD_PKA_2	14	20	PF00069	0.511
MOD_PKA_2	274	280	PF00069	0.694
MOD_PKA_2	369	375	PF00069	0.717
MOD_PKB_1	49	57	PF00069	0.421
MOD_Plk_4	14	20	PF00069	0.611
MOD_Plk_4	196	202	PF00069	0.384
MOD_ProDKin_1	173	179	PF00069	0.494
MOD_ProDKin_1	182	188	PF00069	0.476
MOD_ProDKin_1	32	38	PF00069	0.489
MOD_ProDKin_1	341	347	PF00069	0.737
MOD_ProDKin_1	357	363	PF00069	0.613
MOD_ProDKin_1	376	382	PF00069	0.658
MOD_SUMO_rev_2	189	199	PF00179	0.415
TRG_ENDOCYTIC_2	250	253	PF00928	0.754
TRG_ENDOCYTIC_2	301	304	PF00928	0.626
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.716

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IH37	Leishmania donovani	38%	84%
E9AEH4	Leishmania major	39%	98%
E9AHS1	Leishmania infantum	41%	90%