D-alanyl-glycyl endopeptidase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cysteine peptidase, Clan CA, family C51, putative

Species:

Leishmania braziliensis

UniProt:

A4HLZ4_LEIBR

TriTrypDb:

LbrM.33.3110 , LBRM2903_330039100

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 30
NetGPI	no	yes: 0, no: 30

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	23
GO:0110165	cellular anatomical entity	1	25
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

A4HLZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLZ4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016874	ligase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	193	195	PF00675	0.475
CLV_NRD_NRD_1	25	27	PF00675	0.454
CLV_NRD_NRD_1	305	307	PF00675	0.552
CLV_NRD_NRD_1	66	68	PF00675	0.417
CLV_PCSK_KEX2_1	193	195	PF00082	0.475
CLV_PCSK_KEX2_1	25	27	PF00082	0.482
CLV_PCSK_KEX2_1	305	307	PF00082	0.605
CLV_PCSK_KEX2_1	53	55	PF00082	0.455
CLV_PCSK_KEX2_1	66	68	PF00082	0.420
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.562
CLV_PCSK_SKI1_1	178	182	PF00082	0.592
CLV_PCSK_SKI1_1	44	48	PF00082	0.461
CLV_PCSK_SKI1_1	67	71	PF00082	0.376
DOC_MAPK_gen_1	155	163	PF00069	0.391
DOC_MAPK_MEF2A_6	155	163	PF00069	0.406
DOC_MAPK_MEF2A_6	81	90	PF00069	0.437
DOC_PP2B_LxvP_1	161	164	PF13499	0.246
DOC_PP2B_LxvP_1	247	250	PF13499	0.344
DOC_USP7_UBL2_3	120	124	PF12436	0.350
DOC_WW_Pin1_4	126	131	PF00397	0.339
LIG_14-3-3_CanoR_1	242	250	PF00244	0.177
LIG_14-3-3_CanoR_1	34	40	PF00244	0.650
LIG_BRCT_BRCA1_1	176	180	PF00533	0.281
LIG_deltaCOP1_diTrp_1	185	191	PF00928	0.283
LIG_deltaCOP1_diTrp_1	215	221	PF00928	0.275
LIG_deltaCOP1_diTrp_1	288	296	PF00928	0.329
LIG_eIF4E_1	156	162	PF01652	0.354
LIG_FHA_1	168	174	PF00498	0.394
LIG_FHA_1	229	235	PF00498	0.304
LIG_FHA_1	3	9	PF00498	0.750
LIG_FHA_1	313	319	PF00498	0.393
LIG_FHA_1	43	49	PF00498	0.676
LIG_FHA_1	91	97	PF00498	0.353
LIG_FHA_2	12	18	PF00498	0.559
LIG_FHA_2	180	186	PF00498	0.326
LIG_FHA_2	272	278	PF00498	0.206
LIG_FHA_2	317	323	PF00498	0.338
LIG_FHA_2	34	40	PF00498	0.670
LIG_LIR_Apic_2	293	299	PF02991	0.385
LIG_LIR_Gen_1	185	192	PF02991	0.242
LIG_LIR_Gen_1	220	225	PF02991	0.316
LIG_LIR_Gen_1	85	95	PF02991	0.238
LIG_LIR_Nem_3	129	134	PF02991	0.320
LIG_LIR_Nem_3	153	159	PF02991	0.330
LIG_LIR_Nem_3	179	184	PF02991	0.296
LIG_LIR_Nem_3	185	189	PF02991	0.297
LIG_LIR_Nem_3	220	224	PF02991	0.304
LIG_LIR_Nem_3	85	90	PF02991	0.279
LIG_LIR_Nem_3	93	97	PF02991	0.327
LIG_NRBOX	75	81	PF00104	0.655
LIG_PCNA_yPIPBox_3	324	332	PF02747	0.282
LIG_Pex14_1	217	221	PF04695	0.293
LIG_Pex14_2	100	104	PF04695	0.333
LIG_Pex14_2	191	195	PF04695	0.310
LIG_Pex14_2	87	91	PF04695	0.299
LIG_Pex3_1	76	87	PF04882	0.371
LIG_PTB_Apo_2	215	222	PF02174	0.216
LIG_PTB_Apo_2	99	106	PF02174	0.318
LIG_Rb_pABgroove_1	305	313	PF01858	0.233
LIG_REV1ctd_RIR_1	102	111	PF16727	0.303
LIG_SH2_CRK	138	142	PF00017	0.276
LIG_SH2_CRK	156	160	PF00017	0.206
LIG_SH2_CRK	77	81	PF00017	0.475
LIG_SH2_GRB2like	144	147	PF00017	0.333
LIG_SH2_GRB2like	158	161	PF00017	0.333
LIG_SH2_GRB2like	237	240	PF00017	0.224
LIG_SH2_PTP2	158	161	PF00017	0.399
LIG_SH2_STAP1	303	307	PF00017	0.322
LIG_SH2_STAT3	258	261	PF00017	0.241
LIG_SH2_STAT5	158	161	PF00017	0.362
LIG_SH2_STAT5	175	178	PF00017	0.386
LIG_SH2_STAT5	206	209	PF00017	0.310
LIG_SH2_STAT5	285	288	PF00017	0.309
LIG_TYR_ITIM	75	80	PF00017	0.612
LIG_TYR_ITSM	152	159	PF00017	0.334
LIG_UBA3_1	75	81	PF00899	0.656
LIG_WRC_WIRS_1	91	96	PF05994	0.353
MOD_CK1_1	10	16	PF00069	0.721
MOD_CK1_1	179	185	PF00069	0.204
MOD_CK1_1	226	232	PF00069	0.328
MOD_CK1_1	316	322	PF00069	0.259
MOD_CK2_1	179	185	PF00069	0.269
MOD_CK2_1	33	39	PF00069	0.660
MOD_GlcNHglycan	198	201	PF01048	0.515
MOD_GlcNHglycan	228	231	PF01048	0.540
MOD_GlcNHglycan	292	295	PF01048	0.480
MOD_GlcNHglycan	56	59	PF01048	0.488
MOD_GlcNHglycan	9	12	PF01048	0.524
MOD_GSK3_1	110	117	PF00069	0.504
MOD_GSK3_1	2	9	PF00069	0.625
MOD_GSK3_1	312	319	PF00069	0.386
MOD_N-GLC_1	113	118	PF02516	0.752
MOD_N-GLC_1	167	172	PF02516	0.625
MOD_N-GLC_1	217	222	PF02516	0.552
MOD_N-GLC_1	226	231	PF02516	0.525
MOD_N-GLC_1	301	306	PF02516	0.536
MOD_N-GLC_1	34	39	PF02516	0.521
MOD_NEK2_1	142	147	PF00069	0.313
MOD_NEK2_1	313	318	PF00069	0.356
MOD_NEK2_1	7	12	PF00069	0.740
MOD_NEK2_1	90	95	PF00069	0.362
MOD_NEK2_2	82	87	PF00069	0.487
MOD_PKA_2	21	27	PF00069	0.709
MOD_PKA_2	241	247	PF00069	0.186
MOD_PKA_2	33	39	PF00069	0.781
MOD_Plk_1	217	223	PF00069	0.327
MOD_Plk_1	42	48	PF00069	0.741
MOD_Plk_4	176	182	PF00069	0.330
MOD_Plk_4	206	212	PF00069	0.318
MOD_Plk_4	217	223	PF00069	0.336
MOD_Plk_4	82	88	PF00069	0.416
MOD_Plk_4	90	96	PF00069	0.367
MOD_ProDKin_1	126	132	PF00069	0.336
MOD_SUMO_for_1	123	126	PF00179	0.300
TRG_DiLeu_BaEn_2	42	48	PF01217	0.565
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.618
TRG_ENDOCYTIC_2	138	141	PF00928	0.258
TRG_ENDOCYTIC_2	156	159	PF00928	0.317
TRG_ENDOCYTIC_2	267	270	PF00928	0.330
TRG_ENDOCYTIC_2	77	80	PF00928	0.545
TRG_ER_diArg_1	193	195	PF00400	0.275
TRG_ER_diArg_1	25	27	PF00400	0.581
TRG_ER_diArg_1	305	307	PF00400	0.403
TRG_ER_diArg_1	65	67	PF00400	0.714
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I309	Leptomonas seymouri	27%	100%
A0A0N1I7J8	Leptomonas seymouri	54%	84%
A0A0N1PB04	Leptomonas seymouri	45%	94%
A0A1X0NR98	Trypanosomatidae	44%	100%
A0A1X0NRB4	Trypanosomatidae	31%	98%
A0A1X0NYK9	Trypanosomatidae	24%	100%
A0A3R7KMG1	Trypanosoma rangeli	25%	100%
A0A3R7LYQ4	Trypanosoma rangeli	39%	100%
A0A3S7WZA9	Leishmania donovani	28%	100%
A0A3S7X769	Leishmania donovani	64%	100%
A0A3S7X774	Leishmania donovani	38%	83%
A0A422NKH5	Trypanosoma rangeli	30%	100%
A4HEJ1	Leishmania braziliensis	28%	100%
A4HLZ6	Leishmania braziliensis	39%	87%
A4HLZ7	Leishmania braziliensis	26%	71%
A4I1M7	Leishmania infantum	28%	100%
A4I9C4	Leishmania infantum	60%	91%
A4I9C6	Leishmania infantum	38%	83%
C9ZJ94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZJ95	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AXR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B4C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
E9B4C6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	87%
Q4Q3Q0	Leishmania major	34%	79%
Q4Q3Q2	Leishmania major	66%	100%
Q4Q9R0	Leishmania major	30%	100%
V5BF57	Trypanosoma cruzi	30%	100%
V5DB66	Trypanosoma cruzi	42%	100%
V5DIU8	Trypanosoma cruzi	25%	100%