PWWP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PWWP domain/TFIIS helical bundle-like domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HLZ3_LEIBR

TriTrypDb:

LbrM.33.3100 , LBRM2903_330039000

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HLZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLZ3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006351	DNA-templated transcription	7	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009058	biosynthetic process	2	3
GO:0009059	macromolecule biosynthetic process	4	3
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	3
GO:0018130	heterocycle biosynthetic process	4	3
GO:0019438	aromatic compound biosynthetic process	4	3
GO:0032774	RNA biosynthetic process	5	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0034654	nucleobase-containing compound biosynthetic process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044271	cellular nitrogen compound biosynthetic process	4	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:0097659	nucleic acid-templated transcription	6	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:1901362	organic cyclic compound biosynthetic process	4	3
GO:1901576	organic substance biosynthetic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0005488	binding	1	2
GO:0008270	zinc ion binding	6	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.434
CLV_C14_Caspase3-7	394	398	PF00656	0.586
CLV_C14_Caspase3-7	420	424	PF00656	0.400
CLV_NRD_NRD_1	190	192	PF00675	0.645
CLV_NRD_NRD_1	202	204	PF00675	0.584
CLV_NRD_NRD_1	278	280	PF00675	0.545
CLV_NRD_NRD_1	285	287	PF00675	0.487
CLV_NRD_NRD_1	325	327	PF00675	0.301
CLV_NRD_NRD_1	468	470	PF00675	0.373
CLV_NRD_NRD_1	494	496	PF00675	0.486
CLV_PCSK_FUR_1	200	204	PF00082	0.533
CLV_PCSK_KEX2_1	160	162	PF00082	0.600
CLV_PCSK_KEX2_1	171	173	PF00082	0.603
CLV_PCSK_KEX2_1	200	202	PF00082	0.645
CLV_PCSK_KEX2_1	285	287	PF00082	0.498
CLV_PCSK_KEX2_1	468	470	PF00082	0.373
CLV_PCSK_KEX2_1	493	495	PF00082	0.481
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.611
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.589
CLV_PCSK_SKI1_1	245	249	PF00082	0.533
CLV_PCSK_SKI1_1	326	330	PF00082	0.364
CLV_PCSK_SKI1_1	352	356	PF00082	0.315
CLV_PCSK_SKI1_1	468	472	PF00082	0.443
DEG_SCF_FBW7_1	113	120	PF00400	0.695
DOC_CKS1_1	114	119	PF01111	0.619
DOC_CYCLIN_RxL_1	465	473	PF00134	0.414
DOC_MAPK_DCC_7	494	504	PF00069	0.441
DOC_MAPK_gen_1	326	335	PF00069	0.540
DOC_MAPK_HePTP_8	492	504	PF00069	0.424
DOC_MAPK_MEF2A_6	326	335	PF00069	0.547
DOC_MAPK_MEF2A_6	352	361	PF00069	0.540
DOC_MAPK_MEF2A_6	495	504	PF00069	0.449
DOC_PP4_FxxP_1	354	357	PF00568	0.513
DOC_PP4_FxxP_1	534	537	PF00568	0.655
DOC_USP7_MATH_1	10	14	PF00917	0.461
DOC_USP7_MATH_1	117	121	PF00917	0.740
DOC_USP7_MATH_1	237	241	PF00917	0.604
DOC_USP7_MATH_1	284	288	PF00917	0.485
DOC_USP7_MATH_1	3	7	PF00917	0.609
DOC_USP7_MATH_1	40	44	PF00917	0.506
DOC_USP7_MATH_1	51	55	PF00917	0.451
DOC_USP7_MATH_1	556	560	PF00917	0.495
DOC_USP7_MATH_1	83	87	PF00917	0.495
DOC_USP7_MATH_1	99	103	PF00917	0.546
DOC_USP7_UBL2_3	160	164	PF12436	0.601
DOC_USP7_UBL2_3	166	170	PF12436	0.597
DOC_WW_Pin1_4	113	118	PF00397	0.732
DOC_WW_Pin1_4	266	271	PF00397	0.644
DOC_WW_Pin1_4	505	510	PF00397	0.637
DOC_WW_Pin1_4	516	521	PF00397	0.620
DOC_WW_Pin1_4	528	533	PF00397	0.529
LIG_14-3-3_CanoR_1	285	293	PF00244	0.434
LIG_14-3-3_CanoR_1	352	357	PF00244	0.448
LIG_14-3-3_CanoR_1	540	549	PF00244	0.542
LIG_Actin_WH2_2	314	331	PF00022	0.505
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_BIR_III_2	105	109	PF00653	0.647
LIG_BRCT_BRCA1_1	530	534	PF00533	0.688
LIG_CSL_BTD_1	23	26	PF09270	0.448
LIG_FHA_1	295	301	PF00498	0.457
LIG_FHA_1	317	323	PF00498	0.415
LIG_FHA_1	353	359	PF00498	0.516
LIG_FHA_1	540	546	PF00498	0.547
LIG_FHA_1	579	585	PF00498	0.439
LIG_FHA_2	217	223	PF00498	0.600
LIG_FHA_2	262	268	PF00498	0.668
LIG_FHA_2	3	9	PF00498	0.532
LIG_FHA_2	311	317	PF00498	0.457
LIG_FHA_2	33	39	PF00498	0.393
LIG_FHA_2	392	398	PF00498	0.584
LIG_FHA_2	415	421	PF00498	0.431
LIG_FHA_2	434	440	PF00498	0.416
LIG_FHA_2	508	514	PF00498	0.628
LIG_GSK3_LRP6_1	113	119	PF00069	0.542
LIG_LIR_Apic_2	353	357	PF02991	0.393
LIG_LIR_Apic_2	531	537	PF02991	0.620
LIG_LIR_Apic_2	543	549	PF02991	0.376
LIG_LIR_Gen_1	13	22	PF02991	0.545
LIG_LIR_Gen_1	136	144	PF02991	0.689
LIG_LIR_Gen_1	228	238	PF02991	0.503
LIG_LIR_Nem_3	13	17	PF02991	0.545
LIG_LIR_Nem_3	136	142	PF02991	0.691
LIG_LIR_Nem_3	228	234	PF02991	0.509
LIG_NRBOX	466	472	PF00104	0.424
LIG_PALB2_WD40_1	365	373	PF16756	0.448
LIG_PTB_Apo_2	364	371	PF02174	0.516
LIG_SH2_CRK	278	282	PF00017	0.586
LIG_SH2_CRK	546	550	PF00017	0.457
LIG_SH2_STAP1	561	565	PF00017	0.506
LIG_SH2_STAT3	249	252	PF00017	0.602
LIG_SH2_STAT3	561	564	PF00017	0.548
LIG_SH2_STAT5	477	480	PF00017	0.560
LIG_SH3_3	111	117	PF00018	0.663
LIG_SH3_3	147	153	PF00018	0.527
LIG_SH3_3	20	26	PF00018	0.462
LIG_SH3_3	517	523	PF00018	0.612
LIG_SUMO_SIM_anti_2	41	49	PF11976	0.520
LIG_SUMO_SIM_anti_2	427	432	PF11976	0.402
LIG_SUMO_SIM_par_1	450	455	PF11976	0.398
LIG_TRAF2_1	108	111	PF00917	0.650
LIG_TRAF2_1	209	212	PF00917	0.597
LIG_TRAF2_1	417	420	PF00917	0.403
LIG_TRAF2_1	93	96	PF00917	0.473
LIG_TRFH_1	258	262	PF08558	0.614
LIG_UBA3_1	321	329	PF00899	0.348
LIG_WRC_WIRS_1	351	356	PF05994	0.419
MOD_CDK_SPK_2	266	271	PF00069	0.620
MOD_CDK_SPxxK_3	533	540	PF00069	0.613
MOD_CK1_1	120	126	PF00069	0.667
MOD_CK1_1	2	8	PF00069	0.561
MOD_CK1_1	239	245	PF00069	0.557
MOD_CK1_1	287	293	PF00069	0.402
MOD_CK1_1	391	397	PF00069	0.556
MOD_CK1_1	424	430	PF00069	0.531
MOD_CK1_1	508	514	PF00069	0.593
MOD_CK1_1	519	525	PF00069	0.646
MOD_CK1_1	528	534	PF00069	0.689
MOD_CK1_1	559	565	PF00069	0.653
MOD_CK1_1	86	92	PF00069	0.495
MOD_CK2_1	206	212	PF00069	0.711
MOD_CK2_1	250	256	PF00069	0.577
MOD_CK2_1	286	292	PF00069	0.505
MOD_CK2_1	312	318	PF00069	0.320
MOD_CK2_1	414	420	PF00069	0.423
MOD_GlcNHglycan	1	4	PF01048	0.648
MOD_GlcNHglycan	102	105	PF01048	0.631
MOD_GlcNHglycan	119	122	PF01048	0.777
MOD_GlcNHglycan	221	226	PF01048	0.723
MOD_GlcNHglycan	241	244	PF01048	0.547
MOD_GlcNHglycan	282	285	PF01048	0.611
MOD_GlcNHglycan	286	289	PF01048	0.540
MOD_GlcNHglycan	308	311	PF01048	0.579
MOD_GlcNHglycan	381	384	PF01048	0.563
MOD_GlcNHglycan	454	457	PF01048	0.402
MOD_GlcNHglycan	5	8	PF01048	0.552
MOD_GlcNHglycan	525	530	PF01048	0.536
MOD_GlcNHglycan	53	56	PF01048	0.317
MOD_GlcNHglycan	61	64	PF01048	0.318
MOD_GSK3_1	112	119	PF00069	0.673
MOD_GSK3_1	202	209	PF00069	0.593
MOD_GSK3_1	232	239	PF00069	0.768
MOD_GSK3_1	280	287	PF00069	0.537
MOD_GSK3_1	288	295	PF00069	0.635
MOD_GSK3_1	302	309	PF00069	0.448
MOD_GSK3_1	312	319	PF00069	0.406
MOD_GSK3_1	369	376	PF00069	0.387
MOD_GSK3_1	49	56	PF00069	0.448
MOD_GSK3_1	503	510	PF00069	0.627
MOD_GSK3_1	512	519	PF00069	0.758
MOD_GSK3_1	540	547	PF00069	0.458
MOD_N-GLC_1	331	336	PF02516	0.193
MOD_N-GLC_1	421	426	PF02516	0.402
MOD_NEK2_1	1	6	PF00069	0.582
MOD_NEK2_1	338	343	PF00069	0.508
MOD_NEK2_1	350	355	PF00069	0.508
MOD_NEK2_1	452	457	PF00069	0.466
MOD_NEK2_1	59	64	PF00069	0.418
MOD_OFUCOSY	390	395	PF10250	0.576
MOD_PIKK_1	294	300	PF00454	0.458
MOD_PIKK_1	302	308	PF00454	0.393
MOD_PIKK_1	333	339	PF00454	0.414
MOD_PIKK_1	508	514	PF00454	0.601
MOD_PKA_1	202	208	PF00069	0.535
MOD_PKA_2	202	208	PF00069	0.670
MOD_PKA_2	232	238	PF00069	0.753
MOD_PKA_2	250	256	PF00069	0.594
MOD_PKA_2	284	290	PF00069	0.457
MOD_PKA_2	388	394	PF00069	0.570
MOD_PKA_2	539	545	PF00069	0.526
MOD_PKB_1	200	208	PF00069	0.534
MOD_Plk_1	135	141	PF00069	0.549
MOD_Plk_1	331	337	PF00069	0.481
MOD_Plk_1	421	427	PF00069	0.507
MOD_Plk_1	578	584	PF00069	0.327
MOD_Plk_2-3	206	212	PF00069	0.607
MOD_Plk_2-3	388	394	PF00069	0.601
MOD_Plk_4	10	16	PF00069	0.292
MOD_Plk_4	487	493	PF00069	0.321
MOD_Plk_4	53	59	PF00069	0.596
MOD_ProDKin_1	113	119	PF00069	0.733
MOD_ProDKin_1	266	272	PF00069	0.643
MOD_ProDKin_1	505	511	PF00069	0.637
MOD_ProDKin_1	516	522	PF00069	0.617
MOD_ProDKin_1	528	534	PF00069	0.574
MOD_SUMO_for_1	247	250	PF00179	0.596
TRG_DiLeu_BaEn_1	76	81	PF01217	0.448
TRG_DiLeu_BaEn_2	298	304	PF01217	0.454
TRG_DiLeu_BaLyEn_6	466	471	PF01217	0.426
TRG_ENDOCYTIC_2	278	281	PF00928	0.630
TRG_ER_diArg_1	200	203	PF00400	0.654
TRG_ER_diArg_1	467	469	PF00400	0.393
TRG_ER_diArg_1	492	495	PF00400	0.480
TRG_NLS_Bipartite_1	160	175	PF00514	0.625
TRG_NLS_MonoCore_2	168	173	PF00514	0.574
TRG_NLS_MonoExtC_3	169	174	PF00514	0.587
TRG_NLS_MonoExtC_3	244	250	PF00514	0.617
TRG_NLS_MonoExtN_4	166	173	PF00514	0.683
TRG_Pf-PMV_PEXEL_1	468	473	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5Y6	Leptomonas seymouri	49%	100%
A0A1X0NRB1	Trypanosomatidae	31%	100%
A0A3Q8IKG6	Leishmania donovani	78%	99%
A0A422NKE1	Trypanosoma rangeli	31%	100%
A4I9C3	Leishmania infantum	78%	99%
E9B4C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%
Q4Q3Q3	Leishmania major	78%	100%