Transcription elongation factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription elongation factor-like protein

Species:

Leishmania braziliensis

UniProt:

A4HLZ2_LEIBR

TriTrypDb:

LbrM.33.3090 , LBRM2903_330038900

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005654	nucleoplasm	2	1

Expansion

Sequence features

A4HLZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLZ2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006351	DNA-templated transcription	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0032774	RNA biosynthetic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:0097659	nucleic acid-templated transcription	6	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003746	translation elongation factor activity	4	11
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0008270	zinc ion binding	6	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.746
CLV_C14_Caspase3-7	421	425	PF00656	0.427
CLV_C14_Caspase3-7	58	62	PF00656	0.468
CLV_NRD_NRD_1	170	172	PF00675	0.292
CLV_NRD_NRD_1	350	352	PF00675	0.435
CLV_PCSK_KEX2_1	132	134	PF00082	0.537
CLV_PCSK_KEX2_1	441	443	PF00082	0.336
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.551
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.336
CLV_PCSK_PC7_1	128	134	PF00082	0.568
CLV_PCSK_SKI1_1	186	190	PF00082	0.469
CLV_PCSK_SKI1_1	363	367	PF00082	0.392
CLV_PCSK_SKI1_1	460	464	PF00082	0.258
CLV_PCSK_SKI1_1	74	78	PF00082	0.464
DEG_APCC_DBOX_1	185	193	PF00400	0.355
DEG_Nend_UBRbox_2	1	3	PF02207	0.519
DEG_SCF_SKP2-CKS1_1	384	391	PF00560	0.502
DEG_SCF_TRCP1_1	312	318	PF00400	0.431
DEG_SPOP_SBC_1	289	293	PF00917	0.587
DOC_ANK_TNKS_1	134	141	PF00023	0.458
DOC_MAPK_gen_1	360	370	PF00069	0.497
DOC_MAPK_MEF2A_6	191	199	PF00069	0.354
DOC_MAPK_MEF2A_6	33	41	PF00069	0.322
DOC_MAPK_MEF2A_6	363	370	PF00069	0.477
DOC_MAPK_NFAT4_5	363	371	PF00069	0.401
DOC_PP1_RVXF_1	250	257	PF00149	0.380
DOC_PP1_RVXF_1	277	283	PF00149	0.448
DOC_PP4_FxxP_1	282	285	PF00568	0.440
DOC_USP7_MATH_1	112	116	PF00917	0.693
DOC_USP7_MATH_1	149	153	PF00917	0.649
DOC_USP7_MATH_1	210	214	PF00917	0.351
DOC_USP7_MATH_1	229	233	PF00917	0.382
DOC_USP7_MATH_1	245	249	PF00917	0.587
DOC_USP7_MATH_1	263	267	PF00917	0.431
DOC_USP7_MATH_1	285	289	PF00917	0.613
DOC_USP7_MATH_1	307	311	PF00917	0.495
DOC_USP7_MATH_1	97	101	PF00917	0.537
DOC_USP7_UBL2_3	348	352	PF12436	0.270
DOC_WW_Pin1_4	269	274	PF00397	0.572
DOC_WW_Pin1_4	292	297	PF00397	0.647
DOC_WW_Pin1_4	31	36	PF00397	0.594
DOC_WW_Pin1_4	315	320	PF00397	0.447
DOC_WW_Pin1_4	331	336	PF00397	0.405
DOC_WW_Pin1_4	385	390	PF00397	0.448
LIG_14-3-3_CanoR_1	228	234	PF00244	0.377
LIG_14-3-3_CanoR_1	23	30	PF00244	0.401
LIG_14-3-3_CanoR_1	252	257	PF00244	0.539
LIG_14-3-3_CanoR_1	279	283	PF00244	0.446
LIG_14-3-3_CanoR_1	442	447	PF00244	0.305
LIG_APCC_ABBA_1	10	15	PF00400	0.485
LIG_APCC_ABBAyCdc20_2	9	15	PF00400	0.483
LIG_FHA_1	289	295	PF00498	0.614
LIG_FHA_1	32	38	PF00498	0.508
LIG_FHA_1	457	463	PF00498	0.258
LIG_FHA_2	198	204	PF00498	0.510
LIG_FHA_2	321	327	PF00498	0.541
LIG_FHA_2	356	362	PF00498	0.429
LIG_FHA_2	400	406	PF00498	0.437
LIG_FHA_2	443	449	PF00498	0.388
LIG_FHA_2	461	467	PF00498	0.121
LIG_FHA_2	50	56	PF00498	0.525
LIG_FHA_2	68	74	PF00498	0.322
LIG_LIR_Apic_2	281	285	PF02991	0.439
LIG_LIR_Gen_1	156	166	PF02991	0.474
LIG_LIR_Gen_1	323	332	PF02991	0.405
LIG_LIR_Gen_1	8	17	PF02991	0.377
LIG_LIR_Nem_3	156	161	PF02991	0.610
LIG_LIR_Nem_3	255	259	PF02991	0.568
LIG_LIR_Nem_3	323	328	PF02991	0.405
LIG_LIR_Nem_3	8	14	PF02991	0.357
LIG_SH2_CRK	325	329	PF00017	0.403
LIG_SH2_GRB2like	325	328	PF00017	0.401
LIG_SH2_NCK_1	325	329	PF00017	0.403
LIG_SH2_SRC	13	16	PF00017	0.539
LIG_SH2_SRC	325	328	PF00017	0.544
LIG_SH2_SRC	341	344	PF00017	0.399
LIG_SH2_SRC	4	7	PF00017	0.504
LIG_SH2_STAP1	325	329	PF00017	0.546
LIG_SH2_STAP1	341	345	PF00017	0.394
LIG_SH2_STAT3	392	395	PF00017	0.499
LIG_SH2_STAT3	447	450	PF00017	0.305
LIG_SH2_STAT5	13	16	PF00017	0.541
LIG_SH2_STAT5	198	201	PF00017	0.509
LIG_SH2_STAT5	392	395	PF00017	0.499
LIG_SH2_STAT5	461	464	PF00017	0.328
LIG_SH3_3	219	225	PF00018	0.521
LIG_SH3_3	313	319	PF00018	0.523
LIG_SH3_3	44	50	PF00018	0.462
LIG_TRAF2_1	26	29	PF00917	0.497
LIG_TRAF2_1	407	410	PF00917	0.506
LIG_TYR_ITSM	321	328	PF00017	0.431
LIG_WRC_WIRS_1	230	235	PF05994	0.488
MOD_CDK_SPK_2	385	390	PF00069	0.499
MOD_CDK_SPxK_1	385	391	PF00069	0.500
MOD_CDK_SPxxK_3	269	276	PF00069	0.695
MOD_CDK_SPxxK_3	315	322	PF00069	0.406
MOD_CK1_1	141	147	PF00069	0.500
MOD_CK1_1	213	219	PF00069	0.555
MOD_CK1_1	288	294	PF00069	0.593
MOD_CK1_1	297	303	PF00069	0.576
MOD_CK1_1	310	316	PF00069	0.445
MOD_CK1_1	334	340	PF00069	0.548
MOD_CK2_1	197	203	PF00069	0.501
MOD_CK2_1	213	219	PF00069	0.501
MOD_CK2_1	23	29	PF00069	0.403
MOD_CK2_1	399	405	PF00069	0.461
MOD_CK2_1	442	448	PF00069	0.252
MOD_CK2_1	450	456	PF00069	0.235
MOD_CK2_1	49	55	PF00069	0.464
MOD_CK2_1	67	73	PF00069	0.323
MOD_Cter_Amidation	439	442	PF01082	0.326
MOD_GlcNHglycan	114	117	PF01048	0.633
MOD_GlcNHglycan	155	158	PF01048	0.672
MOD_GlcNHglycan	174	177	PF01048	0.475
MOD_GlcNHglycan	261	264	PF01048	0.593
MOD_GlcNHglycan	265	268	PF01048	0.586
MOD_GlcNHglycan	287	290	PF01048	0.587
MOD_GlcNHglycan	312	315	PF01048	0.700
MOD_GlcNHglycan	383	386	PF01048	0.394
MOD_GlcNHglycan	452	455	PF01048	0.268
MOD_GlcNHglycan	89	92	PF01048	0.470
MOD_GlcNHglycan	99	102	PF01048	0.562
MOD_GSK3_1	134	141	PF00069	0.576
MOD_GSK3_1	149	156	PF00069	0.616
MOD_GSK3_1	167	174	PF00069	0.505
MOD_GSK3_1	259	266	PF00069	0.505
MOD_GSK3_1	285	292	PF00069	0.577
MOD_GSK3_1	294	301	PF00069	0.542
MOD_GSK3_1	331	338	PF00069	0.343
MOD_GSK3_1	381	388	PF00069	0.361
MOD_GSK3_1	456	463	PF00069	0.275
MOD_N-GLC_1	428	433	PF02516	0.404
MOD_N-GLC_2	64	66	PF02516	0.426
MOD_NEK2_1	202	207	PF00069	0.345
MOD_NEK2_1	290	295	PF00069	0.594
MOD_NEK2_1	428	433	PF00069	0.438
MOD_NEK2_1	67	72	PF00069	0.436
MOD_NEK2_1	82	87	PF00069	0.424
MOD_NEK2_2	335	340	PF00069	0.457
MOD_PIKK_1	213	219	PF00454	0.565
MOD_PIKK_1	265	271	PF00454	0.541
MOD_PK_1	191	197	PF00069	0.428
MOD_PKA_1	171	177	PF00069	0.279
MOD_PKA_2	134	140	PF00069	0.525
MOD_PKA_2	278	284	PF00069	0.566
MOD_Plk_1	373	379	PF00069	0.394
MOD_Plk_1	428	434	PF00069	0.387
MOD_Plk_1	82	88	PF00069	0.509
MOD_Plk_4	210	216	PF00069	0.368
MOD_Plk_4	229	235	PF00069	0.378
MOD_Plk_4	320	326	PF00069	0.505
MOD_Plk_4	373	379	PF00069	0.394
MOD_Plk_4	442	448	PF00069	0.261
MOD_Plk_4	467	473	PF00069	0.165
MOD_Plk_4	49	55	PF00069	0.511
MOD_ProDKin_1	269	275	PF00069	0.573
MOD_ProDKin_1	292	298	PF00069	0.646
MOD_ProDKin_1	31	37	PF00069	0.588
MOD_ProDKin_1	315	321	PF00069	0.442
MOD_ProDKin_1	331	337	PF00069	0.406
MOD_ProDKin_1	385	391	PF00069	0.449
MOD_SUMO_rev_2	201	207	PF00179	0.486
MOD_SUMO_rev_2	213	223	PF00179	0.498
TRG_DiLeu_BaEn_1	362	367	PF01217	0.405
TRG_DiLeu_BaEn_3	372	378	PF01217	0.398
TRG_DiLeu_BaEn_4	164	170	PF01217	0.496
TRG_ENDOCYTIC_2	158	161	PF00928	0.553
TRG_ENDOCYTIC_2	325	328	PF00928	0.401
TRG_ENDOCYTIC_2	329	332	PF00928	0.368
TRG_ENDOCYTIC_2	44	47	PF00928	0.484
TRG_ER_diArg_1	368	371	PF00400	0.397
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	236	241	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	351	356	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZC4	Leptomonas seymouri	59%	99%
A0A0S4JM53	Bodo saltans	25%	91%
A0A1X0NRX7	Trypanosomatidae	38%	99%
A0A3Q8IGU5	Leishmania donovani	82%	100%
A0A3R7KDK8	Trypanosoma rangeli	36%	100%
A4I9C2	Leishmania infantum	82%	100%
C9ZJ99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B4C1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q2KI09	Bos taurus	23%	100%
Q4Q3Q4	Leishmania major	81%	99%
V5BJM3	Trypanosoma cruzi	38%	99%