Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLZ1_LEIBR

TriTrypDb:

LbrM.33.3080 , LBRM2903_330038800

Length:

152

Annotations

LeishMANIAdb annotations

Probably not embedded into the membranes.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HLZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLZ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	57	61	PF00656	0.620
CLV_NRD_NRD_1	127	129	PF00675	0.584
CLV_NRD_NRD_1	37	39	PF00675	0.315
CLV_PCSK_KEX2_1	11	13	PF00082	0.367
CLV_PCSK_KEX2_1	127	129	PF00082	0.584
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.367
CLV_PCSK_SKI1_1	110	114	PF00082	0.313
DOC_PP1_RVXF_1	78	85	PF00149	0.548
DOC_WW_Pin1_4	132	137	PF00397	0.401
LIG_14-3-3_CanoR_1	110	119	PF00244	0.421
LIG_14-3-3_CanoR_1	12	18	PF00244	0.664
LIG_14-3-3_CanoR_1	127	131	PF00244	0.371
LIG_14-3-3_CanoR_1	38	44	PF00244	0.553
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_EH1_1	118	126	PF00400	0.404
LIG_FHA_1	12	18	PF00498	0.651
LIG_LIR_Nem_3	113	119	PF02991	0.418
LIG_LIR_Nem_3	129	134	PF02991	0.365
LIG_LIR_Nem_3	78	82	PF02991	0.580
LIG_LYPXL_S_1	130	134	PF13949	0.586
LIG_LYPXL_yS_3	131	134	PF13949	0.388
LIG_PCNA_yPIPBox_3	98	106	PF02747	0.623
LIG_PTB_Phospho_1	146	152	PF10480	0.408
LIG_SH2_CRK	79	83	PF00017	0.547
LIG_SH2_STAT5	90	93	PF00017	0.538
LIG_SH3_3	127	133	PF00018	0.454
LIG_SH3_3	18	24	PF00018	0.636
LIG_SUMO_SIM_anti_2	138	145	PF11976	0.284
MOD_CK1_1	135	141	PF00069	0.472
MOD_Cter_Amidation	125	128	PF01082	0.482
MOD_GlcNHglycan	3	6	PF01048	0.420
MOD_GlcNHglycan	55	59	PF01048	0.301
MOD_GlcNHglycan	92	95	PF01048	0.362
MOD_NEK2_1	1	6	PF00069	0.621
MOD_NEK2_1	25	30	PF00069	0.529
MOD_NEK2_2	126	131	PF00069	0.354
MOD_PIKK_1	110	116	PF00454	0.441
MOD_PKA_1	11	17	PF00069	0.608
MOD_PKA_2	11	17	PF00069	0.672
MOD_PKA_2	126	132	PF00069	0.357
MOD_Plk_1	33	39	PF00069	0.624
MOD_ProDKin_1	132	138	PF00069	0.396
TRG_DiLeu_BaEn_1	72	77	PF01217	0.578
TRG_ENDOCYTIC_2	131	134	PF00928	0.464
TRG_ENDOCYTIC_2	79	82	PF00928	0.547
TRG_ER_diArg_1	66	69	PF00400	0.635
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTD3	Leptomonas seymouri	32%	95%
A0A0N1PDI5	Leptomonas seymouri	66%	100%
A0A0S4JQI6	Bodo saltans	44%	100%
A0A1X0NJU2	Trypanosomatidae	29%	100%
A0A1X0NR99	Trypanosomatidae	45%	100%
A0A3S7WP26	Leishmania donovani	30%	91%
A0A3S7X736	Leishmania donovani	87%	100%
A0A422N2T1	Trypanosoma rangeli	27%	100%
A0A422NKR0	Trypanosoma rangeli	46%	100%
A4H495	Leishmania braziliensis	30%	100%
A4I9C1	Leishmania infantum	87%	100%
C9ZJA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZUD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AKF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	91%
E9B4C0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q3Q5	Leishmania major	85%	100%
V5BJW3	Trypanosoma cruzi	27%	100%
V5DB75	Trypanosoma cruzi	47%	100%