Putative GTP-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTP-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HLZ0_LEIBR

TriTrypDb:

LbrM.33.3070 , LBRM2903_330038700

Length:

850

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLZ0

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003924	GTPase activity	7	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003676	nucleic acid binding	3	8
GO:0003746	translation elongation factor activity	4	8
GO:0008135	translation factor activity, RNA binding	3	8
GO:0045182	translation regulator activity	1	8
GO:0090079	translation regulator activity, nucleic acid binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	554	558	PF00656	0.437
CLV_C14_Caspase3-7	58	62	PF00656	0.571
CLV_NRD_NRD_1	175	177	PF00675	0.415
CLV_NRD_NRD_1	251	253	PF00675	0.511
CLV_NRD_NRD_1	274	276	PF00675	0.437
CLV_NRD_NRD_1	352	354	PF00675	0.532
CLV_NRD_NRD_1	580	582	PF00675	0.241
CLV_NRD_NRD_1	588	590	PF00675	0.231
CLV_NRD_NRD_1	631	633	PF00675	0.414
CLV_NRD_NRD_1	721	723	PF00675	0.374
CLV_NRD_NRD_1	836	838	PF00675	0.558
CLV_PCSK_KEX2_1	158	160	PF00082	0.646
CLV_PCSK_KEX2_1	251	253	PF00082	0.511
CLV_PCSK_KEX2_1	281	283	PF00082	0.543
CLV_PCSK_KEX2_1	351	353	PF00082	0.494
CLV_PCSK_KEX2_1	588	590	PF00082	0.252
CLV_PCSK_KEX2_1	717	719	PF00082	0.435
CLV_PCSK_KEX2_1	836	838	PF00082	0.401
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.560
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.457
CLV_PCSK_PC1ET2_1	717	719	PF00082	0.449
CLV_PCSK_SKI1_1	122	126	PF00082	0.523
CLV_PCSK_SKI1_1	168	172	PF00082	0.521
CLV_PCSK_SKI1_1	492	496	PF00082	0.249
CLV_PCSK_SKI1_1	504	508	PF00082	0.241
CLV_PCSK_SKI1_1	573	577	PF00082	0.248
CLV_PCSK_SKI1_1	804	808	PF00082	0.306
CLV_PCSK_SKI1_1	837	841	PF00082	0.531
CLV_Separin_Metazoa	778	782	PF03568	0.437
DEG_SCF_FBW7_1	216	223	PF00400	0.524
DEG_SCF_TRCP1_1	371	376	PF00400	0.437
DEG_SPOP_SBC_1	208	212	PF00917	0.515
DEG_SPOP_SBC_1	333	337	PF00917	0.797
DEG_SPOP_SBC_1	761	765	PF00917	0.379
DOC_ANK_TNKS_1	810	817	PF00023	0.448
DOC_CKS1_1	480	485	PF01111	0.534
DOC_CYCLIN_yCln2_LP_2	545	551	PF00134	0.437
DOC_MAPK_gen_1	533	543	PF00069	0.437
DOC_MAPK_gen_1	588	595	PF00069	0.448
DOC_MAPK_gen_1	722	728	PF00069	0.437
DOC_MAPK_gen_1	808	817	PF00069	0.504
DOC_MAPK_MEF2A_6	536	545	PF00069	0.437
DOC_MAPK_NFAT4_5	536	544	PF00069	0.448
DOC_MAPK_RevD_3	617	633	PF00069	0.507
DOC_PP1_RVXF_1	802	808	PF00149	0.555
DOC_PP2B_LxvP_1	301	304	PF13499	0.517
DOC_PP2B_LxvP_1	545	548	PF13499	0.460
DOC_PP2B_LxvP_1	575	578	PF13499	0.437
DOC_USP7_MATH_1	118	122	PF00917	0.650
DOC_USP7_MATH_1	208	212	PF00917	0.622
DOC_USP7_MATH_1	218	222	PF00917	0.714
DOC_USP7_MATH_1	315	319	PF00917	0.655
DOC_USP7_MATH_1	332	336	PF00917	0.777
DOC_USP7_MATH_1	457	461	PF00917	0.531
DOC_USP7_MATH_1	466	470	PF00917	0.513
DOC_USP7_MATH_1	487	491	PF00917	0.469
DOC_USP7_MATH_1	843	847	PF00917	0.504
DOC_USP7_UBL2_3	834	838	PF12436	0.585
DOC_WW_Pin1_4	212	217	PF00397	0.670
DOC_WW_Pin1_4	310	315	PF00397	0.613
DOC_WW_Pin1_4	327	332	PF00397	0.785
DOC_WW_Pin1_4	335	340	PF00397	0.671
DOC_WW_Pin1_4	479	484	PF00397	0.547
DOC_WW_Pin1_4	556	561	PF00397	0.437
DOC_WW_Pin1_4	66	71	PF00397	0.715
DOC_WW_Pin1_4	730	735	PF00397	0.495
LIG_14-3-3_CanoR_1	408	413	PF00244	0.455
LIG_14-3-3_CanoR_1	504	513	PF00244	0.450
LIG_14-3-3_CanoR_1	636	642	PF00244	0.434
LIG_14-3-3_CanoR_1	767	775	PF00244	0.437
LIG_Actin_WH2_2	492	509	PF00022	0.437
LIG_Actin_WH2_2	768	783	PF00022	0.437
LIG_APCC_ABBA_1	110	115	PF00400	0.390
LIG_BIR_III_2	557	561	PF00653	0.523
LIG_BRCT_BRCA1_1	648	652	PF00533	0.383
LIG_FHA_1	101	107	PF00498	0.368
LIG_FHA_1	259	265	PF00498	0.469
LIG_FHA_1	338	344	PF00498	0.628
LIG_FHA_1	376	382	PF00498	0.438
LIG_FHA_1	407	413	PF00498	0.450
LIG_FHA_1	42	48	PF00498	0.615
LIG_FHA_1	506	512	PF00498	0.437
LIG_FHA_1	648	654	PF00498	0.374
LIG_FHA_1	663	669	PF00498	0.364
LIG_FHA_1	672	678	PF00498	0.379
LIG_FHA_1	69	75	PF00498	0.636
LIG_FHA_1	810	816	PF00498	0.437
LIG_FHA_1	817	823	PF00498	0.437
LIG_FHA_2	480	486	PF00498	0.485
LIG_FHA_2	49	55	PF00498	0.587
LIG_FHA_2	493	499	PF00498	0.392
LIG_FHA_2	552	558	PF00498	0.437
LIG_FHA_2	56	62	PF00498	0.645
LIG_FHA_2	629	635	PF00498	0.437
LIG_FHA_2	75	81	PF00498	0.486
LIG_GBD_Chelix_1	171	179	PF00786	0.452
LIG_GBD_Chelix_1	5	13	PF00786	0.323
LIG_GBD_Chelix_1	539	547	PF00786	0.339
LIG_LIR_Gen_1	375	381	PF02991	0.379
LIG_LIR_Gen_1	519	527	PF02991	0.459
LIG_LIR_Nem_3	260	265	PF02991	0.396
LIG_LIR_Nem_3	375	380	PF02991	0.379
LIG_LIR_Nem_3	519	523	PF02991	0.459
LIG_LIR_Nem_3	680	685	PF02991	0.400
LIG_LIR_Nem_3	736	740	PF02991	0.450
LIG_LIR_Nem_3	754	760	PF02991	0.562
LIG_MLH1_MIPbox_1	648	652	PF16413	0.383
LIG_PCNA_yPIPBox_3	95	109	PF02747	0.425
LIG_Rb_pABgroove_1	491	499	PF01858	0.437
LIG_SH2_CRK	428	432	PF00017	0.504
LIG_SH2_CRK	520	524	PF00017	0.437
LIG_SH2_NCK_1	497	501	PF00017	0.437
LIG_SH2_SRC	757	760	PF00017	0.437
LIG_SH2_STAP1	520	524	PF00017	0.455
LIG_SH2_STAT3	774	777	PF00017	0.462
LIG_SH2_STAT5	505	508	PF00017	0.437
LIG_SH2_STAT5	774	777	PF00017	0.462
LIG_SH2_STAT5	798	801	PF00017	0.458
LIG_SH3_3	325	331	PF00018	0.640
LIG_SH3_3	439	445	PF00018	0.539
LIG_SH3_3	614	620	PF00018	0.528
LIG_SUMO_SIM_anti_2	146	152	PF11976	0.552
LIG_SUMO_SIM_anti_2	743	748	PF11976	0.437
LIG_SUMO_SIM_par_1	490	498	PF11976	0.449
LIG_SUMO_SIM_par_1	686	692	PF11976	0.479
LIG_TYR_ITIM	426	431	PF00017	0.417
LIG_UBA3_1	574	582	PF00899	0.312
MOD_CDK_SPK_2	479	484	PF00069	0.326
MOD_CDK_SPK_2	730	735	PF00069	0.381
MOD_CK1_1	210	216	PF00069	0.718
MOD_CK1_1	227	233	PF00069	0.729
MOD_CK1_1	313	319	PF00069	0.567
MOD_CK1_1	335	341	PF00069	0.728
MOD_CK1_1	372	378	PF00069	0.298
MOD_CK1_1	379	385	PF00069	0.325
MOD_CK1_1	410	416	PF00069	0.294
MOD_CK1_1	460	466	PF00069	0.347
MOD_CK1_1	612	618	PF00069	0.296
MOD_CK1_1	64	70	PF00069	0.693
MOD_CK1_1	733	739	PF00069	0.437
MOD_CK2_1	408	414	PF00069	0.274
MOD_CK2_1	479	485	PF00069	0.481
MOD_CK2_1	48	54	PF00069	0.606
MOD_CK2_1	698	704	PF00069	0.291
MOD_CK2_1	74	80	PF00069	0.445
MOD_GlcNHglycan	220	223	PF01048	0.609
MOD_GlcNHglycan	227	230	PF01048	0.533
MOD_GlcNHglycan	310	313	PF01048	0.636
MOD_GlcNHglycan	315	318	PF01048	0.628
MOD_GlcNHglycan	371	374	PF01048	0.309
MOD_GlcNHglycan	419	422	PF01048	0.428
MOD_GlcNHglycan	459	462	PF01048	0.379
MOD_GlcNHglycan	472	475	PF01048	0.232
MOD_GlcNHglycan	525	528	PF01048	0.286
MOD_GlcNHglycan	58	61	PF01048	0.694
MOD_GlcNHglycan	699	703	PF01048	0.517
MOD_GlcNHglycan	718	721	PF01048	0.362
MOD_GlcNHglycan	768	771	PF01048	0.321
MOD_GSK3_1	203	210	PF00069	0.740
MOD_GSK3_1	212	219	PF00069	0.747
MOD_GSK3_1	220	227	PF00069	0.673
MOD_GSK3_1	276	283	PF00069	0.526
MOD_GSK3_1	315	322	PF00069	0.644
MOD_GSK3_1	333	340	PF00069	0.719
MOD_GSK3_1	369	376	PF00069	0.324
MOD_GSK3_1	403	410	PF00069	0.277
MOD_GSK3_1	452	459	PF00069	0.429
MOD_GSK3_1	462	469	PF00069	0.345
MOD_GSK3_1	488	495	PF00069	0.291
MOD_GSK3_1	64	71	PF00069	0.640
MOD_GSK3_1	647	654	PF00069	0.412
MOD_GSK3_1	747	754	PF00069	0.391
MOD_GSK3_1	762	769	PF00069	0.303
MOD_GSK3_1	779	786	PF00069	0.286
MOD_N-GLC_1	426	431	PF02516	0.288
MOD_N-GLC_1	612	617	PF02516	0.289
MOD_N-GLC_1	671	676	PF02516	0.433
MOD_NEK2_1	171	176	PF00069	0.404
MOD_NEK2_1	179	184	PF00069	0.419
MOD_NEK2_1	207	212	PF00069	0.640
MOD_NEK2_1	452	457	PF00069	0.279
MOD_NEK2_1	506	511	PF00069	0.306
MOD_NEK2_1	609	614	PF00069	0.309
MOD_NEK2_1	651	656	PF00069	0.476
MOD_NEK2_1	747	752	PF00069	0.297
MOD_PIKK_1	662	668	PF00454	0.337
MOD_PIKK_1	68	74	PF00454	0.593
MOD_PK_1	408	414	PF00069	0.274
MOD_PKA_2	319	325	PF00069	0.538
MOD_PKA_2	407	413	PF00069	0.326
MOD_PKA_2	488	494	PF00069	0.374
MOD_PKA_2	532	538	PF00069	0.274
MOD_PKA_2	766	772	PF00069	0.274
MOD_Plk_1	243	249	PF00069	0.535
MOD_Plk_1	426	432	PF00069	0.323
MOD_Plk_1	564	570	PF00069	0.368
MOD_Plk_1	591	597	PF00069	0.350
MOD_Plk_1	647	653	PF00069	0.360
MOD_Plk_1	671	677	PF00069	0.428
MOD_Plk_1	783	789	PF00069	0.294
MOD_Plk_4	100	106	PF00069	0.525
MOD_Plk_4	160	166	PF00069	0.556
MOD_Plk_4	258	264	PF00069	0.544
MOD_Plk_4	290	296	PF00069	0.514
MOD_Plk_4	339	345	PF00069	0.599
MOD_Plk_4	376	382	PF00069	0.289
MOD_Plk_4	426	432	PF00069	0.360
MOD_Plk_4	492	498	PF00069	0.289
MOD_Plk_4	506	512	PF00069	0.251
MOD_Plk_4	647	653	PF00069	0.400
MOD_Plk_4	655	661	PF00069	0.347
MOD_Plk_4	671	677	PF00069	0.425
MOD_Plk_4	733	739	PF00069	0.324
MOD_Plk_4	74	80	PF00069	0.371
MOD_ProDKin_1	212	218	PF00069	0.670
MOD_ProDKin_1	310	316	PF00069	0.611
MOD_ProDKin_1	327	333	PF00069	0.786
MOD_ProDKin_1	335	341	PF00069	0.655
MOD_ProDKin_1	479	485	PF00069	0.427
MOD_ProDKin_1	556	562	PF00069	0.274
MOD_ProDKin_1	66	72	PF00069	0.712
MOD_ProDKin_1	730	736	PF00069	0.487
MOD_SUMO_for_1	713	716	PF00179	0.395
TRG_DiLeu_BaEn_1	260	265	PF01217	0.451
TRG_DiLeu_BaEn_1	801	806	PF01217	0.350
TRG_DiLeu_BaEn_1	824	829	PF01217	0.478
TRG_DiLeu_LyEn_5	801	806	PF01217	0.350
TRG_ENDOCYTIC_2	428	431	PF00928	0.368
TRG_ENDOCYTIC_2	520	523	PF00928	0.300
TRG_ENDOCYTIC_2	757	760	PF00928	0.418
TRG_ER_diArg_1	250	252	PF00400	0.505
TRG_ER_diArg_1	350	353	PF00400	0.506
TRG_ER_diArg_1	587	589	PF00400	0.295
TRG_ER_diArg_1	835	837	PF00400	0.436
TRG_NLS_Bipartite_1	158	180	PF00514	0.444
TRG_Pf-PMV_PEXEL_1	588	592	PF00026	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4K5	Leptomonas seymouri	69%	100%
A0A0S4JM58	Bodo saltans	52%	100%
A0A1X0NRK6	Trypanosomatidae	48%	98%
A0A3R7MHD3	Trypanosoma rangeli	53%	100%
A0A3S7X775	Leishmania donovani	84%	100%
A4I9C0	Leishmania infantum	84%	100%
C9ZJA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B4B9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q3Q6	Leishmania major	84%	99%
V5BF52	Trypanosoma cruzi	50%	100%