Putative ubiquitin-conjugating enzyme

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-conjugating enzyme

Species:

Leishmania braziliensis

UniProt:

A4HLY8_LEIBR

TriTrypDb:

LbrM.15.0920 , LBRM2903_330038500

Length:

136

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLY8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0016740	transferase activity	2	2
GO:0016874	ligase activity	2	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	94	96	PF00082	0.351
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.351
CLV_PCSK_SKI1_1	104	108	PF00082	0.526
CLV_PCSK_SKI1_1	111	115	PF00082	0.403
CLV_PCSK_SKI1_1	129	133	PF00082	0.289
CLV_PCSK_SKI1_1	70	74	PF00082	0.456
DEG_APCC_DBOX_1	103	111	PF00400	0.351
DOC_CYCLIN_RxL_1	105	116	PF00134	0.351
DOC_MAPK_MEF2A_6	53	60	PF00069	0.351
DOC_SPAK_OSR1_1	53	57	PF12202	0.351
DOC_USP7_MATH_1	30	34	PF00917	0.351
DOC_WW_Pin1_4	44	49	PF00397	0.351
LIG_Actin_RPEL_3	88	107	PF02755	0.351
LIG_APCC_ABBA_1	57	62	PF00400	0.351
LIG_EVH1_2	68	72	PF00568	0.351
LIG_FHA_1	98	104	PF00498	0.412
LIG_Integrin_RGD_1	85	87	PF01839	0.351
LIG_LIR_Nem_3	61	67	PF02991	0.456
LIG_LYPXL_yS_3	64	67	PF13949	0.351
LIG_PDZ_Class_3	131	136	PF00595	0.544
LIG_REV1ctd_RIR_1	70	79	PF16727	0.351
LIG_SH3_2	65	70	PF14604	0.351
LIG_SH3_3	62	68	PF00018	0.351
LIG_SUMO_SIM_par_1	55	62	PF11976	0.351
MOD_CK2_1	30	36	PF00069	0.351
MOD_GlcNHglycan	120	123	PF01048	0.351
MOD_GSK3_1	28	35	PF00069	0.447
MOD_N-GLC_1	80	85	PF02516	0.351
MOD_NEK2_1	72	77	PF00069	0.438
MOD_PKA_2	28	34	PF00069	0.351
MOD_ProDKin_1	44	50	PF00069	0.351
TRG_DiLeu_BaEn_1	126	131	PF01217	0.351
TRG_DiLeu_LyEn_5	126	131	PF01217	0.351
TRG_ENDOCYTIC_2	64	67	PF00928	0.351
TRG_Pf-PMV_PEXEL_1	111	116	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.193
TRG_Pf-PMV_PEXEL_1	9	14	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R4	Leptomonas seymouri	41%	75%
A0A0N1I1Z1	Leptomonas seymouri	35%	88%
A0A0N1I707	Leptomonas seymouri	32%	92%
A0A0N1PB60	Leptomonas seymouri	29%	91%
A0A0S4IWQ9	Bodo saltans	33%	70%
A0A0S4J8W6	Bodo saltans	32%	91%
A0A0S4JGV6	Bodo saltans	32%	92%
A0A0S4JJB5	Bodo saltans	33%	77%
A0A0S4JK56	Bodo saltans	30%	91%
A0A0S4JRZ8	Bodo saltans	34%	84%
A0A0S4JS17	Bodo saltans	30%	92%
A0A0S4KIJ1	Bodo saltans	35%	76%
A0A0S4KJ33	Bodo saltans	33%	92%
A0A1B0GUS4	Homo sapiens	27%	88%
A0A1X0NH68	Trypanosomatidae	32%	92%
A0A1X0NLS0	Trypanosomatidae	38%	91%
A0A1X0NPI5	Trypanosomatidae	33%	84%
A0A1X0NW06	Trypanosomatidae	34%	87%
A0A3Q8II46	Leishmania donovani	34%	92%
A0A3R7K708	Trypanosoma rangeli	34%	90%
A0A3S5H5C0	Leishmania donovani	30%	92%
A0A3S5H604	Leishmania donovani	43%	75%
A0A3S7WYK3	Leishmania donovani	35%	88%
A0A422MVJ2	Trypanosoma rangeli	32%	92%
A0A422MY24	Trypanosoma rangeli	33%	85%
A0A422NWQ7	Trypanosoma rangeli	30%	88%
A0A451EJH5	Leishmania donovani	33%	89%
A4H402	Leishmania braziliensis	30%	100%
A4H533	Leishmania braziliensis	43%	76%
A4HDS4	Leishmania braziliensis	35%	100%
A4HMF2	Leishmania braziliensis	32%	92%
A4HRN6	Leishmania infantum	33%	89%
A4HS64	Leishmania infantum	30%	92%
A4HTB1	Leishmania infantum	43%	75%
A4I122	Leishmania infantum	35%	88%
A4IB24	Leishmania infantum	34%	92%
A5PKP9	Xenopus laevis	32%	93%
A6H795	Bos taurus	26%	90%
A7SE05	Nematostella vectensis	47%	67%
B4L7V4	Drosophila mojavensis	48%	66%
B5DEI4	Rattus norvegicus	26%	90%
C9ZJ18	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	69%
C9ZMR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	83%
C9ZNM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	92%
C9ZUL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	79%
C9ZW85	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	88%
C9ZY61	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	91%
D3ZDK2	Rattus norvegicus	30%	93%
E9ACB4	Leishmania major	33%	89%
E9AJK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	89%
E9AK51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	92%
E9ALA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	75%
E9AX59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	88%
E9B609	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	92%
O00102	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	82%
O00762	Homo sapiens	33%	76%
O09181	Mesocricetus auratus	29%	86%
O13685	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	92%
O14933	Homo sapiens	27%	89%
O23239	Arabidopsis thaliana	30%	84%
O74196	Colletotrichum gloeosporioides	27%	93%
O74201	Candida albicans (strain SC5314 / ATCC MYA-2876)	37%	76%
O74549	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	77%
P06104	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	79%
P0CS16	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	35%	80%
P0CS17	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	35%	80%
P15731	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	92%
P15732	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	92%
P16577	Triticum aestivum	31%	74%
P23566	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	90%
P25153	Drosophila melanogaster	38%	90%
P25865	Arabidopsis thaliana	36%	89%
P25866	Triticum aestivum	36%	89%
P25867	Drosophila melanogaster	31%	93%
P25868	Triticum aestivum	28%	81%
P29340	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	74%
P34477	Caenorhabditis elegans	30%	83%
P35128	Drosophila melanogaster	38%	90%
P35129	Caenorhabditis elegans	31%	93%
P35130	Medicago sativa	36%	89%
P35131	Arabidopsis thaliana	33%	92%
P35132	Arabidopsis thaliana	33%	92%
P35133	Arabidopsis thaliana	34%	92%
P35134	Arabidopsis thaliana	33%	92%
P35135	Solanum lycopersicum	33%	92%
P40984	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	87%
P42743	Arabidopsis thaliana	26%	84%
P42745	Arabidopsis thaliana	36%	89%
P42746	Arabidopsis thaliana	37%	91%
P42747	Arabidopsis thaliana	27%	81%
P42748	Arabidopsis thaliana	30%	73%
P42749	Arabidopsis thaliana	30%	74%
P42750	Arabidopsis thaliana	27%	74%
P43102	Candida albicans	29%	93%
P46595	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	93%
P49459	Homo sapiens	41%	89%
P50623	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	87%
P51668	Homo sapiens	30%	93%
P51965	Homo sapiens	32%	70%
P52478	Caenorhabditis elegans	41%	71%
P52482	Mus musculus	32%	70%
P52487	Drosophila melanogaster	30%	89%
P52490	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	89%
P52492	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	87%
P52493	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	37%	90%
P56616	Xenopus laevis	37%	76%
P60604	Homo sapiens	29%	82%
P60605	Mus musculus	29%	82%
P61077	Homo sapiens	30%	93%
P61078	Rattus norvegicus	30%	93%
P61079	Mus musculus	30%	93%
P61080	Mus musculus	30%	93%
P61085	Bos taurus	34%	68%
P61086	Homo sapiens	34%	68%
P61087	Mus musculus	34%	68%
P61088	Homo sapiens	38%	89%
P61089	Mus musculus	38%	89%
P62253	Homo sapiens	28%	80%
P62254	Mus musculus	28%	80%
P62255	Rattus norvegicus	28%	80%
P62256	Homo sapiens	36%	74%
P62257	Mus musculus	36%	74%
P62837	Homo sapiens	30%	93%
P62838	Mus musculus	30%	93%
P62839	Rattus norvegicus	30%	93%
P62840	Xenopus laevis	30%	93%
P63146	Homo sapiens	42%	89%
P63147	Mus musculus	42%	89%
P63148	Oryctolagus cuniculus	42%	89%
P63149	Rattus norvegicus	42%	89%
P63279	Homo sapiens	31%	86%
P63280	Mus musculus	31%	86%
P63281	Rattus norvegicus	31%	86%
P63282	Xenopus laevis	31%	86%
P63283	Gallus gallus	31%	86%
P68036	Homo sapiens	28%	88%
P68037	Mus musculus	28%	88%
P70711	Rattus norvegicus	28%	93%
P78717	Fusarium solani	37%	90%
Q02159	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	82%
Q06AA9	Sus scrofa	30%	93%
Q08BH7	Danio rerio	36%	70%
Q0P5K3	Bos taurus	38%	89%
Q17QG5	Bos taurus	29%	82%
Q1JPX4	Danio rerio	25%	90%
Q1RMX2	Bos taurus	30%	93%
Q28CQ4	Xenopus tropicalis	31%	86%
Q28FC1	Xenopus tropicalis	26%	90%
Q2EF73	Ictidomys tridecemlineatus	31%	86%
Q2TA10	Bos taurus	30%	93%
Q32LD2	Bos taurus	31%	70%
Q32LN1	Bos taurus	36%	74%
Q32P99	Bos taurus	42%	89%
Q32PA5	Bos taurus	33%	76%
Q3MHP1	Bos taurus	28%	88%
Q3ZCF7	Bos taurus	30%	93%
Q42540	Arabidopsis thaliana	29%	82%
Q42541	Arabidopsis thaliana	30%	82%
Q42551	Arabidopsis thaliana	32%	85%
Q4PFA5	Ustilago maydis (strain 521 / FGSC 9021)	36%	74%
Q4QAB7	Leishmania major	35%	100%
Q4QIK2	Leishmania major	33%	100%
Q4R4I1	Macaca fascicularis	38%	89%
Q4R5N4	Macaca fascicularis	30%	93%
Q4R5Y8	Macaca fascicularis	28%	80%
Q4R9D1	Macaca fascicularis	33%	76%
Q4V8J2	Rattus norvegicus	30%	89%
Q4VBH4	Danio rerio	25%	90%
Q4WLA7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	37%	90%
Q54XS6	Dictyostelium discoideum	34%	89%
Q553F3	Dictyostelium discoideum	34%	90%
Q55EY8	Dictyostelium discoideum	24%	91%
Q58FS2	Trichoderma harzianum	37%	90%
Q5JXB2	Homo sapiens	36%	89%
Q5R4V7	Pongo abelii	30%	93%
Q5R5I4	Pongo abelii	28%	88%
Q5R7J6	Pongo abelii	38%	89%
Q5RF84	Pongo abelii	29%	82%
Q5UQC9	Acanthamoeba polyphaga mimivirus	30%	86%
Q6BU36	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	37%	81%
Q6C093	Yarrowia lipolytica (strain CLIB 122 / E 150)	38%	90%
Q6C9W0	Yarrowia lipolytica (strain CLIB 122 / E 150)	27%	76%
Q6CSW8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	31%	74%
Q6CUD9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	35%	83%
Q6FR76	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	35%	81%
Q6FVQ8	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	33%	73%
Q6Y1Z4	Pagrus major	34%	86%
Q6ZWY6	Mus musculus	28%	93%
Q75AF2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	35%	74%
Q75EB8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	35%	80%
Q7K738	Drosophila melanogaster	26%	88%
Q7ZY08	Xenopus laevis	34%	71%
Q86IZ3	Dictyostelium discoideum	35%	91%
Q86K32	Dictyostelium discoideum	35%	88%
Q8L7T3	Arabidopsis thaliana	40%	76%
Q8LGF7	Arabidopsis thaliana	34%	87%
Q8S919	Oryza sativa subsp. japonica	33%	92%
Q8S920	Oryza sativa subsp. japonica	34%	93%
Q8VDW4	Mus musculus	26%	90%
Q91W82	Mus musculus	35%	68%
Q94490	Dictyostelium discoideum	32%	92%
Q94A97	Arabidopsis thaliana	37%	89%
Q94F47	Arabidopsis thaliana	32%	92%
Q95017	Caenorhabditis elegans	26%	82%
Q95044	Spisula solidissima	35%	77%
Q95XX0	Caenorhabditis elegans	41%	90%
Q96B02	Homo sapiens	26%	90%
Q96LR5	Homo sapiens	35%	68%
Q96UP5	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	37%	90%
Q9C8X7	Arabidopsis thaliana	42%	88%
Q9C9Y7	Arabidopsis thaliana	34%	91%
Q9CQ37	Mus musculus	34%	67%
Q9D1C1	Mus musculus	36%	76%
Q9DDJ0	Danio rerio	31%	87%
Q9EQX9	Rattus norvegicus	38%	89%
Q9FI61	Arabidopsis thaliana	33%	71%
Q9FKT3	Arabidopsis thaliana	35%	92%
Q9FMM0	Arabidopsis thaliana	26%	84%
Q9FWT2	Arabidopsis thaliana	27%	84%
Q9FZ48	Arabidopsis thaliana	36%	89%
Q9GNC1	Leishmania major	34%	100%
Q9LJD7	Arabidopsis thaliana	33%	75%
Q9LJZ5	Arabidopsis thaliana	38%	75%
Q9NED4	Leishmania major	30%	100%
Q9NGP4	Dictyostelium discoideum	30%	86%
Q9NPD8	Homo sapiens	31%	69%
Q9P6I1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	85%
Q9P7R4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	74%
Q9QZU9	Mus musculus	30%	89%
Q9SDY5	Arabidopsis thaliana	30%	74%
Q9SLE4	Arabidopsis thaliana	34%	92%
Q9UTN8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	88%
Q9UVR2	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	29%	93%
Q9VTY6	Drosophila melanogaster	36%	76%
Q9W6H5	Danio rerio	32%	86%
Q9XWF6	Caenorhabditis elegans	28%	89%
Q9Y2X8	Homo sapiens	32%	93%
Q9Y818	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	81%
Q9Z255	Mus musculus	41%	89%
Q9ZU75	Arabidopsis thaliana	31%	74%
V5BDP3	Trypanosoma cruzi	36%	90%
V5BYE2	Trypanosoma cruzi	32%	85%