PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLY7_LEIBR

TriTrypDb:

LbrM.33.3040 , LBRM2903_330038400

Length:

876

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLY7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.537
CLV_C14_Caspase3-7	144	148	PF00656	0.635
CLV_C14_Caspase3-7	194	198	PF00656	0.527
CLV_C14_Caspase3-7	414	418	PF00656	0.620
CLV_C14_Caspase3-7	557	561	PF00656	0.576
CLV_C14_Caspase3-7	619	623	PF00656	0.424
CLV_NRD_NRD_1	250	252	PF00675	0.554
CLV_NRD_NRD_1	578	580	PF00675	0.609
CLV_NRD_NRD_1	659	661	PF00675	0.508
CLV_NRD_NRD_1	691	693	PF00675	0.521
CLV_NRD_NRD_1	769	771	PF00675	0.453
CLV_NRD_NRD_1	801	803	PF00675	0.647
CLV_PCSK_KEX2_1	464	466	PF00082	0.539
CLV_PCSK_KEX2_1	691	693	PF00082	0.521
CLV_PCSK_KEX2_1	807	809	PF00082	0.386
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.495
CLV_PCSK_PC1ET2_1	807	809	PF00082	0.381
CLV_PCSK_SKI1_1	103	107	PF00082	0.580
CLV_PCSK_SKI1_1	117	121	PF00082	0.668
CLV_PCSK_SKI1_1	320	324	PF00082	0.558
CLV_PCSK_SKI1_1	484	488	PF00082	0.539
CLV_PCSK_SKI1_1	679	683	PF00082	0.642
CLV_PCSK_SKI1_1	697	701	PF00082	0.389
CLV_PCSK_SKI1_1	803	807	PF00082	0.377
CLV_PCSK_SKI1_1	808	812	PF00082	0.362
DEG_APCC_DBOX_1	707	715	PF00400	0.419
DEG_APCC_DBOX_1	98	106	PF00400	0.546
DEG_MDM2_SWIB_1	649	656	PF02201	0.438
DEG_SPOP_SBC_1	242	246	PF00917	0.544
DEG_SPOP_SBC_1	3	7	PF00917	0.559
DEG_SPOP_SBC_1	857	861	PF00917	0.467
DOC_CKS1_1	236	241	PF01111	0.563
DOC_CKS1_1	399	404	PF01111	0.556
DOC_CKS1_1	429	434	PF01111	0.516
DOC_CYCLIN_RxL_1	478	491	PF00134	0.599
DOC_CYCLIN_RxL_1	800	809	PF00134	0.403
DOC_CYCLIN_yClb3_PxF_3	592	598	PF00134	0.465
DOC_MAPK_gen_1	265	272	PF00069	0.520
DOC_MAPK_MEF2A_6	216	224	PF00069	0.527
DOC_MAPK_MEF2A_6	336	345	PF00069	0.552
DOC_PP1_SILK_1	609	614	PF00149	0.419
DOC_PP2B_LxvP_1	332	335	PF13499	0.559
DOC_PP4_FxxP_1	272	275	PF00568	0.525
DOC_PP4_FxxP_1	328	331	PF00568	0.572
DOC_USP7_MATH_1	119	123	PF00917	0.551
DOC_USP7_MATH_1	196	200	PF00917	0.537
DOC_USP7_MATH_1	359	363	PF00917	0.711
DOC_USP7_MATH_1	385	389	PF00917	0.638
DOC_USP7_MATH_1	559	563	PF00917	0.673
DOC_USP7_MATH_1	623	627	PF00917	0.434
DOC_USP7_MATH_1	739	743	PF00917	0.648
DOC_USP7_UBL2_3	803	807	PF12436	0.377
DOC_WW_Pin1_4	15	20	PF00397	0.634
DOC_WW_Pin1_4	235	240	PF00397	0.589
DOC_WW_Pin1_4	308	313	PF00397	0.598
DOC_WW_Pin1_4	37	42	PF00397	0.736
DOC_WW_Pin1_4	398	403	PF00397	0.637
DOC_WW_Pin1_4	428	433	PF00397	0.641
DOC_WW_Pin1_4	566	571	PF00397	0.533
DOC_WW_Pin1_4	588	593	PF00397	0.551
DOC_WW_Pin1_4	781	786	PF00397	0.413
DOC_WW_Pin1_4	84	89	PF00397	0.639
LIG_14-3-3_CanoR_1	24	28	PF00244	0.684
LIG_14-3-3_CanoR_1	305	311	PF00244	0.551
LIG_14-3-3_CanoR_1	637	642	PF00244	0.618
LIG_14-3-3_CanoR_1	708	712	PF00244	0.486
LIG_BIR_III_4	417	421	PF00653	0.530
LIG_BRCT_BRCA1_1	535	539	PF00533	0.533
LIG_Clathr_ClatBox_1	762	766	PF01394	0.392
LIG_Clathr_ClatBox_1	854	858	PF01394	0.464
LIG_deltaCOP1_diTrp_1	712	721	PF00928	0.352
LIG_FHA_1	243	249	PF00498	0.782
LIG_FHA_1	283	289	PF00498	0.576
LIG_FHA_1	37	43	PF00498	0.668
LIG_FHA_1	399	405	PF00498	0.631
LIG_FHA_1	447	453	PF00498	0.545
LIG_FHA_1	541	547	PF00498	0.588
LIG_FHA_1	641	647	PF00498	0.469
LIG_FHA_1	696	702	PF00498	0.488
LIG_FHA_1	708	714	PF00498	0.313
LIG_FHA_2	321	327	PF00498	0.703
LIG_FHA_2	335	341	PF00498	0.547
LIG_FHA_2	526	532	PF00498	0.593
LIG_FHA_2	546	552	PF00498	0.511
LIG_FHA_2	784	790	PF00498	0.538
LIG_FHA_2	870	876	PF00498	0.545
LIG_HCF-1_HBM_1	704	707	PF13415	0.424
LIG_Integrin_isoDGR_2	66	68	PF01839	0.559
LIG_LIR_Apic_2	234	240	PF02991	0.522
LIG_LIR_Apic_2	271	275	PF02991	0.523
LIG_LIR_Apic_2	325	331	PF02991	0.566
LIG_LIR_Apic_2	508	512	PF02991	0.510
LIG_LIR_Gen_1	471	477	PF02991	0.573
LIG_LIR_Gen_1	551	561	PF02991	0.500
LIG_LIR_Gen_1	652	659	PF02991	0.415
LIG_LIR_Gen_1	712	722	PF02991	0.353
LIG_LIR_LC3C_4	853	856	PF02991	0.451
LIG_LIR_Nem_3	162	166	PF02991	0.526
LIG_LIR_Nem_3	428	433	PF02991	0.752
LIG_LIR_Nem_3	471	475	PF02991	0.580
LIG_LIR_Nem_3	504	509	PF02991	0.521
LIG_LIR_Nem_3	551	556	PF02991	0.496
LIG_LIR_Nem_3	652	656	PF02991	0.411
LIG_LIR_Nem_3	712	718	PF02991	0.350
LIG_LIR_Nem_3	89	95	PF02991	0.546
LIG_LYPXL_yS_3	92	95	PF13949	0.547
LIG_MAD2	170	178	PF02301	0.646
LIG_MAD2	791	799	PF02301	0.417
LIG_PCNA_PIPBox_1	434	443	PF02747	0.523
LIG_Pex14_1	506	510	PF04695	0.605
LIG_Pex14_2	649	653	PF04695	0.450
LIG_Pex14_2	736	740	PF04695	0.557
LIG_PTB_Apo_2	440	447	PF02174	0.521
LIG_SH2_CRK	237	241	PF00017	0.530
LIG_SH2_GRB2like	441	444	PF00017	0.529
LIG_SH2_NCK_1	237	241	PF00017	0.530
LIG_SH2_SRC	166	169	PF00017	0.516
LIG_SH2_STAP1	163	167	PF00017	0.522
LIG_SH2_STAP1	634	638	PF00017	0.526
LIG_SH2_STAT3	32	35	PF00017	0.551
LIG_SH2_STAT3	664	667	PF00017	0.403
LIG_SH2_STAT5	163	166	PF00017	0.525
LIG_SH2_STAT5	179	182	PF00017	0.495
LIG_SH2_STAT5	203	206	PF00017	0.552
LIG_SH2_STAT5	237	240	PF00017	0.529
LIG_SH2_STAT5	664	667	PF00017	0.433
LIG_SH3_3	172	178	PF00018	0.496
LIG_SH3_3	233	239	PF00018	0.648
LIG_SH3_3	274	280	PF00018	0.607
LIG_SH3_3	281	287	PF00018	0.653
LIG_SH3_3	290	296	PF00018	0.601
LIG_SH3_3	307	313	PF00018	0.666
LIG_SH3_3	353	359	PF00018	0.647
LIG_SH3_3	426	432	PF00018	0.664
LIG_SH3_3	568	574	PF00018	0.555
LIG_SH3_3	587	593	PF00018	0.600
LIG_SH3_3	779	785	PF00018	0.433
LIG_SUMO_SIM_anti_2	710	716	PF11976	0.364
LIG_SUMO_SIM_anti_2	850	856	PF11976	0.430
LIG_SUMO_SIM_par_1	13	18	PF11976	0.538
LIG_SUMO_SIM_par_1	637	643	PF11976	0.589
LIG_SUMO_SIM_par_1	760	766	PF11976	0.391
LIG_SUMO_SIM_par_1	853	861	PF11976	0.464
LIG_TRAF2_1	477	480	PF00917	0.505
LIG_TRFH_1	272	276	PF08558	0.524
LIG_WRC_WIRS_1	372	377	PF05994	0.525
MOD_CK1_1	211	217	PF00069	0.715
MOD_CK1_1	370	376	PF00069	0.733
MOD_CK1_1	388	394	PF00069	0.542
MOD_CK1_1	428	434	PF00069	0.559
MOD_CK1_1	527	533	PF00069	0.648
MOD_CK1_1	640	646	PF00069	0.410
MOD_CK1_1	74	80	PF00069	0.634
MOD_CK1_1	742	748	PF00069	0.534
MOD_CK1_1	87	93	PF00069	0.646
MOD_CK2_1	15	21	PF00069	0.708
MOD_CK2_1	320	326	PF00069	0.685
MOD_CK2_1	545	551	PF00069	0.502
MOD_CK2_1	623	629	PF00069	0.453
MOD_CK2_1	649	655	PF00069	0.382
MOD_CK2_1	781	787	PF00069	0.535
MOD_CK2_1	825	831	PF00069	0.556
MOD_CK2_1	869	875	PF00069	0.617
MOD_DYRK1A_RPxSP_1	781	785	PF00069	0.418
MOD_GlcNHglycan	125	128	PF01048	0.646
MOD_GlcNHglycan	130	133	PF01048	0.675
MOD_GlcNHglycan	147	150	PF01048	0.735
MOD_GlcNHglycan	197	201	PF01048	0.752
MOD_GlcNHglycan	210	213	PF01048	0.602
MOD_GlcNHglycan	313	316	PF01048	0.582
MOD_GlcNHglycan	361	364	PF01048	0.739
MOD_GlcNHglycan	387	390	PF01048	0.656
MOD_GlcNHglycan	417	421	PF01048	0.579
MOD_GlcNHglycan	513	516	PF01048	0.630
MOD_GlcNHglycan	53	56	PF01048	0.614
MOD_GlcNHglycan	535	538	PF01048	0.721
MOD_GlcNHglycan	553	556	PF01048	0.517
MOD_GlcNHglycan	73	76	PF01048	0.643
MOD_GlcNHglycan	741	744	PF01048	0.486
MOD_GlcNHglycan	849	852	PF01048	0.471
MOD_GlcNHglycan	89	92	PF01048	0.640
MOD_GSK3_1	119	126	PF00069	0.781
MOD_GSK3_1	191	198	PF00069	0.614
MOD_GSK3_1	208	215	PF00069	0.717
MOD_GSK3_1	216	223	PF00069	0.589
MOD_GSK3_1	231	238	PF00069	0.563
MOD_GSK3_1	242	249	PF00069	0.635
MOD_GSK3_1	320	327	PF00069	0.705
MOD_GSK3_1	367	374	PF00069	0.653
MOD_GSK3_1	452	459	PF00069	0.594
MOD_GSK3_1	501	508	PF00069	0.454
MOD_GSK3_1	523	530	PF00069	0.605
MOD_GSK3_1	533	540	PF00069	0.724
MOD_GSK3_1	71	78	PF00069	0.619
MOD_GSK3_1	83	90	PF00069	0.607
MOD_N-GLC_1	3	8	PF02516	0.518
MOD_N-GLC_2	408	410	PF02516	0.560
MOD_NEK2_1	270	275	PF00069	0.522
MOD_NEK2_1	343	348	PF00069	0.564
MOD_NEK2_1	43	48	PF00069	0.573
MOD_NEK2_1	446	451	PF00069	0.651
MOD_NEK2_1	524	529	PF00069	0.614
MOD_NEK2_1	533	538	PF00069	0.603
MOD_NEK2_1	539	544	PF00069	0.528
MOD_NEK2_1	607	612	PF00069	0.586
MOD_NEK2_1	649	654	PF00069	0.495
MOD_NEK2_1	695	700	PF00069	0.505
MOD_NEK2_1	713	718	PF00069	0.398
MOD_NEK2_1	744	749	PF00069	0.465
MOD_NEK2_1	769	774	PF00069	0.445
MOD_NEK2_1	847	852	PF00069	0.422
MOD_NEK2_2	425	430	PF00069	0.522
MOD_OFUCOSY	498	503	PF10250	0.500
MOD_PIKK_1	31	37	PF00454	0.583
MOD_PIKK_1	388	394	PF00454	0.610
MOD_PIKK_1	713	719	PF00454	0.381
MOD_PK_1	637	643	PF00069	0.443
MOD_PKA_2	109	115	PF00069	0.642
MOD_PKA_2	140	146	PF00069	0.559
MOD_PKA_2	23	29	PF00069	0.625
MOD_PKA_2	468	474	PF00069	0.582
MOD_PKA_2	510	516	PF00069	0.644
MOD_PKA_2	707	713	PF00069	0.350
MOD_PKA_2	751	757	PF00069	0.441
MOD_PKA_2	769	775	PF00069	0.459
MOD_Plk_1	22	28	PF00069	0.535
MOD_Plk_1	270	276	PF00069	0.523
MOD_Plk_1	3	9	PF00069	0.518
MOD_Plk_1	43	49	PF00069	0.666
MOD_Plk_1	446	452	PF00069	0.524
MOD_Plk_1	559	565	PF00069	0.570
MOD_Plk_1	834	840	PF00069	0.373
MOD_Plk_1	857	863	PF00069	0.474
MOD_Plk_2-3	615	621	PF00069	0.575
MOD_Plk_4	220	226	PF00069	0.516
MOD_Plk_4	231	237	PF00069	0.502
MOD_Plk_4	259	265	PF00069	0.578
MOD_Plk_4	425	431	PF00069	0.585
MOD_Plk_4	468	474	PF00069	0.658
MOD_Plk_4	501	507	PF00069	0.466
MOD_Plk_4	607	613	PF00069	0.545
MOD_Plk_4	75	81	PF00069	0.549
MOD_ProDKin_1	15	21	PF00069	0.634
MOD_ProDKin_1	235	241	PF00069	0.590
MOD_ProDKin_1	308	314	PF00069	0.601
MOD_ProDKin_1	37	43	PF00069	0.739
MOD_ProDKin_1	398	404	PF00069	0.638
MOD_ProDKin_1	428	434	PF00069	0.640
MOD_ProDKin_1	566	572	PF00069	0.531
MOD_ProDKin_1	588	594	PF00069	0.538
MOD_ProDKin_1	781	787	PF00069	0.412
MOD_ProDKin_1	84	90	PF00069	0.636
MOD_SUMO_for_1	669	672	PF00179	0.405
MOD_SUMO_for_1	806	809	PF00179	0.378
TRG_DiLeu_BaLyEn_6	284	289	PF01217	0.578
TRG_DiLeu_BaLyEn_6	338	343	PF01217	0.574
TRG_DiLeu_BaLyEn_6	634	639	PF01217	0.604
TRG_ENDOCYTIC_2	92	95	PF00928	0.547
TRG_ER_diArg_1	135	138	PF00400	0.566
TRG_ER_diArg_1	264	267	PF00400	0.604
TRG_ER_diArg_1	691	693	PF00400	0.492
TRG_ER_diArg_1	746	749	PF00400	0.716
TRG_ER_diArg_1	778	781	PF00400	0.409
TRG_ER_diArg_1	799	802	PF00400	0.541
TRG_NES_CRM1_1	833	846	PF08389	0.376
TRG_NLS_MonoCore_2	250	255	PF00514	0.549
TRG_Pf-PMV_PEXEL_1	295	300	PF00026	0.647
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	484	488	PF00026	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6M4	Leptomonas seymouri	31%	98%
A0A3S5H7V3	Leishmania donovani	51%	96%
A4I9B6	Leishmania infantum	52%	100%
E9B4B6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
Q4Q3Q9	Leishmania major	53%	94%