DUF4520 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4520), putative

Species:

Leishmania braziliensis

UniProt:

A4HLY6_LEIBR

TriTrypDb:

LbrM.33.3030 , LBRM2903_330038300

Length:

1107

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLY6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	305	309	PF00656	0.682
CLV_C14_Caspase3-7	33	37	PF00656	0.586
CLV_C14_Caspase3-7	650	654	PF00656	0.670
CLV_C14_Caspase3-7	720	724	PF00656	0.606
CLV_C14_Caspase3-7	82	86	PF00656	0.650
CLV_NRD_NRD_1	183	185	PF00675	0.612
CLV_NRD_NRD_1	189	191	PF00675	0.610
CLV_NRD_NRD_1	283	285	PF00675	0.561
CLV_NRD_NRD_1	616	618	PF00675	0.606
CLV_NRD_NRD_1	685	687	PF00675	0.553
CLV_NRD_NRD_1	69	71	PF00675	0.685
CLV_NRD_NRD_1	894	896	PF00675	0.349
CLV_PCSK_KEX2_1	183	185	PF00082	0.608
CLV_PCSK_KEX2_1	189	191	PF00082	0.616
CLV_PCSK_KEX2_1	283	285	PF00082	0.561
CLV_PCSK_KEX2_1	590	592	PF00082	0.780
CLV_PCSK_KEX2_1	685	687	PF00082	0.553
CLV_PCSK_KEX2_1	69	71	PF00082	0.682
CLV_PCSK_KEX2_1	894	896	PF00082	0.349
CLV_PCSK_PC1ET2_1	590	592	PF00082	0.780
CLV_PCSK_SKI1_1	1102	1106	PF00082	0.668
CLV_PCSK_SKI1_1	115	119	PF00082	0.515
CLV_PCSK_SKI1_1	129	133	PF00082	0.587
CLV_PCSK_SKI1_1	366	370	PF00082	0.619
CLV_PCSK_SKI1_1	618	622	PF00082	0.585
CLV_PCSK_SKI1_1	631	635	PF00082	0.516
CLV_PCSK_SKI1_1	841	845	PF00082	0.349
CLV_PCSK_SKI1_1	865	869	PF00082	0.349
DEG_APCC_DBOX_1	1083	1091	PF00400	0.495
DEG_APCC_DBOX_1	128	136	PF00400	0.520
DEG_APCC_DBOX_1	840	848	PF00400	0.408
DEG_Nend_Nbox_1	1	3	PF02207	0.687
DEG_SPOP_SBC_1	234	238	PF00917	0.536
DEG_SPOP_SBC_1	757	761	PF00917	0.533
DEG_SPOP_SBC_1	967	971	PF00917	0.561
DOC_ANK_TNKS_1	818	825	PF00023	0.408
DOC_CKS1_1	1	6	PF01111	0.595
DOC_CKS1_1	204	209	PF01111	0.608
DOC_CKS1_1	663	668	PF01111	0.539
DOC_CYCLIN_yCln2_LP_2	130	136	PF00134	0.601
DOC_CYCLIN_yCln2_LP_2	904	910	PF00134	0.521
DOC_MAPK_gen_1	113	120	PF00069	0.505
DOC_MAPK_gen_1	283	291	PF00069	0.540
DOC_MAPK_MEF2A_6	283	291	PF00069	0.540
DOC_MAPK_MEF2A_6	366	375	PF00069	0.615
DOC_MAPK_MEF2A_6	631	638	PF00069	0.552
DOC_MAPK_NFAT4_5	366	374	PF00069	0.616
DOC_PP1_RVXF_1	833	839	PF00149	0.349
DOC_PP1_RVXF_1	893	900	PF00149	0.503
DOC_PP2B_LxvP_1	130	133	PF13499	0.527
DOC_PP2B_LxvP_1	454	457	PF13499	0.624
DOC_USP7_MATH_1	1018	1022	PF00917	0.634
DOC_USP7_MATH_1	1049	1053	PF00917	0.682
DOC_USP7_MATH_1	213	217	PF00917	0.691
DOC_USP7_MATH_1	218	222	PF00917	0.615
DOC_USP7_MATH_1	233	237	PF00917	0.555
DOC_USP7_MATH_1	262	266	PF00917	0.698
DOC_USP7_MATH_1	307	311	PF00917	0.552
DOC_USP7_MATH_1	392	396	PF00917	0.666
DOC_USP7_MATH_1	399	403	PF00917	0.648
DOC_USP7_MATH_1	43	47	PF00917	0.660
DOC_USP7_MATH_1	482	486	PF00917	0.547
DOC_USP7_MATH_1	625	629	PF00917	0.619
DOC_USP7_MATH_1	688	692	PF00917	0.557
DOC_USP7_MATH_1	703	707	PF00917	0.505
DOC_USP7_MATH_1	755	759	PF00917	0.599
DOC_USP7_MATH_1	778	782	PF00917	0.568
DOC_USP7_MATH_1	915	919	PF00917	0.652
DOC_USP7_MATH_1	961	965	PF00917	0.664
DOC_USP7_UBL2_3	109	113	PF12436	0.438
DOC_WW_Pin1_4	1033	1038	PF00397	0.705
DOC_WW_Pin1_4	203	208	PF00397	0.603
DOC_WW_Pin1_4	229	234	PF00397	0.561
DOC_WW_Pin1_4	324	329	PF00397	0.658
DOC_WW_Pin1_4	441	446	PF00397	0.547
DOC_WW_Pin1_4	46	51	PF00397	0.682
DOC_WW_Pin1_4	468	473	PF00397	0.602
DOC_WW_Pin1_4	662	667	PF00397	0.677
DOC_WW_Pin1_4	718	723	PF00397	0.762
DOC_WW_Pin1_4	776	781	PF00397	0.648
LIG_14-3-3_CanoR_1	150	158	PF00244	0.577
LIG_14-3-3_CanoR_1	284	290	PF00244	0.535
LIG_14-3-3_CanoR_1	500	505	PF00244	0.535
LIG_14-3-3_CanoR_1	51	55	PF00244	0.603
LIG_14-3-3_CanoR_1	512	516	PF00244	0.552
LIG_14-3-3_CanoR_1	558	566	PF00244	0.622
LIG_14-3-3_CanoR_1	689	695	PF00244	0.557
LIG_14-3-3_CanoR_1	715	725	PF00244	0.763
LIG_14-3-3_CanoR_1	732	738	PF00244	0.521
LIG_14-3-3_CanoR_1	841	847	PF00244	0.349
LIG_14-3-3_CanoR_1	871	879	PF00244	0.351
LIG_14-3-3_CanoR_1	939	943	PF00244	0.710
LIG_14-3-3_CanoR_1	989	994	PF00244	0.706
LIG_Actin_WH2_2	268	285	PF00022	0.579
LIG_Actin_WH2_2	737	755	PF00022	0.493
LIG_APCC_ABBA_1	289	294	PF00400	0.554
LIG_APCC_ABBA_1	834	839	PF00400	0.349
LIG_FHA_1	1054	1060	PF00498	0.579
LIG_FHA_1	1099	1105	PF00498	0.533
LIG_FHA_1	163	169	PF00498	0.690
LIG_FHA_1	176	182	PF00498	0.616
LIG_FHA_1	222	228	PF00498	0.605
LIG_FHA_1	261	267	PF00498	0.583
LIG_FHA_1	286	292	PF00498	0.535
LIG_FHA_1	293	299	PF00498	0.559
LIG_FHA_1	319	325	PF00498	0.657
LIG_FHA_1	353	359	PF00498	0.610
LIG_FHA_1	528	534	PF00498	0.689
LIG_FHA_1	650	656	PF00498	0.697
LIG_FHA_1	659	665	PF00498	0.631
LIG_FHA_1	675	681	PF00498	0.617
LIG_FHA_1	815	821	PF00498	0.349
LIG_FHA_1	831	837	PF00498	0.349
LIG_FHA_1	859	865	PF00498	0.349
LIG_FHA_1	968	974	PF00498	0.638
LIG_FHA_2	236	242	PF00498	0.622
LIG_FHA_2	272	278	PF00498	0.568
LIG_FHA_2	303	309	PF00498	0.673
LIG_FHA_2	543	549	PF00498	0.622
LIG_FHA_2	758	764	PF00498	0.539
LIG_GBD_Chelix_1	371	379	PF00786	0.624
LIG_HP1_1	630	634	PF01393	0.560
LIG_LIR_Apic_2	297	303	PF02991	0.556
LIG_LIR_Gen_1	1025	1033	PF02991	0.585
LIG_LIR_Gen_1	277	287	PF02991	0.562
LIG_LIR_Gen_1	40	48	PF02991	0.637
LIG_LIR_Gen_1	825	834	PF02991	0.349
LIG_LIR_Nem_3	1025	1029	PF02991	0.597
LIG_LIR_Nem_3	1058	1063	PF02991	0.567
LIG_LIR_Nem_3	277	282	PF02991	0.570
LIG_LIR_Nem_3	40	44	PF02991	0.628
LIG_LIR_Nem_3	825	829	PF02991	0.349
LIG_LIR_Nem_3	995	1000	PF02991	0.558
LIG_NRBOX	1086	1092	PF00104	0.592
LIG_PCNA_yPIPBox_3	807	819	PF02747	0.279
LIG_Pex14_2	296	300	PF04695	0.543
LIG_SH2_CRK	1026	1030	PF00017	0.591
LIG_SH2_CRK	889	893	PF00017	0.349
LIG_SH2_NCK_1	889	893	PF00017	0.408
LIG_SH2_SRC	83	86	PF00017	0.694
LIG_SH2_STAT3	351	354	PF00017	0.535
LIG_SH2_STAT3	574	577	PF00017	0.672
LIG_SH2_STAT5	258	261	PF00017	0.592
LIG_SH2_STAT5	351	354	PF00017	0.489
LIG_SH2_STAT5	552	555	PF00017	0.565
LIG_SH2_STAT5	645	648	PF00017	0.632
LIG_SH2_STAT5	733	736	PF00017	0.592
LIG_SH2_STAT5	770	773	PF00017	0.635
LIG_SH2_STAT5	815	818	PF00017	0.408
LIG_SH2_STAT5	83	86	PF00017	0.718
LIG_SH2_STAT5	886	889	PF00017	0.366
LIG_SH2_STAT5	896	899	PF00017	0.476
LIG_SH3_2	133	138	PF14604	0.545
LIG_SH3_3	1027	1033	PF00018	0.628
LIG_SH3_3	1036	1042	PF00018	0.613
LIG_SH3_3	130	136	PF00018	0.753
LIG_SH3_3	139	145	PF00018	0.606
LIG_SH3_3	169	175	PF00018	0.612
LIG_SH3_3	201	207	PF00018	0.662
LIG_SH3_3	295	301	PF00018	0.547
LIG_SH3_3	325	331	PF00018	0.691
LIG_SH3_3	334	340	PF00018	0.810
LIG_SH3_3	355	361	PF00018	0.607
LIG_SH3_3	563	569	PF00018	0.584
LIG_SH3_3	629	635	PF00018	0.582
LIG_SH3_3	660	666	PF00018	0.656
LIG_SH3_3	697	703	PF00018	0.536
LIG_SH3_5	79	83	PF00018	0.584
LIG_SUMO_SIM_anti_2	809	815	PF11976	0.279
LIG_SUMO_SIM_anti_2	842	848	PF11976	0.408
LIG_SUMO_SIM_par_1	177	182	PF11976	0.630
LIG_SUMO_SIM_par_1	634	640	PF11976	0.687
LIG_SUMO_SIM_par_1	677	684	PF11976	0.564
LIG_UBA3_1	130	138	PF00899	0.549
LIG_WRC_WIRS_1	31	36	PF05994	0.510
LIG_WRC_WIRS_1	38	43	PF05994	0.617
LIG_WRC_WIRS_1	823	828	PF05994	0.386
MOD_CDK_SPK_2	46	51	PF00069	0.682
MOD_CDK_SPxxK_3	203	210	PF00069	0.608
MOD_CK1_1	1022	1028	PF00069	0.654
MOD_CK1_1	1031	1037	PF00069	0.767
MOD_CK1_1	1075	1081	PF00069	0.515
MOD_CK1_1	1098	1104	PF00069	0.526
MOD_CK1_1	137	143	PF00069	0.618
MOD_CK1_1	221	227	PF00069	0.587
MOD_CK1_1	253	259	PF00069	0.605
MOD_CK1_1	327	333	PF00069	0.564
MOD_CK1_1	444	450	PF00069	0.598
MOD_CK1_1	46	52	PF00069	0.638
MOD_CK1_1	514	520	PF00069	0.637
MOD_CK1_1	609	615	PF00069	0.613
MOD_CK1_1	648	654	PF00069	0.564
MOD_CK1_1	706	712	PF00069	0.658
MOD_CK1_1	758	764	PF00069	0.539
MOD_CK1_1	776	782	PF00069	0.660
MOD_CK1_1	809	815	PF00069	0.419
MOD_CK1_1	938	944	PF00069	0.583
MOD_CK1_1	959	965	PF00069	0.656
MOD_CK1_1	987	993	PF00069	0.635
MOD_CK2_1	120	126	PF00069	0.650
MOD_CK2_1	193	199	PF00069	0.833
MOD_CK2_1	2	8	PF00069	0.510
MOD_CK2_1	235	241	PF00069	0.658
MOD_CK2_1	271	277	PF00069	0.572
MOD_CK2_1	542	548	PF00069	0.620
MOD_CK2_1	668	674	PF00069	0.511
MOD_CK2_1	815	821	PF00069	0.279
MOD_CK2_1	915	921	PF00069	0.699
MOD_CK2_1	968	974	PF00069	0.610
MOD_GlcNHglycan	1021	1024	PF01048	0.624
MOD_GlcNHglycan	211	214	PF01048	0.707
MOD_GlcNHglycan	215	218	PF01048	0.647
MOD_GlcNHglycan	224	227	PF01048	0.578
MOD_GlcNHglycan	252	255	PF01048	0.601
MOD_GlcNHglycan	341	344	PF01048	0.614
MOD_GlcNHglycan	401	404	PF01048	0.586
MOD_GlcNHglycan	428	431	PF01048	0.593
MOD_GlcNHglycan	446	449	PF01048	0.523
MOD_GlcNHglycan	484	487	PF01048	0.640
MOD_GlcNHglycan	627	630	PF01048	0.735
MOD_GlcNHglycan	647	650	PF01048	0.565
MOD_GlcNHglycan	695	698	PF01048	0.674
MOD_GlcNHglycan	708	711	PF01048	0.573
MOD_GlcNHglycan	785	788	PF01048	0.670
MOD_GlcNHglycan	790	793	PF01048	0.630
MOD_GlcNHglycan	802	805	PF01048	0.533
MOD_GlcNHglycan	917	920	PF01048	0.631
MOD_GlcNHglycan	956	959	PF01048	0.606
MOD_GSK3_1	1018	1025	PF00069	0.594
MOD_GSK3_1	1028	1035	PF00069	0.582
MOD_GSK3_1	1049	1056	PF00069	0.684
MOD_GSK3_1	144	151	PF00069	0.649
MOD_GSK3_1	209	216	PF00069	0.675
MOD_GSK3_1	218	225	PF00069	0.603
MOD_GSK3_1	229	236	PF00069	0.699
MOD_GSK3_1	256	263	PF00069	0.665
MOD_GSK3_1	26	33	PF00069	0.557
MOD_GSK3_1	327	334	PF00069	0.660
MOD_GSK3_1	390	397	PF00069	0.648
MOD_GSK3_1	408	415	PF00069	0.627
MOD_GSK3_1	46	53	PF00069	0.602
MOD_GSK3_1	499	506	PF00069	0.664
MOD_GSK3_1	514	521	PF00069	0.561
MOD_GSK3_1	538	545	PF00069	0.767
MOD_GSK3_1	580	587	PF00069	0.557
MOD_GSK3_1	606	613	PF00069	0.574
MOD_GSK3_1	645	652	PF00069	0.619
MOD_GSK3_1	658	665	PF00069	0.584
MOD_GSK3_1	675	682	PF00069	0.707
MOD_GSK3_1	755	762	PF00069	0.532
MOD_GSK3_1	770	777	PF00069	0.532
MOD_GSK3_1	802	809	PF00069	0.706
MOD_GSK3_1	83	90	PF00069	0.582
MOD_GSK3_1	937	944	PF00069	0.637
MOD_GSK3_1	961	968	PF00069	0.702
MOD_GSK3_1	989	996	PF00069	0.822
MOD_N-GLC_1	151	156	PF02516	0.643
MOD_N-GLC_1	482	487	PF02516	0.560
MOD_N-GLC_1	508	513	PF02516	0.602
MOD_N-GLC_1	693	698	PF02516	0.563
MOD_N-GLC_1	806	811	PF02516	0.551
MOD_N-GLC_1	830	835	PF02516	0.349
MOD_N-GLC_1	865	870	PF02516	0.408
MOD_N-GLC_2	439	441	PF02516	0.568
MOD_NEK2_1	100	105	PF00069	0.579
MOD_NEK2_1	1053	1058	PF00069	0.677
MOD_NEK2_1	148	153	PF00069	0.804
MOD_NEK2_1	162	167	PF00069	0.637
MOD_NEK2_1	26	31	PF00069	0.446
MOD_NEK2_1	446	451	PF00069	0.592
MOD_NEK2_1	499	504	PF00069	0.609
MOD_NEK2_1	559	564	PF00069	0.662
MOD_NEK2_1	647	652	PF00069	0.665
MOD_NEK2_1	858	863	PF00069	0.373
MOD_NEK2_1	872	877	PF00069	0.495
MOD_NEK2_1	966	971	PF00069	0.617
MOD_NEK2_1	978	983	PF00069	0.542
MOD_NEK2_1	993	998	PF00069	0.814
MOD_NEK2_2	1049	1054	PF00069	0.573
MOD_PIKK_1	446	452	PF00454	0.594
MOD_PIKK_1	50	56	PF00454	0.660
MOD_PIKK_1	610	616	PF00454	0.599
MOD_PIKK_1	742	748	PF00454	0.581
MOD_PIKK_1	872	878	PF00454	0.487
MOD_PKA_2	209	215	PF00069	0.677
MOD_PKA_2	285	291	PF00069	0.506
MOD_PKA_2	292	298	PF00069	0.582
MOD_PKA_2	318	324	PF00069	0.682
MOD_PKA_2	426	432	PF00069	0.725
MOD_PKA_2	499	505	PF00069	0.752
MOD_PKA_2	50	56	PF00069	0.660
MOD_PKA_2	511	517	PF00069	0.624
MOD_PKA_2	688	694	PF00069	0.554
MOD_PKA_2	872	878	PF00069	0.361
MOD_PKA_2	938	944	PF00069	0.586
MOD_Plk_1	1065	1071	PF00069	0.521
MOD_Plk_1	151	157	PF00069	0.580
MOD_Plk_1	27	33	PF00069	0.447
MOD_Plk_1	352	358	PF00069	0.548
MOD_Plk_1	806	812	PF00069	0.526
MOD_Plk_1	839	845	PF00069	0.349
MOD_Plk_1	978	984	PF00069	0.602
MOD_Plk_4	1006	1012	PF00069	0.809
MOD_Plk_4	1055	1061	PF00069	0.577
MOD_Plk_4	144	150	PF00069	0.727
MOD_Plk_4	175	181	PF00069	0.597
MOD_Plk_4	235	241	PF00069	0.554
MOD_Plk_4	27	33	PF00069	0.459
MOD_Plk_4	271	277	PF00069	0.572
MOD_Plk_4	37	43	PF00069	0.611
MOD_Plk_4	538	544	PF00069	0.560
MOD_Plk_4	640	646	PF00069	0.690
MOD_Plk_4	668	674	PF00069	0.535
MOD_Plk_4	675	681	PF00069	0.562
MOD_Plk_4	733	739	PF00069	0.603
MOD_Plk_4	806	812	PF00069	0.718
MOD_Plk_4	842	848	PF00069	0.408
MOD_Plk_4	938	944	PF00069	0.583
MOD_Plk_4	968	974	PF00069	0.656
MOD_ProDKin_1	1033	1039	PF00069	0.709
MOD_ProDKin_1	203	209	PF00069	0.606
MOD_ProDKin_1	229	235	PF00069	0.559
MOD_ProDKin_1	324	330	PF00069	0.658
MOD_ProDKin_1	441	447	PF00069	0.541
MOD_ProDKin_1	46	52	PF00069	0.683
MOD_ProDKin_1	468	474	PF00069	0.601
MOD_ProDKin_1	662	668	PF00069	0.674
MOD_ProDKin_1	718	724	PF00069	0.760
MOD_ProDKin_1	776	782	PF00069	0.649
MOD_SUMO_rev_2	611	620	PF00179	0.617
TRG_DiLeu_BaEn_1	126	131	PF01217	0.573
TRG_DiLeu_BaEn_1	980	985	PF01217	0.671
TRG_DiLeu_BaLyEn_6	130	135	PF01217	0.630
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.641
TRG_DiLeu_LyEn_5	126	131	PF01217	0.573
TRG_ENDOCYTIC_2	1026	1029	PF00928	0.601
TRG_ENDOCYTIC_2	496	499	PF00928	0.609
TRG_ER_diArg_1	1084	1087	PF00400	0.503
TRG_ER_diArg_1	188	190	PF00400	0.661
TRG_ER_diArg_1	282	284	PF00400	0.586
TRG_ER_diArg_1	440	443	PF00400	0.561
TRG_ER_diArg_1	599	602	PF00400	0.569
TRG_ER_diArg_1	685	687	PF00400	0.553
TRG_ER_diArg_1	869	872	PF00400	0.279
TRG_ER_diArg_1	893	895	PF00400	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXR0	Leptomonas seymouri	40%	100%
A0A3Q8IF35	Leishmania donovani	66%	100%
A4I9B5	Leishmania infantum	66%	100%
E9B4B5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	97%
Q4Q3R0	Leishmania major	64%	100%