Eukaryotic translation initiation factor 5B

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation initiation factor IF-2, putative

Species:

Leishmania braziliensis

UniProt:

A4HLY5_LEIBR

TriTrypDb:

LbrM.33.3020 , LBRM2903_330038200

Length:

817

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 3
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLY5

Function

Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003743	translation initiation factor activity	4	11
GO:0003824	catalytic activity	1	11
GO:0003924	GTPase activity	7	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.711
CLV_NRD_NRD_1	179	181	PF00675	0.547
CLV_NRD_NRD_1	196	198	PF00675	0.550
CLV_NRD_NRD_1	205	207	PF00675	0.539
CLV_NRD_NRD_1	49	51	PF00675	0.554
CLV_NRD_NRD_1	61	63	PF00675	0.601
CLV_NRD_NRD_1	622	624	PF00675	0.260
CLV_NRD_NRD_1	723	725	PF00675	0.520
CLV_NRD_NRD_1	83	85	PF00675	0.559
CLV_NRD_NRD_1	86	88	PF00675	0.588
CLV_PCSK_FUR_1	341	345	PF00082	0.337
CLV_PCSK_KEX2_1	179	181	PF00082	0.547
CLV_PCSK_KEX2_1	205	207	PF00082	0.595
CLV_PCSK_KEX2_1	343	345	PF00082	0.320
CLV_PCSK_KEX2_1	49	51	PF00082	0.557
CLV_PCSK_KEX2_1	611	613	PF00082	0.252
CLV_PCSK_KEX2_1	621	623	PF00082	0.258
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.595
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.337
CLV_PCSK_PC1ET2_1	611	613	PF00082	0.258
CLV_PCSK_PC1ET2_1	621	623	PF00082	0.258
CLV_PCSK_PC7_1	201	207	PF00082	0.557
CLV_PCSK_SKI1_1	179	183	PF00082	0.691
CLV_PCSK_SKI1_1	271	275	PF00082	0.202
CLV_PCSK_SKI1_1	460	464	PF00082	0.441
CLV_PCSK_SKI1_1	498	502	PF00082	0.258
CLV_PCSK_SKI1_1	519	523	PF00082	0.258
CLV_PCSK_SKI1_1	561	565	PF00082	0.574
CLV_PCSK_SKI1_1	595	599	PF00082	0.271
CLV_PCSK_SKI1_1	791	795	PF00082	0.497
CLV_PCSK_SKI1_1	810	814	PF00082	0.468
DEG_MDM2_SWIB_1	383	390	PF02201	0.537
DEG_SCF_FBW7_2	296	303	PF00400	0.458
DEG_SPOP_SBC_1	579	583	PF00917	0.458
DOC_CKS1_1	297	302	PF01111	0.458
DOC_CKS1_1	500	505	PF01111	0.458
DOC_CKS1_1	716	721	PF01111	0.415
DOC_CKS1_1	748	753	PF01111	0.544
DOC_CYCLIN_RxL_1	495	502	PF00134	0.458
DOC_MAPK_DCC_7	681	690	PF00069	0.387
DOC_MAPK_gen_1	132	141	PF00069	0.541
DOC_MAPK_gen_1	25	32	PF00069	0.639
DOC_MAPK_gen_1	283	291	PF00069	0.488
DOC_MAPK_gen_1	341	351	PF00069	0.464
DOC_MAPK_gen_1	408	416	PF00069	0.458
DOC_MAPK_gen_1	519	529	PF00069	0.458
DOC_MAPK_gen_1	621	633	PF00069	0.488
DOC_MAPK_gen_1	646	652	PF00069	0.471
DOC_MAPK_gen_1	677	685	PF00069	0.426
DOC_MAPK_gen_1	724	733	PF00069	0.570
DOC_MAPK_gen_1	98	106	PF00069	0.680
DOC_MAPK_MEF2A_6	132	141	PF00069	0.541
DOC_MAPK_MEF2A_6	522	529	PF00069	0.458
DOC_MAPK_MEF2A_6	626	633	PF00069	0.450
DOC_PP2B_LxvP_1	289	292	PF13499	0.458
DOC_PP2B_LxvP_1	812	815	PF13499	0.450
DOC_PP4_FxxP_1	633	636	PF00568	0.537
DOC_USP7_MATH_1	137	141	PF00917	0.670
DOC_USP7_MATH_1	273	277	PF00917	0.539
DOC_USP7_MATH_1	600	604	PF00917	0.451
DOC_USP7_UBL2_3	130	134	PF12436	0.695
DOC_USP7_UBL2_3	25	29	PF12436	0.351
DOC_USP7_UBL2_3	445	449	PF12436	0.421
DOC_USP7_UBL2_3	7	11	PF12436	0.637
DOC_USP7_UBL2_3	794	798	PF12436	0.564
DOC_USP7_UBL2_3	813	817	PF12436	0.619
DOC_USP7_UBL2_3	88	92	PF12436	0.601
DOC_WW_Pin1_4	224	229	PF00397	0.387
DOC_WW_Pin1_4	296	301	PF00397	0.458
DOC_WW_Pin1_4	499	504	PF00397	0.448
DOC_WW_Pin1_4	715	720	PF00397	0.402
DOC_WW_Pin1_4	747	752	PF00397	0.555
LIG_14-3-3_CanoR_1	311	316	PF00244	0.448
LIG_14-3-3_CanoR_1	411	417	PF00244	0.537
LIG_14-3-3_CanoR_1	735	740	PF00244	0.484
LIG_14-3-3_CanoR_1	784	788	PF00244	0.559
LIG_Actin_WH2_2	676	693	PF00022	0.545
LIG_Actin_WH2_2	702	717	PF00022	0.474
LIG_Clathr_ClatBox_1	294	298	PF01394	0.458
LIG_Clathr_ClatBox_1	430	434	PF01394	0.458
LIG_CtBP_PxDLS_1	752	758	PF00389	0.564
LIG_EH1_1	466	474	PF00400	0.510
LIG_FAT_LD_1	587	595	PF03623	0.458
LIG_FHA_1	239	245	PF00498	0.458
LIG_FHA_1	259	265	PF00498	0.325
LIG_FHA_1	276	282	PF00498	0.450
LIG_FHA_1	466	472	PF00498	0.522
LIG_FHA_1	539	545	PF00498	0.542
LIG_FHA_1	698	704	PF00498	0.485
LIG_FHA_2	157	163	PF00498	0.650
LIG_FHA_2	183	189	PF00498	0.650
LIG_FHA_2	445	451	PF00498	0.412
LIG_FHA_2	453	459	PF00498	0.357
LIG_GBD_Chelix_1	321	329	PF00786	0.258
LIG_LIR_Apic_2	533	539	PF02991	0.458
LIG_LIR_Apic_2	568	572	PF02991	0.537
LIG_LIR_Gen_1	167	174	PF02991	0.559
LIG_LIR_Gen_1	624	635	PF02991	0.537
LIG_LIR_Nem_3	167	173	PF02991	0.579
LIG_LIR_Nem_3	303	308	PF02991	0.458
LIG_LIR_Nem_3	385	390	PF02991	0.537
LIG_LIR_Nem_3	624	630	PF02991	0.537
LIG_LIR_Nem_3	663	668	PF02991	0.515
LIG_NRBOX	586	592	PF00104	0.458
LIG_Pex14_2	383	387	PF04695	0.537
LIG_Rb_pABgroove_1	352	360	PF01858	0.488
LIG_Rb_pABgroove_1	656	664	PF01858	0.458
LIG_SH2_CRK	627	631	PF00017	0.488
LIG_SH2_GRB2like	405	408	PF00017	0.508
LIG_SH2_GRB2like	668	671	PF00017	0.483
LIG_SH2_PTP2	536	539	PF00017	0.510
LIG_SH2_SRC	515	518	PF00017	0.458
LIG_SH2_SRC	536	539	PF00017	0.537
LIG_SH2_SRC	569	572	PF00017	0.380
LIG_SH2_STAP1	627	631	PF00017	0.488
LIG_SH2_STAT5	515	518	PF00017	0.471
LIG_SH2_STAT5	536	539	PF00017	0.510
LIG_SH2_STAT5	569	572	PF00017	0.380
LIG_SH3_3	138	144	PF00018	0.631
LIG_SH3_3	713	719	PF00018	0.430
LIG_SH3_4	130	137	PF00018	0.682
LIG_Sin3_3	319	326	PF02671	0.458
LIG_SUMO_SIM_anti_2	317	322	PF11976	0.458
LIG_SUMO_SIM_anti_2	429	434	PF11976	0.459
LIG_SUMO_SIM_anti_2	468	473	PF11976	0.537
LIG_SUMO_SIM_anti_2	541	547	PF11976	0.407
LIG_SUMO_SIM_anti_2	727	734	PF11976	0.494
LIG_SUMO_SIM_anti_2	800	807	PF11976	0.543
LIG_SUMO_SIM_par_1	293	299	PF11976	0.458
LIG_SUMO_SIM_par_1	319	324	PF11976	0.458
LIG_SUMO_SIM_par_1	429	434	PF11976	0.459
LIG_SUMO_SIM_par_1	705	710	PF11976	0.536
LIG_SUMO_SIM_par_1	744	750	PF11976	0.558
LIG_SUMO_SIM_par_1	800	807	PF11976	0.543
LIG_TRAF2_1	144	147	PF00917	0.693
LIG_TRAF2_1	208	211	PF00917	0.455
LIG_TRAF2_1	277	280	PF00917	0.408
LIG_TRAF2_1	35	38	PF00917	0.567
LIG_TRAF2_1	44	47	PF00917	0.527
LIG_UBA3_1	22	29	PF00899	0.542
LIG_UBA3_1	590	598	PF00899	0.458
LIG_UBA3_1	804	813	PF00899	0.423
LIG_WRC_WIRS_1	590	595	PF05994	0.488
MOD_CK1_1	310	316	PF00069	0.458
MOD_CK1_1	420	426	PF00069	0.458
MOD_CK1_1	578	584	PF00069	0.537
MOD_CK1_1	761	767	PF00069	0.467
MOD_CK1_1	780	786	PF00069	0.403
MOD_CK2_1	158	164	PF00069	0.605
MOD_CK2_1	182	188	PF00069	0.649
MOD_CK2_1	273	279	PF00069	0.500
MOD_CK2_1	452	458	PF00069	0.369
MOD_DYRK1A_RPxSP_1	715	719	PF00069	0.536
MOD_GlcNHglycan	275	278	PF01048	0.370
MOD_GlcNHglycan	393	397	PF01048	0.351
MOD_GlcNHglycan	419	422	PF01048	0.258
MOD_GlcNHglycan	529	532	PF01048	0.351
MOD_GlcNHglycan	720	723	PF01048	0.502
MOD_GlcNHglycan	760	763	PF01048	0.465
MOD_GSK3_1	220	227	PF00069	0.498
MOD_GSK3_1	235	242	PF00069	0.410
MOD_GSK3_1	303	310	PF00069	0.446
MOD_GSK3_1	378	385	PF00069	0.488
MOD_GSK3_1	412	419	PF00069	0.458
MOD_GSK3_1	575	582	PF00069	0.497
MOD_GSK3_1	589	596	PF00069	0.380
MOD_GSK3_1	693	700	PF00069	0.575
MOD_NEK2_1	452	457	PF00069	0.372
MOD_NEK2_1	575	580	PF00069	0.530
MOD_NEK2_1	593	598	PF00069	0.380
MOD_NEK2_1	804	809	PF00069	0.403
MOD_PIKK_1	258	264	PF00454	0.458
MOD_PIKK_1	492	498	PF00454	0.458
MOD_PIKK_1	538	544	PF00454	0.558
MOD_PK_1	679	685	PF00069	0.569
MOD_PK_1	726	732	PF00069	0.562
MOD_PKA_1	179	185	PF00069	0.656
MOD_PKA_1	197	203	PF00069	0.650
MOD_PKA_2	179	185	PF00069	0.611
MOD_PKA_2	247	253	PF00069	0.458
MOD_PKA_2	310	316	PF00069	0.453
MOD_PKA_2	333	339	PF00069	0.455
MOD_PKA_2	663	669	PF00069	0.489
MOD_PKA_2	783	789	PF00069	0.412
MOD_PKB_1	309	317	PF00069	0.458
MOD_Plk_1	726	732	PF00069	0.597
MOD_Plk_4	239	245	PF00069	0.458
MOD_Plk_4	264	270	PF00069	0.458
MOD_Plk_4	412	418	PF00069	0.458
MOD_Plk_4	452	458	PF00069	0.372
MOD_Plk_4	589	595	PF00069	0.488
MOD_Plk_4	726	732	PF00069	0.595
MOD_Plk_4	804	810	PF00069	0.413
MOD_ProDKin_1	224	230	PF00069	0.384
MOD_ProDKin_1	296	302	PF00069	0.458
MOD_ProDKin_1	499	505	PF00069	0.448
MOD_ProDKin_1	715	721	PF00069	0.398
MOD_ProDKin_1	747	753	PF00069	0.552
MOD_SUMO_for_1	28	31	PF00179	0.632
MOD_SUMO_for_1	390	393	PF00179	0.471
MOD_SUMO_for_1	793	796	PF00179	0.484
MOD_SUMO_rev_2	193	200	PF00179	0.685
MOD_SUMO_rev_2	48	58	PF00179	0.550
MOD_SUMO_rev_2	649	658	PF00179	0.377
MOD_SUMO_rev_2	795	799	PF00179	0.541
MOD_SUMO_rev_2	80	90	PF00179	0.647
TRG_DiLeu_BaEn_1	335	340	PF01217	0.458
TRG_DiLeu_BaEn_4	209	215	PF01217	0.592
TRG_DiLeu_BaEn_4	37	43	PF01217	0.535
TRG_DiLeu_LyEn_5	335	340	PF01217	0.458
TRG_ENDOCYTIC_2	627	630	PF00928	0.488
TRG_ENDOCYTIC_2	659	662	PF00928	0.458
TRG_ER_diArg_1	308	311	PF00400	0.458
TRG_ER_diArg_1	39	42	PF00400	0.513
TRG_ER_diArg_1	49	52	PF00400	0.510
TRG_ER_diArg_1	509	512	PF00400	0.458
TRG_NES_CRM1_1	678	689	PF08389	0.514
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.258
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P688	Leptomonas seymouri	78%	99%
A0A1X0NR88	Trypanosomatidae	71%	99%
A0A3Q8IHQ5	Leishmania donovani	95%	100%
A0A3R7NFT4	Trypanosoma rangeli	69%	98%
A0B8Q6	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	36%	100%
A1RGX5	Shewanella sp. (strain W3-18-1)	27%	93%
A1RUX2	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	33%	100%
A1RXH6	Thermofilum pendens (strain DSM 2475 / Hrk 5)	36%	100%
A1TSK3	Acidovorax citrulli (strain AAC00-1)	27%	87%
A1VXL9	Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)	26%	94%
A1W8Z4	Acidovorax sp. (strain JS42)	26%	87%
A2BJZ8	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	35%	100%
A2STM8	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	37%	100%
A3CSP4	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	36%	100%
A3DMS0	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	37%	100%
A3MTU7	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	35%	100%
A3QGU5	Shewanella loihica (strain ATCC BAA-1088 / PV-4)	27%	92%
A4FZQ3	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	36%	100%
A4G7S7	Herminiimonas arsenicoxydans	27%	87%
A4I9B4	Leishmania infantum	95%	100%
A4WIK2	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	34%	100%
A4Y9C0	Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)	27%	93%
A4YCQ5	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	36%	100%
A5UJM9	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	31%	100%
A6MVX8	Rhodomonas salina	26%	100%
A6URS1	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	35%	100%
A6UVG0	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	36%	100%
A6VIS4	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	36%	100%
A7GZZ3	Campylobacter curvus (strain 525.92)	29%	90%
A7H1L5	Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)	26%	96%
A7IAP7	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	36%	100%
A8A8D3	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	36%	100%
A8FJU1	Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)	26%	94%
A8MBV9	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	36%	100%
A9A813	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	36%	100%
B0R6U5	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	37%	100%
B1KRR0	Shewanella woodyi (strain ATCC 51908 / MS32)	27%	91%
B1YCQ7	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	34%	100%
B2FN90	Stenotrophomonas maltophilia (strain K279a)	27%	93%
B2GUV7	Rattus norvegicus	47%	67%
B4RXT8	Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)	26%	94%
B5EI57	Citrifermentans bemidjiense (strain ATCC BAA-1014 / DSM 16622 / JCM 12645 / Bem)	26%	83%
B6YWH3	Thermococcus onnurineus (strain NA1)	36%	100%
B9KEV0	Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060)	27%	93%
B9LQL7	Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)	34%	100%
C1DFK9	Azotobacter vinelandii (strain DJ / ATCC BAA-1303)	26%	98%
C4L8X4	Tolumonas auensis (strain DSM 9187 / TA4)	26%	90%
C6A1V3	Thermococcus sibiricus (strain DSM 12597 / MM 739)	35%	100%
C6E2Q0	Geobacter sp. (strain M21)	26%	83%
C9ZJA9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	98%
E9B4B4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
G0S8G9	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	52%	73%
O26359	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	35%	100%
O29490	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	37%	100%
O58822	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	33%	78%
O60841	Homo sapiens	47%	67%
P39730	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	82%
P75590	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	27%	100%
P95691	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	34%	100%
Q05D44	Mus musculus	47%	67%
Q0VSS1	Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2)	26%	91%
Q0W8X2	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	37%	100%
Q10251	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	76%
Q12Z93	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	34%	100%
Q18FT0	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	34%	100%
Q1QEP5	Psychrobacter cryohalolentis (strain ATCC BAA-1226 / DSM 17306 / VKM B-2378 / K5)	28%	90%
Q2FU48	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	37%	100%
Q2NGM6	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	33%	100%
Q2SML3	Hahella chejuensis (strain KCTC 2396)	26%	95%
Q30WJ0	Oleidesulfovibrio alaskensis (strain ATCC BAA-1058 / DSM 17464 / G20)	25%	83%
Q38W81	Latilactobacillus sakei subsp. sakei (strain 23K)	26%	87%
Q3IMS5	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	33%	100%
Q3YS01	Ehrlichia canis (strain Jake)	25%	96%
Q466D5	Methanosarcina barkeri (strain Fusaro / DSM 804)	34%	100%
Q4FVL5	Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4)	28%	90%
Q4Q3R1	Leishmania major	92%	100%
Q54XP6	Dictyostelium discoideum	47%	78%
Q57710	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	35%	71%
Q5FJN6	Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)	26%	93%
Q5HX30	Campylobacter jejuni (strain RM1221)	26%	94%
Q5JGR9	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	35%	71%
Q5QTY8	Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)	26%	91%
Q5RDE1	Pongo abelii	46%	67%
Q5UXU6	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	35%	100%
Q609C0	Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)	27%	94%
Q6FF40	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	29%	91%
Q6M0I6	Methanococcus maripaludis (strain S2 / LL)	36%	100%
Q835U8	Enterococcus faecalis (strain ATCC 700802 / V583)	25%	100%
Q8PU78	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	33%	100%
Q8TQL5	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	34%	100%
Q8TV06	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	35%	100%
Q8U1R8	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	34%	83%
Q8ZX20	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	35%	100%
Q976A1	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	35%	100%
Q97BK4	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	32%	100%
Q980Q8	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	35%	100%
Q9HJ60	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	32%	100%
Q9HNQ2	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	37%	100%
Q9PIZ1	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	27%	94%
Q9UZK7	Pyrococcus abyssi (strain GE5 / Orsay)	34%	82%
Q9Y9B3	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	35%	100%
V5AV36	Trypanosoma cruzi	69%	92%