Mitochondrial guide RNA binding complex subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

guide RNA associated protein 1, putative

Species:

Leishmania braziliensis

UniProt:

A4HLY4_LEIBR

TriTrypDb:

LbrM.33.3010 , LBRM2903_330038100

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4HLY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLY4

Function

Biological processes
Term	Name	Level	Count
GO:0000959	mitochondrial RNA metabolic process	6	2
GO:0000963	mitochondrial RNA processing	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	2
GO:0010467	gene expression	4	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	1
GO:0016556	mRNA modification	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0140053	mitochondrial gene expression	5	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	328	332	PF00656	0.515
CLV_C14_Caspase3-7	389	393	PF00656	0.483
CLV_NRD_NRD_1	159	161	PF00675	0.605
CLV_NRD_NRD_1	231	233	PF00675	0.481
CLV_NRD_NRD_1	324	326	PF00675	0.451
CLV_NRD_NRD_1	413	415	PF00675	0.354
CLV_NRD_NRD_1	432	434	PF00675	0.468
CLV_PCSK_KEX2_1	159	161	PF00082	0.589
CLV_PCSK_KEX2_1	231	233	PF00082	0.481
CLV_PCSK_KEX2_1	324	326	PF00082	0.467
CLV_PCSK_KEX2_1	375	377	PF00082	0.372
CLV_PCSK_KEX2_1	432	434	PF00082	0.397
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.421
CLV_PCSK_SKI1_1	11	15	PF00082	0.684
CLV_PCSK_SKI1_1	256	260	PF00082	0.462
CLV_PCSK_SKI1_1	493	497	PF00082	0.422
DOC_MAPK_gen_1	159	167	PF00069	0.566
DOC_MAPK_gen_1	265	273	PF00069	0.475
DOC_MAPK_gen_1	432	438	PF00069	0.407
DOC_MAPK_gen_1	459	468	PF00069	0.266
DOC_MAPK_MEF2A_6	357	365	PF00069	0.376
DOC_MAPK_MEF2A_6	419	428	PF00069	0.419
DOC_PP1_RVXF_1	230	237	PF00149	0.423
DOC_PP1_RVXF_1	254	260	PF00149	0.478
DOC_SPAK_OSR1_1	349	353	PF12202	0.392
DOC_SPAK_OSR1_1	364	368	PF12202	0.370
DOC_USP7_MATH_1	206	210	PF00917	0.502
DOC_USP7_MATH_1	290	294	PF00917	0.389
DOC_USP7_MATH_1	315	319	PF00917	0.424
DOC_USP7_MATH_1	497	501	PF00917	0.682
DOC_USP7_MATH_1	99	103	PF00917	0.398
DOC_WW_Pin1_4	396	401	PF00397	0.431
DOC_WW_Pin1_4	431	436	PF00397	0.405
LIG_14-3-3_CanoR_1	268	272	PF00244	0.455
LIG_14-3-3_CanoR_1	41	48	PF00244	0.655
LIG_14-3-3_CanoR_1	493	501	PF00244	0.427
LIG_Actin_WH2_2	158	173	PF00022	0.540
LIG_Actin_WH2_2	375	390	PF00022	0.516
LIG_BIR_II_1	1	5	PF00653	0.542
LIG_deltaCOP1_diTrp_1	149	156	PF00928	0.599
LIG_deltaCOP1_diTrp_1	235	242	PF00928	0.404
LIG_deltaCOP1_diTrp_1	58	64	PF00928	0.455
LIG_FHA_1	268	274	PF00498	0.582
LIG_FHA_1	351	357	PF00498	0.458
LIG_FHA_1	423	429	PF00498	0.373
LIG_FHA_1	432	438	PF00498	0.398
LIG_FHA_1	54	60	PF00498	0.558
LIG_FHA_2	130	136	PF00498	0.616
LIG_FHA_2	138	144	PF00498	0.631
LIG_FHA_2	196	202	PF00498	0.483
LIG_GBD_Chelix_1	303	311	PF00786	0.441
LIG_LIR_Gen_1	163	172	PF02991	0.544
LIG_LIR_Gen_1	174	184	PF02991	0.514
LIG_LIR_Gen_1	449	460	PF02991	0.361
LIG_LIR_Gen_1	51	60	PF02991	0.416
LIG_LIR_Nem_3	163	167	PF02991	0.560
LIG_LIR_Nem_3	174	179	PF02991	0.543
LIG_LIR_Nem_3	449	455	PF02991	0.365
LIG_LIR_Nem_3	51	55	PF02991	0.431
LIG_SH2_CRK	184	188	PF00017	0.426
LIG_SH2_CRK	260	264	PF00017	0.480
LIG_SH2_CRK	475	479	PF00017	0.479
LIG_SH2_SRC	281	284	PF00017	0.435
LIG_SH2_SRC	381	384	PF00017	0.384
LIG_SH2_STAP1	176	180	PF00017	0.512
LIG_SH2_STAP1	450	454	PF00017	0.313
LIG_SH2_STAT3	79	82	PF00017	0.399
LIG_SH2_STAT5	215	218	PF00017	0.494
LIG_SH2_STAT5	286	289	PF00017	0.468
LIG_SH2_STAT5	355	358	PF00017	0.364
LIG_SH2_STAT5	381	384	PF00017	0.525
LIG_SH2_STAT5	407	410	PF00017	0.360
LIG_SH2_STAT5	80	83	PF00017	0.398
LIG_SH3_3	340	346	PF00018	0.494
LIG_SH3_3	394	400	PF00018	0.453
LIG_SH3_3	451	457	PF00018	0.362
LIG_SH3_3	91	97	PF00018	0.675
LIG_SUMO_SIM_anti_2	451	457	PF11976	0.484
LIG_SUMO_SIM_anti_2	461	467	PF11976	0.525
LIG_SUMO_SIM_anti_2	88	96	PF11976	0.385
LIG_SUMO_SIM_par_1	434	439	PF11976	0.439
LIG_SUMO_SIM_par_1	464	471	PF11976	0.465
LIG_SUMO_SIM_par_1	88	96	PF11976	0.385
LIG_TYR_ITIM	258	263	PF00017	0.455
LIG_TYR_ITIM	448	453	PF00017	0.378
MOD_CK1_1	189	195	PF00069	0.467
MOD_CK1_1	393	399	PF00069	0.425
MOD_CK1_1	53	59	PF00069	0.487
MOD_CK1_1	88	94	PF00069	0.576
MOD_CK2_1	137	143	PF00069	0.699
MOD_CK2_1	292	298	PF00069	0.413
MOD_CK2_1	70	76	PF00069	0.411
MOD_CMANNOS	61	64	PF00535	0.399
MOD_GlcNHglycan	112	115	PF01048	0.496
MOD_GlcNHglycan	124	128	PF01048	0.610
MOD_GlcNHglycan	19	22	PF01048	0.652
MOD_GlcNHglycan	190	194	PF01048	0.564
MOD_GlcNHglycan	246	249	PF01048	0.372
MOD_GlcNHglycan	292	295	PF01048	0.499
MOD_GlcNHglycan	44	47	PF01048	0.645
MOD_GlcNHglycan	72	75	PF01048	0.350
MOD_GSK3_1	386	393	PF00069	0.426
MOD_GSK3_1	489	496	PF00069	0.575
MOD_N-GLC_1	117	122	PF02516	0.487
MOD_N-GLC_1	244	249	PF02516	0.292
MOD_NEK2_1	1	6	PF00069	0.627
MOD_NEK2_1	241	246	PF00069	0.404
MOD_NEK2_1	259	264	PF00069	0.564
MOD_NEK2_1	338	343	PF00069	0.405
MOD_NEK2_1	350	355	PF00069	0.356
MOD_NEK2_1	36	41	PF00069	0.731
MOD_NEK2_1	428	433	PF00069	0.369
MOD_NEK2_1	436	441	PF00069	0.461
MOD_NEK2_1	491	496	PF00069	0.525
MOD_NEK2_1	70	75	PF00069	0.360
MOD_PIKK_1	355	361	PF00454	0.360
MOD_PIKK_1	417	423	PF00454	0.517
MOD_PKA_1	100	106	PF00069	0.570
MOD_PKA_2	17	23	PF00069	0.715
MOD_PKA_2	267	273	PF00069	0.591
MOD_PKA_2	387	393	PF00069	0.495
MOD_Plk_1	117	123	PF00069	0.475
MOD_Plk_1	137	143	PF00069	0.680
MOD_Plk_1	50	56	PF00069	0.480
MOD_Plk_1	88	94	PF00069	0.397
MOD_Plk_4	100	106	PF00069	0.467
MOD_Plk_4	393	399	PF00069	0.425
MOD_Plk_4	4	10	PF00069	0.735
MOD_Plk_4	88	94	PF00069	0.667
MOD_ProDKin_1	396	402	PF00069	0.425
MOD_ProDKin_1	431	437	PF00069	0.408
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.410
TRG_ENDOCYTIC_2	164	167	PF00928	0.612
TRG_ENDOCYTIC_2	176	179	PF00928	0.377
TRG_ENDOCYTIC_2	184	187	PF00928	0.381
TRG_ENDOCYTIC_2	260	263	PF00928	0.456
TRG_ENDOCYTIC_2	286	289	PF00928	0.401
TRG_ENDOCYTIC_2	450	453	PF00928	0.347
TRG_ENDOCYTIC_2	475	478	PF00928	0.482
TRG_ER_diArg_1	230	232	PF00400	0.392
TRG_ER_diArg_1	323	325	PF00400	0.417
TRG_ER_diArg_1	367	370	PF00400	0.377
TRG_NES_CRM1_1	298	313	PF08389	0.529
TRG_NLS_MonoExtC_3	373	379	PF00514	0.407
TRG_NLS_MonoExtN_4	372	378	PF00514	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK37	Leptomonas seymouri	28%	100%
A0A0N1IKX3	Leptomonas seymouri	80%	92%
A0A0S4IN88	Bodo saltans	29%	93%
A0A0S4JQR1	Bodo saltans	57%	93%
A0A1X0NRA1	Trypanosomatidae	70%	98%
A0A1X0NTQ0	Trypanosomatidae	30%	100%
A0A3Q8II17	Leishmania donovani	87%	100%
A0A3S7WX47	Leishmania donovani	29%	100%
A0A422NDT8	Trypanosoma rangeli	30%	100%
A0A422NKD3	Trypanosoma rangeli	68%	100%
A4HCA9	Leishmania braziliensis	27%	100%
A4HZU2	Leishmania infantum	29%	100%
A4I9B3	Leishmania infantum	87%	100%
C9ZJB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
C9ZRN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AVP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B4B3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q3R2	Leishmania major	88%	100%
Q4QBT2	Leishmania major	29%	100%
V5BAI0	Trypanosoma cruzi	69%	100%
V5BVS4	Trypanosoma cruzi	30%	100%