Beta-ketoacyl-[acyl-carrier-protein] synthase I

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta-ketoacyl synthase family protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HLY3_LEIBR

TriTrypDb:

LbrM.33.3000 , LBRM2903_330037900

Length:

459

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLY3

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0006633	fatty acid biosynthetic process	5	2
GO:0008152	metabolic process	1	2
GO:0008610	lipid biosynthetic process	4	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0016053	organic acid biosynthetic process	4	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0046394	carboxylic acid biosynthetic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0072330	monocarboxylic acid biosynthetic process	6	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004312	fatty acid synthase activity	5	11
GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	6	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	317	319	PF00675	0.312
CLV_PCSK_KEX2_1	317	319	PF00082	0.312
DEG_SCF_FBW7_1	409	415	PF00400	0.353
DEG_SPOP_SBC_1	440	444	PF00917	0.264
DOC_CKS1_1	1	6	PF01111	0.435
DOC_CKS1_1	409	414	PF01111	0.353
DOC_MAPK_gen_1	213	221	PF00069	0.266
DOC_MAPK_MEF2A_6	125	132	PF00069	0.253
DOC_PP1_RVXF_1	96	103	PF00149	0.408
DOC_USP7_MATH_1	190	194	PF00917	0.247
DOC_USP7_MATH_1	361	365	PF00917	0.170
DOC_USP7_MATH_1	385	389	PF00917	0.247
DOC_WW_Pin1_4	162	167	PF00397	0.232
DOC_WW_Pin1_4	227	232	PF00397	0.247
DOC_WW_Pin1_4	247	252	PF00397	0.126
DOC_WW_Pin1_4	284	289	PF00397	0.295
DOC_WW_Pin1_4	364	369	PF00397	0.364
DOC_WW_Pin1_4	408	413	PF00397	0.359
LIG_14-3-3_CanoR_1	239	244	PF00244	0.269
LIG_14-3-3_CanoR_1	360	366	PF00244	0.290
LIG_Actin_WH2_2	346	362	PF00022	0.312
LIG_BRCT_BRCA1_1	164	168	PF00533	0.261
LIG_BRCT_BRCA1_1	254	258	PF00533	0.222
LIG_BRCT_BRCA1_1	441	445	PF00533	0.266
LIG_FHA_1	285	291	PF00498	0.281
LIG_FHA_1	341	347	PF00498	0.247
LIG_FHA_1	40	46	PF00498	0.395
LIG_FHA_1	404	410	PF00498	0.380
LIG_FHA_1	450	456	PF00498	0.281
LIG_FHA_2	119	125	PF00498	0.262
LIG_FHA_2	343	349	PF00498	0.247
LIG_FHA_2	428	434	PF00498	0.456
LIG_FHA_2	6	12	PF00498	0.312
LIG_FHA_2	91	97	PF00498	0.290
LIG_LIR_Nem_3	11	16	PF02991	0.266
LIG_LIR_Nem_3	444	450	PF02991	0.308
LIG_NRBOX	378	384	PF00104	0.290
LIG_PDZ_Class_1	454	459	PF00595	0.297
LIG_Pex14_2	32	36	PF04695	0.380
LIG_SH2_CRK	161	165	PF00017	0.247
LIG_SH2_GRB2like	337	340	PF00017	0.247
LIG_SH2_NCK_1	161	165	PF00017	0.300
LIG_SH2_SRC	337	340	PF00017	0.247
LIG_SH2_STAT5	146	149	PF00017	0.371
LIG_SH2_STAT5	337	340	PF00017	0.247
LIG_SH2_STAT5	371	374	PF00017	0.187
LIG_SH3_3	303	309	PF00018	0.326
LIG_SH3_3	60	66	PF00018	0.276
LIG_SUMO_SIM_anti_2	348	354	PF11976	0.312
LIG_SUMO_SIM_par_1	272	277	PF11976	0.226
LIG_TRAF2_1	430	433	PF00917	0.250
LIG_TYR_ITIM	159	164	PF00017	0.247
MOD_CDK_SPK_2	284	289	PF00069	0.295
MOD_CK1_1	252	258	PF00069	0.315
MOD_CK1_1	364	370	PF00069	0.190
MOD_CK2_1	427	433	PF00069	0.464
MOD_CK2_1	5	11	PF00069	0.408
MOD_CK2_1	90	96	PF00069	0.266
MOD_GlcNHglycan	142	146	PF01048	0.236
MOD_GlcNHglycan	20	23	PF01048	0.274
MOD_GlcNHglycan	252	255	PF01048	0.401
MOD_GlcNHglycan	373	376	PF01048	0.457
MOD_GlcNHglycan	74	77	PF01048	0.216
MOD_GSK3_1	235	242	PF00069	0.297
MOD_GSK3_1	360	367	PF00069	0.329
MOD_GSK3_1	403	410	PF00069	0.310
MOD_GSK3_1	5	12	PF00069	0.339
MOD_GSK3_1	86	93	PF00069	0.218
MOD_N-GLC_1	247	252	PF02516	0.315
MOD_N-GLC_1	407	412	PF02516	0.479
MOD_NEK2_1	118	123	PF00069	0.265
MOD_NEK2_1	258	263	PF00069	0.312
MOD_NEK2_1	370	375	PF00069	0.266
MOD_NEK2_1	454	459	PF00069	0.291
MOD_NEK2_1	5	10	PF00069	0.318
MOD_PIKK_1	242	248	PF00454	0.269
MOD_PIKK_1	361	367	PF00454	0.170
MOD_PK_1	41	47	PF00069	0.159
MOD_PKA_2	359	365	PF00069	0.380
MOD_Plk_1	141	147	PF00069	0.288
MOD_Plk_1	39	45	PF00069	0.261
MOD_Plk_4	207	213	PF00069	0.288
MOD_ProDKin_1	162	168	PF00069	0.232
MOD_ProDKin_1	227	233	PF00069	0.247
MOD_ProDKin_1	247	253	PF00069	0.126
MOD_ProDKin_1	284	290	PF00069	0.291
MOD_ProDKin_1	364	370	PF00069	0.364
MOD_ProDKin_1	408	414	PF00069	0.354
TRG_DiLeu_BaEn_2	27	33	PF01217	0.312
TRG_ENDOCYTIC_2	161	164	PF00928	0.262
TRG_ENDOCYTIC_2	291	294	PF00928	0.380
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.247
TRG_Pf-PMV_PEXEL_1	241	246	PF00026	0.170

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5Z2	Leptomonas seymouri	71%	93%
A0A1X0NR83	Trypanosomatidae	52%	91%
A0A3Q8IDZ5	Leishmania donovani	86%	100%
A0A3R7KVG4	Trypanosoma rangeli	56%	99%
A4I9B2	Leishmania infantum	86%	100%
C9ZJB4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	92%
E9B4B2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O34340	Bacillus subtilis (strain 168)	35%	100%
O69473	Mycobacterium leprae (strain TN)	34%	100%
O94297	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
P04683	Rhizobium leguminosarum bv. viciae	34%	100%
P04684	Rhizobium leguminosarum bv. trifolii	36%	100%
P06230	Rhizobium meliloti (strain 1021)	32%	100%
P0AAI5	Escherichia coli (strain K12)	34%	100%
P0AAI6	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	34%	100%
P0AAI7	Escherichia coli O157:H7	34%	100%
P0AAI8	Shigella flexneri	34%	100%
P16538	Streptomyces glaucescens	34%	100%
P16539	Streptomyces glaucescens	23%	100%
P16540	Streptomyces violaceoruber	34%	100%
P23155	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	33%	100%
P23902	Hordeum vulgare	33%	99%
P39525	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P41175	Streptomyces virginiae	33%	100%
P43678	Streptomyces rimosus	32%	100%
P43710	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	34%	100%
P52410	Arabidopsis thaliana	38%	97%
P55338	Vibrio harveyi	38%	100%
P56902	Rhizobium meliloti (strain 1021)	39%	100%
P57193	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	32%	100%
P63457	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	36%	100%
P73283	Synechocystis sp. (strain PCC 6803 / Kazusa)	36%	100%
P9WQD6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	36%	100%
P9WQD7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	36%	100%
Q02059	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	32%	98%
Q02578	Streptomyces cyaneus	34%	100%
Q02K94	Pseudomonas aeruginosa (strain UCBPP-PA14)	31%	100%
Q05356	Streptomyces halstedii	33%	100%
Q0CZH1	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	26%	69%
Q0VCA7	Bos taurus	38%	100%
Q4Q3R4	Leishmania major	85%	100%
Q5HHA1	Staphylococcus aureus (strain COL)	40%	100%
Q5TKS0	Staphylococcus aureus	40%	100%
Q6GAU2	Staphylococcus aureus (strain MSSA476)	40%	100%
Q6GIA3	Staphylococcus aureus (strain MRSA252)	40%	100%
Q7A6F8	Staphylococcus aureus (strain N315)	39%	100%
Q83E37	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	36%	100%
Q89AY4	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	32%	100%
Q8KA28	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	31%	100%
Q8L3X9	Arabidopsis thaliana	40%	100%
Q8NXE1	Staphylococcus aureus (strain MW2)	40%	100%
Q99VA6	Staphylococcus aureus (strain Mu50 / ATCC 700699)	39%	100%
Q9C9P4	Arabidopsis thaliana	34%	85%
Q9D404	Mus musculus	39%	100%
Q9KQH9	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	38%	100%
Q9NWU1	Homo sapiens	40%	100%
V5AV31	Trypanosoma cruzi	54%	98%