Complex1_LYR_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Complex 1 protein (LYR family), putative

Species:

Leishmania braziliensis

UniProt:

A4HLY2_LEIBR

TriTrypDb:

LbrM.33.2990 , LBRM2903_330037800

Length:

165

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLY2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.618
CLV_NRD_NRD_1	107	109	PF00675	0.652
CLV_NRD_NRD_1	59	61	PF00675	0.382
CLV_PCSK_KEX2_1	107	109	PF00082	0.527
CLV_PCSK_KEX2_1	163	165	PF00082	0.610
CLV_PCSK_KEX2_1	74	76	PF00082	0.293
CLV_PCSK_KEX2_1	88	90	PF00082	0.214
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.392
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.180
CLV_PCSK_SKI1_1	45	49	PF00082	0.297
CLV_PCSK_SKI1_1	61	65	PF00082	0.388
CLV_PCSK_SKI1_1	98	102	PF00082	0.480
DEG_APCC_DBOX_1	44	52	PF00400	0.297
DOC_CYCLIN_RxL_1	95	105	PF00134	0.555
DOC_MAPK_gen_1	88	96	PF00069	0.389
DOC_PP1_RVXF_1	59	66	PF00149	0.410
DOC_USP7_MATH_1	155	159	PF00917	0.633
DOC_WW_Pin1_4	6	11	PF00397	0.612
LIG_FHA_1	38	44	PF00498	0.357
LIG_FHA_1	6	12	PF00498	0.456
LIG_FHA_2	108	114	PF00498	0.616
LIG_LIR_Gen_1	120	129	PF02991	0.463
LIG_LIR_Nem_3	120	126	PF02991	0.460
LIG_LIR_Nem_3	29	33	PF02991	0.471
LIG_NRP_CendR_1	163	165	PF00754	0.602
LIG_PTB_Apo_2	29	36	PF02174	0.388
LIG_PTB_Phospho_1	29	35	PF10480	0.395
LIG_SH2_GRB2like	140	143	PF00017	0.573
LIG_SH2_SRC	140	143	PF00017	0.573
LIG_SH2_STAP1	140	144	PF00017	0.653
LIG_SH2_STAT3	151	154	PF00017	0.555
LIG_SH2_STAT3	35	38	PF00017	0.473
LIG_SH2_STAT5	151	154	PF00017	0.596
LIG_SH2_STAT5	42	45	PF00017	0.410
LIG_TRAF2_1	56	59	PF00917	0.201
LIG_WRC_WIRS_1	27	32	PF05994	0.468
MOD_GlcNHglycan	129	132	PF01048	0.494
MOD_GlcNHglycan	155	158	PF01048	0.663
MOD_GlcNHglycan	83	86	PF01048	0.334
MOD_GSK3_1	140	147	PF00069	0.598
MOD_GSK3_1	155	162	PF00069	0.578
MOD_GSK3_1	22	29	PF00069	0.476
MOD_NEK2_2	37	42	PF00069	0.438
MOD_PIKK_1	150	156	PF00454	0.557
MOD_PKA_1	107	113	PF00069	0.646
MOD_PKA_2	107	113	PF00069	0.646
MOD_Plk_1	140	146	PF00069	0.598
MOD_Plk_4	37	43	PF00069	0.410
MOD_ProDKin_1	6	12	PF00069	0.614
MOD_SUMO_rev_2	58	63	PF00179	0.355
TRG_DiLeu_BaEn_1	59	64	PF01217	0.297
TRG_DiLeu_BaLyEn_6	7	12	PF01217	0.552
TRG_ENDOCYTIC_2	44	47	PF00928	0.313
TRG_ER_diArg_1	106	108	PF00400	0.560
TRG_ER_diArg_1	163	165	PF00400	0.659
TRG_ER_diArg_1	65	68	PF00400	0.298
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZD1	Leptomonas seymouri	82%	99%
A0A0S4JQG9	Bodo saltans	47%	92%
A0A1X0NRJ6	Trypanosomatidae	63%	100%
A0A3Q8IU86	Leishmania donovani	88%	99%
A0A422N9P9	Trypanosoma rangeli	64%	100%
A4I9B1	Leishmania infantum	89%	99%
C9ZJB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9B4B1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q3R5	Leishmania major	89%	100%