DNA replication licensing factor MCM3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA replication licensing factor MCM3, putative

Species:

Leishmania braziliensis

UniProt:

A4HLY1_LEIBR

TriTrypDb:

LbrM.33.2980 , LBRM2903_330037700

Length:

876

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0032991	protein-containing complex	1	11
GO:0042555	MCM complex	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HLY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLY1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006270	DNA replication initiation	5	11
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0000727	double-strand break repair via break-induced replication	8	1
GO:0006271	DNA strand elongation involved in DNA replication	6	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0022402	cell cycle process	2	1
GO:0022616	DNA strand elongation	5	1
GO:0033554	cellular response to stress	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:1902292	cell cycle DNA replication initiation	3	1
GO:1902315	nuclear cell cycle DNA replication initiation	4	1
GO:1902975	mitotic DNA replication initiation	4	1
GO:1903047	mitotic cell cycle process	3	1
GO:0006260	DNA replication	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003678	DNA helicase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008094	ATP-dependent activity, acting on DNA	2	12
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003697	single-stranded DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.435
CLV_C14_Caspase3-7	251	255	PF00656	0.554
CLV_C14_Caspase3-7	272	276	PF00656	0.439
CLV_C14_Caspase3-7	548	552	PF00656	0.570
CLV_C14_Caspase3-7	554	558	PF00656	0.605
CLV_C14_Caspase3-7	64	68	PF00656	0.554
CLV_C14_Caspase3-7	641	645	PF00656	0.535
CLV_C14_Caspase3-7	737	741	PF00656	0.481
CLV_C14_Caspase3-7	762	766	PF00656	0.686
CLV_C14_Caspase3-7	824	828	PF00656	0.602
CLV_NRD_NRD_1	15	17	PF00675	0.246
CLV_NRD_NRD_1	355	357	PF00675	0.326
CLV_NRD_NRD_1	523	525	PF00675	0.249
CLV_NRD_NRD_1	572	574	PF00675	0.779
CLV_NRD_NRD_1	812	814	PF00675	0.469
CLV_PCSK_KEX2_1	15	17	PF00082	0.239
CLV_PCSK_KEX2_1	523	525	PF00082	0.249
CLV_PCSK_KEX2_1	572	574	PF00082	0.779
CLV_PCSK_KEX2_1	617	619	PF00082	0.318
CLV_PCSK_KEX2_1	727	729	PF00082	0.653
CLV_PCSK_KEX2_1	812	814	PF00082	0.458
CLV_PCSK_KEX2_1	849	851	PF00082	0.331
CLV_PCSK_PC1ET2_1	617	619	PF00082	0.335
CLV_PCSK_PC1ET2_1	727	729	PF00082	0.653
CLV_PCSK_PC1ET2_1	849	851	PF00082	0.331
CLV_PCSK_SKI1_1	16	20	PF00082	0.335
CLV_PCSK_SKI1_1	261	265	PF00082	0.249
CLV_PCSK_SKI1_1	384	388	PF00082	0.252
CLV_PCSK_SKI1_1	431	435	PF00082	0.249
CLV_PCSK_SKI1_1	45	49	PF00082	0.260
CLV_PCSK_SKI1_1	492	496	PF00082	0.242
CLV_PCSK_SKI1_1	5	9	PF00082	0.452
CLV_PCSK_SKI1_1	610	614	PF00082	0.309
CLV_Separin_Metazoa	816	820	PF03568	0.474
DEG_APCC_DBOX_1	182	190	PF00400	0.473
DEG_APCC_DBOX_1	260	268	PF00400	0.460
DEG_APCC_DBOX_1	505	513	PF00400	0.449
DEG_Kelch_Keap1_1	582	587	PF01344	0.500
DEG_Nend_Nbox_1	1	3	PF02207	0.509
DEG_SCF_TRCP1_1	779	784	PF00400	0.769
DEG_SPOP_SBC_1	270	274	PF00917	0.492
DEG_SPOP_SBC_1	393	397	PF00917	0.489
DOC_ANK_TNKS_1	565	572	PF00023	0.525
DOC_CKS1_1	185	190	PF01111	0.449
DOC_CKS1_1	651	656	PF01111	0.535
DOC_CKS1_1	721	726	PF01111	0.503
DOC_CYCLIN_RxL_1	42	52	PF00134	0.467
DOC_MAPK_DCC_7	384	394	PF00069	0.449
DOC_MAPK_gen_1	43	50	PF00069	0.554
DOC_MAPK_gen_1	727	735	PF00069	0.758
DOC_MAPK_gen_1	849	855	PF00069	0.328
DOC_MAPK_MEF2A_6	261	269	PF00069	0.460
DOC_MAPK_MEF2A_6	343	350	PF00069	0.449
DOC_MAPK_MEF2A_6	364	371	PF00069	0.446
DOC_MAPK_MEF2A_6	43	50	PF00069	0.460
DOC_MAPK_MEF2A_6	92	101	PF00069	0.446
DOC_MAPK_NFAT4_5	343	351	PF00069	0.462
DOC_MAPK_NFAT4_5	43	51	PF00069	0.473
DOC_PP1_RVXF_1	490	496	PF00149	0.449
DOC_PP2B_LxvP_1	792	795	PF13499	0.489
DOC_PP4_FxxP_1	126	129	PF00568	0.429
DOC_PP4_FxxP_1	651	654	PF00568	0.535
DOC_USP7_MATH_1	300	304	PF00917	0.598
DOC_USP7_MATH_1	411	415	PF00917	0.469
DOC_USP7_MATH_1	472	476	PF00917	0.443
DOC_USP7_MATH_1	742	746	PF00917	0.658
DOC_USP7_UBL2_3	176	180	PF12436	0.449
DOC_WW_Pin1_4	132	137	PF00397	0.413
DOC_WW_Pin1_4	184	189	PF00397	0.439
DOC_WW_Pin1_4	617	622	PF00397	0.509
DOC_WW_Pin1_4	650	655	PF00397	0.512
DOC_WW_Pin1_4	670	675	PF00397	0.535
DOC_WW_Pin1_4	720	725	PF00397	0.711
LIG_14-3-3_CanoR_1	142	148	PF00244	0.456
LIG_14-3-3_CanoR_1	156	164	PF00244	0.428
LIG_14-3-3_CanoR_1	299	305	PF00244	0.452
LIG_14-3-3_CanoR_1	356	363	PF00244	0.535
LIG_14-3-3_CanoR_1	419	428	PF00244	0.449
LIG_14-3-3_CanoR_1	473	477	PF00244	0.439
LIG_14-3-3_CanoR_1	5	14	PF00244	0.427
LIG_14-3-3_CanoR_1	531	541	PF00244	0.581
LIG_14-3-3_CanoR_1	662	670	PF00244	0.449
LIG_14-3-3_CanoR_1	689	693	PF00244	0.521
LIG_Actin_WH2_2	656	673	PF00022	0.449
LIG_Actin_WH2_2	836	851	PF00022	0.430
LIG_AP2alpha_1	18	22	PF02296	0.449
LIG_BRCT_BRCA1_1	275	279	PF00533	0.470
LIG_BRCT_BRCA1_1	604	608	PF00533	0.539
LIG_FHA_1	185	191	PF00498	0.449
LIG_FHA_1	195	201	PF00498	0.449
LIG_FHA_1	235	241	PF00498	0.449
LIG_FHA_1	405	411	PF00498	0.449
LIG_FHA_1	456	462	PF00498	0.449
LIG_FHA_1	508	514	PF00498	0.460
LIG_FHA_2	122	128	PF00498	0.282
LIG_FHA_2	176	182	PF00498	0.460
LIG_FHA_2	202	208	PF00498	0.457
LIG_FHA_2	217	223	PF00498	0.423
LIG_FHA_2	270	276	PF00498	0.420
LIG_FHA_2	4	10	PF00498	0.524
LIG_FHA_2	546	552	PF00498	0.580
LIG_FHA_2	673	679	PF00498	0.449
LIG_FHA_2	735	741	PF00498	0.583
LIG_Integrin_RGD_1	364	366	PF01839	0.249
LIG_Integrin_RGD_1	559	561	PF01839	0.525
LIG_Integrin_RGD_1	776	778	PF01839	0.530
LIG_LIR_Apic_2	124	129	PF02991	0.300
LIG_LIR_Apic_2	648	654	PF02991	0.535
LIG_LIR_Gen_1	111	117	PF02991	0.450
LIG_LIR_Gen_1	276	285	PF02991	0.401
LIG_LIR_Gen_1	291	302	PF02991	0.466
LIG_LIR_Gen_1	437	446	PF02991	0.449
LIG_LIR_Gen_1	508	515	PF02991	0.450
LIG_LIR_Gen_1	765	775	PF02991	0.509
LIG_LIR_Nem_3	111	115	PF02991	0.424
LIG_LIR_Nem_3	276	282	PF02991	0.431
LIG_LIR_Nem_3	291	297	PF02991	0.443
LIG_LIR_Nem_3	508	514	PF02991	0.450
LIG_LIR_Nem_3	55	59	PF02991	0.483
LIG_LIR_Nem_3	745	749	PF02991	0.494
LIG_LIR_Nem_3	765	770	PF02991	0.424
LIG_LRP6_Inhibitor_1	82	88	PF00058	0.316
LIG_PCNA_PIPBox_1	11	20	PF02747	0.317
LIG_PCNA_yPIPBox_3	811	823	PF02747	0.336
LIG_Pex14_2	18	22	PF04695	0.439
LIG_Pex14_2	507	511	PF04695	0.449
LIG_Pex14_2	608	612	PF04695	0.535
LIG_PTB_Apo_2	478	485	PF02174	0.449
LIG_PTB_Phospho_1	478	484	PF10480	0.449
LIG_SH2_CRK	298	302	PF00017	0.410
LIG_SH2_CRK	527	531	PF00017	0.554
LIG_SH2_CRK	767	771	PF00017	0.508
LIG_SH2_NCK_1	541	545	PF00017	0.672
LIG_SH2_PTP2	56	59	PF00017	0.535
LIG_SH2_PTP2	635	638	PF00017	0.449
LIG_SH2_PTP2	93	96	PF00017	0.489
LIG_SH2_SRC	541	544	PF00017	0.672
LIG_SH2_SRC	56	59	PF00017	0.535
LIG_SH2_STAP1	140	144	PF00017	0.449
LIG_SH2_STAP1	27	31	PF00017	0.460
LIG_SH2_STAT3	487	490	PF00017	0.535
LIG_SH2_STAT5	112	115	PF00017	0.434
LIG_SH2_STAT5	170	173	PF00017	0.449
LIG_SH2_STAT5	271	274	PF00017	0.418
LIG_SH2_STAT5	415	418	PF00017	0.460
LIG_SH2_STAT5	56	59	PF00017	0.535
LIG_SH2_STAT5	635	638	PF00017	0.449
LIG_SH2_STAT5	93	96	PF00017	0.473
LIG_SH3_3	130	136	PF00018	0.423
LIG_SH3_3	264	270	PF00018	0.497
LIG_SH3_3	369	375	PF00018	0.449
LIG_SH3_3	494	500	PF00018	0.449
LIG_SH3_3	673	679	PF00018	0.373
LIG_SUMO_SIM_anti_2	260	266	PF11976	0.485
LIG_SUMO_SIM_anti_2	281	286	PF11976	0.372
LIG_SUMO_SIM_par_1	146	151	PF11976	0.449
LIG_SUMO_SIM_par_1	368	374	PF11976	0.446
LIG_SUMO_SIM_par_1	390	397	PF11976	0.440
LIG_SUMO_SIM_par_1	46	52	PF11976	0.554
LIG_TRAF2_1	675	678	PF00917	0.535
LIG_TYR_ITIM	525	530	PF00017	0.434
LIG_TYR_ITIM	539	544	PF00017	0.465
LIG_TYR_ITIM	54	59	PF00017	0.422
LIG_UBA3_1	433	441	PF00899	0.317
LIG_WRC_WIRS_1	217	222	PF05994	0.271
MOD_CDK_SPK_2	132	137	PF00069	0.413
MOD_CDK_SPK_2	650	655	PF00069	0.422
MOD_CDK_SPxxK_3	720	727	PF00069	0.505
MOD_CK1_1	278	284	PF00069	0.391
MOD_CK1_1	358	364	PF00069	0.414
MOD_CK1_1	502	508	PF00069	0.301
MOD_CK1_1	552	558	PF00069	0.488
MOD_CK1_1	585	591	PF00069	0.710
MOD_CK1_1	602	608	PF00069	0.495
MOD_CK1_1	844	850	PF00069	0.601
MOD_CK2_1	121	127	PF00069	0.420
MOD_CK2_1	132	138	PF00069	0.402
MOD_CK2_1	175	181	PF00069	0.301
MOD_CK2_1	201	207	PF00069	0.336
MOD_CK2_1	3	9	PF00069	0.477
MOD_CK2_1	559	565	PF00069	0.713
MOD_CK2_1	581	587	PF00069	0.502
MOD_CK2_1	595	601	PF00069	0.546
MOD_CK2_1	672	678	PF00069	0.302
MOD_CK2_1	706	712	PF00069	0.604
MOD_CK2_1	827	833	PF00069	0.576
MOD_Cter_Amidation	570	573	PF01082	0.780
MOD_DYRK1A_RPxSP_1	132	136	PF00069	0.516
MOD_GlcNHglycan	321	324	PF01048	0.373
MOD_GlcNHglycan	401	404	PF01048	0.301
MOD_GlcNHglycan	421	424	PF01048	0.306
MOD_GlcNHglycan	567	570	PF01048	0.654
MOD_GlcNHglycan	584	587	PF01048	0.649
MOD_GlcNHglycan	59	62	PF01048	0.319
MOD_GlcNHglycan	750	753	PF01048	0.690
MOD_GlcNHglycan	761	764	PF01048	0.637
MOD_GlcNHglycan	778	782	PF01048	0.726
MOD_GlcNHglycan	783	786	PF01048	0.698
MOD_GlcNHglycan	843	846	PF01048	0.584
MOD_GSK3_1	152	159	PF00069	0.316
MOD_GSK3_1	171	178	PF00069	0.182
MOD_GSK3_1	190	197	PF00069	0.305
MOD_GSK3_1	216	223	PF00069	0.271
MOD_GSK3_1	269	276	PF00069	0.420
MOD_GSK3_1	288	295	PF00069	0.388
MOD_GSK3_1	373	380	PF00069	0.289
MOD_GSK3_1	394	401	PF00069	0.301
MOD_GSK3_1	409	416	PF00069	0.118
MOD_GSK3_1	5	12	PF00069	0.457
MOD_GSK3_1	545	552	PF00069	0.578
MOD_GSK3_1	581	588	PF00069	0.633
MOD_GSK3_1	592	599	PF00069	0.526
MOD_GSK3_1	617	624	PF00069	0.386
MOD_GSK3_1	683	690	PF00069	0.450
MOD_GSK3_1	759	766	PF00069	0.710
MOD_GSK3_1	777	784	PF00069	0.614
MOD_GSK3_1	844	851	PF00069	0.596
MOD_N-GLC_1	3	8	PF02516	0.480
MOD_N-GLC_1	596	601	PF02516	0.649
MOD_N-GLC_1	869	874	PF02516	0.353
MOD_NEK2_1	189	194	PF00069	0.301
MOD_NEK2_1	215	220	PF00069	0.276
MOD_NEK2_1	392	397	PF00069	0.306
MOD_NEK2_1	507	512	PF00069	0.317
MOD_NEK2_1	592	597	PF00069	0.551
MOD_NEK2_1	687	692	PF00069	0.394
MOD_NEK2_1	78	83	PF00069	0.407
MOD_NEK2_1	848	853	PF00069	0.529
MOD_PIKK_1	220	226	PF00454	0.301
MOD_PIKK_1	288	294	PF00454	0.510
MOD_PIKK_1	377	383	PF00454	0.301
MOD_PIKK_1	441	447	PF00454	0.448
MOD_PIKK_1	696	702	PF00454	0.612
MOD_PKA_2	155	161	PF00069	0.301
MOD_PKA_2	306	312	PF00069	0.556
MOD_PKA_2	355	361	PF00069	0.422
MOD_PKA_2	472	478	PF00069	0.301
MOD_PKA_2	565	571	PF00069	0.761
MOD_PKA_2	592	598	PF00069	0.533
MOD_PKA_2	661	667	PF00069	0.277
MOD_PKA_2	688	694	PF00069	0.403
MOD_Plk_1	190	196	PF00069	0.317
MOD_Plk_1	3	9	PF00069	0.478
MOD_Plk_1	417	423	PF00069	0.301
MOD_Plk_1	507	513	PF00069	0.317
MOD_Plk_1	869	875	PF00069	0.414
MOD_Plk_2-3	545	551	PF00069	0.681
MOD_Plk_2-3	827	833	PF00069	0.570
MOD_Plk_4	143	149	PF00069	0.324
MOD_Plk_4	216	222	PF00069	0.262
MOD_Plk_4	278	284	PF00069	0.418
MOD_Plk_4	332	338	PF00069	0.322
MOD_Plk_4	472	478	PF00069	0.293
MOD_Plk_4	499	505	PF00069	0.301
MOD_Plk_4	507	513	PF00069	0.301
MOD_Plk_4	599	605	PF00069	0.534
MOD_Plk_4	9	15	PF00069	0.430
MOD_ProDKin_1	132	138	PF00069	0.414
MOD_ProDKin_1	184	190	PF00069	0.288
MOD_ProDKin_1	617	623	PF00069	0.386
MOD_ProDKin_1	650	656	PF00069	0.389
MOD_ProDKin_1	670	676	PF00069	0.422
MOD_ProDKin_1	720	726	PF00069	0.712
MOD_SUMO_rev_2	274	279	PF00179	0.534
MOD_SUMO_rev_2	755	762	PF00179	0.495
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.301
TRG_DiLeu_BaLyEn_6	618	623	PF01217	0.386
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.301
TRG_ENDOCYTIC_2	112	115	PF00928	0.434
TRG_ENDOCYTIC_2	298	301	PF00928	0.415
TRG_ENDOCYTIC_2	527	530	PF00928	0.434
TRG_ENDOCYTIC_2	541	544	PF00928	0.475
TRG_ENDOCYTIC_2	56	59	PF00928	0.422
TRG_ENDOCYTIC_2	635	638	PF00928	0.301
TRG_ENDOCYTIC_2	746	749	PF00928	0.496
TRG_ENDOCYTIC_2	767	770	PF00928	0.506
TRG_ENDOCYTIC_2	93	96	PF00928	0.358
TRG_ER_diArg_1	117	120	PF00400	0.501
TRG_ER_diArg_1	14	16	PF00400	0.301
TRG_ER_diArg_1	161	164	PF00400	0.302
TRG_ER_diArg_1	523	525	PF00400	0.301
TRG_ER_diArg_1	812	814	PF00400	0.477
TRG_NES_CRM1_1	501	515	PF08389	0.301
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.301
TRG_Pf-PMV_PEXEL_1	5	9	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	628	633	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	819	824	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P686	Leptomonas seymouri	78%	100%
A0A0N0P860	Leptomonas seymouri	33%	88%
A0A0S4IW18	Bodo saltans	32%	100%
A0A0S4JM41	Bodo saltans	66%	100%
A0A1X0NSY3	Trypanosomatidae	65%	100%
A0A1X0NT66	Trypanosomatidae	33%	100%
A0A1X0NZT6	Trypanosomatidae	33%	93%
A0A3Q8IAX4	Leishmania donovani	31%	90%
A0A3R7K9K0	Trypanosoma rangeli	67%	100%
A0A3R7NBN0	Trypanosoma rangeli	33%	92%
A0A3S5H7S8	Leishmania donovani	34%	100%
A0A3S7X726	Leishmania donovani	88%	99%
A0A422NDD9	Trypanosoma rangeli	32%	100%
A0A422NDR0	Trypanosoma rangeli	28%	100%
A0A422NZW3	Trypanosoma rangeli	34%	100%
A4FUD9	Bos taurus	40%	100%
A4H5K0	Leishmania braziliensis	30%	95%
A4HGC9	Leishmania braziliensis	32%	90%
A4HKT9	Leishmania braziliensis	34%	100%
A4I3G2	Leishmania infantum	31%	90%
A4I8B8	Leishmania infantum	34%	100%
A4I9B0	Leishmania infantum	88%	99%
B8AEH3	Oryza sativa subsp. indica	31%	100%
B8AZ14	Oryza sativa subsp. indica	31%	100%
B8AZ99	Oryza sativa subsp. indica	41%	100%
B8BKI8	Oryza sativa subsp. indica	32%	91%
B9FKM7	Oryza sativa subsp. japonica	31%	100%
C9ZJB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
D0A4I0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A7X6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	92%
D0A999	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D3ZVK1	Rattus norvegicus	28%	100%
E9AZQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	90%
E9B377	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B4B0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O80786	Arabidopsis thaliana	33%	100%
P24279	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	90%
P25205	Homo sapiens	40%	100%
P25206	Mus musculus	40%	100%
P29469	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P29496	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P30664	Xenopus laevis	31%	100%
P30666	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	100%
P33991	Homo sapiens	32%	100%
P33993	Homo sapiens	34%	100%
P49717	Mus musculus	32%	100%
P49736	Homo sapiens	32%	97%
P49739	Xenopus laevis	41%	100%
P55861	Xenopus laevis	32%	99%
P97310	Mus musculus	32%	97%
Q0DHC4	Oryza sativa subsp. japonica	41%	100%
Q0V9Q6	Xenopus tropicalis	29%	100%
Q21902	Caenorhabditis elegans	31%	100%
Q24849	Entamoeba histolytica	37%	100%
Q28BS0	Xenopus tropicalis	41%	100%
Q29JI9	Drosophila pseudoobscura pseudoobscura	31%	100%
Q2R482	Oryza sativa subsp. japonica	32%	91%
Q3ZBH9	Bos taurus	34%	100%
Q43704	Zea mays	40%	100%
Q4Q3R6	Leishmania major	89%	100%
Q4Q8I2	Leishmania major	32%	90%
Q54CP4	Dictyostelium discoideum	31%	100%
Q561P5	Xenopus tropicalis	30%	100%
Q5F310	Xenopus laevis	27%	100%
Q5R8G6	Pongo abelii	40%	100%
Q5XK83	Xenopus laevis	31%	100%
Q5ZMN2	Gallus gallus	42%	100%
Q61881	Mus musculus	33%	100%
Q6DIH3	Xenopus tropicalis	31%	99%
Q6GL41	Xenopus tropicalis	31%	100%
Q6KAJ4	Oryza sativa subsp. japonica	31%	100%
Q6PCI7	Xenopus laevis	30%	100%
Q7ZXZ0	Xenopus laevis	41%	100%
Q9FL33	Arabidopsis thaliana	41%	100%
Q9LPD9	Arabidopsis thaliana	31%	94%
Q9SF37	Arabidopsis thaliana	30%	100%
Q9SX03	Zea mays	41%	100%
Q9SX04	Zea mays	41%	100%
Q9U1E0	Leishmania major	34%	100%
Q9V461	Drosophila melanogaster	31%	100%
Q9XYU1	Drosophila melanogaster	40%	100%
V5BAH7	Trypanosoma cruzi	67%	100%
V5BQA9	Trypanosoma cruzi	32%	100%
V5BSG2	Trypanosoma cruzi	34%	100%