DNAJ family-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ family-like protein

Species:

Leishmania braziliensis

UniProt:

A4HLY0_LEIBR

TriTrypDb:

LbrM.33.2970 , LBRM2903_330037600

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLY0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.452
CLV_NRD_NRD_1	256	258	PF00675	0.623
CLV_NRD_NRD_1	83	85	PF00675	0.358
CLV_NRD_NRD_1	87	89	PF00675	0.329
CLV_PCSK_KEX2_1	258	260	PF00082	0.585
CLV_PCSK_KEX2_1	83	85	PF00082	0.358
CLV_PCSK_KEX2_1	87	89	PF00082	0.329
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.585
CLV_PCSK_PC7_1	83	89	PF00082	0.444
CLV_PCSK_SKI1_1	10	14	PF00082	0.497
CLV_PCSK_SKI1_1	104	108	PF00082	0.416
CLV_PCSK_SKI1_1	111	115	PF00082	0.344
CLV_PCSK_SKI1_1	174	178	PF00082	0.588
CLV_Separin_Metazoa	108	112	PF03568	0.233
CLV_Separin_Metazoa	213	217	PF03568	0.616
DEG_APCC_DBOX_1	110	118	PF00400	0.233
DEG_Nend_UBRbox_2	1	3	PF02207	0.522
DEG_SCF_FBW7_1	51	57	PF00400	0.680
DEG_SPOP_SBC_1	54	58	PF00917	0.470
DOC_CKS1_1	203	208	PF01111	0.475
DOC_CKS1_1	51	56	PF01111	0.671
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.625
DOC_MAPK_gen_1	228	235	PF00069	0.507
DOC_MAPK_gen_1	83	93	PF00069	0.348
DOC_MAPK_MEF2A_6	84	93	PF00069	0.444
DOC_USP7_MATH_1	54	58	PF00917	0.693
DOC_USP7_MATH_1	62	66	PF00917	0.690
DOC_USP7_UBL2_3	230	234	PF12436	0.585
DOC_WW_Pin1_4	202	207	PF00397	0.472
DOC_WW_Pin1_4	29	34	PF00397	0.752
DOC_WW_Pin1_4	50	55	PF00397	0.659
LIG_14-3-3_CanoR_1	10	18	PF00244	0.496
LIG_14-3-3_CanoR_1	83	87	PF00244	0.447
LIG_14-3-3_CanoR_1	88	92	PF00244	0.441
LIG_BRCT_BRCA1_1	89	93	PF00533	0.401
LIG_deltaCOP1_diTrp_1	243	250	PF00928	0.471
LIG_FHA_1	198	204	PF00498	0.479
LIG_FHA_1	227	233	PF00498	0.632
LIG_FHA_1	71	77	PF00498	0.559
LIG_FHA_2	11	17	PF00498	0.690
LIG_FHA_2	110	116	PF00498	0.375
LIG_LIR_Gen_1	205	215	PF02991	0.590
LIG_LIR_Gen_1	262	266	PF02991	0.482
LIG_LIR_Gen_1	41	51	PF02991	0.496
LIG_LIR_Nem_3	262	266	PF02991	0.482
LIG_LIR_Nem_3	41	46	PF02991	0.466
LIG_LIR_Nem_3	85	89	PF02991	0.358
LIG_PDZ_Class_1	261	266	PF00595	0.543
LIG_Pex14_1	246	250	PF04695	0.488
LIG_SH2_CRK	86	90	PF00017	0.444
LIG_SH2_STAT5	126	129	PF00017	0.566
LIG_SH2_STAT5	263	266	PF00017	0.482
LIG_SH2_STAT5	45	48	PF00017	0.513
LIG_SUMO_SIM_anti_2	73	78	PF11976	0.428
LIG_SUMO_SIM_par_1	71	78	PF11976	0.440
LIG_TRAF2_1	143	146	PF00917	0.718
LIG_TRAF2_1	184	187	PF00917	0.551
LIG_WRC_WIRS_1	40	45	PF05994	0.599
MOD_CK1_1	197	203	PF00069	0.582
MOD_CK1_1	226	232	PF00069	0.504
MOD_CK1_1	241	247	PF00069	0.622
MOD_CK1_1	3	9	PF00069	0.649
MOD_CK1_1	58	64	PF00069	0.538
MOD_CK2_1	10	16	PF00069	0.558
MOD_CK2_1	109	115	PF00069	0.481
MOD_GlcNHglycan	138	141	PF01048	0.720
MOD_GlcNHglycan	240	243	PF01048	0.645
MOD_GSK3_1	1	8	PF00069	0.718
MOD_GSK3_1	109	116	PF00069	0.429
MOD_GSK3_1	194	201	PF00069	0.625
MOD_GSK3_1	29	36	PF00069	0.653
MOD_GSK3_1	50	57	PF00069	0.602
MOD_GSK3_1	58	65	PF00069	0.698
MOD_N-GLC_1	29	34	PF02516	0.590
MOD_NEK2_1	1	6	PF00069	0.641
MOD_NEK2_1	199	204	PF00069	0.619
MOD_PKA_1	87	93	PF00069	0.444
MOD_PKA_2	82	88	PF00069	0.447
MOD_Plk_1	70	76	PF00069	0.606
MOD_Plk_4	113	119	PF00069	0.414
MOD_Plk_4	72	78	PF00069	0.433
MOD_ProDKin_1	202	208	PF00069	0.474
MOD_ProDKin_1	29	35	PF00069	0.733
MOD_ProDKin_1	50	56	PF00069	0.670
TRG_DiLeu_BaEn_1	231	236	PF01217	0.390
TRG_ENDOCYTIC_2	263	266	PF00928	0.482
TRG_ENDOCYTIC_2	45	48	PF00928	0.417
TRG_ENDOCYTIC_2	86	89	PF00928	0.344
TRG_ER_diArg_1	82	84	PF00400	0.358
TRG_ER_diArg_1	86	88	PF00400	0.329
TRG_NLS_MonoExtC_3	256	261	PF00514	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5Q0	Leptomonas seymouri	60%	100%
A0A1X0NSQ5	Trypanosomatidae	35%	100%
A0A3Q8IH27	Leishmania donovani	73%	100%
A4I9A9	Leishmania infantum	73%	100%
C9ZJB7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B4A9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q3R7	Leishmania major	78%	100%
V5BF66	Trypanosoma cruzi	38%	100%