Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLX9_LEIBR

TriTrypDb:

LbrM.33.2960 , LBRM2903_330037500

Length:

841

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLX9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.539
CLV_C14_Caspase3-7	11	15	PF00656	0.525
CLV_C14_Caspase3-7	188	192	PF00656	0.529
CLV_C14_Caspase3-7	314	318	PF00656	0.533
CLV_C14_Caspase3-7	426	430	PF00656	0.467
CLV_NRD_NRD_1	249	251	PF00675	0.619
CLV_NRD_NRD_1	449	451	PF00675	0.584
CLV_NRD_NRD_1	494	496	PF00675	0.707
CLV_NRD_NRD_1	50	52	PF00675	0.694
CLV_NRD_NRD_1	574	576	PF00675	0.503
CLV_NRD_NRD_1	600	602	PF00675	0.497
CLV_NRD_NRD_1	636	638	PF00675	0.668
CLV_NRD_NRD_1	716	718	PF00675	0.771
CLV_NRD_NRD_1	731	733	PF00675	0.558
CLV_NRD_NRD_1	771	773	PF00675	0.629
CLV_NRD_NRD_1	776	778	PF00675	0.627
CLV_NRD_NRD_1	815	817	PF00675	0.489
CLV_NRD_NRD_1	83	85	PF00675	0.690
CLV_NRD_NRD_1	98	100	PF00675	0.590
CLV_PCSK_FUR_1	247	251	PF00082	0.557
CLV_PCSK_FUR_1	446	450	PF00082	0.493
CLV_PCSK_FUR_1	492	496	PF00082	0.663
CLV_PCSK_FUR_1	774	778	PF00082	0.697
CLV_PCSK_KEX2_1	166	168	PF00082	0.524
CLV_PCSK_KEX2_1	249	251	PF00082	0.619
CLV_PCSK_KEX2_1	448	450	PF00082	0.558
CLV_PCSK_KEX2_1	491	493	PF00082	0.704
CLV_PCSK_KEX2_1	494	496	PF00082	0.728
CLV_PCSK_KEX2_1	50	52	PF00082	0.694
CLV_PCSK_KEX2_1	599	601	PF00082	0.460
CLV_PCSK_KEX2_1	636	638	PF00082	0.668
CLV_PCSK_KEX2_1	716	718	PF00082	0.767
CLV_PCSK_KEX2_1	730	732	PF00082	0.596
CLV_PCSK_KEX2_1	771	773	PF00082	0.656
CLV_PCSK_KEX2_1	776	778	PF00082	0.681
CLV_PCSK_KEX2_1	83	85	PF00082	0.617
CLV_PCSK_KEX2_1	87	89	PF00082	0.621
CLV_PCSK_KEX2_1	98	100	PF00082	0.682
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.524
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.534
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.460
CLV_PCSK_PC1ET2_1	776	778	PF00082	0.652
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.571
CLV_PCSK_PC7_1	772	778	PF00082	0.632
CLV_PCSK_PC7_1	83	89	PF00082	0.640
CLV_PCSK_SKI1_1	148	152	PF00082	0.556
CLV_PCSK_SKI1_1	167	171	PF00082	0.599
CLV_PCSK_SKI1_1	19	23	PF00082	0.541
CLV_PCSK_SKI1_1	351	355	PF00082	0.557
CLV_PCSK_SKI1_1	396	400	PF00082	0.672
CLV_PCSK_SKI1_1	439	443	PF00082	0.454
DEG_COP1_1	289	296	PF00400	0.532
DEG_SPOP_SBC_1	130	134	PF00917	0.587
DEG_SPOP_SBC_1	168	172	PF00917	0.515
DEG_SPOP_SBC_1	414	418	PF00917	0.546
DOC_CKS1_1	622	627	PF01111	0.519
DOC_CYCLIN_RxL_1	436	445	PF00134	0.452
DOC_MAPK_gen_1	143	151	PF00069	0.530
DOC_PIKK_1	738	746	PF02985	0.703
DOC_PP1_RVXF_1	146	152	PF00149	0.455
DOC_PP1_RVXF_1	17	23	PF00149	0.537
DOC_PP4_FxxP_1	666	669	PF00568	0.518
DOC_USP7_MATH_1	184	188	PF00917	0.634
DOC_USP7_MATH_1	216	220	PF00917	0.510
DOC_USP7_MATH_1	261	265	PF00917	0.727
DOC_USP7_MATH_1	286	290	PF00917	0.734
DOC_USP7_MATH_1	421	425	PF00917	0.540
DOC_USP7_MATH_1	457	461	PF00917	0.650
DOC_USP7_MATH_1	463	467	PF00917	0.570
DOC_USP7_MATH_1	512	516	PF00917	0.689
DOC_USP7_MATH_1	675	679	PF00917	0.444
DOC_USP7_MATH_1	726	730	PF00917	0.687
DOC_USP7_MATH_1	74	78	PF00917	0.526
DOC_USP7_MATH_1	754	758	PF00917	0.668
DOC_USP7_MATH_1	761	765	PF00917	0.594
DOC_USP7_MATH_1	783	787	PF00917	0.783
DOC_USP7_MATH_1	801	805	PF00917	0.534
DOC_USP7_UBL2_3	439	443	PF12436	0.530
DOC_WW_Pin1_4	204	209	PF00397	0.689
DOC_WW_Pin1_4	419	424	PF00397	0.607
DOC_WW_Pin1_4	461	466	PF00397	0.550
DOC_WW_Pin1_4	621	626	PF00397	0.721
DOC_WW_Pin1_4	665	670	PF00397	0.558
LIG_14-3-3_CanoR_1	287	292	PF00244	0.697
LIG_14-3-3_CanoR_1	351	361	PF00244	0.590
LIG_14-3-3_CanoR_1	37	47	PF00244	0.706
LIG_14-3-3_CanoR_1	717	723	PF00244	0.759
LIG_14-3-3_CanoR_1	782	788	PF00244	0.691
LIG_APCC_ABBAyCdc20_2	601	607	PF00400	0.468
LIG_BIR_II_1	1	5	PF00653	0.565
LIG_BRCT_BRCA1_1	133	137	PF00533	0.511
LIG_BRCT_BRCA1_1	218	222	PF00533	0.567
LIG_BRCT_BRCA1_1	545	549	PF00533	0.517
LIG_BRCT_BRCA1_1	662	666	PF00533	0.555
LIG_EH1_1	826	834	PF00400	0.534
LIG_FHA_1	131	137	PF00498	0.541
LIG_FHA_1	15	21	PF00498	0.551
LIG_FHA_1	174	180	PF00498	0.580
LIG_FHA_1	325	331	PF00498	0.684
LIG_FHA_1	406	412	PF00498	0.584
LIG_FHA_1	429	435	PF00498	0.450
LIG_FHA_1	462	468	PF00498	0.654
LIG_FHA_1	530	536	PF00498	0.643
LIG_FHA_1	592	598	PF00498	0.413
LIG_FHA_1	700	706	PF00498	0.537
LIG_FHA_2	169	175	PF00498	0.521
LIG_FHA_2	186	192	PF00498	0.483
LIG_FHA_2	312	318	PF00498	0.536
LIG_FHA_2	379	385	PF00498	0.630
LIG_FHA_2	415	421	PF00498	0.559
LIG_FHA_2	424	430	PF00498	0.450
LIG_FHA_2	606	612	PF00498	0.489
LIG_Integrin_RGD_1	637	639	PF01839	0.607
LIG_Integrin_RGD_1	779	781	PF01839	0.614
LIG_LIR_Apic_2	407	412	PF02991	0.525
LIG_LIR_Apic_2	663	669	PF02991	0.532
LIG_LIR_Gen_1	2	8	PF02991	0.551
LIG_LIR_Gen_1	23	29	PF02991	0.572
LIG_LIR_Gen_1	333	344	PF02991	0.566
LIG_LIR_Gen_1	685	695	PF02991	0.661
LIG_LIR_Nem_3	2	7	PF02991	0.554
LIG_LIR_Nem_3	23	27	PF02991	0.569
LIG_LIR_Nem_3	279	283	PF02991	0.522
LIG_LIR_Nem_3	333	339	PF02991	0.589
LIG_LIR_Nem_3	360	364	PF02991	0.582
LIG_LIR_Nem_3	470	474	PF02991	0.542
LIG_LIR_Nem_3	607	613	PF02991	0.516
LIG_LIR_Nem_3	685	690	PF02991	0.650
LIG_MLH1_MIPbox_1	662	666	PF16413	0.555
LIG_MYND_1	365	369	PF01753	0.567
LIG_PCNA_yPIPBox_3	658	666	PF02747	0.482
LIG_PTB_Apo_2	274	281	PF02174	0.512
LIG_SH2_CRK	146	150	PF00017	0.444
LIG_SH2_CRK	336	340	PF00017	0.567
LIG_SH2_CRK	409	413	PF00017	0.533
LIG_SH2_STAP1	4	8	PF00017	0.549
LIG_SH2_STAT3	45	48	PF00017	0.703
LIG_SH2_STAT5	474	477	PF00017	0.511
LIG_SH3_3	288	294	PF00018	0.530
LIG_SH3_3	359	365	PF00018	0.579
LIG_SH3_3	619	625	PF00018	0.717
LIG_SH3_3	720	726	PF00018	0.552
LIG_SH3_3	797	803	PF00018	0.608
LIG_Sin3_3	759	766	PF02671	0.517
LIG_SUMO_SIM_par_1	368	377	PF11976	0.629
LIG_TRAF2_1	371	374	PF00917	0.533
LIG_TRAF2_1	417	420	PF00917	0.694
LIG_TRAF2_1	580	583	PF00917	0.453
LIG_WRC_WIRS_1	662	667	PF05994	0.623
MOD_CK1_1	132	138	PF00069	0.652
MOD_CK1_1	173	179	PF00069	0.607
MOD_CK1_1	202	208	PF00069	0.679
MOD_CK1_1	238	244	PF00069	0.560
MOD_CK1_1	248	254	PF00069	0.630
MOD_CK1_1	295	301	PF00069	0.553
MOD_CK1_1	352	358	PF00069	0.502
MOD_CK1_1	41	47	PF00069	0.625
MOD_CK1_1	508	514	PF00069	0.652
MOD_CK1_1	515	521	PF00069	0.602
MOD_CK1_1	529	535	PF00069	0.763
MOD_CK1_1	542	548	PF00069	0.514
MOD_CK1_1	566	572	PF00069	0.566
MOD_CK1_1	627	633	PF00069	0.653
MOD_CK1_1	661	667	PF00069	0.520
MOD_CK1_1	699	705	PF00069	0.587
MOD_CK1_1	82	88	PF00069	0.634
MOD_CK1_1	89	95	PF00069	0.637
MOD_CK2_1	368	374	PF00069	0.692
MOD_CK2_1	378	384	PF00069	0.645
MOD_CK2_1	414	420	PF00069	0.725
MOD_CK2_1	533	539	PF00069	0.570
MOD_CK2_1	566	572	PF00069	0.530
MOD_CK2_1	605	611	PF00069	0.488
MOD_GlcNHglycan	138	141	PF01048	0.537
MOD_GlcNHglycan	191	195	PF01048	0.608
MOD_GlcNHglycan	223	226	PF01048	0.720
MOD_GlcNHglycan	257	260	PF01048	0.628
MOD_GlcNHglycan	269	272	PF01048	0.700
MOD_GlcNHglycan	294	297	PF01048	0.637
MOD_GlcNHglycan	399	402	PF01048	0.600
MOD_GlcNHglycan	455	458	PF01048	0.651
MOD_GlcNHglycan	459	462	PF01048	0.665
MOD_GlcNHglycan	510	513	PF01048	0.570
MOD_GlcNHglycan	58	61	PF01048	0.677
MOD_GlcNHglycan	615	618	PF01048	0.785
MOD_GlcNHglycan	652	655	PF01048	0.597
MOD_GlcNHglycan	677	680	PF01048	0.469
MOD_GlcNHglycan	718	721	PF01048	0.774
MOD_GlcNHglycan	756	759	PF01048	0.618
MOD_GSK3_1	103	110	PF00069	0.583
MOD_GSK3_1	125	132	PF00069	0.661
MOD_GSK3_1	168	175	PF00069	0.631
MOD_GSK3_1	199	206	PF00069	0.685
MOD_GSK3_1	217	224	PF00069	0.716
MOD_GSK3_1	235	242	PF00069	0.702
MOD_GSK3_1	245	252	PF00069	0.614
MOD_GSK3_1	278	285	PF00069	0.682
MOD_GSK3_1	311	318	PF00069	0.559
MOD_GSK3_1	349	356	PF00069	0.624
MOD_GSK3_1	378	385	PF00069	0.620
MOD_GSK3_1	415	422	PF00069	0.763
MOD_GSK3_1	453	460	PF00069	0.619
MOD_GSK3_1	463	470	PF00069	0.629
MOD_GSK3_1	508	515	PF00069	0.629
MOD_GSK3_1	526	533	PF00069	0.563
MOD_GSK3_1	539	546	PF00069	0.433
MOD_GSK3_1	555	562	PF00069	0.450
MOD_GSK3_1	599	606	PF00069	0.618
MOD_GSK3_1	620	627	PF00069	0.660
MOD_GSK3_1	661	668	PF00069	0.710
MOD_GSK3_1	675	682	PF00069	0.437
MOD_GSK3_1	696	703	PF00069	0.702
MOD_GSK3_1	74	81	PF00069	0.647
MOD_GSK3_1	761	768	PF00069	0.697
MOD_GSK3_1	82	89	PF00069	0.732
MOD_N-GLC_1	235	240	PF02516	0.658
MOD_N-GLC_1	276	281	PF02516	0.513
MOD_N-GLC_1	315	320	PF02516	0.526
MOD_N-GLC_1	38	43	PF02516	0.697
MOD_N-GLC_1	658	663	PF02516	0.492
MOD_N-GLC_1	697	702	PF02516	0.691
MOD_N-GLC_1	89	94	PF02516	0.604
MOD_NEK2_1	102	107	PF00069	0.555
MOD_NEK2_1	129	134	PF00069	0.550
MOD_NEK2_1	178	183	PF00069	0.620
MOD_NEK2_1	185	190	PF00069	0.631
MOD_NEK2_1	203	208	PF00069	0.798
MOD_NEK2_1	221	226	PF00069	0.515
MOD_NEK2_1	304	309	PF00069	0.534
MOD_NEK2_1	353	358	PF00069	0.501
MOD_NEK2_1	38	43	PF00069	0.591
MOD_NEK2_1	382	387	PF00069	0.549
MOD_NEK2_1	413	418	PF00069	0.538
MOD_NEK2_1	467	472	PF00069	0.620
MOD_NEK2_1	541	546	PF00069	0.563
MOD_NEK2_1	560	565	PF00069	0.391
MOD_PIKK_1	415	421	PF00454	0.555
MOD_PIKK_1	599	605	PF00454	0.539
MOD_PK_1	287	293	PF00069	0.631
MOD_PK_1	555	561	PF00069	0.476
MOD_PK_1	658	664	PF00069	0.486
MOD_PKA_1	249	255	PF00069	0.613
MOD_PKA_1	599	605	PF00069	0.461
MOD_PKA_1	716	722	PF00069	0.719
MOD_PKA_1	83	89	PF00069	0.598
MOD_PKA_2	125	131	PF00069	0.719
MOD_PKA_2	248	254	PF00069	0.704
MOD_PKA_2	286	292	PF00069	0.693
MOD_PKA_2	515	521	PF00069	0.653
MOD_PKA_2	599	605	PF00069	0.494
MOD_PKA_2	716	722	PF00069	0.775
MOD_PKA_2	724	730	PF00069	0.636
MOD_PKA_2	82	88	PF00069	0.641
MOD_PKB_1	247	255	PF00069	0.616
MOD_PKB_1	54	62	PF00069	0.681
MOD_PKB_1	730	738	PF00069	0.636
MOD_Plk_1	173	179	PF00069	0.527
MOD_Plk_1	332	338	PF00069	0.579
MOD_Plk_1	530	536	PF00069	0.585
MOD_Plk_1	658	664	PF00069	0.486
MOD_Plk_4	107	113	PF00069	0.726
MOD_Plk_4	132	138	PF00069	0.559
MOD_Plk_4	199	205	PF00069	0.810
MOD_Plk_4	217	223	PF00069	0.556
MOD_Plk_4	334	340	PF00069	0.634
MOD_Plk_4	555	561	PF00069	0.476
MOD_Plk_4	605	611	PF00069	0.488
MOD_Plk_4	661	667	PF00069	0.550
MOD_Plk_4	701	707	PF00069	0.634
MOD_Plk_4	783	789	PF00069	0.689
MOD_ProDKin_1	204	210	PF00069	0.689
MOD_ProDKin_1	419	425	PF00069	0.606
MOD_ProDKin_1	461	467	PF00069	0.551
MOD_ProDKin_1	621	627	PF00069	0.724
MOD_ProDKin_1	665	671	PF00069	0.555
MOD_SUMO_for_1	442	445	PF00179	0.535
MOD_SUMO_rev_2	569	578	PF00179	0.539
TRG_ENDOCYTIC_2	146	149	PF00928	0.531
TRG_ENDOCYTIC_2	336	339	PF00928	0.687
TRG_ENDOCYTIC_2	4	7	PF00928	0.553
TRG_ENDOCYTIC_2	437	440	PF00928	0.451
TRG_ER_diArg_1	142	145	PF00400	0.564
TRG_ER_diArg_1	247	250	PF00400	0.627
TRG_ER_diArg_1	446	449	PF00400	0.533
TRG_ER_diArg_1	492	495	PF00400	0.705
TRG_ER_diArg_1	635	637	PF00400	0.777
TRG_ER_diArg_1	730	732	PF00400	0.646
TRG_ER_diArg_1	771	774	PF00400	0.572
TRG_NES_CRM1_1	818	830	PF08389	0.717
TRG_NLS_MonoCore_2	773	778	PF00514	0.699
TRG_NLS_MonoExtC_3	490	495	PF00514	0.534
TRG_NLS_MonoExtC_3	773	778	PF00514	0.623
TRG_NLS_MonoExtN_4	771	778	PF00514	0.623
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	552	557	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I487	Leptomonas seymouri	38%	96%
A0A3Q8IKF4	Leishmania donovani	63%	100%
A4I9A8	Leishmania infantum	63%	100%
E9B4A8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
Q4Q3R8	Leishmania major	63%	98%