Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLX8_LEIBR

TriTrypDb:

LbrM.33.2950 , LBRM2903_330037400

Length:

1193

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLX8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0031267	small GTPase binding	5	1
GO:0051020	GTPase binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.619
CLV_C14_Caspase3-7	368	372	PF00656	0.465
CLV_C14_Caspase3-7	78	82	PF00656	0.543
CLV_NRD_NRD_1	1002	1004	PF00675	0.468
CLV_NRD_NRD_1	1008	1010	PF00675	0.513
CLV_NRD_NRD_1	1046	1048	PF00675	0.518
CLV_NRD_NRD_1	1094	1096	PF00675	0.646
CLV_NRD_NRD_1	1146	1148	PF00675	0.563
CLV_NRD_NRD_1	349	351	PF00675	0.478
CLV_NRD_NRD_1	431	433	PF00675	0.587
CLV_NRD_NRD_1	634	636	PF00675	0.444
CLV_NRD_NRD_1	721	723	PF00675	0.421
CLV_NRD_NRD_1	970	972	PF00675	0.490
CLV_NRD_NRD_1	984	986	PF00675	0.475
CLV_PCSK_KEX2_1	1029	1031	PF00082	0.510
CLV_PCSK_KEX2_1	1094	1096	PF00082	0.639
CLV_PCSK_KEX2_1	1146	1148	PF00082	0.563
CLV_PCSK_KEX2_1	420	422	PF00082	0.536
CLV_PCSK_KEX2_1	431	433	PF00082	0.587
CLV_PCSK_KEX2_1	484	486	PF00082	0.467
CLV_PCSK_KEX2_1	634	636	PF00082	0.578
CLV_PCSK_KEX2_1	721	723	PF00082	0.594
CLV_PCSK_KEX2_1	970	972	PF00082	0.527
CLV_PCSK_KEX2_1	984	986	PF00082	0.490
CLV_PCSK_PC1ET2_1	1029	1031	PF00082	0.527
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.423
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.391
CLV_PCSK_PC7_1	1090	1096	PF00082	0.737
CLV_PCSK_SKI1_1	1009	1013	PF00082	0.519
CLV_PCSK_SKI1_1	1095	1099	PF00082	0.735
CLV_PCSK_SKI1_1	431	435	PF00082	0.478
CLV_PCSK_SKI1_1	554	558	PF00082	0.625
CLV_PCSK_SKI1_1	562	566	PF00082	0.505
CLV_PCSK_SKI1_1	598	602	PF00082	0.612
CLV_PCSK_SKI1_1	634	638	PF00082	0.407
CLV_PCSK_SKI1_1	970	974	PF00082	0.424
DEG_APCC_DBOX_1	266	274	PF00400	0.488
DEG_APCC_DBOX_1	773	781	PF00400	0.478
DEG_Nend_Nbox_1	1	3	PF02207	0.562
DEG_SCF_FBW7_2	434	440	PF00400	0.436
DEG_SPOP_SBC_1	197	201	PF00917	0.631
DEG_SPOP_SBC_1	214	218	PF00917	0.580
DOC_CKS1_1	16	21	PF01111	0.509
DOC_CKS1_1	184	189	PF01111	0.562
DOC_CKS1_1	434	439	PF01111	0.435
DOC_MAPK_DCC_7	774	782	PF00069	0.518
DOC_MAPK_FxFP_2	1173	1176	PF00069	0.574
DOC_MAPK_gen_1	834	841	PF00069	0.467
DOC_MAPK_MEF2A_6	774	782	PF00069	0.566
DOC_PP4_FxxP_1	1173	1176	PF00568	0.769
DOC_SPAK_OSR1_1	84	88	PF12202	0.526
DOC_USP7_MATH_1	1093	1097	PF00917	0.607
DOC_USP7_MATH_1	1105	1109	PF00917	0.487
DOC_USP7_MATH_1	1116	1120	PF00917	0.460
DOC_USP7_MATH_1	1155	1159	PF00917	0.613
DOC_USP7_MATH_1	1169	1173	PF00917	0.591
DOC_USP7_MATH_1	129	133	PF00917	0.592
DOC_USP7_MATH_1	149	153	PF00917	0.518
DOC_USP7_MATH_1	175	179	PF00917	0.684
DOC_USP7_MATH_1	185	189	PF00917	0.621
DOC_USP7_MATH_1	240	244	PF00917	0.800
DOC_USP7_MATH_1	379	383	PF00917	0.465
DOC_USP7_MATH_1	404	408	PF00917	0.537
DOC_USP7_MATH_1	409	413	PF00917	0.533
DOC_USP7_MATH_1	692	696	PF00917	0.570
DOC_USP7_MATH_1	901	905	PF00917	0.399
DOC_USP7_UBL2_3	1010	1014	PF12436	0.526
DOC_USP7_UBL2_3	764	768	PF12436	0.568
DOC_WW_Pin1_4	1112	1117	PF00397	0.538
DOC_WW_Pin1_4	1157	1162	PF00397	0.687
DOC_WW_Pin1_4	1174	1179	PF00397	0.644
DOC_WW_Pin1_4	1183	1188	PF00397	0.668
DOC_WW_Pin1_4	120	125	PF00397	0.606
DOC_WW_Pin1_4	133	138	PF00397	0.706
DOC_WW_Pin1_4	15	20	PF00397	0.588
DOC_WW_Pin1_4	183	188	PF00397	0.782
DOC_WW_Pin1_4	387	392	PF00397	0.724
DOC_WW_Pin1_4	433	438	PF00397	0.437
DOC_WW_Pin1_4	516	521	PF00397	0.545
LIG_14-3-3_CanoR_1	1030	1039	PF00244	0.478
LIG_14-3-3_CanoR_1	1094	1098	PF00244	0.514
LIG_14-3-3_CanoR_1	1099	1109	PF00244	0.511
LIG_14-3-3_CanoR_1	219	224	PF00244	0.708
LIG_14-3-3_CanoR_1	230	235	PF00244	0.530
LIG_14-3-3_CanoR_1	281	289	PF00244	0.454
LIG_14-3-3_CanoR_1	403	413	PF00244	0.588
LIG_14-3-3_CanoR_1	615	622	PF00244	0.417
LIG_14-3-3_CanoR_1	721	726	PF00244	0.596
LIG_14-3-3_CanoR_1	84	88	PF00244	0.606
LIG_14-3-3_CanoR_1	866	874	PF00244	0.389
LIG_Actin_WH2_2	1119	1135	PF00022	0.428
LIG_BRCT_BRCA1_1	1171	1175	PF00533	0.787
LIG_BRCT_BRCA1_1	137	141	PF00533	0.527
LIG_CtBP_PxDLS_1	360	364	PF00389	0.450
LIG_deltaCOP1_diTrp_1	1062	1070	PF00928	0.402
LIG_deltaCOP1_diTrp_1	4	12	PF00928	0.485
LIG_EVH1_1	1175	1179	PF00568	0.571
LIG_EVH1_2	1082	1086	PF00568	0.549
LIG_FHA_1	299	305	PF00498	0.440
LIG_FHA_1	4	10	PF00498	0.478
LIG_FHA_1	489	495	PF00498	0.552
LIG_FHA_1	786	792	PF00498	0.585
LIG_FHA_2	1023	1029	PF00498	0.532
LIG_FHA_2	15	21	PF00498	0.512
LIG_FHA_2	199	205	PF00498	0.556
LIG_FHA_2	309	315	PF00498	0.537
LIG_FHA_2	449	455	PF00498	0.448
LIG_FHA_2	546	552	PF00498	0.622
LIG_FHA_2	615	621	PF00498	0.482
LIG_FHA_2	76	82	PF00498	0.548
LIG_FHA_2	771	777	PF00498	0.525
LIG_FHA_2	891	897	PF00498	0.523
LIG_FHA_2	909	915	PF00498	0.351
LIG_HCF-1_HBM_1	579	582	PF13415	0.623
LIG_Integrin_RGD_1	59	61	PF01839	0.527
LIG_LIR_Apic_2	1172	1178	PF02991	0.788
LIG_LIR_Gen_1	1125	1132	PF02991	0.500
LIG_LIR_Gen_1	670	678	PF02991	0.397
LIG_LIR_Gen_1	827	835	PF02991	0.411
LIG_LIR_Gen_1	83	92	PF02991	0.527
LIG_LIR_Nem_3	1067	1073	PF02991	0.637
LIG_LIR_Nem_3	1096	1101	PF02991	0.522
LIG_LIR_Nem_3	1125	1130	PF02991	0.501
LIG_LIR_Nem_3	670	674	PF02991	0.394
LIG_LIR_Nem_3	827	832	PF02991	0.470
LIG_LIR_Nem_3	83	88	PF02991	0.527
LIG_NRBOX	781	787	PF00104	0.485
LIG_Pex14_1	807	811	PF04695	0.480
LIG_PTAP_UEV_1	186	191	PF05743	0.552
LIG_PTB_Apo_2	1167	1174	PF02174	0.570
LIG_SH2_NCK_1	119	123	PF00017	0.765
LIG_SH2_STAP1	276	280	PF00017	0.581
LIG_SH2_STAP1	582	586	PF00017	0.404
LIG_SH2_STAT5	119	122	PF00017	0.550
LIG_SH3_3	1074	1080	PF00018	0.583
LIG_SH3_3	1173	1179	PF00018	0.571
LIG_SH3_3	181	187	PF00018	0.595
LIG_SH3_3	239	245	PF00018	0.653
LIG_SUMO_SIM_anti_2	695	700	PF11976	0.567
LIG_SUMO_SIM_par_1	163	170	PF11976	0.557
LIG_TRAF2_1	1066	1069	PF00917	0.483
LIG_TRAF2_1	365	368	PF00917	0.446
LIG_TRAF2_1	437	440	PF00917	0.434
LIG_TRAF2_1	490	493	PF00917	0.406
LIG_TRAF2_1	535	538	PF00917	0.572
LIG_TRAF2_1	617	620	PF00917	0.595
LIG_TRAF2_1	652	655	PF00917	0.481
LIG_TRAF2_1	904	907	PF00917	0.615
LIG_TRAF2_1	911	914	PF00917	0.506
LIG_TRAF2_1	918	921	PF00917	0.411
LIG_UBA3_1	477	484	PF00899	0.382
LIG_UBA3_1	738	746	PF00899	0.528
LIG_WRC_WIRS_1	231	236	PF05994	0.529
MOD_CK1_1	1104	1110	PF00069	0.532
MOD_CK1_1	1112	1118	PF00069	0.503
MOD_CK1_1	1135	1141	PF00069	0.722
MOD_CK1_1	1162	1168	PF00069	0.731
MOD_CK1_1	123	129	PF00069	0.753
MOD_CK1_1	176	182	PF00069	0.761
MOD_CK1_1	188	194	PF00069	0.648
MOD_CK1_1	212	218	PF00069	0.779
MOD_CK1_1	232	238	PF00069	0.656
MOD_CK1_1	298	304	PF00069	0.438
MOD_CK1_1	382	388	PF00069	0.661
MOD_CK1_1	448	454	PF00069	0.450
MOD_CK1_1	516	522	PF00069	0.622
MOD_CK1_1	614	620	PF00069	0.414
MOD_CK1_1	724	730	PF00069	0.443
MOD_CK2_1	1142	1148	PF00069	0.580
MOD_CK2_1	198	204	PF00069	0.642
MOD_CK2_1	409	415	PF00069	0.482
MOD_CK2_1	46	52	PF00069	0.557
MOD_CK2_1	545	551	PF00069	0.624
MOD_CK2_1	614	620	PF00069	0.501
MOD_CK2_1	70	76	PF00069	0.576
MOD_CK2_1	770	776	PF00069	0.540
MOD_CK2_1	837	843	PF00069	0.378
MOD_CK2_1	890	896	PF00069	0.528
MOD_CK2_1	901	907	PF00069	0.426
MOD_CK2_1	908	914	PF00069	0.360
MOD_CK2_1	952	958	PF00069	0.480
MOD_CMANNOS	2	5	PF00535	0.482
MOD_GlcNHglycan	1057	1060	PF01048	0.459
MOD_GlcNHglycan	1103	1106	PF01048	0.708
MOD_GlcNHglycan	1111	1114	PF01048	0.552
MOD_GlcNHglycan	1136	1140	PF01048	0.720
MOD_GlcNHglycan	1151	1154	PF01048	0.771
MOD_GlcNHglycan	125	128	PF01048	0.719
MOD_GlcNHglycan	158	161	PF01048	0.579
MOD_GlcNHglycan	175	178	PF01048	0.667
MOD_GlcNHglycan	187	190	PF01048	0.599
MOD_GlcNHglycan	193	196	PF01048	0.628
MOD_GlcNHglycan	237	240	PF01048	0.643
MOD_GlcNHglycan	270	273	PF01048	0.467
MOD_GlcNHglycan	297	300	PF01048	0.522
MOD_GlcNHglycan	381	384	PF01048	0.488
MOD_GlcNHglycan	454	458	PF01048	0.589
MOD_GlcNHglycan	528	531	PF01048	0.611
MOD_GlcNHglycan	54	57	PF01048	0.596
MOD_GlcNHglycan	61	65	PF01048	0.758
MOD_GlcNHglycan	868	871	PF01048	0.441
MOD_GlcNHglycan	90	93	PF01048	0.541
MOD_GSK3_1	1100	1107	PF00069	0.527
MOD_GSK3_1	1112	1119	PF00069	0.532
MOD_GSK3_1	1155	1162	PF00069	0.727
MOD_GSK3_1	129	136	PF00069	0.783
MOD_GSK3_1	149	156	PF00069	0.578
MOD_GSK3_1	205	212	PF00069	0.766
MOD_GSK3_1	214	221	PF00069	0.641
MOD_GSK3_1	229	236	PF00069	0.686
MOD_GSK3_1	280	287	PF00069	0.463
MOD_GSK3_1	419	426	PF00069	0.598
MOD_GSK3_1	42	49	PF00069	0.577
MOD_GSK3_1	445	452	PF00069	0.461
MOD_GSK3_1	524	531	PF00069	0.669
MOD_GSK3_1	70	77	PF00069	0.598
MOD_GSK3_1	705	712	PF00069	0.553
MOD_GSK3_1	781	788	PF00069	0.480
MOD_GSK3_1	83	90	PF00069	0.587
MOD_N-GLC_1	14	19	PF02516	0.481
MOD_N-GLC_1	817	822	PF02516	0.473
MOD_NEK2_1	1012	1017	PF00069	0.548
MOD_NEK2_1	1156	1161	PF00069	0.625
MOD_NEK2_1	141	146	PF00069	0.524
MOD_NEK2_1	209	214	PF00069	0.682
MOD_NEK2_1	295	300	PF00069	0.436
MOD_NEK2_1	373	378	PF00069	0.577
MOD_NEK2_1	495	500	PF00069	0.447
MOD_NEK2_1	515	520	PF00069	0.538
MOD_NEK2_1	528	533	PF00069	0.531
MOD_NEK2_1	564	569	PF00069	0.397
MOD_NEK2_1	611	616	PF00069	0.423
MOD_NEK2_1	62	67	PF00069	0.539
MOD_NEK2_1	88	93	PF00069	0.560
MOD_NEK2_1	923	928	PF00069	0.483
MOD_NEK2_2	1093	1098	PF00069	0.510
MOD_NEK2_2	409	414	PF00069	0.471
MOD_PIKK_1	1014	1020	PF00454	0.628
MOD_PIKK_1	1030	1036	PF00454	0.465
MOD_PIKK_1	1064	1070	PF00454	0.496
MOD_PIKK_1	1085	1091	PF00454	0.647
MOD_PIKK_1	1164	1170	PF00454	0.787
MOD_PIKK_1	117	123	PF00454	0.549
MOD_PIKK_1	252	258	PF00454	0.772
MOD_PIKK_1	419	425	PF00454	0.540
MOD_PIKK_1	488	494	PF00454	0.507
MOD_PIKK_1	495	501	PF00454	0.483
MOD_PIKK_1	593	599	PF00454	0.391
MOD_PIKK_1	606	612	PF00454	0.367
MOD_PIKK_1	640	646	PF00454	0.429
MOD_PIKK_1	952	958	PF00454	0.480
MOD_PK_1	663	669	PF00069	0.401
MOD_PK_1	721	727	PF00069	0.432
MOD_PKA_1	721	727	PF00069	0.422
MOD_PKA_1	970	976	PF00069	0.383
MOD_PKA_2	1093	1099	PF00069	0.513
MOD_PKA_2	1101	1107	PF00069	0.500
MOD_PKA_2	1142	1148	PF00069	0.563
MOD_PKA_2	173	179	PF00069	0.563
MOD_PKA_2	205	211	PF00069	0.681
MOD_PKA_2	218	224	PF00069	0.618
MOD_PKA_2	229	235	PF00069	0.529
MOD_PKA_2	280	286	PF00069	0.453
MOD_PKA_2	295	301	PF00069	0.426
MOD_PKA_2	52	58	PF00069	0.580
MOD_PKA_2	614	620	PF00069	0.439
MOD_PKA_2	721	727	PF00069	0.522
MOD_PKA_2	83	89	PF00069	0.583
MOD_PKA_2	970	976	PF00069	0.383
MOD_Plk_1	100	106	PF00069	0.547
MOD_Plk_1	1105	1111	PF00069	0.532
MOD_Plk_1	692	698	PF00069	0.517
MOD_Plk_1	75	81	PF00069	0.551
MOD_Plk_1	807	813	PF00069	0.480
MOD_Plk_1	817	823	PF00069	0.472
MOD_Plk_1	837	843	PF00069	0.312
MOD_Plk_1	996	1002	PF00069	0.480
MOD_Plk_2-3	100	106	PF00069	0.534
MOD_Plk_2-3	308	314	PF00069	0.494
MOD_Plk_2-3	837	843	PF00069	0.468
MOD_Plk_2-3	908	914	PF00069	0.605
MOD_Plk_2-3	949	955	PF00069	0.482
MOD_Plk_4	1122	1128	PF00069	0.418
MOD_Plk_4	205	211	PF00069	0.553
MOD_Plk_4	392	398	PF00069	0.561
MOD_Plk_4	694	700	PF00069	0.437
MOD_Plk_4	724	730	PF00069	0.660
MOD_Plk_4	792	798	PF00069	0.462
MOD_ProDKin_1	1112	1118	PF00069	0.536
MOD_ProDKin_1	1157	1163	PF00069	0.686
MOD_ProDKin_1	1174	1180	PF00069	0.644
MOD_ProDKin_1	1183	1189	PF00069	0.667
MOD_ProDKin_1	120	126	PF00069	0.604
MOD_ProDKin_1	133	139	PF00069	0.700
MOD_ProDKin_1	15	21	PF00069	0.594
MOD_ProDKin_1	183	189	PF00069	0.780
MOD_ProDKin_1	387	393	PF00069	0.729
MOD_ProDKin_1	433	439	PF00069	0.436
MOD_ProDKin_1	516	522	PF00069	0.548
MOD_SUMO_for_1	335	338	PF00179	0.505
MOD_SUMO_for_1	413	416	PF00179	0.426
MOD_SUMO_for_1	841	844	PF00179	0.597
MOD_SUMO_for_1	918	921	PF00179	0.610
MOD_SUMO_rev_2	291	295	PF00179	0.428
MOD_SUMO_rev_2	684	690	PF00179	0.685
TRG_DiLeu_BaEn_1	1069	1074	PF01217	0.527
TRG_DiLeu_BaEn_1	473	478	PF01217	0.389
TRG_DiLeu_BaEn_1	539	544	PF01217	0.432
TRG_DiLeu_BaEn_4	907	913	PF01217	0.481
TRG_DiLeu_BaLyEn_6	775	780	PF01217	0.556
TRG_DiLeu_LyEn_5	473	478	PF01217	0.389
TRG_ER_diArg_1	431	433	PF00400	0.593
TRG_ER_diArg_1	540	543	PF00400	0.651
TRG_ER_diArg_1	720	722	PF00400	0.416
TRG_ER_diArg_1	970	972	PF00400	0.494
TRG_ER_diArg_1	983	985	PF00400	0.502
TRG_NES_CRM1_1	714	726	PF08389	0.529
TRG_NES_CRM1_1	776	789	PF08389	0.404
TRG_Pf-PMV_PEXEL_1	1003	1007	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	468	473	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	562	566	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	910	914	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	978	982	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	989	993	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXK7	Leptomonas seymouri	42%	88%
A0A3Q8IGT3	Leishmania donovani	55%	97%
A4I9A7	Leishmania infantum	55%	97%
E9B4A7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	97%
Q4Q3R9	Leishmania major	55%	100%