CCHC-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLX7_LEIBR

TriTrypDb:

LbrM.33.2940 , LBRM2903_330037300

Length:

1150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLX7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1085	1089	PF00656	0.569
CLV_C14_Caspase3-7	1145	1149	PF00656	0.668
CLV_C14_Caspase3-7	54	58	PF00656	0.523
CLV_C14_Caspase3-7	609	613	PF00656	0.689
CLV_C14_Caspase3-7	874	878	PF00656	0.610
CLV_C14_Caspase3-7	892	896	PF00656	0.744
CLV_C14_Caspase3-7	901	905	PF00656	0.562
CLV_NRD_NRD_1	1012	1014	PF00675	0.738
CLV_NRD_NRD_1	1070	1072	PF00675	0.618
CLV_NRD_NRD_1	1136	1138	PF00675	0.770
CLV_NRD_NRD_1	120	122	PF00675	0.526
CLV_NRD_NRD_1	183	185	PF00675	0.523
CLV_NRD_NRD_1	222	224	PF00675	0.650
CLV_NRD_NRD_1	376	378	PF00675	0.738
CLV_NRD_NRD_1	59	61	PF00675	0.521
CLV_NRD_NRD_1	919	921	PF00675	0.574
CLV_NRD_NRD_1	975	977	PF00675	0.674
CLV_NRD_NRD_1	982	984	PF00675	0.655
CLV_PCSK_FUR_1	1133	1137	PF00082	0.714
CLV_PCSK_FUR_1	220	224	PF00082	0.538
CLV_PCSK_FUR_1	374	378	PF00082	0.679
CLV_PCSK_KEX2_1	1012	1014	PF00082	0.738
CLV_PCSK_KEX2_1	1070	1072	PF00082	0.584
CLV_PCSK_KEX2_1	1133	1135	PF00082	0.773
CLV_PCSK_KEX2_1	1136	1138	PF00082	0.776
CLV_PCSK_KEX2_1	120	122	PF00082	0.526
CLV_PCSK_KEX2_1	183	185	PF00082	0.523
CLV_PCSK_KEX2_1	220	222	PF00082	0.655
CLV_PCSK_KEX2_1	376	378	PF00082	0.740
CLV_PCSK_KEX2_1	59	61	PF00082	0.521
CLV_PCSK_KEX2_1	735	737	PF00082	0.465
CLV_PCSK_KEX2_1	918	920	PF00082	0.580
CLV_PCSK_KEX2_1	982	984	PF00082	0.681
CLV_PCSK_PC1ET2_1	735	737	PF00082	0.453
CLV_PCSK_SKI1_1	17	21	PF00082	0.696
CLV_PCSK_SKI1_1	247	251	PF00082	0.512
CLV_PCSK_SKI1_1	30	34	PF00082	0.490
CLV_PCSK_SKI1_1	631	635	PF00082	0.553
CLV_PCSK_SKI1_1	735	739	PF00082	0.451
CLV_PCSK_SKI1_1	819	823	PF00082	0.633
CLV_PCSK_SKI1_1	977	981	PF00082	0.492
CLV_Separin_Metazoa	685	689	PF03568	0.505
DEG_APCC_DBOX_1	222	230	PF00400	0.608
DEG_APCC_DBOX_1	308	316	PF00400	0.728
DEG_APCC_DBOX_1	536	544	PF00400	0.580
DEG_APCC_DBOX_1	807	815	PF00400	0.551
DEG_SPOP_SBC_1	870	874	PF00917	0.543
DOC_CDC14_PxL_1	640	648	PF14671	0.723
DOC_CYCLIN_RxL_1	627	637	PF00134	0.421
DOC_CYCLIN_RxL_1	861	872	PF00134	0.674
DOC_CYCLIN_yCln2_LP_2	508	514	PF00134	0.492
DOC_MAPK_gen_1	1133	1142	PF00069	0.705
DOC_MAPK_gen_1	138	145	PF00069	0.526
DOC_MAPK_gen_1	309	317	PF00069	0.485
DOC_MAPK_gen_1	384	392	PF00069	0.640
DOC_MAPK_gen_1	59	66	PF00069	0.405
DOC_MAPK_gen_1	964	972	PF00069	0.503
DOC_MAPK_MEF2A_6	386	394	PF00069	0.381
DOC_MAPK_MEF2A_6	4	11	PF00069	0.580
DOC_PP2B_LxvP_1	355	358	PF13499	0.607
DOC_PP2B_LxvP_1	508	511	PF13499	0.488
DOC_PP2B_LxvP_1	866	869	PF13499	0.797
DOC_PP4_FxxP_1	316	319	PF00568	0.664
DOC_PP4_FxxP_1	581	584	PF00568	0.600
DOC_USP7_MATH_1	1086	1090	PF00917	0.580
DOC_USP7_MATH_1	188	192	PF00917	0.536
DOC_USP7_MATH_1	249	253	PF00917	0.540
DOC_USP7_MATH_1	268	272	PF00917	0.337
DOC_USP7_MATH_1	299	303	PF00917	0.493
DOC_USP7_MATH_1	528	532	PF00917	0.741
DOC_USP7_MATH_1	547	551	PF00917	0.323
DOC_USP7_MATH_1	582	586	PF00917	0.577
DOC_USP7_MATH_1	621	625	PF00917	0.660
DOC_USP7_MATH_1	778	782	PF00917	0.804
DOC_USP7_MATH_1	793	797	PF00917	0.712
DOC_USP7_MATH_1	869	873	PF00917	0.611
DOC_USP7_MATH_1	90	94	PF00917	0.468
DOC_USP7_MATH_1	936	940	PF00917	0.755
DOC_WW_Pin1_4	104	109	PF00397	0.388
DOC_WW_Pin1_4	145	150	PF00397	0.489
DOC_WW_Pin1_4	329	334	PF00397	0.752
DOC_WW_Pin1_4	395	400	PF00397	0.647
DOC_WW_Pin1_4	506	511	PF00397	0.732
DOC_WW_Pin1_4	72	77	PF00397	0.535
DOC_WW_Pin1_4	753	758	PF00397	0.700
DOC_WW_Pin1_4	764	769	PF00397	0.611
DOC_WW_Pin1_4	942	947	PF00397	0.584
DOC_WW_Pin1_4	948	953	PF00397	0.510
LIG_14-3-3_CanoR_1	1058	1066	PF00244	0.617
LIG_14-3-3_CanoR_1	1070	1075	PF00244	0.435
LIG_14-3-3_CanoR_1	1106	1114	PF00244	0.697
LIG_14-3-3_CanoR_1	187	195	PF00244	0.662
LIG_14-3-3_CanoR_1	259	265	PF00244	0.656
LIG_14-3-3_CanoR_1	30	37	PF00244	0.505
LIG_14-3-3_CanoR_1	311	316	PF00244	0.632
LIG_14-3-3_CanoR_1	350	356	PF00244	0.541
LIG_14-3-3_CanoR_1	376	381	PF00244	0.796
LIG_14-3-3_CanoR_1	384	389	PF00244	0.498
LIG_14-3-3_CanoR_1	393	398	PF00244	0.343
LIG_14-3-3_CanoR_1	471	480	PF00244	0.484
LIG_14-3-3_CanoR_1	627	634	PF00244	0.556
LIG_14-3-3_CanoR_1	67	76	PF00244	0.604
LIG_14-3-3_CanoR_1	724	734	PF00244	0.684
LIG_14-3-3_CanoR_1	964	972	PF00244	0.567
LIG_14-3-3_CanoR_1	993	999	PF00244	0.622
LIG_Actin_WH2_2	417	433	PF00022	0.601
LIG_Actin_WH2_2	536	554	PF00022	0.667
LIG_Actin_WH2_2	815	833	PF00022	0.678
LIG_BRCT_BRCA1_1	270	274	PF00533	0.375
LIG_BRCT_BRCA1_1	943	947	PF00533	0.774
LIG_eIF4E_1	628	634	PF01652	0.392
LIG_EVH1_2	510	514	PF00568	0.491
LIG_FHA_1	1029	1035	PF00498	0.581
LIG_FHA_1	105	111	PF00498	0.511
LIG_FHA_1	1109	1115	PF00498	0.571
LIG_FHA_1	241	247	PF00498	0.675
LIG_FHA_1	575	581	PF00498	0.473
LIG_FHA_1	628	634	PF00498	0.640
LIG_FHA_1	652	658	PF00498	0.523
LIG_FHA_1	679	685	PF00498	0.610
LIG_FHA_1	767	773	PF00498	0.532
LIG_FHA_2	1089	1095	PF00498	0.622
LIG_FHA_2	146	152	PF00498	0.473
LIG_FHA_2	410	416	PF00498	0.514
LIG_FHA_2	474	480	PF00498	0.629
LIG_FHA_2	570	576	PF00498	0.452
LIG_FHA_2	651	657	PF00498	0.516
LIG_FHA_2	693	699	PF00498	0.566
LIG_FHA_2	778	784	PF00498	0.726
LIG_FHA_2	878	884	PF00498	0.692
LIG_HP1_1	108	112	PF01393	0.451
LIG_Integrin_isoDGR_2	22	24	PF01839	0.557
LIG_LIR_Apic_2	314	319	PF02991	0.714
LIG_LIR_Gen_1	107	115	PF02991	0.337
LIG_LIR_Nem_3	107	112	PF02991	0.332
LIG_LIR_Nem_3	271	277	PF02991	0.619
LIG_PCNA_yPIPBox_3	279	292	PF02747	0.511
LIG_Rb_LxCxE_1	874	897	PF01857	0.546
LIG_REV1ctd_RIR_1	1021	1031	PF16727	0.361
LIG_SH2_CRK	168	172	PF00017	0.452
LIG_SH2_CRK	562	566	PF00017	0.400
LIG_SH2_GRB2like	600	603	PF00017	0.380
LIG_SH2_PTP2	109	112	PF00017	0.451
LIG_SH2_SRC	1146	1149	PF00017	0.528
LIG_SH2_STAT3	600	603	PF00017	0.526
LIG_SH2_STAT5	1035	1038	PF00017	0.609
LIG_SH2_STAT5	109	112	PF00017	0.451
LIG_SH2_STAT5	1146	1149	PF00017	0.528
LIG_SH2_STAT5	185	188	PF00017	0.561
LIG_SH2_STAT5	212	215	PF00017	0.600
LIG_SH2_STAT5	291	294	PF00017	0.613
LIG_SH2_STAT5	436	439	PF00017	0.529
LIG_SH2_STAT5	628	631	PF00017	0.476
LIG_SH2_STAT5	989	992	PF00017	0.577
LIG_SH3_3	1063	1069	PF00018	0.585
LIG_SH3_3	107	113	PF00018	0.465
LIG_SH3_3	228	234	PF00018	0.447
LIG_SH3_3	377	383	PF00018	0.677
LIG_SH3_3	478	484	PF00018	0.519
LIG_SH3_3	576	582	PF00018	0.502
LIG_SH3_3	799	805	PF00018	0.653
LIG_SH3_3	84	90	PF00018	0.593
LIG_SH3_3	946	952	PF00018	0.670
LIG_SUMO_SIM_par_1	141	146	PF11976	0.448
LIG_SUMO_SIM_par_1	393	398	PF11976	0.535
LIG_TRAF2_1	332	335	PF00917	0.574
LIG_TRAF2_1	445	448	PF00917	0.516
LIG_TRAF2_1	476	479	PF00917	0.527
LIG_TRAF2_1	737	740	PF00917	0.669
LIG_UBA3_1	544	552	PF00899	0.477
LIG_WW_1	731	734	PF00397	0.528
MOD_CDK_SPK_2	395	400	PF00069	0.647
MOD_CK1_1	1004	1010	PF00069	0.626
MOD_CK1_1	1101	1107	PF00069	0.700
MOD_CK1_1	1108	1114	PF00069	0.542
MOD_CK1_1	236	242	PF00069	0.517
MOD_CK1_1	506	512	PF00069	0.695
MOD_CK1_1	690	696	PF00069	0.688
MOD_CK1_1	70	76	PF00069	0.714
MOD_CK1_1	749	755	PF00069	0.686
MOD_CK1_1	767	773	PF00069	0.662
MOD_CK1_1	941	947	PF00069	0.693
MOD_CK2_1	1004	1010	PF00069	0.744
MOD_CK2_1	1070	1076	PF00069	0.429
MOD_CK2_1	1088	1094	PF00069	0.669
MOD_CK2_1	328	334	PF00069	0.601
MOD_CK2_1	414	420	PF00069	0.504
MOD_CK2_1	473	479	PF00069	0.537
MOD_CK2_1	510	516	PF00069	0.608
MOD_CK2_1	569	575	PF00069	0.524
MOD_CK2_1	650	656	PF00069	0.503
MOD_CK2_1	690	696	PF00069	0.680
MOD_CK2_1	700	706	PF00069	0.815
MOD_CK2_1	777	783	PF00069	0.724
MOD_CK2_1	792	798	PF00069	0.649
MOD_CK2_1	877	883	PF00069	0.692
MOD_Cter_Amidation	57	60	PF01082	0.517
MOD_GlcNHglycan	1059	1062	PF01048	0.741
MOD_GlcNHglycan	1100	1103	PF01048	0.587
MOD_GlcNHglycan	235	238	PF01048	0.602
MOD_GlcNHglycan	24	27	PF01048	0.659
MOD_GlcNHglycan	270	273	PF01048	0.386
MOD_GlcNHglycan	301	304	PF01048	0.736
MOD_GlcNHglycan	37	40	PF01048	0.468
MOD_GlcNHglycan	473	476	PF01048	0.549
MOD_GlcNHglycan	496	499	PF01048	0.418
MOD_GlcNHglycan	505	508	PF01048	0.462
MOD_GlcNHglycan	53	56	PF01048	0.601
MOD_GlcNHglycan	530	533	PF01048	0.747
MOD_GlcNHglycan	635	639	PF01048	0.489
MOD_GlcNHglycan	689	692	PF01048	0.629
MOD_GlcNHglycan	70	73	PF01048	0.732
MOD_GlcNHglycan	702	705	PF01048	0.697
MOD_GlcNHglycan	712	715	PF01048	0.781
MOD_GlcNHglycan	779	783	PF01048	0.555
MOD_GlcNHglycan	873	876	PF01048	0.601
MOD_GlcNHglycan	934	939	PF01048	0.747
MOD_GlcNHglycan	940	943	PF01048	0.688
MOD_GSK3_1	1094	1101	PF00069	0.753
MOD_GSK3_1	1108	1115	PF00069	0.710
MOD_GSK3_1	1142	1149	PF00069	0.657
MOD_GSK3_1	143	150	PF00069	0.467
MOD_GSK3_1	196	203	PF00069	0.704
MOD_GSK3_1	22	29	PF00069	0.642
MOD_GSK3_1	236	243	PF00069	0.629
MOD_GSK3_1	307	314	PF00069	0.682
MOD_GSK3_1	409	416	PF00069	0.618
MOD_GSK3_1	494	501	PF00069	0.545
MOD_GSK3_1	506	513	PF00069	0.681
MOD_GSK3_1	524	531	PF00069	0.733
MOD_GSK3_1	547	554	PF00069	0.546
MOD_GSK3_1	622	629	PF00069	0.647
MOD_GSK3_1	634	641	PF00069	0.528
MOD_GSK3_1	652	659	PF00069	0.527
MOD_GSK3_1	66	73	PF00069	0.675
MOD_GSK3_1	686	693	PF00069	0.539
MOD_GSK3_1	710	717	PF00069	0.802
MOD_GSK3_1	742	749	PF00069	0.606
MOD_GSK3_1	760	767	PF00069	0.473
MOD_GSK3_1	877	884	PF00069	0.699
MOD_GSK3_1	889	896	PF00069	0.711
MOD_GSK3_1	934	941	PF00069	0.671
MOD_GSK3_1	994	1001	PF00069	0.626
MOD_LATS_1	65	71	PF00433	0.679
MOD_N-GLC_1	718	723	PF02516	0.578
MOD_NEK2_1	250	255	PF00069	0.507
MOD_NEK2_1	298	303	PF00069	0.740
MOD_NEK2_1	337	342	PF00069	0.708
MOD_NEK2_1	503	508	PF00069	0.506
MOD_NEK2_1	622	627	PF00069	0.650
MOD_NEK2_1	634	639	PF00069	0.528
MOD_NEK2_1	686	691	PF00069	0.705
MOD_NEK2_1	718	723	PF00069	0.600
MOD_NEK2_1	889	894	PF00069	0.679
MOD_NEK2_1	940	945	PF00069	0.780
MOD_NEK2_1	965	970	PF00069	0.557
MOD_NEK2_1	972	977	PF00069	0.586
MOD_NEK2_2	547	552	PF00069	0.519
MOD_PIKK_1	1001	1007	PF00454	0.489
MOD_PIKK_1	1086	1092	PF00454	0.788
MOD_PIKK_1	1101	1107	PF00454	0.607
MOD_PIKK_1	190	196	PF00454	0.490
MOD_PIKK_1	291	297	PF00454	0.514
MOD_PIKK_1	43	49	PF00454	0.482
MOD_PIKK_1	678	684	PF00454	0.700
MOD_PIKK_1	690	696	PF00454	0.606
MOD_PK_1	1070	1076	PF00069	0.429
MOD_PK_1	1136	1142	PF00069	0.685
MOD_PK_1	376	382	PF00069	0.810
MOD_PKA_1	1070	1076	PF00069	0.429
MOD_PKA_1	1136	1142	PF00069	0.684
MOD_PKA_1	376	382	PF00069	0.815
MOD_PKA_2	1057	1063	PF00069	0.712
MOD_PKA_2	1070	1076	PF00069	0.462
MOD_PKA_2	1098	1104	PF00069	0.593
MOD_PKA_2	1105	1111	PF00069	0.602
MOD_PKA_2	1136	1142	PF00069	0.645
MOD_PKA_2	376	382	PF00069	0.809
MOD_PKA_2	626	632	PF00069	0.635
MOD_PKA_2	66	72	PF00069	0.651
MOD_PKA_2	666	672	PF00069	0.553
MOD_PKA_2	687	693	PF00069	0.672
MOD_PKA_2	707	713	PF00069	0.754
MOD_PKA_2	783	789	PF00069	0.785
MOD_PKB_1	1134	1142	PF00069	0.732
MOD_PKB_1	309	317	PF00069	0.691
MOD_PKB_1	374	382	PF00069	0.655
MOD_PKB_1	604	612	PF00069	0.600
MOD_Plk_1	227	233	PF00069	0.553
MOD_Plk_1	676	682	PF00069	0.613
MOD_Plk_1	889	895	PF00069	0.535
MOD_Plk_4	1136	1142	PF00069	0.696
MOD_Plk_4	114	120	PF00069	0.480
MOD_Plk_4	250	256	PF00069	0.564
MOD_Plk_4	311	317	PF00069	0.693
MOD_Plk_4	456	462	PF00069	0.457
MOD_Plk_4	498	504	PF00069	0.467
MOD_Plk_4	742	748	PF00069	0.446
MOD_Plk_4	760	766	PF00069	0.580
MOD_Plk_4	767	773	PF00069	0.763
MOD_Plk_4	889	895	PF00069	0.681
MOD_Plk_4	90	96	PF00069	0.536
MOD_ProDKin_1	104	110	PF00069	0.377
MOD_ProDKin_1	145	151	PF00069	0.486
MOD_ProDKin_1	329	335	PF00069	0.753
MOD_ProDKin_1	395	401	PF00069	0.654
MOD_ProDKin_1	506	512	PF00069	0.736
MOD_ProDKin_1	72	78	PF00069	0.534
MOD_ProDKin_1	753	759	PF00069	0.703
MOD_ProDKin_1	764	770	PF00069	0.606
MOD_ProDKin_1	942	948	PF00069	0.583
TRG_DiLeu_BaEn_4	478	484	PF01217	0.519
TRG_DiLeu_BaEn_4	825	831	PF01217	0.609
TRG_DiLeu_BaLyEn_6	641	646	PF01217	0.623
TRG_DiLeu_BaLyEn_6	949	954	PF01217	0.739
TRG_ENDOCYTIC_2	109	112	PF00928	0.451
TRG_ENDOCYTIC_2	168	171	PF00928	0.453
TRG_ENDOCYTIC_2	562	565	PF00928	0.514
TRG_ER_diArg_1	1012	1014	PF00400	0.511
TRG_ER_diArg_1	1069	1071	PF00400	0.610
TRG_ER_diArg_1	1132	1135	PF00400	0.770
TRG_ER_diArg_1	119	121	PF00400	0.505
TRG_ER_diArg_1	183	185	PF00400	0.514
TRG_ER_diArg_1	220	223	PF00400	0.657
TRG_ER_diArg_1	309	312	PF00400	0.641
TRG_ER_diArg_1	374	377	PF00400	0.737
TRG_ER_diArg_1	59	61	PF00400	0.521
TRG_ER_diArg_1	917	920	PF00400	0.606
TRG_ER_diArg_1	982	984	PF00400	0.687
TRG_NES_CRM1_1	812	826	PF08389	0.504
TRG_Pf-PMV_PEXEL_1	631	635	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P548	Leptomonas seymouri	45%	100%
A0A3S7X755	Leishmania donovani	72%	99%
A4I9A6	Leishmania infantum	70%	100%
E9B4A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	99%
Q4Q3S0	Leishmania major	73%	100%