LIM zinc-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLX5_LEIBR

TriTrypDb:

LbrM.33.2920 , LBRM2903_330037100

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLX5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	328	332	PF00656	0.501
CLV_C14_Caspase3-7	34	38	PF00656	0.646
CLV_NRD_NRD_1	188	190	PF00675	0.388
CLV_NRD_NRD_1	209	211	PF00675	0.312
CLV_NRD_NRD_1	273	275	PF00675	0.660
CLV_PCSK_KEX2_1	115	117	PF00082	0.624
CLV_PCSK_KEX2_1	188	190	PF00082	0.388
CLV_PCSK_KEX2_1	208	210	PF00082	0.313
CLV_PCSK_KEX2_1	273	275	PF00082	0.628
CLV_PCSK_KEX2_1	322	324	PF00082	0.490
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.624
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.393
CLV_PCSK_SKI1_1	278	282	PF00082	0.591
DEG_SPOP_SBC_1	45	49	PF00917	0.652
DEG_SPOP_SBC_1	85	89	PF00917	0.576
DOC_USP7_MATH_1	191	195	PF00917	0.324
DOC_USP7_MATH_1	22	26	PF00917	0.528
DOC_USP7_MATH_1	224	228	PF00917	0.312
DOC_USP7_MATH_1	46	50	PF00917	0.645
DOC_USP7_MATH_1	85	89	PF00917	0.587
DOC_USP7_UBL2_3	54	58	PF12436	0.536
DOC_WW_Pin1_4	179	184	PF00397	0.231
DOC_WW_Pin1_4	342	347	PF00397	0.664
LIG_14-3-3_CanoR_1	273	280	PF00244	0.709
LIG_14-3-3_CanoR_1	311	320	PF00244	0.500
LIG_BIR_II_1	1	5	PF00653	0.524
LIG_BRCT_BRCA1_1	129	133	PF00533	0.498
LIG_BRCT_BRCA1_1	193	197	PF00533	0.312
LIG_CtBP_PxDLS_1	299	303	PF00389	0.550
LIG_FHA_1	1	7	PF00498	0.569
LIG_FHA_1	10	16	PF00498	0.617
LIG_FHA_1	115	121	PF00498	0.472
LIG_FHA_1	347	353	PF00498	0.724
LIG_FHA_1	46	52	PF00498	0.626
LIG_FHA_1	78	84	PF00498	0.688
LIG_FHA_2	143	149	PF00498	0.484
LIG_FHA_2	326	332	PF00498	0.496
LIG_Integrin_isoDGR_2	365	367	PF01839	0.555
LIG_Integrin_RGD_1	254	256	PF01839	0.608
LIG_LIR_Gen_1	256	263	PF02991	0.524
LIG_LIR_Gen_1	317	326	PF02991	0.465
LIG_LIR_Nem_3	148	153	PF02991	0.392
LIG_LIR_Nem_3	256	261	PF02991	0.526
LIG_MLH1_MIPbox_1	129	133	PF16413	0.467
LIG_MLH1_MIPbox_1	193	197	PF16413	0.312
LIG_SH2_CRK	143	147	PF00017	0.402
LIG_SH2_CRK	163	167	PF00017	0.477
LIG_SH2_CRK	250	254	PF00017	0.461
LIG_SH2_NCK_1	258	262	PF00017	0.529
LIG_SH2_STAP1	77	81	PF00017	0.666
LIG_SH2_STAT3	326	329	PF00017	0.484
LIG_SH2_STAT5	132	135	PF00017	0.519
LIG_SH2_STAT5	168	171	PF00017	0.662
LIG_SH2_STAT5	217	220	PF00017	0.338
LIG_SH2_STAT5	327	330	PF00017	0.482
LIG_SH3_2	183	188	PF14604	0.388
LIG_SH3_3	128	134	PF00018	0.471
LIG_SH3_3	170	176	PF00018	0.526
LIG_SH3_3	180	186	PF00018	0.324
LIG_SH3_3	294	300	PF00018	0.453
LIG_SH3_3	88	94	PF00018	0.678
MOD_CK1_1	135	141	PF00069	0.592
MOD_CK1_1	314	320	PF00069	0.555
MOD_CK1_1	47	53	PF00069	0.643
MOD_CK1_1	79	85	PF00069	0.646
MOD_CK1_1	97	103	PF00069	0.568
MOD_CK2_1	142	148	PF00069	0.486
MOD_Cter_Amidation	54	57	PF01082	0.537
MOD_GlcNHglycan	101	104	PF01048	0.585
MOD_GlcNHglycan	134	137	PF01048	0.638
MOD_GlcNHglycan	24	27	PF01048	0.604
MOD_GlcNHglycan	313	316	PF01048	0.552
MOD_GlcNHglycan	340	343	PF01048	0.696
MOD_GlcNHglycan	88	91	PF01048	0.602
MOD_GSK3_1	310	317	PF00069	0.534
MOD_GSK3_1	338	345	PF00069	0.637
MOD_GSK3_1	45	52	PF00069	0.653
MOD_GSK3_1	75	82	PF00069	0.581
MOD_GSK3_1	95	102	PF00069	0.740
MOD_N-GLC_1	311	316	PF02516	0.576
MOD_N-GLC_2	172	174	PF02516	0.483
MOD_N-GLC_2	178	180	PF02516	0.373
MOD_NEK2_1	197	202	PF00069	0.231
MOD_NEK2_1	63	68	PF00069	0.541
MOD_NEK2_1	96	101	PF00069	0.603
MOD_NEK2_2	191	196	PF00069	0.312
MOD_PIKK_1	325	331	PF00454	0.503
MOD_PKA_1	208	214	PF00069	0.231
MOD_PKA_1	56	62	PF00069	0.527
MOD_PKA_2	208	214	PF00069	0.388
MOD_PKA_2	272	278	PF00069	0.515
MOD_PKA_2	310	316	PF00069	0.476
MOD_PKA_2	94	100	PF00069	0.753
MOD_Plk_1	126	132	PF00069	0.628
MOD_Plk_2-3	30	36	PF00069	0.508
MOD_Plk_4	127	133	PF00069	0.553
MOD_Plk_4	191	197	PF00069	0.335
MOD_Plk_4	233	239	PF00069	0.487
MOD_Plk_4	38	44	PF00069	0.589
MOD_ProDKin_1	179	185	PF00069	0.231
MOD_ProDKin_1	342	348	PF00069	0.667
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.486
TRG_ENDOCYTIC_2	143	146	PF00928	0.398
TRG_ENDOCYTIC_2	217	220	PF00928	0.312
TRG_ENDOCYTIC_2	250	253	PF00928	0.548
TRG_ENDOCYTIC_2	258	261	PF00928	0.515
TRG_ER_diArg_1	187	189	PF00400	0.388
TRG_ER_diArg_1	208	210	PF00400	0.231
TRG_NLS_MonoExtC_3	55	60	PF00514	0.531
TRG_NLS_MonoExtN_4	54	60	PF00514	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCS1	Leptomonas seymouri	50%	94%
A0A3S7X718	Leishmania donovani	65%	86%
A4I9A4	Leishmania infantum	65%	86%
E9B4A4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	86%
Q4Q3S2	Leishmania major	65%	100%